• Nuclear Engineering and Technology
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• v.24 no.2
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• pp.154-162
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• 1992

Two major goals for chemical cleaning on the secondary side of nuclear steam generators are to remove sludge effectively and to minimize corrosion of base metals. In this work, electrochemical and sludge dissolution behaviors have been investigated in order to find out which parameters are critical and important during a copper removal process for chemical cleaning and to evaluate safety aspects and effectiveness of two major copper removal processes developed commercially in foreign countries. Hydrogen peroxide is vert effective for the process to use EDTA, NH$_4$OH and EDA at 38$^{\circ}C$ to control the potential of copper in a potential range sood for copper sludge removal. Corrosion rates for carbon steel SA 285 Gr.C and Alloy 600 are very small during this process if it is controlled properly. However, the corrosion rate of SA 285 Gr.C will be increased greatly if its corrosion potential is maintained below -450mV. The process to use EDA and ammonium carbonate is effective at 6$0^{\circ}C$ to dissolve copper sludge if the corrosion potential of copper can be controlled above -200mV. However, it is very difficult to raise the corrosion potential of copper to this range by air blowing and stirring.

• Radiation Oncology Journal
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• v.12 no.2
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• pp.191-199
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• 1994

Purpose : This study was undertaken to show the clinical results of combined radiotherapy and hyperthermia in primary hepatoma Materials and Methods : Between December 1989 and March 1993, 50 patients with hepatomas were treated by combined radiotherapy and hyperthermia. Among them, we analyzed retrospectively 33 patients who received the complete course of treatment. The ages of the patients ranged from 36 to 75(mean age: 55.5 years). Twenty-six patients ($78.8\%$) were men, and 7 ($21.2\%$ were women. According to Child's classification, nine patients ($27.3{\%}$) were A group, 9 ($27.3\%$) were B group, 15 ($45.4\%$) were C group. Radiation therapy was done by a 6 MV and 15 MV linear accelerator. Patients were treated with daily fractions of 150-180 cCy to doses of 2550 cGy -4950 cGy (median : 3000 cGy). Local hyperthermia was done by 8 MHZ RF capacitive heating device (Cancermia. Green Cross Co., Korea), 50-60 min/session, 1-2 sessions/wk, and 8.5 sessions (median number)/patient. We analyzed the prognostic factors including age, sex, tumor type, Child's classification, $\alpha$-fetoprotein, liver cirrhosis, ascites, portal vein invasion, esophageal varix, number of hyperthermia, chemotherapy, total bilirubin level, Karnofsky perfomance status. Results : The overall 1-year survival was $24.2\%$, with a mean survival of 10months. Of 33 patients, tumor regression (PR+MR) was seen in $30.4\%$, no response was seen in $52.2\%,\;17.4\%$ patient was progressed. In patients who had tumor regression, the overall 1-year survival was $42.1\%$ with a mean survival of 14 months. Factors influencing the survival were sex (p=0.05), tumor type (p=0.0248), Child's classification (p=0.0001), liver cirrhosis (p=0.0108), ascites (p=0.0009), and Karnofsky perfomance status (p=0.0028). Complications developed in 28 patients, including 18 hot pain,5 fat necrosis, 3 transient fever, 2 nausea and vomiting. Conclusion : In this study, the results suggests that combined radiotherauy and hyperthermia may improve the survival rate of hepatoma.

• The Journal of the Korean life insurance medical association
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• v.2 no.1
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• pp.152-181
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• 1985

A statistical analysis on the cardiothoracic ratio in insurance medicine was carried out for 5,200 insured persons who were medically examined including photofluorography of the chest at the Honam medical department, Dong Bang life insurance Company, Ltd from November, 1979 to August, 1984. The results were as follows: 1. The mean value of the cardiothoracic ratio in all of the insured was $44.2{\pm}4.3%$. The mean value of the cardiothoracic ratio was $43.1{\pm}4.1%$ in all males and $45.2{\pm}4.2%$ in all females, and the difference of the values between males and females showed statistical significance(P<0.001). In each age group, the mean value of the cardiothoracic ratios of female was higher than that of male without exception and the difference of the values between males and females showed statistical significance(P<0.001). The mean value of the cardiothoracic ratio showed gradual increase with age from the second to sixth decade in male(P<0.05 or 0.001 after fourth decade) and from the second to seventh decade in female(P<0.05 or 0.001 from the second to sixth decade). 2. Correlation between both sexes and among age groups relating to the cardiothoracic ratios of the insureds seen to be a physiological phenomenon of the cardiac size and should be considered on the rating of the cardiothoracic ratio. Based on the correlation above mentioned and an author's assumption that the incidence of normal and abnormal cardiothoracic ratios in each age group would show the same rate in male and female, author prepared a modified rating table from the existing table; in male group the existing rating table is used and in female group the ratings of 0, 30-50, 50-100 and 100-D are to calculate by the cardiothoracic ratio of 51%or under, 52-56%, 57-61% and 62% or over respectively in the age group below 39, by the cardiothoracic ratio of 52% or under, 53-57%, 58%-62% and 63% or over respectively in the age group of 40-49, by the cardiothoracic ratio of 53% or under, 54-58%, 59-63% and 64% or over respectively in the age group over 60. 3. The relative frequency distribution polygons of the cardiothoracic ratio of both sexes drawn in a pair on one coordinate plane revealed lying in juxtaposition each other horizontally and showed the shifting of females polygon to male's one toward the direction of greater value of the cardiothoracic ratio at a short distance which increased gradually with age. 4. The minimum cardiothoracic ratio was 31.2% and the maximum cardiothoracic ratio was 63.6% in all of the insured. 5. In each age group, no significant sex difference was found in the relative frequency distribution of ratings by the cardiothoracic ratios of 5,200 insureds by using the rating table modified by author, while significant sex difference was found by using the existing rating table.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.5
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• pp.458-465
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• 2020

The purpose of this study is to analyze the effect of policy in Jeju, using a macro-economic forecasting model of Jeju. First, the model's reality explanatory power improved by updating its statistics to 2017 and expanding new policy variables and modules. Also, the industrial structure of the model was further subdivided and extended to be considered simultaneously in the demand side of Keynesian theory. Second, it was determined that the predictive power for the model of this study was better than that of the existing model. However, with some endogenous variables, it was possible to identify implications that should be developed and considered when the model is improved with additional data in the future. Third, when the second airport construction was considered, it was observed that its effect was an increase of 1.25 times for GRDP, 1.2 times for employment, 1.48 times for private consumption, and 2.06 times for investment. Also, the economic growth rate was estimated to be 1.6% point higher than when the second airport was not constructed. Finally, the results of this study are expected to be used for policy decision making of the Jeju Government.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.7
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• pp.2645-2651
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• 2015

Background: The phosphatidylinositol 3'-kinase/Akt (PI3K/Akt) pathway is a key regulator for HER2-overexpressing breast cancer, but data about whether activation of PI3K/Akt is associated with poor prognosis and resistance to trastuzumab therapy is controversial. In this study we investigated predictive and prognostic significance of expression of p27, Akt, PTEN and PI3K, which are components of the PI3K/Akt signaling pathway, in HER2-positive metastatic breast cancer (MBC), retrospectively. Materials and Methods: Fifty-four HER2-positive MBC patients who had received first-line trastuzumab-based therapy were recruited for the study group. All of the patient's breast tissue samples were examined for p27 and Akt expression. In addition, twenty-five patients with sufficient amount of tumor tissue were also examined for PTEN and PI3K expression. p27, Akt, PTEN and PI3K were evaluated by immunohistochemistry and their relationship with patient demographic features, tumor characteristics, response to trastuzumab-based treatment and survival outcomes were analyzed. Results: p27, Akt, PTEN and PI3K were positive in 25.9%, 70.4%, 24% and 96% of the cases, respectively. Nomne were significantly associated with response to trastuzumab and time to progression (TTP). A trend toward statistical significance for longer overall survival (OS) was found for PTEN-positive patients (p=0.058); there was no significant relationship between the other immunohistochemical variables and OS. When we analyzed groups regarding co-expression, the PTEN-negative/Akt-negative group had a significantly lower objective response rate (ORR) (20% vs 80%, p=0.023) and the PTEN-negative/p27-negative and PTEN-negative/Akt-negative groups had significantly lower median OS compared to other patients (26.4 months vs 76.1 months, p=0.005 and 25.6 months vs 52.0 months, p=0.007, respectively). Conclusions: p27, Akt, PTEN and PI3K expression is not statistically significantly associated with ORR, TTP and OS, individually. However, the combined evaluation of p27, Akt and PTEN could be helpful to predict the response to trastuzumab-based therapy and prognosis in HER2-positive MBC.

• Journal of Gastric Cancer
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• v.6 no.3
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• pp.181-188
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• 2006

Purpose: Heregulin is a natural ligand for erbB3 and erbB4. However, very little is known about their roles in the gastric cancer This retrospective study was performed to evaluate the frequencies of heregulin and erbB family protein expression and to compare their expressions with clinicopathologic parameters. Materials and Methods: Immunohistochemical expressions of heregulin and erbB family proteins were examined with tissue micro-array slides. A total of 251 gastric adenocarcinomas were classified as early cancers and advanced cancers and as having and not having lymph node metastases. Results: The positive rates of the heregulin, erbB1, erbB2, erbB3, and erbB4 protein stainings were 64%, 68%, 6%, 88%, and 76%, respectively. Intestinal type gastric adenocarcinomas showed higher expression of heregulin, erbB2, erbB3, and erbB4 proteins. Heregulin and erbB4 proteins showed lower expressions in advanced gastric carcinomas. However, erbB2 protein showed higher expression in advanced gastric carcinomas. The protein expressions of heregulin and erbB family proteins showed no relationship with survival rate. Co-expression groups of heregulin and erbB3 proteins or heregulin and erbB4 proteins showed higher expressions in intestinal type adenocarcinomas and early gastric carcinomas. Conclusion: Heregulin, erbB3, and erbB4 proteins may play a role in the early stage of adenocarcinomas.

• KSBB Journal
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• v.14 no.3
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• pp.303-308
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• 1999

An in vitro culture method for entomopathogenic nematode Steinernema glaseri was developed. A symbiotic bacterium was isolated from Steinernema glaseri and identified as Xenorhabdus nematophilus. Phase variation that differed in some biochemical characteristics of symbiotic bacterium was observed. Entomopathogenic nematodes carried only phase I bacterium in their guts. Phase I bacterium could be converted into phase II form in in vitro culture medium consisting of 5% yeast extract, 0.5% NaCl, 0.05% $K_2HPO_4$, $0.02% MgSO_4$.$7H_2O$. The optimum temperature for bacterial growth was $28^{\circ}C$. The pH of the culture medium increased up to 9.0-9.5 during the exponential growth period of the culture, regardless of initial pH 6-7. Various culture media such as chicken offal, dog food, bovine liver, peanut, and so on were tested for in vitro culture of the nematodes. The best medium for Steinernema glaseri production was obtained from concentrated homogenate of bovine liver and the nematode growth was highest at 80% bovine liver. In the co-culture of entomopathogenic nematode with its symbiont, the growth rate of nematodes was 2 times faster than that without its symbiont and the nematode concentration reached about $5.5\times10^4$/mL within 15 days.

• Journal of Korean Society of Environmental Engineers
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• v.37 no.4
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• pp.240-245
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• 2015

This study aimed to provide the basic data to establish measures for the management of the public toilets and reduction of the offensive odor through the air dilution olfactory method and instrumental analysis about offensive odor dilution rate of public toilets, focusing on the Dong-gu, Daejeon Metropolitan City, Korea. The offensive odor intensities ranged from 10 degree to 669 degrees in the urinal toilets and from 31 to 464 in closet bowl toilets. Meanwhile, toilets that had offensive odor of more than 2.5, of which a civil complaint can be filed, were researched 6 (33%). Offensive odor intensities were different according to the closet bowl toilets of the flush, fermented and conventional methods and the year of their installation, but not according to the area of the toilets. As a result of the instrumental analysis targeting 6 public toilets to identify the offensive odor substance, the maximal concentration of $NH_3$ was 2.04 ppm and the average concentration was 0.67 ppm, but $H_2S$, $CH_3SH$ and $(CH_3)_3N$ were not detected. In the fermented and conventional public toilets were not soaps, air fresheners and wastebaskets. Just 50% of the flush toilets had toilet tissue.

• The Korean Journal of Pesticide Science
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• v.16 no.4
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• pp.288-293
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• 2012

The dissipation patterns of amisulbrom in cucumber under a greenhouse condition was investigated to establish biological half-life and pre-harvest residue limit (PHRL). Amisulbrom residue in/on cucumber on the day of application under standard application condition was $0.15mg\;kg^{-1}$ and decreased to $0.06mg\;kg^{-1}$ after 5 days after treatment, so that biological half-life calculated 3.6 day, while initial concentration of amisulbrom twice application 3 days interval under standard application condition was $0.35mg\;kg^{-1}$ and decreased to $0.09mg\;kg^{-1}$ after same period and the biological half-life calculated 2.4 day. PHRL was suggested by prediction curve calculated from the decay constant of amisulbrom at standard rate. For example, $1.83mg\;kg^{-1}$ at 5 days before harvest and $1.03mg\;kg^{-1}$ at 2 days before harvest were suggested.

• Journal of the Institute of Convergence Signal Processing
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• v.2 no.4
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• pp.22-30
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• 2001

In this paper we propose three classification algorithms to classify breast tumors that occur in duct into Benign, DCIS(ductal carcinoma in situ) NOS(invasive ductal carcinoma) The general approach for a creating classifier is composed of 2 steps: feature extraction and classification Above all feature extraction for a good classifier is very significance, because the classification performance depends on the extracted features, Therefore in the feature extraction step, we extracted morphology features describing the size of nuclei and texture features The internal structures of the tumor are reflected from wavelet transformed images with 10$\times$ and 40$\times$ magnification. Pariticulary to find the correlation between correct classification rates and wavelet depths we applied 1, 2, 3 and 4-level wavelet transforms to the images and extracted texture feature from the transformed images The morphology features used are area, perimeter, width of X axis width of Y axis and circularity The texture features used are entropy energy contrast and homogeneity. In the classification step, we created three classifiers from each of extracted features using discriminant analysis The first classifier was made by morphology features. The second and the third classifiers were made by texture features of wavelet transformed images with 10$\times$ and 40$\times$ magnification. Finally we analyzed and compared the correct classification rate of the three classifiers. In this study, we found that the best classifier was made by texture features of 3-level wavelet transformed images.