• Journal of The Korean Society of Inherited Metabolic disease
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• v.18 no.1
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• pp.23-29
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• 2018

Carbamoyl phosphate synthetase 1 deficiency (CPS1D) is a rare autosomal recessive urea cycle disorder characterized by hyperammonemia. CPS1D is caused by mutations in the CPS1 gene on chromosome 2q35. Based on the age of onset, there are two phenotypes: the neonatal type and the delayed-onset type. The severity of clinical manifestation depends on the degree of CPS1 residual enzymatic activity, and can result in hyperammonemia and neurological dysfunction. We report a case of CPS1D in a neonate who developed vomiting, decreased consciousness and hyperammonemia at 25th day after birth. She showed excellent response to treatment including hydration, ammonia-lowering drugs and a low-protein diet without hemodialysis. Her growth, development and neurological outcomes were fair at the last follow-up at 17 months of age.

• The Transactions of the Korean Institute of Electrical Engineers P
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• v.64 no.4
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• pp.207-211
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• 2015

In this paper, we proposed a broadband planar Yagi-Uda dipole antenna with dual tapered balance and unblance (balun) by CPW-fed to CPS. This antenna consisted of driver, three directors, dual tapered balun and CPS-fed to CPS. The fed structure of CPW-fed to CPS had a benefit points much simpler than other planar Yagi-Uda antennas and provided design more flexibility in arranging the reflector. The proposed antenna is introduced dual tapered balun to improve the impedance matching. It balun is inserted between the CPW-ground and the CPS. The proposed antenna is exhibited the bandwidth of 4.78 GHz (1.94~6.72 GHz) (S11 < -10 dB) and the gain of 4.9~7.2 dBi within that bandwidth. This antenna will applicate wireless communication.

• The Plant Pathology Journal
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• v.37 no.3
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• pp.232-242
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• 2021

Glomerella leaf spot (GLS) is a severe infectious disease of apple whose infective area is growing gradually and thus poses a huge economic threat to the world. Different species of Colletotrichum including Colletotrichum gloeosporioides are responsible for GLS. For efficient GLS control, it is important to understand the mechanism by which the cruciferous crops and C. gloeosporioides interact. Arginine is among one of the several types of amino acids, which plays crucial role in biochemical and physiological functions of fungi. The arginine biosynthesis pathway involved in virulence among plant pathogenic fungi is poorly understood. In this study, CgCPS1 gene encoding carbamoyl phosphate synthase involved in arginine biosynthesis has been identified and inactivated experimentally. To assess the effects of CgCPS1, we knocked out CgCPS1 in C. gloeosporioides and evaluated its effects on virulence and stress tolerance. The results showed that deletion of CgCPS1 resulted in loss of pathogenicity. The ∆cgcps1 mutants showed slow growth rate, defects in appressorium formation and failed to develop lesions on apple leaves and fruits leading to loss of virulence while complementation strain (CgCPS1-C) fully restored its pathogenicity. Furthermore, mutant strains showed extreme sensitivity to high osmotic stress displaying that CgCPS1 plays a vital role in stress response. These findings suggest that CgCPS1 is major factor that mediates pathogenicity in C. gloeosporioides by encoding carbamoyl phosphate that is involved in arginine biosynthesis and conferring virulence in C. gloeosporioides.

• Journal of Veterinary Clinics
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• v.17 no.1
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• pp.145-151
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• 2000

황색포도상구균이 Capsular polysaccharide (CPS)는 백혈구의 탐식에 저항하기 때문에 젖소의 유방염 발생의 중요한 병원상 인자로 오랫동안 연구자들의 관심이 집중되어 왔다. 따라서 CPS는 젖소의 유방염을 최소화시키기 위한 유방염 백신개발에 있어 잠재적인 백신 항원물질로 알려져 왔다. 본 연구의 복적은 황색포도상구균의 CPS 항원물질을 좀더 효과적으로 발현시키고 향후 백신항원으로 사용시 좀 더 간편하게 정제하는 방법을 찾아보고자 본 연구를 수행하였다. CPS는 락토스와 덱스트로스를 첨가한 brain heart infusion media 에서도 부분적으로 발현되었지만 CPS가 가장 잘 발현되는 배지 조건은 젖소 유래의 유청을 10% 첨가한 조건에서 가장 발현율이 높았다. 또한 CPS발현은 salt agglutination test, india ink법 및 투과전자현미경을 이용하여 확인하였으며 균체표면의 hydrophobicity에서는 락토스, 덱스트로스 및 젖소 유래의 유청을 첨가한 배지조건에서 다른 조건에 비해 높았다. CPS의 가장 손쉬운 검사법은 균체를 절편하지 않고 직접 투과전자현미경상에서 염색없이 관찰하는 것이 가장 간편한 방법이었다. CPS정제는 상층액을 농축시킨후 이온교환크로마토그라피와 젤 여과법을 이용하여 정제하였으며 CPS의 분자량은 대부분 97kDa이상이었다. CPS 회수율은 배지와 균체 1리터당 1.5mg이었다. 결론적으로 CPS를 백신항원으로 포함하고자 할 경우, CPS의 최적 발현조건은 젖소 유래의 유청을 10% 첨가한 Brain heart infusion 배지에서 배양하여 사용하는 것이 가장 좋은 방법이라고 생각된다.

• Journal of Soil and Groundwater Environment
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• v.28 no.1
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• pp.1-14
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• 2023

In this study, column tests using relatively uniform Jumunjin sand media were conducted to evaluate the feasibility of calcium polysulfide (CaS_x, CPS) in removing high concentration of Zn²⁺ in groundwater. The injected CPS solution reacted rapidly with Zn²⁺ in artificial groundwater and effectively reduced Zn²⁺ by more than 99% through metal sulfide precipitation. Since the density (d = 1.27 g/cm³ ) of CPS solution was greater than that of water, CPS solution settled down rapidly while capturing Zn²⁺ and formed stable CPS layer similar to dense nonaqueous phase liquid. Mass balance analysis on Zn²⁺ in CPS solution suggested that CPS solution effectively reacted with Zn²⁺ to form metal sulfide precipitates except for high groundwater seepage velocity of 400 cm/d. With greater groundwater seepage velocity, injected CPS did not completely dissolve at the CPS-water interface, but a partially-misible CPS layer continuously moved and reacted with Zn²⁺+ in the direction of groundwater flow. Since hydraulic conductivity (K_h) decreased slightly due to the generated metal precipitates in the inter-pores of media, injection of CPS solution should be optimized to prevent clogging. As evidenced by both XRF and SEM/EDS results, ZnS precipitates were clearly observed through the reaction between the CPS solution and Zn²⁺. Further study is warranted to evaluate the feasibility of CPS to remove high-concentration heavy metalcontaminated groundwater in complex and heterogeneous media.

• The Journal of Korean Medicine
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• v.25 no.2
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• pp.22-32
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• 2004

Objectives: In order to determine the effect of CPs, experimental studies were performed in hyperlipidemia humans. The contents of serum total cholesterol, TG (triglyceride), LDL cholesterol, HDL cholesterol, AST/ALT and BUN/creatinine were measured. Methods: We made a comparative study of total cholesterol, TG (triglyceride), LDL cholesterol, HDL cholesterol, AST/ALT and BUN/creatinine during one month off and on for twenty patients with hyperlipidemia who visited Gunpo Oriental Medical Center of Wonkwang University from December 2002 to July 2003. Results: The following result were obtained: 1. The serum TG and total cholesterol of patients who took CPs for one month showed significant (p<0.01) decrease. 2. The serum HDL-cholesterol and LDL-cholesterol of patients who took CPs for one month showed significantly increase in HDL, and decrease in LDL (p<0.05). 3. The serum AST/ALT and BUN/creatinine of patients who took CPs for one month showed no significant effects. Conclusions: According to the results mentioned above, the effects of CPs on serum triglyceride and total cholesterol of hyperlipidemia patients were significantly confirmed for decreasing effects.

• 한국노년학
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• v.30 no.1
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• pp.81-91
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• 2010

The purpose of this study was to test a validity and reliability of Cognitive Performance Scale(CPS), a cognitive measure generated from 5 items(comatose status, decision making, short-term memory, making self understood, and eating). Method: 393 patients in 2 hospitals for the elderly with dementia were measured with CPS by two nurses independently. The inter-rater agreement was tested by comparing two scores. The CPS score was compared with GDS, which was measured by doctors and nurses, and MMSE score which was drawn from the claim data of Health Insurance Review & Assessment Service. Result: The correlation coefficient between CPS and GDS was 0.742(p<0.0001), CPS and MMSE was -0.794(p<0.0001). The Cronbach's coefficient alpha of CPS was 0.742, Kappa value was 0.772~1.000. The CPS showed high validity and reliability in long term care hospitals of Korea.

• Journal of Haehwa Medicine
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• v.20 no.2
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• pp.1-16
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• 2012

In order to study the effect of CPS in the treatment of atopic dermatitis (AD), its role on various immune related cytokines were tested. Levels of liver and kidney function markers such as ALT, AST, BUN in NC/Nga mice were all normal indicating no toxicity in CPS treated group. Significant recovery from AD could be observed in CPS treated group through naked eye observation. Dermatitis index was significantly decreased after 11, 12, and 13 weeks of treatment. CD4+, CD8+, CD3+ /CD69+ immune cell ratio in DLN were decreased significantly by 37.2%, 49%, 20.8% in CPS treated group. CD4+ and CD11b+ /Gr-1+ immune cell ratio in dorsal skin were decreased significantly by 50.8% and 59.2% in CPS treated group. Expression of IL-4, IL-5, IL-6, IL-13 and TNF-${\alpha}$ in spleen were decreased by 78.8%, 97.8%, 64.7%, 73.6%, and 68.4%, respectively in CPS treated group. The results above strongly indicated the significant immune modulatory effect of CPS and thus clinical application of CPS on AD treatment.

• Journal of Embryo Transfer
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• v.21 no.1
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• pp.53-58
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• 2006

This study was conducted to comparing on vitrification of mouse oocytes and embryos using CPS, conventional straws and CPS by evaluating in morphological survival for oocytes, and embryonic cleavages and blastocyst formation for embryos. The morphological survival in vitro after thawing of vitrified oocytes using CPS (75%) and conventional straws (72%) were significantly higher (p<0.05) than that using OPS (68%). The blastocyst formation rates of vitrified embryos using CPS (48.6%) and unfrozen control embryos (56.0%) were significantly higher (p<0.05) than those of conventional straws (43.4%) and OPS (37.7%). The rates of morula formation were also higher to control, CPS, conventional straws and OPS in orderly. These results show that CPS has the advantages of achieving a high survival and safety preservation.

• Journal of Institute of Control, Robotics and Systems
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• v.17 no.1
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• pp.1-5
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• 2011

The basic signals for electronic engine control are velocity and degree of the engine cam shaft. The CPS sensor used for this signal and magnetic pick-up type CPS sensor is more popular. It is very important thing analyze this signal correctly. If there are some mistakes at the analysis, like a noise, The engine do not working at the best status, it will generate some noise, emit exhaust fumes and waste more gases. In general way to analysis this signal, you use zero-level detector circuit and in order to reduce the error you must use another sensor like a TDC sensor. In this paper, We proposed the analysis method using electronics circuits for magnetic pick-up type CPS sensor. We designed Comparison level detector circuit, Differential circuit and Full-rectifier circuit for detected the Long tooth and Short tooth level correctly without another sensor. We expected it is useful for more reliable engine control.