• Annual Conference on Human and Language Technology
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• 2013.10a
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• pp.18-23
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• 2013

기존 대화시스템과 달리 대화형 개인 비서 시스템은 사용자에게 정보를 제공하기 위해 앱(APP)을 구동하는 방법을 사용한다. 사용자가 앱을 통해 정보를 얻고자 할 때, 사용자가 필요로 하는 정보를 제공해주기 위해서는 사용자의 목적을 정확하게 인식하는 작업이 필요하다. 그 작업 중 중요한 두 요소는 개체명 인식과 문장목적 인식이다. 문장목적 인식이란, 사용자의 문장을 분석해 하나의 앱에 존재하는 여러 정보 중 사용자가 원하는 정보(문장의 목적)가 무엇인지 찾아주는 인식작업이다. 이러한 인식시스템을 구축하는 방법 중 대표적인 방법은 사전규칙방법과 기계학습방법이다. 사전규칙은 사전정보와 규칙을 적용하는 방법으로, 시간이 지남에 따라 새로운 규칙을 추가해야하는 문제가 있으며, 규칙이 일반화되지 않을 경우 오류가 증가하는 문제가 있다. 또 두 인식작업을 파이프라인 방식으로 적용 할 경우, 개체명 인식단계에서의 오류를 가지고 문장목적 인식단계로 넘어가기 때문에 두 단계에 걸친 성능저하와 속도저하를 초래할 수 있다. 이러한 문제점을 해결하기 위해 우리는 통계기반의 기계학습방법인 Conditional Random Fields(CRF)를 사용한다. 또한 사전정보를 CRF와 결합함으로써, 단독으로 수행하는 CRF방식의 성능을 개선시킨다. 개체명과 문장목적인식의 구조를 분석한 결과, 비슷한 자질을 사용할 수 있다고 판단하여, 두 작업을 동시에 수행하는 방법을 제안한다. 실험결과, 사전규칙방법보다 제안한 방법이 문장단위 2.67% 성능개선을 보였다.

• The Korean Journal of Physiology and Pharmacology
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• v.16 no.6
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• pp.379-386
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• 2012

The purpose of this study was to evaluate whether berberine (BER) administration could attenuate depression- and anxiety-like behaviors and increase corticotrophin-releasing factor (CRF) and tyrosine hydroxylase (TH) expression following chronic morphine withdrawal in rats. Male rats were exposed to chronic, intermittent, escalating morphine (10~50 mg/kg) for 10 days. After the last morphine injection, depression- and anxiety-like beahvior associated with morphine discontinuation persisted for at least three days during withdrawal without any change in ambulatory activity. Daily BER administration significantly decreased immobility in the forced swimming test and increased open-arm exploration in the elevated plus maze test. BER administration also significantly blocked the increase in hypothalamic CRF expression and TH expression in the locus coeruleus (LC) and the decrease in hippocampal brain-derived neurotrophic factor (BDNF) mRNA expression. Taken together, these findings demonstrated that BER administration significantly reduced morphine withdrawal-associated behaviors following discontinuation of repeated morphine administration in rats, possibly through modulation of hypothalamic CRF and the central noradrenergic system. BER may be a useful agent for treating or alleviating complex withdrawal symptoms and preventing morphine use relapses.

• International Journal of Internet, Broadcasting and Communication
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• v.14 no.2
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• pp.55-62
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• 2022

A smart tourism chatbot is needed as a user interface to efficiently provide smart tourism services such as recommended travel products, tourist information, my travel itinerary, and tour guide service to tourists. We have been developed a smart tourism app and a smart tourism information system that provide smart tourism services to tourists. We also developed a smart tourism chatbot service consisting of khaiii morpheme analyzer, rule-based intention classification, and tourism information knowledge base using Neo4j graph database. In this paper, we develop the Korean and English smart tourism Name Entity (NE) datasets required for the development of the NER model using the pre-trained language models (PLMs) for the smart tourism chatbot system. We create the tourism information NER datasets by collecting source data through smart tourism app, visitJeju web of Jeju Tourism Organization (JTO), and web search, and preprocessing it using Korean and English tourism information Name Entity dictionaries. We perform training on the KoBERT-CRF NER model using the developed Korean and English tourism information NER datasets. The weight-averaged precision, recall, and f1 scores are 0.94, 0.92 and 0.94 on Korean and English tourism information NER datasets.

• International Journal of Computer Science & Network Security
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• v.23 no.7
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• pp.131-140
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• 2023

Network security situational awareness systems helps in better managing the security concerns of a network, by monitoring for any anomalies in the network connections and recommending remedial actions upon detecting an attack. An Intrusion Detection System helps in identifying the security concerns of a network, by monitoring for any anomalies in the network connections. We have proposed a CRF based IDS system using genetic search feature selection algorithm for network security situational awareness to detect any anomalies in the network. The conditional random fields being discriminative models are capable of directly modeling the conditional probabilities rather than joint probabilities there by achieving better classification accuracy. The genetic search feature selection algorithm is capable of identifying the optimal subset among the features based on the best population of features associated with the target class. The proposed system, when trained and tested on the bench mark NSL-KDD dataset exhibited higher accuracy in identifying an attack and also classifying the attack category.

• Health Policy and Management
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• v.16 no.2
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• pp.96-116
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• 2006

To assess the economic value of pharmaceutical therapy with Kremezin, we investigated the maximum amount of willingness-to-pay (WTP) of patients with chronic renal failure (CRF) for a hypothetical effect of Kremezin in delaying the initiation of dialysis treatments. A face-to-face survey was carried out in a sample of 141 CRF patients from 2 dialysis centers, composed of 82 hemodialysis patients, 38 peritoneal dialysis patients, and 21 non-dialysis CRF patients. Using a bidding game method with a starting point of 320,000 Won, which is the average monthly out-of-pocket payment for dialysis treatment, we asked the study subjects how much they would pay per month to receive Kremezin therapy. The mean out-of-pocket monthly WTP for Kremezin was 310,000, 430,000, and 520,000 Won (p<0.05, repeated one-way ANOVA)) when Kremezin delays the initiation of dialysis treatments by 1, 2, and 4 years. Significant correlation between the respondent's WTP and income $(r=0.266{\sim}0.368,\;p<0.05)$ confirmed the construct validity of the WTP instrument. Regression results showed that patients with a higher education, with diabetes as a major causes of CRF, and undergoing hemodialysis treatments tended to express higher WTP for Kremezin. The economic value of WTP from the perspective of patients varied from 310,000 to 520,000 Won depending on the effect size of Kremezin. The mean WTP was higher than 32,000 Won, only when the hypothetical effect of Kremezin in delaying the initiation of dialysis is for 2 years. This implies that Kremezin might be the preferred choice of therapy by CRF patients if it delays the initiation of dialysis treatment for at least 2 years.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.3
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• pp.696-704
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• 2005

This experiment examined the effect of Samultang-gamibang (SGB) on hair growth in spontaneous alopecia areata C57BL/6N mice. We first investigated hair growth effect of SGB compare to control groups after apply to oral administration for 10 weeks and regional treatment in skin for last 4 weeks. We second investigated the number of hair follicle and mast cells after treatment of SGB in spontaneous alopecia areata C57BL/6N mice for 10 weeks. We third investigated immunoreactive density of neuropeptides in skin of spontaneous alopecia areata C57BL/6N mice by immunohistochemical methods. The results were as follows : Hair growing effect of experimental group was observed from 7 weeks after administration of SGB (87.5%). In experimental group, the number of mast cells and eosinophils was significantly decreased compare to control group. Immunoreactive density of substance P and corticotropin releasing factor (CRF) in skin of experimental group was weakly stained in epidermis and subcutaneous tissue compare to control group. Immunoreactive density of CRF-receptor (CRF-R), CRF-binding protein (CRF-BP) in skin of experimental group was increased in epidermis, sebaceous gland, inner root sheath, outer root sheath and secondary hair germ epithelium compare to control group. These results suggest that SGB may be used in treatment of alopecia areata.

• Journal of Preventive Medicine and Public Health
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• v.39 no.2
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• pp.149-158
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• 2006

Objectives : We wanted to evaluate the economic value of a pharmaceutical product, Kremezin, for treating patients with chronic renal failure (CRF) by estimating the amount of cost savings due to its effect for delaying the initiation of dialysis treatments. Methods : We defined a conventional treatment for CRF accompanied by Kremezin therapy as 'the treatment group' and only conventional treatment as 'the alternative group.' The types of costs included were direct medical and nonmedical costs and costs of productivity loss. The information on the effect of Kremezin was obtained from the results of earlier clinical studies. Cost information was derived from the administrative data for 20 hemodialysis and 20 peritoneal dialysis patients from one tertiary care hospital, and also from the administrative data of 10 hemodialysis patients from one free-standing dialysis center. Per-capita cost savings resulting from Kremezin therapy were separately estimated for the cases with delay for the onset of hemodialysis and the cases with immediate performance of peritoneal dialysis. By computing the weighted average for the cases of hemodialysis and peritoneal dialysis, the expected per-capita cost savings of a patient with CRF was obtained. Using a discount rate of 5%, future cost savings were converted to the present value. Results : The present value of cumulative cost savings per patient with CRF from the societal perspective would be $18,555,000{\sim}29,410,000$ Won or $72,104,000{\sim}112,523,000$ Won if Kremezin delays the initiation of dialysis by 1 or 4 years. Conclusions : The estimated amount of cost savings resulting from treating CRF patients with Kremezin confirms that its effect for delaying the onset of dialysis treatments has a considerable economic value.

• Korean Journal of Soil Science and Fertilizer
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• v.40 no.6
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• pp.495-500
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• 2007

Recently we are interest in organic farming of rice. The technology of paper mulching was practised without herbicide in machine transplanting cultivation of paddy. A field experiment was conducted in Gangseo series (coarse loamy, mixed, nonacid, mesic family of Aquic Fluventic Eutrochrepts) at the National Institute of Crop Science (NICS), RDA, Suwon, Gyeonggi province, Republic of Korea in 2004. This experiment was carried out to evaluate soil redox potential, weed control and rice growth by the different organic matter in paper mulching transplanting. Compost, rice straw and soiling rye were incorporated as organic matter. The nitrogen amount of controlled-release fertilizer (CRF) plot was 80% compared with nitrogen amount ($110kg\;ha^{-1}$) of conventional fertilization. Mulching paper consisted of recycled paper which was coated with biodegradable plastics. There were no difference between conventional rice transplanting and paper mulching on missing hills after organic matter application. Weed control were the highest at added soiling rye plot. The redox potential of soil was the lowest in rice straw + CRF 80% plot at tillering stage. The $NH_4{^+}-N$ in soil was the highest at soiling rye + CRF 80% tillering stage. There was no difference in yield between soiling rye + CRF 80%, compost + CRF 80% and conventional fertilization plot.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.64 no.3
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• pp.204-212
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• 2019

The optimal application rate of a controlled release fertilizer (CRF) on the growth, yield, and seeding time of rice grown on seedling trays was investigated. The experimental field was located at $37^{\circ}22^{\prime}10^{{\prime}{\prime}}N$ latitude and $127^{\circ}03^{\prime}85^{{\prime}{\prime}}E$ longitude in Hwaseong, Gyeonggi-do, Republic of Korea. The soil in the paddy field was a clay loam. The CRF used in the experiment contained $300g\;kg^{-1}$ of nitrogen, $60g\;kg^{-1}$ of phosphate, and $60g\;kg^{-1}$ of potassium, respectively. The CRF was applied at the rate of 0, 200, 300, 400, 500, and 600 grams on rice seedling tray compared with the field application based on soil testing (control), respectively. The CRF can be applied as single application(which can replace basal fertilizer application and two top dressing application) directly to the seedling tray, and showed the minimum release at the seedling period. Considering the plant growth, nitrogen use efficency and yield of rice, the optimal application rate of developed CRF was 500 g per seedling tray and the yield of rice at this application rate was $4.92{\sim}5.04Mg\;ha^{-1}$. The regression formula between the rice yield and application rates of CRF was as follows ; "$Y=0.0002{\chi}^2+0.0963{\chi}+411.6$($R^2$ : 0.9922) in 2010 and $Y=8E-6{\chi}^2+0.2723{\chi}+344.04$($R^2$:0.9864) in 2011, Y : Rice yield ($Mg\;ha^{-1}$), ${\chi}$ : Application rate (grams) of controlled release fertilizer". The optimum application rates of CRF per rice seedling tray by regression formula was 498 grams in 2010 and 513 grams in 2011.

• 한국HCI학회:학술대회논문집
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• 2006.02a
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• pp.1252-1255
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• 2006

본 논문은 정보검색, 정보추출, 번역, 자연어처리 등의 작업을 위한 통계적 방법론에서 필요한 학습 데이터 구축을 효율적으로 하기 위한 학습 데이터 반자동 구축 장치 및 그 방법에 대하여 기술한다. 본 논문에서는 학습 데이터 구축양을 줄이기 위해서 능동 학습을 이용한다. 또한 최근 각광 받고 있는 Conditional Random Fields(CRF)를 능동학습에 이용하기 위해서 CRF를 이용한 Confidence measure를 정의한다.