• 대한방사선기술학회지:방사선기술과학
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• 제19권1호
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• pp.89-94
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• 1996

Misalignment between the electronic and mechanical axes of rotation will result in artifact generation and image degradation during single photon emission computed tomography(SPECT) reconstruction. Acceptance and quality control testing procedures have not emphasized the variability in center of rotation(COR) measurements caused by collimators and the need to verify uniformity across the full collimator field of view (FOV). Variation from the mean COR across the FOV was tested in four different collimators using multiple point source acquisitions. The mean COR was different for each collimator and one of the four had a > 0.5 pixel difference from the mean COR on some area of the FOV, This variation makes this collimator unacceptable for SPECT acquisition. Thus, initial acceptance testing of SPECT collimators should verify a uniform COR across the full FOV and collimators with a variability from the mean COR > 0.5 pixels should be rejected.

• 대한화장품학회지
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• 제24권1호
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• pp.113-126
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• 1998

Inner nutshell of Castanea crenata has been used as an anti-aging and anti-wrinkle agent from the ancient time in east Asia. In order to develop new anti-aging and anti-wrinkle, ethanolic extract of inner nutshell of Castanea crenata was prepared and various biological activities were evaluated. Cor-285 possessed potent tree radical scavenging activity in vitro compared to gallic acid. Cor-285 showed the preventive effect against UV-induced cytotoxicity of fibroblast at concentration of 25-250mg/ml. When Cor-285 was evaluated for its anti-allergic activity, it effectively inhibited histamine release from mast cells induced by compound 48/80. The inhibitory activity was stronger than that of glycyrrhizinate. Cor-285 also showed on vivo inhibition against delayed hypersensitivity as well as croton-oil induced ear edema in mice when topically applied. These results strongly suggest that Cor-285 may reduce immunoregulatory/inflammatory skin trouble. From the attempts to isolate the scavenger, were isolated. In a clinical trial of twenty healthy volunteers with aged skin, 6 weeks application of Cor-285 decreased wrinkle about 26% and increased moisturizing 20% on the skin. All of these results indicate that Cor-285 may be an effective anti-aging and anti-wrinkle agent.

• 핵의학기술
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• 제16권1호
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• pp.70-75
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• 2012

SPECT 검사는 여러 가지 물리적인 요소들에 의해서 영향을 받기 때문에 정확한 데이터를 획득하는 것이 중요하다. 본 실험은 여러 가지 요인 중 COR에서 심장의 위치를 달리하여 두 중심이 일치할 때와 일치하지 않았을 때 영상의 균일도에 대해서 알아보고자 하였다. Philips사의 Cardio MD장비를 이용하여 cylindrical uniform phantom (직경 6.7 cm, 높이 9 cm), heart insert phantom을 COR과 각각 상 하 좌 우 100 mm 위치에서 실험하였다. Cylindrical uniform phantom과 heart insert phantom에서 획득한 영상은 line profile을 이용하여 phantom과 심장 양쪽 벽에 대한 계수 차이를 비교하였다. 육안평가는 heart insert phantom과 volunteer test를 하였다. Heart insert phantom 실험은 COR과 상 하 좌 우 100 mm 위치에서 수평으로 T-A curve를 나타내면 계수 차가 2.6%, 12.1%, 6.7%, 13.8%, 1.4%로 나타났고, 수직에서는 3.9%, 21.9%, 3.5%, 23.9%, 14.0%로 나타났다. Cylindrical phantom 실험은 수평에서 계수 차가 4.3%, 0.3%, 3.3%, 2.6%, 0.7%로 나타났고, 수직에서는 2.7%, 3.0%, 1.0%, 0.3%, 3.4%로 나타났다. Heart insert phantom과 volunteer test에서 획득한 영상의 육안평가는 COR 위치에서 가장 균등하였고, COR 제외한 위치에서는 약간의 왜곡현상이 나타났다. Phantom 종류에 따라 결과의 차이가 있었지만 육안평가와 종합해보면 심장과 COR 위치가 일치할 때 영상이 가장 균일하였다. 따라서 myocardiac SPECT 검사 시 심장과 COR의 두 중심을 일치시킴으로써 심근관류의 감쇠 또는 증가되는 왜곡현상을 예방하여 진단의 정확성을 높일 수 있을 것이다.

• 척추신경추나의학회지
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• 제10권1호
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• pp.35-45
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• 2015

Objectives : To evaluate the clinical effectiveness of Flexible brace(SpineCor Brace). Methods : CNKI, PubMed databases and Korean Journal of Oriental Medicine in 1999-2014 were searched for studies on SpineCor. This study researched 4 randomized controlled trial studies. Results : The results suggested that the SpineCor brace reduced the probability of the progression of early idiopathic scoliosis comparing with its natural history or rigid brace. But some studies showed that there is no significant difference between SpineCor and rigid brace. Conclusions : These results indicate that SpineCor have obvious effects on treatment of scoliosis and no adverse reactions, therefore we need to study more researches on SpineCor.

• 대한화장품학회지
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• 제24권3호
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• pp.17-23
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• 1998

Inner nutshell of Castanea mollisima BL (chestnut) has been used as an anti-aging and anti-wrinkle agent from the ancient time in east Asia. In order to develop new anti-aging and anti-wrinkle, ethanolic extract of inner nutshell of Castanea mollisima BL (Cor-285) was prepared and various biological activities were evaluated. Cor-285 showed potent antioxidant activity, Especially, Cor-285 possessed potent free radical scavenging activity in vitro (IC50:7.6 g/ml) compared to gallic acid (IC50:12.5 g/ml), Cor-285 showed the preventive effect against UV-induced cytotoxicity of fibroblast at concentration of 25-250 g/ml. When Cor-285 was evaluated for its anti-allergic activity, it effectively inhibited histamine release from mast cells induced by compound 48/80 (86% inhibition at 10 mg/ml). The inhibitory activity was stronger than that of glycyrrhiznate. Cor-285 also showed in vivo inhibition against delayed hypersensitivity as well as croton-oil induced ear edema in mice when topically applied These results strongly suggest that Cor-285 may reduce immunoregulatory 1 inflammatory skin trouble. From the attempts to isolate the constituents, citropten (simple coumarin) and ellagic acid, a well known radical scavenger, were isolated. In a clinical trial of twenty healthy volunteers with aged skin,6 weeks application of Cor-285 (3% cream) decreased wrinkle about 26% and increased moisturizing 20% on the skin. All of these results indicate that Cor-285 may be an effective anti-aging and anti-wrinkle agent.

• Journal of Chest Surgery
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• 제26권7호
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• pp.543-547
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• 1993

Cor triatriatum is a rare entity of congenital heart disease characterized by the presence of a fibrousmuscular diaphragm that subdivides the left atrium into a proximal or "accessory" chamber and a distal or "true" left atrial chamber. In the other hand, cor triatriatum is a variant of abnormal connection between the pulmonary vein and true left atrium which is separated from accessory left atrium receiving pulmonary venous blood flow by fibromuscular diaphragm. We experienced two cases of cor triatriatum. One of them was classical, and the other case was combined with atrial septal defect and all pulmonary veins were drained into the " common pulmonary venous chamber " which connected with right atrium and there was no direct communication between the accessory chamber and true left atrium. The abnormal diaphragms were excised and the atrial septal defect was repaired with pericardial patch in case II. The postoperative courses were not eventful and the patients were discharged with good result, and have been in good condition upto now.n good condition upto now.

• Journal of Chest Surgery
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• 제32권12호
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• pp.1111-1114
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• 1999

Cor triatriatum is a rare congenital heart disease that is often lethal in children if not correctly identified and properly managed, Characteristically an anomalous membrane divides the left atrium into two chambers one located posterosuperiorly which is connected to the common pulmonary venous trunk and the other anteroinferiorly which is connected to the left atrial appendage and the mitral valve. Eight patients with Cor triatriatum were been seen at our hospital from 1984 to 1999. The clinical presentation diagnostic evaluation and surgical results are outlined in this retrospective review. Resection of the obstructing anomalous atrial membrane was performed using a hypothermic cardiopulmonary bypass in all cases. Right atriotomy was performed in all patients and left atriotomy was performed in a patient who had poor preoperative general conditions and serious cardiac defects(TAPVR & hypoplastic left ventricle) died of low cardiac output during the immediate postoperative period. The postoperative course has been excellent in the remaining. Cor triatriatum is amenable to surgical repair with excellent results when diagnosed early and in those who are not complicated by other complex cardiac anomalies.

• 한국보육지원학회지
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• 제9권6호
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• pp.309-337
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• 2013

본 연구는 루브릭 형태로 개발된 유아 평가 중 타당성과 신뢰성을 검증받은 미국 하이스코프 재단의 유아용 Child Observation Record-II를 국내 유아를 대상으로 사용할 수 있도록 타당화하여 유아관찰기록척도(K-COR-II)로 명명하는데 있다. 이를 위해 서울, 인천, 대전, 경기 및 충북에 소재한 8개 어린이집의 만 3세부터 만 6세 유아 255명과 담임교사 32명을 대상으로 2개월 이상의 관찰 후 K-COR-II를 사용하여 평정을 실시하였고, 공인타당도 확보를 위하여 K-CDI를 함께 실시하였다. 신뢰도와 문항양호도 검중 및 타당도 검증을 위해 상관분석과 탐색적, 확인적 요인분석 및 AVE와 개념신뢰도 지수를 산출하였다. 그 결과 K-COR-II 각 항목의 내용타당도는 높게 나타났으나, 판별타당도 분석 결과 하위영역 간의 차별성은 떨어지는 것으로 밝혀졌다. 확인적 요인분석과 AVE 및 개념신뢰도 지수 산출 검토 결과 집중타당도는 만족스러운 것으로 나타났으며, K-CDI를 이용한 공인타당도 결과 각 영역 간 상관은 통계적으로 유의미한 수준으로 나타났다. 관찰자간 신뢰도와 영역별 항목간 내적합치도 또한 만족스러운 수준으로 판단되어 신뢰도 또한 확보되었으며, 각 문항별로 상 하 집단 간의 유의한 평균 차이가 있는지를 알아본 결과, 문항변별도 또한 만족스러운 것으로 판단되었다. 이에 타당화된 K-COR-II가 유아교육 및 보육현장에서 유아의 발달 수준을 가늠하는데 활용가능한 신뢰롭고 타당한 도구로 판단되었다.

• Mycobiology
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• 제50권1호
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• pp.86-95
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• 2022

Inflammaging in male reproductive organs covers a wide variety of problems, including sexual dysfunction and infertility. In this study, the beneficial effects of cordycepin (COR), isolated from potential medicinal fungi Cordyceps militaris, in aging-associated testicular inflammation and serum biochemical changes in naturally aged rats were investigated. Male Sprague Dawley rats were divided into young control (YC), aged control (AC), and COR (5, 10, and 20 mg/kg) treated aged rat groups. Aging-associated serum biochemical changes and inflammatory parameters were analyzed by biochemical assay kits, Western blotting, and real-time RT-PCR. Results showed a significant (p < 0.05) alteration in the total blood cell count, lipid metabolism, and liver functional parameters in AC group when compared with YC group. However, COR-treated aged rats ameliorated the altered biochemical parameters significantly (p < 0.05 and p < 0.01 at 5, 10, and 20 mg/kg, respectively). Furthermore, the increase in the expression of inflammatory mediators (COX-2, interleukin (IL)-6, IL-1β, and tissue necrosis factor-alpha) in aged rat testis was significant (p < 0.05) when compared with YC group. Treatment with COR at 20 mg/kg to aged rats attenuated the increased expression of inflammatory mediators significantly (p < 0.05). Mechanistic studies revealed that the potential attenuating effects exhibited by COR in aged rats was mediated by regulation of NF-κB activation and MAPKs (c-Jun N-terminal kinase, extracellular signal-regulated kinase 1/2, and p38) signaling. In conclusion, COR restored the altered serum biochemical parameters in aged rats and ameliorated the aging-associated testicular inflammation proving the therapeutic benefits of COR targeting inflammaging-associated male sexual dysfunctions.

• Journal of Chest Surgery
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• 제27권4호
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• pp.259-265
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• 1994

Cor triatriatum is a relatively rare cardiac anomaly, whose major feature is a fenestrated membrane separating an upper common pulmonary venous chamber from a lower true left atrial cavity. Interatrial communications may be present between the right atrium and the common pulmonary venous chamber or the true left atrium. From April 1981 to April 1992, 24 patients with cor triatriatum were treated at Seoul National University Hospital. Ages ranged from 1 month to 24 years with mean of 7.4 years. Twenty patients had interatrial communications through a patent foramen ovale, primum or secundum defect of the atrial septum. Four had no interatrial communications. Fourteen patients had associated anomalies; partial anomalous pulmonary venous connection in 3, total anomalous pulmonary venous connection in 2, persistent left superior vena cava in 3, and other anomalies in 6 patients. Surgical corrections were performed through right atriotomy in 18 patients, left atriotomy in 4, and both atriotomy in 2. Three patients [12.5%] died early after operation; two of them were associated with single ventricle. Six out of 21 survivors [28.6%] experienced complications; recurrent pneumonia, pulmonary embolism, ischemic encephalopathy, diaphragmatic palsy and tachyarrhythmias. At the time of follow up, all survivors, except one, were in functional class I. Surgical correction of cor triatriatum restored normal hemodynamic status with relatively low operative mortality, especially in patients not complicated with severe anomalies. This report summarizes the clinical diagnosis, associated anomalies, interatrial communications, surgical approach and late result of 24 patients underwent surgical corrections in our hospital.