• Journal of Auto-vehicle Safety Association
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• v.5 no.2
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• pp.39-44
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• 2013

Motor vehicle crashes are the leading cause (70%) of children injury and fatality. 98% of Children under the age of 9 who came to emergency room with a traffic accident are not seated in CRS. Reduction in mortality when using CRS (NHTSA study), 71% for infants of 1-2 years old, 54% for 3-6 years old and 7-12 years old. It is very important and essential to use CRS for child passenger safety. But in Korean market, the CRS fitment rate is relatively low (20~40%). For European market, at the start of 2013, Euro NCAP started to check how easy it is to install the most common seats. And US market, NHTSA is planning a new consumer information program of CRS fitment for near future. This study examines CRS installation performance of 3 vehicles which are produced by GM Korea and 21 CRS which are based on sales volume in Korean market. Purpose of this study is to identify both vehicle and CRS design that causes bad interaction for CRS installation.

• Asia pacific journal of information systems
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• v.1 no.1
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• pp.165-181
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• 1991

This paper presents a developmental approach undertaken by Asiana Airlines to implement computerized reservation system (CRS), Asiana Airlines is a new entrant into the once monopolized airline business in Korea. As a new entrant, it was absolutely necessary to develop CRS fast to begin the business in a relatively short period of time. By taking the risk of choosing Airline Control System which no airlines has yet implemented CRS with, Asiana Airlines was able to shorten development time considerably as well as integrate CRS with internal management information systems. This enhances system flexibility greatly. It is initially viewed that developing CRS is not to get competitive advantage but to overcome competitive disadvantage at Asiana Airlines. The paper also surveys the changing environment of CRS in general and the future implementation plan for ARTIS(Asiana Airline Reservation and Travel Information System) to be more of a competitive weapon in increasingly competitive international air travel market.

• Journal of Soil and Groundwater Environment
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• v.13 no.6
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• pp.62-71
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• 2008

Soil quality standards (SQS) are necessary to protect the human health and soil biota from the exposure to soil pollutants. The current SQS in Korea contain only sixteen substances, and it is scheduled to expand the number of substances. Chemical ranking and scoring (CRS) system is very effective to screen the priority chemicals for the future SQS in terms of their toxicity and exposure potential. In this study, several CRS systems were extensively compared to propose the assessment factors that required for the screening of soil pollutants The CRS systems considered in this study include the CHEMS-1 (Chemical Hazard Evaluation for Management Strategies), SCRAM (Scoring and Ranking Assessment Model), EURAM (European Union Risk Ranking Method), ARET (Accelerated Reduction/Elimination of Toxics), CRSKorea, and other systems. The additional assessment factors of CRS suitable for soil pollutants were suggested. We suggest soil adsorption factor as an appropriate factor of CRS system to consider chemical transport from soil to groundwater. Other factors such as soil emission rate and cases of accident of soil pollutants were included. These results were reflected to screen the priority chemicals in Korea, as a part of the project entitled ‘Setting the Priority of Soil Contaminants'.

• Journal of The Korean Association For Science Education
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• v.34 no.3
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• pp.273-283
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• 2014

The purpose of this study was to examine the potential of the use of the Classroom Response System (CRS), a kind of new ICT medium, in a quiz problem-solving oriented high school life science class. To find the usefulness of CRS as a teaching and learning strategy, the CRS group (n=34) sent prompt individual answers to the teachers' questions using the CRS terminal (Clicker), and the teacher then asked additional reasons of the individuals and gave personalized feedback. In the control group (n=35), the CRS was not used while the teacher asked overall questions and gave feedback in an undifferentiated way. As a result, the CRS increased students' interest and concentration during class, but there were no significant differences in study achievement between the two groups. However, there were significant differences between the medium-level groups when the two groups were divided into smaller ones based on their pre-scores. We suggest that, for effective use of the CRS for diagnostic and formative assessment, teachers should develop a teaching and learning strategy that can produce appropriate questions of various levels in advance, investigate the exact reasons for students' answers, and give customized feedback by individual as much as possible.

• Environmental Analysis Health and Toxicology
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• v.24 no.2
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• pp.95-105
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• 2009

Chemical Ranking and Scoring (CRS) system is a useful tool to screen priority chemicals of large body of substances. The relative ranking of chemicals based on CRS system has served as a decision-making support tools. Exposure potential and toxicity are significant parameters in CRS system, and there are differences in evaluating those parameters in each CRS system. In this study, the parameters of exposure potential, human toxicity, and ecotoxicity were extensively compared. In addition the scoring methods in each parameter were analyzed. The CRS systems considered in this study include the CHEMS-1 (Chemical Hazard Evaluation for Management Strategies), SCRAM (Scoring and Ranking Assessment Model), EURAM (European Union Risk Ranking Method), ARET (Accelerated Reduction/Elimination of Toxics), and CRS-Korea. An comparative analysis of the several CRS systems is presented based on their assessment parameters and scoring methods.

• Environmental Analysis Health and Toxicology
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• v.25 no.1
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• pp.41-55
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• 2010

The aims of this study were to develop the suitable "system software" in chemical ranking and scoring (CRS) for the food hazardous chemicals associated with environmental emission and to suggest the priority lists of food contamination by environmental-origined pollutants. Study materials were selected with reference to the priority pollutants list for environment and food management from domestic and foreign research and the number of study materials is 103 pollutants (18 heavy metals, 10 PBTs, 10 EDs, and 65 organic compounds). The Food-CRS-Korea system consisted of the environmental fate model via multimedia, transfer environment to food model, and health risk assessment by contaminated food intake. We have established that health risks of excess cancer risks, hazard quotients (HQs) by chronic toxicity and HQs by reproductive toxicity convert to score, respectively. The creditable scoring system was designed to consider uncertainty of quantitative risk assessment based on VOI (Value-Of-Information). The predictability of the Food-CRS-Korea model was evaluated by comparing the presumable values and the measured ones of the environmental media and foodstuffs. The priority lists based on emissions with background-level-correction are 15 pollutants such as arsenic, cadmium, and etc. The priority lists based on environmental monitoring date are 17 pollutants including DEHP, TCDD, and so on. Consequently, we suggested the priority lists of 13 pollutants by considering the several emission and exposure scenarios. According to the Food-CRS-Korea system, arsenics, cadmium, chromes, DEHP, leads, and nickels have high health risk rates and reliable grades.

• Nutrition Research and Practice
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• v.6 no.6
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• pp.505-512
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• 2012

Many aging male suffer various andropause symptoms including loss of physical and mental activities. This study evaluated the putative alleviative effects of CRS-10 dandelion and rooibos extract complex (CRS-10) on the symptoms of andropause. The survival rate of TM3 Leydig cells (TM3 cells) treated with CRS-10 was measured based on typical physiological stress. After daily intake of CRS-10 for 4 weeks, the level of testosterone, physical activity and both the number and activity of sperm in older rats (18 weeks) were measured. Furthermore, thirty males were surveyed with AMS (Aging Males' Symptoms) questionnaire after intake of 400 mg of CRS-10. Overall, CRS-10 protected TM3 cells from serum restriction and oxidative stress via activation of ERK and Akt pathways. The level of testosterone and activation of spermatogenesis in rats were significantly enhanced. In addition, physical locomotion was markedly improved. Daily intake of 400 mg of CRS-10 improved the quality of life among agingmale respondents, according to a clinical survey using the AMS. The results indicate the potential of CRS-10 as a safe and efficacious natural substance for reducing or alleviating andropause symptoms.

• Environmental Analysis Health and Toxicology
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• v.20 no.4 s.51
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• pp.311-325
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• 2005

A chemical ranking and scoring system, CRS - Korea, has recently been developed and proposed to use to prioritize on a screening level the toxic chemicals for monitoring and risk assessment. As CRS-Korea requires rigorous assessments prior to its wide application, an assessment was conducted in this study by examining the contribution of individual parameter score to the final chemical score or ranking. The sensitivity of the system to the default values for various parameters of missing data was also tested. The chemical ranking/score was round to depend primarily on the score of a single parameter, i. e., the chemical release, while toxicity scores show little correlation with the priority Further analysis indicated that the dominating effect of the chemical release results from i) its multiplicative relationship with the other two exposure parameters (biodegradation and persistent) and ii) the fact that a maximum score of 10 was assigned to the chemical release parameter while 5 was assigned for all others. AE the fraction of the data that are missing exceeded $70\%$ for various toxicity parameters at compared to less than $10\%$ for exposure parameters, the sensitivity of the ranking to the default value was not significant (rank correlation coefficient = 0.98) for toxicity parameters. Bated on this assessment, an improved CRS system (CRS - Korea II) was proposed in which the impact of the chemical release was properly adjusted by changing the multiplicative relationship to additive one and the maximum score to 5. Chemical priority was derived for each of 16 provinces by using CRS-Korea II. The chemical priority was found to significantly vary among the provinces. It was concluded that not only the national chemical priority but the local chemical priority should be taken into account in setting the nationwide chemical monitoring and risk assessment strategy.

• Journal of Ginseng Research
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• v.45 no.6
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• pp.695-705
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• 2021

Background: Ginsenosides have beneficial effects on several airway inflammatory disorders primarily through glucocorticosteroid-like anti-inflammatory activity. Among inflammatory cells, eosinophils play a major pathogenic role in conferring a risk of severe refractory diseases including chronic rhinosinusitis (CRS). However, the role of ginsenosides in reducing eosinophilic inflammation and CRS pathogenesis is unexplored. Methods: We investigated the therapeutic efficacy and underlying mechanism of ginsenoside F1 (G-F1) in comparison with those of dexamethasone, a representative glucocorticosteroid, in a murine model of CRS. The effects of G-F1 or dexamethasone on sinonasal abnormalities and infiltration of eosinophils and mast cells were evaluated by histological analyses. The changes in inflammatory cytokine levels in sinonasal tissues, macrophages, and NK cells were assessed by qPCR, ELISA, and immunohistochemistry. Results: We found that G-F1 significantly attenuated eosinophilic inflammation, mast cell infiltration, epithelial hyperplasia, and mucosal thickening in the sinonasal mucosa of CRS mice. Moreover, G-F1 reduced the expression of IL-4 and IL-13, as well as hematopoietic prostaglandin D synthase required for prostaglandin D2 production. This therapeutic efficacy was associated with increased NK cell function, without suppression of macrophage inflammatory responses. In comparison, dexamethasone potently suppressed macrophage activation. NK cell depletion nullified the therapeutic effects of G-F1, but not dexamethasone, in CRS mice, supporting a causal link between G-F1 and NK cell activity. Conclusion: Our results suggest that potentiating NK cell activity, for example with G-F1, is a promising strategy for resolving eosinophilic inflammation in CRS.

• Journal of Rhinology
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• v.60 no.1
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• pp.20-28
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• 2022

Background: Whether the use of electronic cigarettes (ECs) is associated with upper airway diseases, including chronic rhinosinusitis (CRS) and allergic rhinitis (AR), remains unclear. Methods: We analyzed data from the nationwide cross-sectional surveys: the Korea National Health and Nutrition Examination Survey VI (2013-2015), VII (2016-2018), and VIII (2019). Logistic regression analysis was performed to assess the association between EC use and CRS or AR. Results: Among a total of 38,413 participants, 6.4% were former EC users and 2.5% were current EC users. Former EC users and current EC showed a significantly increased OR for CRS or AR compared with never EC users. In the subgroup analysis, the "current CC (conventional cigarette)-current EC" and the "current CC-formal EC" group had a significantly higher OR for CRS or AR than the "current CC-never EC" group. In addition, former CC smokers who currently use ECs showed a significantly higher OR for AR than former CC smokers without EC use. Conclusions: EC use is significantly associated with a high prevalence of CRS and AR in the adult population. These results indicate that the use of ECs may increase the risk of upper airway disease.