• The Korean Journal of Physiology and Pharmacology
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• v.24 no.6
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• pp.481-492
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• 2020

The present study aimed to examine the effect of allyl isothiocyanate (AITC) on chronic obstructive pulmonary disease and to investigate whether upregulation of multidrug resistance-associated protein 1 (MRP1) associated with the activation of the PARK7 (DJ-1)/nuclear factor erythroid 2-related factor 2 (Nrf2) axis. Lung function indexes and histopathological changes in mice were assessed by lung function detection and H&E staining. The expression levels of Nrf2, MRP1, heme oxygenase-1 (HO-1), and DJ-1 were determined by immunohistochemistry, Western blotting and reverse transcription-quantitative polymerase chain reaction. Next, the expression of DJ-1 in human bronchial epithelial (16HBE) cells was silenced by siRNA, and the effect of DJ-1 expression level on cigarette smoke extract (CSE)-stimulated protein degradation and AITC-induced protein expression was examined. The expression of DJ-1, Nrf2, HO-1, and MRP1 was significantly decreased in the wild type model group, while the expression of each protein was significantly increased after administration of AITC. Silencing the expression of DJ-1 in 16HBE cells accelerated CSE-induced protein degradation, and significantly attenuated the AITC-induced mRNA and protein expression of Nrf2 and MRP1. The present study describes a novel mechanism by which AITC induces MRP1 expression by protecting against CS/CSE-mediated DJ-1 protein degradation via activation of the DJ-1/Nrf2 axis.

• Advances in environmental research
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• v.9 no.2
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• pp.135-150
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• 2020

Many industries, such as textiles, chemical refineries, leather, plastics and paper, use different dyes in various process steps. At the same time, these industrial sectors are responsible for discharging contaminants that are harmful and toxic to humans and microorganisms by introducing synthetic dyes into wastewater. Of these dyes, methylene blue dye, which is classified as basic dyes, is accepted as a model dye. For this reason, methylene blue dye was selected in the study and its removal from the water was studied. In this study, two efficient biosorbents were developed from chitosan and sunflower waste, an agro-industrial waste and modified using iron nanoparticles. The biosorption efficiency was evaluated for methylene blue (MB) dye removal from aqueous solution under various parameters such as treating agent, solution pH, biosorbent dosage, contact time, initial dye concentration and temperature. We investigated the kinetic properties of dye removal from water for Chitosan-Sunflower (CS), Chitosan-Sunflower-Nanoiron (CSN). When the wavelength of MB dye was spectrophotometrically scanned, the maximum absorbance was determined as 660 nm. For the core shell biosorbents we obtained, we found that the optimum time for removal of MB from wastewater was 60 min. The pH of the best pH was determined as 5 in the studied pH. The most suitable temperature for the experiment was determined as 30℃. SEM-EDAX, TEM, XRD, and FTIR techniques were used to characterize biosorbents produced and modified in the experimental stage and to monitor the change of biosorbent after dye removal. The interactions of the paint with the surface used for removal were explained by these techniques. It was calculated that 80% of CS and 88% of CSN removed MB in optimum conditions. Also, the absorption of MB dye onto the surface was investigated by Langmiur and Frendlinch isotherms and it was determined from the results that the removal was more compatible with Langmiur isotherm.

• Nuclear Engineering and Technology
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• v.52 no.5
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• pp.1029-1035
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• 2020

The detector suffers from pulse pileup by overlapping of the signals when it was used in high radiation fields. The pulse pileup deteriorates the energy spectrum and causes count losses due to random co-incidences, which might not resolve within the resolving time of the detection system. In this study, it is aimed to propose a new pulse pileup correction method. The proposed method is to correct the start point of the pileup pulse. The parameters are obtained from the fitted exponential curve using the peak point of the previous pulse and the start point of the pileup pulse. The amplitude at the corrected start point of the pileup pulse can be estimated by the peak time of the pileup pulse. The system is composed of a NaI (Tl) scintillation crystal, a photomultiplier tube, and an oscilloscope. A 61 μCi ¹³⁷Cs check-source was placed at a distance of 3 cm, 5 cm, and 10 cm, respectively. The gamma energy spectra for the radioisotope of ¹³⁷Cs were obtained to verify the proposed method. As a result, the correction of the pulse pileup through the proposed method shows a remarkable improvement of FWHM at 662 keV by 29, 39, and 7%, respectively.

• The korean journal of orthodontics
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• v.51 no.2
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• pp.95-104
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• 2021

Objective: To evaluate the trueness and precision of full-arch scans acquired using five intraoral scanners and investigate the factors associated with the dimensional accuracy of the intraoral scan data. Methods: Nine adult participants (mean age, 34.3 ± 8.3 years) were recruited. Four zirconium spheres (Ø 6 mm) were bonded to the canines and the molars. Following acquisition of reference scans using an industrial-grade scanner, five intraoral scanners, namely i500, CS3600, Trios 3, iTero, and CEREC Omnicam, were used to scan the arches. Linear distances between the four reference spheres were automatically calculated, and linear mixed model analysis was performed to compare the trueness and precision of the intraoral scan data among the different scanners. Results: The absolute mean trueness and precision values for all intraoral scanners were 76.6 ± 79.3 and 56.6 ± 52.4 ㎛, respectively. The type of scanner and the measured linear distances had significant effects on the accuracy of the intraoral scan data. With regard to trueness, errors in the intermolar dimension and the distance from the canine to the contralateral molar were greater with Omnicam than with the other scanners. With regard to precision, the error in the linear distance from the canine to the molar in the same quadrant was greater with Omnicam and CS3600 than with the other scanners. Conclusions: The dimensional accuracy of intraoral scan data may differ significantly according to the type of scanner, with the amount of error in terms of trueness being clinically significant.

• Nuclear Engineering and Technology
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• v.10 no.3
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• pp.153-163
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• 1978

The problems of solid waste disposal into the ground in connection with environmental aspects in the vicinity of a site would be very significant, though ground disposal for solid waste is safe and economical method. Studies of the waste-movement and migration of radionuclides (Sr-90 and Cs-137) for the disposal into the ground were performed under laboratory and field conditions. Affinity of the soils for radionuclide solution was higher than that in the acid solution. The sorption of radionuclides by the soils showed a time-dependent reation. The migration rates of radiostrontium and radiocesium were a range of 3.73$\times$10$^{-3}$ to 10.9$\times$10$^{-3}$ cm/day. The nuclides in the soil migrate much more slowly than the water, probably due to its high exchange capacity. The observed distribution of tritium was compared with that calculated by a mathematical model based on diffusivity. This study suggests that the tritiated water can be used to trace the movement of ground water.

• International conference on construction engineering and project management
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• 2009.05a
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• pp.409-416
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• 2009

This paper presents a tool called Quality-Cost optimization system (QCOS), which integrates Multi-Objective Genetic Algorithm (MOGA) and Quality Function Deployment (QFD), for tradeoff between quality and cost of the unitized metal curtain-wall unit. A construction owner as the external customer pursues to maximize the quality of the curtain-wall unit. However, the contractor as the internal customer pursues to minimize the cost involved in designing, manufacturing and installing the curtain-wall unit. It is crucial for project manager to find the tradeoff point which satisfies the conflicting interests pursued by the both parties. The system would be beneficial to establish a quality plan satisfying the both parties. Survey questionnaires were administered to the construction owner who has an experience of curtain-wall project, the architects who are the independent assessor, and the contractors who were involved in curtain-wall design and installation. The Customer Requirements (CRs) and their importance weights, the relationship between CRs and Technical Attributes (TAs) consisting of a curtain-wall unit, and the cost ratios of each components consisting curtain-wall unit are obtained from the three groups mentioned previously. The data obtained from the surveys were used as the QFD input to compute the Owner Satisfaction (OS) and Contractor Satisfaction (CS). MOGA is applied to optimize resource allocation under limited budget when multi-objectives, OS and CS, are pursued at the same time. The deterministic multi-objective optimization method using MOGA and QFD is extended to stochastic model to better deal with the uncertainties of QFD input and the variability of QFD output. A case study demonstrates the system and verifies the system conformance.

• International Journal of Computer Science & Network Security
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• v.24 no.4
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• pp.60-66
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• 2024

Host's data during transmission. Data tempering results in loss of host's sensitive information, which includes number of VM, storage availability, and other information. In the distributed cloud environment, each server (computing server (CS)) configured with Local Resource Monitors (LRMs) which runs independently and performs Virtual Machine (VM) migrations to nearby servers. Approaches like predictive VM migration [21] [22] by each server considering nearby server's CPU usage, roatative decision making capacity [21] among the servers in distributed cloud environment has been proposed. This approaches usage underlying server's computing power for predicting own server's future resource utilization and nearby server's resource usage computation. It results in running VM and its running application to remain in waiting state for computing power. In order to reduce this, a decentralized decision making hybrid model for VM migration need to be proposed where servers in decentralized cloud receives, future resource usage by analytical computing system and takes decision for migrating VM to its neighbor servers. Host's in the decentralized cloud shares, their detail with peer servers after fixed interval, this results in chance to tempering messages that would be exchanged in between HC and CH. At the same time, it reduces chance of over utilization of peer servers, caused due to compromised host. This paper discusses, an roatative decisive (RD) approach for VM migration among peer computing servers (CS) in decentralized cloud environment, preserving confidentiality and integrity of the host's data. Experimental result shows that, the proposed predictive VM migration approach reduces extra VM migration caused due over utilization of identified servers and reduces number of active servers in greater extent, and ensures confidentiality and integrity of peer host's data.

• Wind and Structures
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• v.26 no.3
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• pp.147-161
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• 2018

For wind engineering applications downbursts are, presently, almost exclusively modeled, both experimentally and numerically, as transient impinging momentum jets (IJ), even though that model contains none of the physics of real events. As a result, there is no connection between the IJ-simulated downburst wind fields and the conditions of formation of the event. The cooling source (CS) model offers a significant improvement since it incorporates the negative buoyancy forcing and baroclinic vorticity generation that occurs in nature. The present work aims at using large-scale numerical simulation of downburst-producing thunderstorms to develop a simpler model that replicates some of the key physics whilst maintaining the relative simplicity of the IJ model. Using an example of such a simulated event it is found that the non-linear scaling of the velocity field, based on the peak potential temperature (and, hence, density) perturbation forcing immediately beneath the storm cloud, produces results for the radial location of the peak radial outflow wind speeds near the ground, the magnitude of that peak and the time at which the peak occurs that match well (typically within 5%) of those produced from a simple axi-symmetric constant-density dense source simulation. The evolution of the downdraft column within the simulated thunderstorm is significantly more complex than in any axi-symmetric model, with a sequence of downdraft winds that strengthen then weaken within a much longer period (>17 minutes) of consistently downwards winds over almost all heights up to at least 2,500 m.

• Journal of Convergence Society for SMB
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• v.6 no.2
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• pp.11-17
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• 2016

Recently, As the IT skills development, the different kinds of data (or information) generated by the company are becoming more frequent leaked to outside organizations and individuals. However, it is insufficient situation to reduce the dysfunctional corporate information at the enterprise level. In this paper, we propose a role-based enterprise information processing model to minimize the dysfunctions of corporate information. The proposed model is to allow you to set protect corporate information through the relevant departments for the management and supervision of enterprise information, and rapid and systematic recovery and operating strategy was to improve the efficiency of enterprise information services. The proposed model is caught blocking access to information access to information to establish a rapid and systematic recovery and operational continuity strategy after the administrator user permissions and roles that access to information is centrally managed by the user when the abnormality. In experimental results, virus damage was lower 48.8% than the previous model. In addition, information on the number of dysfunction distribution occurring within the company gained 17.9% lower results than the previous model.

• Journal of Convergence for Information Technology
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• v.10 no.7
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• pp.138-146
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• 2020

The paper deals with comparative study of characteristics of surrogate models and sensitivity evaluation using design of experiments in order to enhance and analysis the structure design of an automatic salt collector under various design load conditions. Orthogonal array design based on numerical analysis was used for the design of experiments. The thickness sizing variables of main structure member were considered the design factors, and the output responses were selected from the strength performances as well as the weight. The quantitative effects on responses for each design factor were evaluated from the orthogonal array experiment. Optimum design case was also identified to improve the strength performances with weight minimization. Using the orthogonal array experiment. various surrogate models such as response surface model, Kriging model, and Chebyshev orthogonal polynomial were generated. The orthogonal array experiment results were validated by the surrogate modeling results. The most suitable surrogate model was the response surface model for the exploration of design space of the automatic salt collector.