• 대한약침학회지
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• 제10권1호통권22호
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• pp.109-119
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• 2007

In order to study the effects of Pinus densiflora on hyperlipidemia and lipid in rats, we divided the rats into groups(Normal group, Control group and Sample group) and perfomed the experimental research. Hyperlipidemia and lipid in rats were induced by high fat diets for 8weeks. The sample group was administerd the extract of Pinus densiflora for 14 days and control group was administerd equal dose of oral. And then we measured the amount of serum triglyceride, Total cholesterol, LDL-cholesterol, HDL-cholesterol, Free Fatty Acid, phospholipid, Insuline, Laptin, Body weight, epididymis fat weight & rate, epididymis fat cell, Cardiac Risk Factor(CRF). The results were as followers : 1. Sample Group showed decreasing effects on Total cholesterol, Trigylceride, LDL-cholesterol, and Phospholipid levels in serum and CRF significantly. 2. Sample Group showed increasing effects on HDL-cholesterol level in serum significantly. 3. Sample Group showed decreasing effects on Insuline in serum significantly. 4. Sample Group showed increasing effects on Laptin in serum significantly. 5. Sample Group showed decreasing effects on Body weight, epididymis fat weight & rate, epididymis fat cell significantly. According to the above results, Pinus densiflora showed significant decreasing effects on hyperlipidemia and lipid in rats, it is considered that it is appropriate to apply for hyperlipidemia, obesity.

• 한국정보과학회논문지:소프트웨어및응용
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• 제41권7호
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• pp.523-532
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• 2014

본 논문에서는 래티스상의 구조적 분류에 기반한 한국어 형태소 분석 및 품사 태깅을 수행하는 방법을 제안한다. 제안하는 방법은 입력문이 주어질 때 어휘 사전(lexicon)을 참조하여, 형태소를 노드로 취하고 인접형태소간의 에지를 갖도록 래티스를 구성하며, 구성된 래티스상 가장 점수가 높은 경로상에 있는 형태소들을 분석 결과로 제시하는 방법이다. 실험 결과, ETRI 품사 부착 코퍼스에서 기존의 1차 linear-chain CRF에 기반한 방법보다 높은 어절 정확률 그리고 문장 정확률을 얻었다.

• 한국정보과학회 언어공학연구회:학술대회논문집(한글 및 한국어 정보처리)
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• 한국정보과학회언어공학연구회 2018년도 제30회 한글 및 한국어 정보처리 학술대회
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• pp.167-171
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• 2018

개체명 인식은 문서에서 인명, 지명, 기관명 등의 고유한 의미를 나타내는 단위인 개체명을 추출하고, 추출된 개체명의 범주를 결정하는 작업이다. 최근 개체명 인식과 관련된 연구는 입력 데이터의 앞, 뒤를 고려하기 위한 Bi-RNNs와 출력 데이터 간의 전이 확률을 이용한 CRFs를 결합한 방식을 기반으로 다양한 변형의 심층학습 방법론이 제안되고 있다. 그러나 대부분의 연구는 입력 단위를 단어나 형태소로 사용하고 있으며, 성능 향상을 위해 띄어쓰기 정보, 개체명 사전 자질, 품사 분포 정보 등 다양한 정보를 필요로 한다는 어려움이 있다. 본 논문은 기본적인 학습 말뭉치에서 얻을 수 있는 문자 기반의 입력 정보와 Multi-Head Attention을 추가한 Bi-GRU/CRFs을 이용한 다국어 개체명 인식 방법을 제안한다. 한국어, 일본어, 중국어, 영어에 제안 모델을 적용한 결과 한국어와 일본어에서는 우수한 성능(한국어 $F_1$ 84.84%, 일본어 $F_1$ 89.56%)을 보였다. 영어에서는 $F_1$ 80.83%의 성능을 보였으며, 중국어는 $F_1$ 21.05%로 가장 낮은 성능을 보였다.

• 대한한의학방제학회지
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• 제17권1호
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• pp.129-140
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• 2009

Objectives : The goal of this study was to investigate the effect of Moutan Cortex as antidepressant in forced swimming test(FST) model. Methods : The expressions of corticotropin-releasing Factor(CRF), c-Fos and tyrosine hydroxylase(TH) were measured with immunohistochemical method at paraventricular nucleus (PVN), locus coeruleus(LC) and ventral tegmental area(VTA). Results : The duration of immobility in the forced swimming test was significantly decreased in the Moutan Cortex 100 mg/kg treated group in comparison with the control group(p<0.01). CRF and c-Fos expressions at PVN were decreased in the Moutan Cortex 100mg/kg treated group in comparison with the control group. But only the expression of c-Fos was shown the significance(p<0.05). TH expressions at LC and VTA were significantly decreased in the Moutan Cortex 100mg/kg and 400mg/kg treated group in comparison with the control group(p<0.001). Conclusion : According to the results, Moutan Cortex has the antidepressant effect by showing the reduced immobility through the reduction of c-Fos expression at PVN and the reduction of TH expression at LC and VTA.

• 사상체질의학회지
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• 제24권2호
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• pp.47-53
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• 2012

1. Objectives : The aim of the present study was to describe the Korea Constitutional Multicenter Bank (KCMB), which was various clinical data bank for scientific advancement of constitutional diagnosis and treatment. 2. Methods and Results : The KCMB is based on the 28 multi-institute cooperative clinical research networks including domestic and international institute. Since the KCMB was founded in 2006, data have been accumulated from 10,412 subjects. The KCMB consists of three parts: The clinical constitutional data, the measurement data, and the biological data. The method of data entry is via web based electronic Case Report From (eCRF). The eCRF has been developed and programed to ensure the efficient entry of data. We also developed coding manual, ongoing quality control assessment to obtain high-quality data. 3. Conclusions : The KCMB with various data contribute to providing the scientification of Sasang Constitutional Medicine.

• 한국정보과학회 언어공학연구회:학술대회논문집(한글 및 한국어 정보처리)
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• 한국정보과학회언어공학연구회 2011년도 제23회 한글 및 한국어 정보처리 학술대회
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• pp.90-93
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• 2011

구분분석은 문장을 분석하여 문장의 구문 구조를 밝히는 작업으로, 문장이 길어질수록 문장의 중의성이 높아져 구문분석 복잡도를 증사시키고 성능이 떨어진다. 구문분석의 복잡도를 감소시키기 위한 방법 중 하나로 구묶음을 하는데 본 논문에서는 하나의 명사처럼 쓰일 수 있는 둘 이상의 연속된 명사, 대명사, 수사, 숫자와 이를 수식하는 관형사, 접두사 및 접미사를 묶어서 복합명사 상당어구라고 정의하고 복합명사 상당어구 인식 시스템을 제안한다. 본 논문은 복합명사 상당어구 인식을 기계학습을 이용한 태그 부착 문제로 간주하였다. 문장 내 띄어쓰기, 어절의 어휘 정보, 어절 내 형태소들의 품사 정보와 품사-어휘 정보를 함께 자질로 사용하였다. 실험을 위하여 세종 구문분석 말뭉치 7만여 문장을 학습과 평가에 사용했으며, 실험결과는 95.97%의 정확률과 95.11%의 재현율, 95.54%의 $F_1$-평가치를 보였고, 구문분석의 전처리로써 사용하였을 때 구문분석의 성능과 속도가 향상됨을 보였다.

• Computers and Concrete
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• 제20권4호
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• pp.461-468
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• 2017

With the increasing demand in the production of concrete, there is a need for adopting a feasible, economical and sustainable technique to fulfill practical requirements. Self-Compacting Concrete (SCC) is one such technique which addresses the concrete industry in providing eco-friendly and cost effective concrete. The objective of the present study is to develop a mix design for SCC with Crushed Rock Fines (CRF) as fine aggregate based on the plastic viscosity of the mix and validate the same for its fresh and hardened properties. Effect of plastic viscosity on the fresh and hardened properties of SCC is also addressed in the present study. SCC mixes are made with binary and ternary blends of Fly Ash (FA) and Ground Granulated Blast Slag (GGBS) with varying percentages as a partial replacement to Ordinary Portland Cement (OPC). The proposed mix design is validated successfully with the experimental investigations. The results obtained, indicated that the fresh properties are best achieved for SCC mix with ternary blend followed by binary blend with GGBS, Fly Ash and mix with pure OPC. It is also observed that the replacement of sand with 100% CRF resulted in a workable and cohesive mix.

• Journal of Chest Surgery
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• 제27권8호
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• pp.669-676
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• 1994

Because the number of patients who require maintenance hemodialysis is increasing in number recently, angioaccess has become important to many vascular surgeons participating in the management of such patients.The authors created 269 arteriovenous fistulas[AVF] for angioaccess in 229 patients with chronic renal failure[CRF] at the Department of Thoracic and Cardiovascular Surgery in Chungnam National University Hospital during the period from August 1990 to March 1993. We analyzed the results of 260 operations for 220 patients except 9 patients who were lost during the follow up period. We performed snuffbox AVF in 171 cases, classic radiocephalic AVF in 46 cases, direct AVF at other site in 5 cases, forearm Gore-Tex AVF in 29 cases, and upper arm Gore-Tex AVF in 9 cases. We experienced 13 cases of operative failures, 11 cases of early complications, and 60 cases of late complications including obstructions during follow-up period. The 1 year, 2 year and 3 year patency rates of snuffbox AVF[Group 1], classic radiocephalic AVF[Group 2], and Gore-Tex AVF[Group 3] are like followings; 89, 84, 76% in group 1, 84, 75, 68% in group 2, and 79, 66, 55% in group 3. It showed a statistically significant difference between group 1, 2 and group 3.

• 대한한방부인과학회지
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• 제27권4호
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• pp.25-42
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• 2014

Objectives: To observe the effects of Herb medication on Polycystic Ovary (PCO) in rats. Methods: Riss (Research Information Sharing Service) was searched for Oriental medicine about PCO on 2000~2014. So, Experimental studies using PCO model induced by Estradiol Valerate (EV) was selected to analyze how effects they were. Consequently, 10 studies published on 2000~2014 were selected to analyze about weight of model and both ovaries, the number aries, the number of follicle and corpus of follicle and corpus luteum, the level of serum Androstenedione (ADD) and total estrogen, the level of Nerve Growth Factor (NGF) and Corticotropin Releasing Factor (CRF), the crossover rate and the number of implantation. Results: Among them, there was significantly difference between treatment group and control group in weight of both ovaries, the number of follicle and corpora lutea, the crossover rate and the number of implantation. Conclusions: The effects of Herb medication was observed on making weight of ovaries with PCO to promote. The study about effect of Herb medication on NGF and CRF with PCOS had to be conducted. The further research have to focus on treatment of subfertility and infertility, that is field showing the advantage of Oriental medicine.

• 생물치료정신의학
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• 제24권3호
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• pp.142-155
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• 2018

Insomnia in patients with hematopoietic stem cell transplantation(HSCT) has been underdiagnosed and undertreated. This study reviewed the frequency, characteristics, physical and psychological effects, and treatments of insomnia in HSCT patients to highlight clinical importance in this specialized population. Furthermore, the authors intended to suggest a model that would conceptualize insomnia in the context of HSCT. In the pre-transplant period, about half of patients with HSCT suffered from sleep disturbance. A substantial number of patients experienced distressing insomnia during the HSCT procedure and recovered to the level of the pre-transplant period. However, sleep disruption could be a chronic symptom in HSCT survivors and could negatively impact quality of control, cancer-related fatigue(CRF), immune function, and psychological distress. The 3P's model(Predisposing, Precipitating, Perpetuating) explains insomnia in cancer population and could be also relevant to HSCT patients with specific consideration of CRF, graft-versus-host diseases, specific properties of hematological disease, and protective isolated milieu. Effective treatment of insomnia in HSCT includes non-pharmacological(e.g., cognitive behavioral therapy, environmental modification) and pharmacological interventions. The decision of pharmacological treatment should be based on the issue of safety due to high risk of potential drug-drug interactions. Screening, treatment, and further research of insomnia in HSCT patients using validated subjective and/or objective measures are warranted.