• IMMUNE NETWORK
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• 제20권4호
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• pp.28.1-28.25
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• 2020

The recent emergence of the novel coronavirus (CoV) or severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) poses a global threat to human health and economy. As of June 26, 2020, over 9.4 million cases of infection, including 482,730 deaths, had been confirmed across 216 countries. To combat a devastating virus pandemic, numerous studies on vaccine development are urgently being accelerated. In this review article, we take a brief look at the characteristics of SARS-CoV-2 in comparison to SARS and Middle East respiratory syndrome (MERS)-CoVs and discuss recent approaches to coronavirus disease-2019 (COVID-19) vaccine development.

• Journal of Digestive Cancer Research
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• 제10권2호
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• pp.107-111
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• 2022

In 2019, coronavirus disease (COVID-19), which originated in Wuhan, has spread worldwide. In most people, COVID-19 symptoms are not severe. However, the mortality rate and severity were high in risk groups such as in older people and patients with underlying diseases. As patients with cancer are one of the risk groups, the vaccination for COVID-19 is emphasized in these patients. However, COVID-19 vaccines are not tested enough in special groups such as in patients with cancer because these vaccines are developed at an unprecedented speed. This causes confusion about whether patients undergoing chemotherapy should be vaccinated or not. In this study, international guidelines and studies were reviewed. Most of the studies recommended vaccination. No evidences of any negative effects for the efficacy or safety were recorded in patients undergoing cytotoxic, targeted, and immune agents. However, in critical conditions such as cytopenia, vaccination must be decided according to the patient's condition. COVID-19 vaccines were also recommended for patients on surgery or radiation therapy. If possible, vaccine is given before surgery to avoid confusion between surgical complications and side effects of the vaccine. The radiation recall phenomenon after vaccination has been reported in some cases of radiation therapy. Clinicians should consider these situations before vaccinating each patient. We hope that clearer guidelines will be established by accumulating verified data.

• 항공우주의학회지
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• 제31권1호
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• pp.21-23
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• 2021

Purpose: Human papillomavirus (HPV) vaccination schedule is recommended by Strategic Advisory Group of Experts on Immunization of World Health Organization to achieve high efficacy and immunogenicity. However, the patients often cannot keep up their schedule for several reasons. Methods: Monthly numbers of visitors for HPV vaccination between 2019 and 2021 were analyzed to measure the impact of coronavirus disease-19 (COVID-19) outbreak which was the main cause of this delay. Results: In February 2020, the number of foreign patients vaccinated with HPV was dropped suddenly due to COVID-19. Prior to this impact, the average patients per month for HPV vaccination was 160 (95% confidence interval [CI]: 143-176). It was then 30 (95% CI: 20-40). However recent trends show a gradual recovery. Conclusion: If a woman is pregnant after starting the HPV vaccine series, the reminder doses should be delayed until she is no longer pregnant. If this series is interrupted for any length of time, it can be resumed without restarting the series. HPV vaccine series need to be administered with a minimum interval of 14 days before or after administration of COVID-19 vaccines.

• 대한족부족관절학회지
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• 제26권1호
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• pp.48-53
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• 2022

The current SARS-CoV-2 coronavirus disease 2019 (COVID-19) pandemic has been a particular challenge for diabetes patients. Since these patients are at a higher risk of COVID-19, they have been prioritized for vaccination. In this report, we describe the case of a patient scheduled for diabetic foot amputation who received the first dose of ChAdOx1 nCov-19 vaccine and subsequently developed severe purpura in his genitalia and both of his hands and feet, accompanied by acute renal failure. The operation had to be postponed as severe limb purpura appeared just before the operation. With adequate management for acute renal failure and topical steroid application for the severe purpura lesions, a successful outcome could be obtained after the delayed first ray amputation. We recommend that COVID-19 vaccination should be carefully administered in patients with a diabetic foot requiring amputation.

• Journal of Ginseng Research
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• 제45권4호
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• pp.535-537
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• 2021

In the 1918 influenza pandemic, more than 95% of mortalities were ascribed to bacterial pneumonia. After the primary influenza infection, the innate immune system is attenuated, and the susceptibility to bacteria is increased. Subsequent bacterial pneumonia exacerbates morbidity and increases the mortality rate. Similarly, COVID-19 infection attenuates innate immunity and results in pneumonia. In addition, the current pneumococcal conjugate vaccine may have limited defense against secondary pneumococcal infection after influenza infection. Therefore, until a fully protective vaccine is available, a method of increasing immunity may be helpful. Ginseng has been shown to increase the defense against influenza in clinical trials and animal experiments, as well as the defense against pneumococcal pneumonia in animal experiments. Based on these findings, ginseng is suspected to be helpful for providing immunity against COVID-19.

• Archives of Plastic Surgery
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• 제49권3호
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• pp.310-314
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• 2022

The emergence of vaccines for coronavirus disease 2019 (COVID-19) raises risk of possible adverse events from interaction between the vaccines and facial aesthetic care. A 47-year-old female with no medical comorbidities visited our emergency room due to midface painful swelling after 3 hours following receiving the second dose of the messenger RNA BNT162b2 COVID-19 vaccine. About 14 years ago, she underwent nonsurgical augmentation on the nasojugal groove with a calcium hydroxylapatite dermal filler. We performed incision and drainage under general anesthesia on the next day. During operation, yellowish pus-like materials bulged out. After an operation, we performed a combination therapy with antibiotics and methylprednisolone. Her symptoms improved day by day after surgery, and then a complete recovery was achieved at 3 weeks after the treatment. In conclusion, providers of aesthetic procedures are to be aware of the potential risks of such vaccines for patients who already had or seek to receive dermal filler injections.

• 문화기술의 융합
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• 제8권2호
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• pp.109-116
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• 2022

코로나 19 위기 상황에서 정부의 대책이 소셜미디어를 통해 어떻게 확산했는지 알아보기 위해 이 연구는 유튜브에서 코로나 19 방역과 백신 접종 관련 이슈의 확산 과정을 네트워크 분석했다. 마스크 대란, 확진자 급증, 백신 수급 문제에 대한 네트워크 분석결과 코로나 19 상황을 전달하는 언론사 채널의 영향력이 컸고, 조회 수도 높게 나타났다. 다만 보수 성향의 채널에서 감정적 헤드라인이 더 많았고, 보수 성향의 개인 채널이 정부에 대한 부정적 메시지를 확산했고 동영상 조회 수도 높게 나타났다. 정부는 소셜미디어에서 확산되는 부정적인 메시지와 허위정보에 대응하기 위해 정확한 정보를 적극적으로 알리고, 언론은 부정확한 정보, 허위정보에 대한 팩트체크를 해야 할 것이다.

• Journal of Medicine and Life Science
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• 제19권2호
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• pp.74-77
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• 2022

We present a fatal case of cerebral arterial thrombosis after corona virus disease 19 (COVID-19) vaccination with ChAdOx1 nCOV-19. The deceased was a 63-year-old woman with no relevant medical history. She presented symptoms of nausea, fatigue, and headache immediately after vaccination. Ten days after vaccination, she suddenly started vomiting and developed high blood pressure. The patient eventually died 23 days after vaccination. Autopsy findings showed that the cerebral arteries and internal carotid arteries were fully enlarged and were compacted with thrombi. The brain stem showed ischemic necrosis, and extravasation from this necrotic lesion led to focal subarachnoid hemorrhage around the brain stem where large blood clots still remained. No aneurysms or atherosclerotic changes were found in these arteries. We note the following three facts. Firstly, all symptoms occurred immediately after vaccination; secondly, the main cause of death was consistent with known side effects of the vaccine; and lastly, the mechanism of thrombus formation in this case goes beyond the general category of thrombogenesis known so far. While the authors know that this case does not fall into known categories of vaccine side effects, we presenting this case to demonstrate that a comprehensive review of various possibilities related to vaccine side effects is needed to establish a COVID-19 defense system.

• Pediatric Infection and Vaccine
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• 제29권1호
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• pp.28-36
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• 2022

목적: 5-11세 소아에서 코로나19 백신의 효능과 안전성을 평가하기 위해서 체계적 문헌고찰을 시행하였다. 방법: 2022년 1월 4일까지 Ovid-MEDLINE 및 medRxiv를 검색하여 문헌을 선정하고 자료를 추출하였다. 근거 수준을 평가하기 위해 GRADE 도구를 사용하였다. 결과: 총 1,675 건의 연구가 일차적으로 검색되었고 최종적으로 5편의 연구가 포함되었다. 서로 다른 4개의 코로나19 백신(BNT162b2, mRNA-1273, CoronaVac, BBIBP-CorV)에 대한 무작위 대조군 연구 결과들은 5-11세 연령에서 각 백신의 양호한 면역원성과 안전성을 보여주었다. 미국에서 5-11세 소아 연령에서 BNT162b2 백신 접종 후 이상사례 모니터링 연구에서는 승인 전 임상시험을 통해 예상되었던 국소반응 및 전신반응이 보고되었으나 중대한 이상사례는 거의 보고되지 않았다. 결론: 5-11세 연령에서 코로나19 백신 접종에 대한 데이터는 제한적이다. 이 연령에서 코로나19 백신의 안전성과 효과에 대한 체계적인 평가를 위해 지속적이고 포괄적인 모니터링이 필요할 것으로 보인다.

• 정보관리학회지
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• 제38권4호
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• pp.113-128
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• 2021

본 연구는 코로나바이러스감염증-19(이하 코로나바이러스) 백신에 대한 사회적 의견을 파악하기 위해 트위터에서 작성된 백신 관련 게시물들을 분석하였다. 2020년 3월 16일부터 2021 3월 15일까지 1년간 트위터에서 작성된 코로나바이러스 백신 이름을 키워드로 포함한 45,413개의 게시물을 수집하여 분석하였다. 데이터 수집을 위해 활용된 코로나바이러스 백신 키워드는 총 12개이며, 수집된 게시물 수순으로 '화이자', '아스트라제네카', '모더나', '얀센', '노바백스', '시노팜', '시노백', '스푸트니크', '바라트', '캔시노', '추마코프', '벡토르'이다. 수집된 게시물들은 수기와 자동화된 방법을 동시 활용하여 키워드 분석, 감성 분석, 및 토픽모델링을 통하여 백신들에 대한 의견을 탐색하였다. 연구결과에 따르면 전반적으로 백신에 대한 부정적인 반응이 많았으며, 백신 접종 후유증에 대한 불안 및 백신의 효능에 대한 불신이 백신들에 대한 부정적인 주요 요소로 파악되었다. 이와는 반대로, 백신 접종에 따른 코로나바이러스 확산 억제에 대한 기대감이 백신에 대한 긍정적인 사회적 요소인 것을 확인할 수 있었다. 본 연구는 기존의 선행연구들이 뉴스 등 대중매체 데이터를 통해 코로나바이러스 백신에 대한 사회적 분위기를 파악하고자 했던 것과 달리, 소셜 미디어 데이터 수집 및 이를 활용한 키워드 분석, 감성 분석, 토픽 모델링 등의 여러 분석방법들을 사용하여 대중들의 의견을 파악하는 것으로 학술적 의의를 지닌다. 또한, 본 연구의 결과는 백신에 대한 사회적 분위기를 반영한 백신 접종 권장 정책 수립 기여라는 실질적 함의를 시사한다.