• 대한전자공학회논문지SD
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• 제40권5호
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• pp.369-378
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• 2003

본논문은 ATM/AAL 처리를 위한 재조립 처리기으 설계 및 VLSI 구현에 대하여 기술한다. ATM/AAL 재조립 처리기는 물리계층으로부터 수신된 ATM셀을 처리하는 장치로서 AAL5 패킷의 유료부하를 호스트의 메모리에 정렬하고 이를 전송하며 망 관련 정보와 패킷의 오류 사항을 점검한다. ATM 셀매칭 알고리즘과 지능형 분산 방식의 개념을 적용하여 여러 개의 채널을 동시에 운영할 때 시간 지연 없이 처리할 수 있도록 설계하였다. 셀매칭 알고리즘은 ATM의 헤더로부터 해당정보의 위치를 신속하게 찾을 수 있도록 해쉬함수를 이용하여 구현되었고 이로써 VCI/VPI 값의 할당에 있어서 시간상의 제약을 완화하였으며 지능형 분산 방식과 DMA를 이용하여 메모리의 낭비를 최소화하면서 데이터를 호스트 쪽으로 25Mbps의 속도로 전송이 가능하도록 하였다. 상용시스템과 통신을 수행하여 칩의 정확한 동작과 CRC, 오류 점검 등의 동작을 점검하였다. 본 재조립 처릭는 0.6㎛ CMOS 공정을 통하여 제작되었다.

• Journal of Microbiology and Biotechnology
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• 제32권7호
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• pp.938-948
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• 2022

Gastric cancers (GC) are generally malignant tumors, occurring with high incidence and threatening public health around the world. Circular RNAs (circRNAs) play crucial roles in modulating various cancers, including GC. However, the functions of circRNAs and their regulatory mechanism in colorectal cancer (CRC) remain largely unknown. This study focuses on both the role of circCOL1A2 in CRC progression as well as its downstream molecular mechanism. Quantitative polymerase chain reaction (qPCR) and western blot were adopted for gene expression analysis. Functional experiments were performed to study the biological functions. Fluorescence in situ hybridization (FISH) and subcellular fraction assays were employed to detect the subcellular distribution. Luciferase reporter, RNA-binding protein immunoprecipitation (RIP), co-immunoprecipitation (Co-IP), RNA pull-down, and immunofluorescence (IF) and immunoprecipitation (IP) assays were used to explore the underlying mechanisms. Our results found circCOL1A2 to be not only upregulated in GC cells, but that it also propels the migration and invasion of GC cells. CircCOL1A2 functions as a competing endogenous RNA (ceRNA) by sequestering microRNA-1286 (miR-1286) to modulate ubiquitin-specific peptidase 10 (USP10), which in turn spurs the migration and invasion of GC cells by regulating RFC2. In sum, CircCOL1A2 sponges miR-1286 to promote cell invasion and migration of GC by elevating the expression of USP10 to downregulate the level of RFC2 ubiquitination. Our study offers a potential novel target for the early diagnosis and treatment of GC.

• Asian Pacific Journal of Cancer Prevention
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• 제15권4호
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• pp.1845-1849
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• 2014

Background: There is no standard treatment for patients with colorectal cancer (CRC) progressing after irinotecan and oxaliplatin treatment. Here we aimed to retrospectively evaluate the efficacy and tolerability of raltitrexed in combination with oral 5-fluoropyrimidine (uracil tegafur-UFT) or mitomycin C as salvage therapy in mCRC patients. Materials and Methods: A total of 62 patients who had received raltitrexed combined with UFT or mitomycin C were identified between December 2008 and June 2013. They were given raltitrexed 2.6 $mg/m^2$ (max 5 mg) i.v. on day 1 in combination with either oral UFT 500 mg/day on days 1-14 every 3 weeks (group A) or mitomycin C 6 $mg/m^2$ i.v. on day every 3 weeks (group B). Results: Forty-two patients (67.7%) were in group A and 20 (32.2%) in group B. In 15 patients (24%) grade 3/4 toxicity was observed, resulting in dose reduction, and in 13 patients (20.9%) dose delay was necessary. The median progression free survival (PFS) was 3 months (95%CI 2.65-3.34) and median overall survival (OS) was 6 months (95%CI 2.09-9.90) in the whole group. Median PFS was 3 months (95%CI 2.60-3.39) in group A vs 3 months (95%CI 1.64-4.35) in group B (p=0.90). Median OS was 6 months (95%CI 2.47-9.53) in group A vs 12 months (95%CI 2.83-21.1) in group B (p=0.46). Conclusions: The combination of raltitrexed with UFT or mitomycin C seem to be a salvage therapy option due to safety profile and moderate clinical activity in heavily-pretreated mCRC patients.

• 아동학회지
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• 제32권2호
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• pp.53-70
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• 2011

Child Friendly Cities (CFC) is a framework for action with the aim of implementing the UN CRC led by local government in an urban context. A number of surveys with 755 children and adolescents were conducted in order to assess the community's child-friendliness level of Seoul. The results of this study were as follows : 1) Comprehensive assessment of the city's child-friendliness was overall seen to be negative. 2) In regards to the city's child-friendliness, the assessments of Children were more positive than those of the adolescents. 3) Boys assessed the city's child-friendliness more positively than girls. 4) The children and adolescents living in more wealthy communities assessed the city's child-friendliness more positively than those living in poorer areas. This study suggested that a local action plan for the Child Friendly Cities must be implemented to fulfill the CFC standards.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2001년도 추계학술발표논문집 (하)
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• pp.1379-1382
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• 2001

본 논문에서는 ATM 망에서의 통합 네트워크 구현을 위한 IP data packet를 처리하기 위한 AAL type5 프로토콜 프로세서를 설계 및 구현하였다. AAL 계층의 중요 기능들은 ITU-T Recommendation 1.363과 1.363.5 에 근거하여 설계하였다. AAL 계층의 주요한 역할은 데이터의 Segmentation 및 셀의 Reassembly를 하는 것으로, Segmentation 과정에서는 상위 계층의 연속적인 데이터를 Segmentation하여 53-byte 크기의 ATM 셀을 구성하는 기능이다. Reassembly 과정에서는 들어오는 셀들을 연속적인 데이터로 만들어 AAL 계층 보다 상위 계층으로 전달하는 것이다. 이 과정에서 셀의 Header 를 확인한 후 crc-32를 통한 오류 검정을 거치게 되며, 데이터에 오류가 있을 경우에는 해당 셀을 버리고 오류가 없을 시에만 상위 계층으로 전달한다. 본 논문에서 구현한 AAL Type 5 프로세서는 향후 모든 Type의 data를 수용하는 칩 개발에 유용할 것으로 사료된다. 본 논문에서 원할한 테스트를 위해 데이터의 loop back 신호 DLB를 사용했다 VHDL 해석기로는 Synopsys 사의 VHDL Analyzer를 사용하였고, Design Compiler로 회로를 합성하였다.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.205.2-206
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• 2003

This experiment was designed to evaluate the immune responses after treatment of diabetes by using water extract of traditional herbal drugs on the splenocytes and peritoneal macrophages in vivo. We found two herbal materials of the hypoglycemic agents based on inhibitory activity of ${\alpha}$-glucosidase. These potential herbal drugs which remarkably inhibited ${\alpha}$-glucosidase in STZ-induced diabetic mices (STZ 150 mg/kg, i.p.) were Mori radicis Cortex(MRC, 2.32 mg/mouse) and Cudraniae radicis Cortex (CRC, 2.24mg/mouse). (omitted)

• 대한전기학회:학술대회논문집
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• 대한전기학회 2004년도 하계학술대회 논문집 D
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• pp.2562-2564
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• 2004

This paper addresses a simulation for the Ethernet based data transmission between the CIC(Centralized Traffic Control System) and the SCADA(Supervisory Control and Data Acquisition) system. Fame error rate and throughput are calculated and compared for the two cases that the CTC/SCADA has an extra error control scheme besides the internal CRC32 of the Ethernet and that no extra error control has been done. Simulation program is constructed with the Matlab and the Matlab GUI and then converted into a stand-alone $c^{++}$ program to be used on any non-Matlab environments.

• 한국정보통신학회논문지
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• 제19권1호
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• pp.185-191
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• 2015

본 논문에서는 원자력 안전등급 제어기기의 안전 통신망 구현을 위한 원자력 안전등급 통신 보드를 제안한다. 원자로 보호계통이 아날로그에서 디지털화되면서 디지털 통신망을 사용하게 되었다. 디지털 통신망은 원자력 안전등급에 사용되는 통신망으로 안전등급에서 요구하는 성능 및 시험을 통과한 통신보드가 제공되어야 한다. 통신 프로토콜 계층은 OSI 7 계층 중 물리계층, 데이터링크 계층, 어플리케이션계층만을 사용한다. 데이터 링크 계층에서는 사이버 보안을 위해 데이터 패키지를 변경하였다. 데이터 건전성을 위해 CRC32를 사용 하였으며 데이터 수신에 대해서는 재요청 및 응답을 하지 않는 단방향 통신만을 함으로써 원자력 안전계통에 영향을 주지 않게 설계 되었다. 또한 원자력안전등급을 획득하기 위해서 요건, 설계, 검증의 절차에 따라 설계하였다. 하드웨어검증을 위해 전자파 시험, 노화분석 시험, 육안검사, 번인시험, 내환경 시험 및 내진 시험과 같은 기기 검증을 수행 하였다. 또한 FPGA 펌웨어 검증을 위해 IEEE 1074의 생명주기를 준수하여 단위시험과 통합 시험을 실행 하였다[1-3].

• Asian Pacific Journal of Cancer Prevention
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• 제14권8호
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• pp.4839-4842
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• 2013

Aims and Background: To improve understanding of the relationship between schistosome-related enteropathy and colorectal carcinoma with particular focus on endoscopic findings and clinicopathological characteristics of colonic schistosomiasis. Materials and Methods: All cases of intestinal schistosomiasis diagnosed at West China Hospital, Chengdu, China, between October 2006 and October 2012 were included in this study. A total of 179 cases of colonic schistosomiasis diagnosed through colonoscopy and pathological examinations were collected for analysis and the demographics, symptoms, endoscopic findings and clinicopathological characteristics were retrospectively evaluated. Results: Of the 179 colonic schistosomiasis patients, 32 combined with colorectal cancer (CRC) were found, between the ages of 44 and 85 years (24 males, 75%). These 32 lesions were classified as 12 endophytic/ulcerative (37.5%), 10 exophytic/fungating (31.2%), 4 annular (12.5%), 3 giant polypus (9.4%), and 3 IIc (superficial depressed type) (9.4%). The segments of rectum and sigmoid colon were involved in 19 patients (59.4%) and 6 patients (18.8%), respectively. The histopathologic types were classified as follows: 30 welldifferentiated adenocarcinomas, one mucinous adenocarcinoma and one poorly differentiated adenocarcinoma. The pathological findings suggest colorectal malignancy with deposited schistosome ova. Conclusions: Chronic schistosomal infestation has a probable etiological role in promoting genesis of colorectal neoplasms.

• Asian Pacific Journal of Cancer Prevention
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• 제16권16호
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• pp.7179-7188
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• 2015

Cancer is a major health obstacle around the world, with hepatocellular carcinoma (HCC) and colorectal cancer (CRC) as major causes of morbidity and mortality. Nowadays, there isgrowing interest in the therapeutic use of natural products for HCC and CRC, owing to the anticancer activity of their bioactive constituents. Boswellia serrata oleo gum resin has long been used in Ayurvedic and traditional Chinese medicine to alleviate a variety of health problems such as inflammatory and arthritic diseases. The current study aimed to identify and explore the in vitro anticancer effect of B. Serrata bioactive constituents on HepG2 and HCT 116 cell lines. Phytochemical analysis of volatile oils of B. Serrata oleo gum resin was carried out using gas chromatography-mass spectrometry (GC/MS). Oleo-gum-resin of B. Serrata was then successively extracted with petroleum ether (extract 1) and methanol (extract 2). Gas-liquid chromatography (GLC) analysis of the lipoidal matter was also performed. In addition, a methanol extract of B. Serrata oleo gum resin was phytochemically studied using column chromatography (CC) and thin layer chromatography (TLC) to obtain four fractions (I, II, III and IV). Sephadex columns were used to isolate ${\beta}$-boswellic acid and identification of the pure compound was done using UV, mass spectra, $^1H$ NMR and $^{13}C$ NMR analysis. Total extracts, fractions and volatile oils of B. Serrata oleo-gum resin were subsequently applied to HCC cells (HepG2 cell line) and CRC cells (HCT 116 cell line) to assess their cytotoxic effects. GLC analysis of the lipoidal matter resulted in identification of tricosane (75.32%) as a major compound with the presence of cholesterol, stigmasterol and ${\beta}$-sitosterol. Twenty two fatty acids were identified of which saturated fatty acids represented 25.6% and unsaturated fatty acids 74.4% of the total saponifiable fraction. GC/MS analysis of three chromatographic fractions (I,II and III) of B. Serrata oleo gum resin revealed the presence of pent-2-ene-1,4-dione, 2-methyl- levulinic acid methyl ester, 3,5- dimethyl- 1-hexane, methyl-1-methylpentadecanoate, 1,1- dimethoxy cyclohexane, 1-methoxy-4-(1-propenyl)benzene and 17a-hydroxy-17a-cyano, preg-4-en-3-one. GC/MS analysis of volatile oils of B. Serrata oleo gum resin revealed the presence of sabinene (19.11%), terpinen-4-ol (14.64%) and terpinyl acetate (13.01%) as major constituents. The anti-cancer effect of two extracts (1 and 2) and four fractions (I, II, III and IV) as well as volatile oils of B. Serrata oleo gum resin on HepG2 and HCT 116 cell lines was investigated using SRB assay. Regarding HepG2 cell line, extracts 1 and 2 elicited the most pronounced cytotoxic activity with $IC_{50}$ values equal 1.58 and $5.82{\mu}g/mL$ at 48 h, respectively which were comparable to doxorubicin with an $IC_{50}$ equal $4.68{\mu}g/mL$ at 48 h. With respect to HCT 116 cells, extracts 1 and 2 exhibited the most obvious cytotoxic effect; with $IC_{50}$ values equal 0.12 and $6.59{\mu}g/mL$ at 48 h, respectively which were comparable to 5-fluorouracil with an $IC_{50}$ equal $3.43{\mu}g/mL$ at 48 h. In conclusion, total extracts, fractions and volatile oils of B. Serrata oleo gum resin proved their usefulness as cytotoxic mediators against HepG2 and HCT 116 cell lines with different potentiality (extracts > fractions > volatile oil). In the two studied cell lines the cytotoxic acivity of each of extract 1 and 2 was comparable to doxorubicin and 5-fluorouracil, respectively. Extensive in vivo research is warranted to explore the precise molecular mechanisms of these bioactive natural products in cytotoxicity against HCC and CRC cells.