• 한국IT서비스학회:학술대회논문집
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• 한국IT서비스학회 2009년도 추계학술대회
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• pp.225-233
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• 2009

날이 갈수록 치열해지는 글로벌 경쟁 환경하에서 살아남기 위해 많은 기업들은 조직 구성원들의 역량 강화를 통한 기업의 경쟁력 강화를 위하여 다양한 활동들을 하고 있으며, 이러한 활동중 하나로 액션러닝을 많은 기업들이 채택하여 활용하고 있다. 그러나 액션러닝 과정은 경영층과 팀 리더 차원에서의 적극적인 지원 및 관심뿐만 아니라 참여하는 구성원들도 적극성을 갖고 수행되어야 역량 향상을 기대할 수 있다. 또한 기업의 문화 및 제도 역시 액션러닝이 원활하게 진행될 수 있도록 뒷받침되어야만 성공할 수 있다. 본 연구에서는 LG CNS에 도입하여 성공적으로 운영하고 있는 액션러닝의 역량강화 사례를 살펴보고 그 효과성을 분석해 봄으로서 글로벌 경쟁에서 살아남고 더 나아가 글로벌 IT서비스 기업과 대등한 수준에서 경쟁하기 위해 역량 강화를 원하는 여러 IT서비스 업체들에게 역량 향상을 위한 하나의 방향성을 제시하고자 한다.

• 한국IT서비스학회:학술대회논문집
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• 한국IT서비스학회 2003년도 춘계학술대회
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• pp.215-221
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• 2003

In today's rapidly changing business environment, quality of responsiveness to customer requirements for short order cycles and on time delivery is becoming more important and considered as one of critical success factors in supply chain management. Yet despite its importance on reducing transportation cost and improving customer service, little attention has been given to the transportation planning system in Korea SI industry. In this paper, we present development of transportation planning system especially to deal with vehicle routing problem which has the goal to minimize the costs of daily transportation operation and to maximize customer delivery service. The system architecture with other enterprise application is presented and real-world constraints are well incorporated into the system by combining constraints programming and meta heuristics.

• Journal of Korean Neurosurgical Society
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• 제61권3호
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• pp.386-392
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• 2018

Radiation therapy is highly effective for the management of pediatric malignant central nervous system (CNS) tumors including embryonal tumors. With the increment of long-term survivors from malignant CNS tumors, the radiation-related toxicities have become a major concern and we need to improve the treatment strategies to reduce the late complications without compromising the treatment outcomes. One of such strategies is to reduce the radiation dose to craniospinal axis or radiation volume and to avoid or defer radiation therapy until after the age of three. Another strategy is using particle beam therapy such as proton beams instead of photon beams. Proton beams have distinct physiologic advantages over photon beams and greater precision in radiation delivery to the tumor while preserving the surrounding healthy tissues. In this review, I provide the treatment principles of pediatric CNS embryonal tumors and the strategic improvements of radiation therapy to reduce treatment-related late toxicities, and finally introduce the increasing availability of proton beam therapy for pediatric CNS embryonal tumors compared with photon beam therapy.

• Bulletin of the Korean Chemical Society
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• 제32권3호
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• pp.873-879
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• 2011

5-Fluorouracil (5-FU), an anticancer agent was covalently attached to the recently developed sorbitol-based G8 transporter, and the conjugate (7) with FITC was found to have an affinity toward mitochondria and to readily cross BBB to gain an entry into mouse brain. Measured by $IC_{50}$, the conjugate (9) without the fluorophore showed enhanced cytotoxic activity toward two types of multidrug-resistant cell lines. These results strongly suggest that the sorbitol-based G8 transporter can be utilized as a good CNS delivery vector.

• 한국경영과학회:학술대회논문집
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• 한국경영과학회 2003년도 추계학술대회 및 정기총회
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• pp.252-255
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• 2003

This article concerns the event management of the transportation and delivery system in the real time environment. Until now mainstream researches in the transportation and delivery area have largely focused how to create optimized vehicle routing schedule fast and stably, although the execution and event management area has a lot of opportunities which could make logistics efficient and especially customers satisfied. This paper suggests to-be model processes how to execute vehicle routing schedule correctly and when events are occurred how to cope with them effectively. To embody such ideas GIS, GPS and Mobile technologies are attached on optimizing scheduler engine, TMS, WMS, ATP and Monitoring system.

• BMB Reports
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• 제35권1호
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• pp.94-105
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• 2002

Apoptotic cell death is a fundamental and highly regulated biological process in which a cell is instructed to actively participate in its own demise. This process of cellular suicide is activated by developmental and environmental cues and normally plays an essential role in eliminating superfluous, damaged, and senescent cells of many tissue types. In recent years, a number of experimental studies have provided evidence of widespread neuronal and glial apoptosis following injury to the central nervous system (CNS). These studies indicate that injury-induced apoptosis can be detected from hours to days following injury and may contribute to neurological dysfunction. Given these findings, understanding the biochemical signaling events controlling apoptosis is a first step towards developing therapeutic agents that target this cell death process. This review will focus on molecular cell death pathways that are responsible for generating the apoptotic phenotype. It will also summarize what is currently known about the apoptotic signals that are activated in the injured CNS, and what potential strategies might be pursued to reduce this cell death process as a means to promote functional recovery.

• 한국IT서비스학회:학술대회논문집
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• 한국IT서비스학회 2009년도 춘계학술대회
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• pp.165-168
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• 2009

현재 IT서비스 업체에서 새로운 성장동력으로 떠오르고 있는 분야가 융복합사업(IT+IT, IT+장비, IT+장비+시공)이라고 불리우는 컨버전스 프로젝트이다. 기존의 IT분야의 프로젝트와는 전혀 다른 특성을 갖고 있는 컨버전스 프로젝트에 대한 IT서비스 업체의 준비는 아직 미흡한 것이 현실이다. LG CNS에서는 이런 현실에서 컨버전스 프로젝트의 특성에 맞추어 기존 프로젝트 관리자(Project Manager)의 역할을 재정의하고 이를 현장에 적용시키기 위해 그동안의 컨버전스 프로젝트를 수행하면서 얻은 이슈에 HPT(Human Performance Technology; 수행공학)를 적용하여 조직적인 차원에서 프로젝트 관리자의 육성 로드맵을 만들고 이를 확산시키는 활동을 진행하고 있다. 이에 본 발표에서는 HPT측면에서 컨버전스 프로젝트 이행역량을 강화하기 위한 사례를 소개하고자 한다.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1998년도 Proceedings of UNESCO-internetwork Cooperative Regional Seminar and Workshop on Bioassay Guided Isolation of Bioactive Substances from Natural Products and Microbial Products
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• pp.152-153
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• 1998

Oxytocin (OT) is a neurohypophyseal nonapeptide which plays an important role in CNS function as well as uterine contraction during delivery. Furthermore, recently it has been reported that OT may also have analgesic effect and found that the release of OT is related with opioid receptors, especially $\kappa$ and ${\mu}$.

• Molecules and Cells
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• 제37권7호
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• pp.518-525
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• 2014

Gammaherpesvirus (${\gamma}HV$) infection of the central nervous system (CNS) has been implicated in diverse neurological diseases, and murine ${\gamma}HV$-68 (MHV-68) is known to persist in the brain after cerebral infection. The underlying molecular mechanisms of persistency of virus in the brain are poorly understood. Here, we characterized a unique pattern of MHV-68 persistent infection in neuroblastoma cells. On infection with MHV-68, both murine and human neuroblastoma cells expressed viral lytic proteins and produced virions. However, the infected cells survived productive infection and could be cultured for multiple passages without affecting their cellular growth. Latent infection as well as productive replication was established in these prolonged cultures, and lytic replication was further increased by treatment with lytic inducers. Our results provide a novel system to study persistent infection of ${\gamma}HVs$ in vitro following de novo infection and suggest application of MHV-68 as a potential gene transfer vector to the brain.

• 대한핵의학회지
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• 제38권2호
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• pp.161-170
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• 2004

분자영상은 살아있는 개체의 몸 속에서 일어나는 생물학적 반응이나 특정한 표적분자를 비관혈적이며 반복적으로 영상화하는 기술이다. 이를 위해서는 두 가지 기본 요소가 요구되는 바 하나는 관심 생물현상에 의해 농도나 분광특성이 변하는 분자영상용 추적자이며 다른 하나는 이런 추적자를 모니터링하는 장비이다. 분자 핵의학 영상기술은 이제 신경과학분야에서도 활발히 적용되고 있으며 신경관련 기초연구나 뇌질환 관련 신약개발에 이미 중요한 역할을 하고 있다. 최근에는 살아있는 개체에서 약제 투여가 뇌에 미치는 약물학적, 생리적 영향을 조사하는 데에도 이용되고 있다. 다가오는 미래에는 각종 뇌질환에서 특이적 표적을 공략하는 새로운 분자치료가 개발되어 뇌질환 치료에 혁명적인 변화를 가져올 것으로 예상되고 있다. 그 예로, 파킨슨씨 병과 같은 퇴행성 신경질환에 줄기세포를 이용한 자가수선, 신경보호, 약물분비 치료, 성장인자와의 병행치료 등이 개발되고, 유전자 치료도 이용될 것으로 보인다. 신경 분자 핵의학 영상은 이와 같은 새로운 뇌질환 치료기술의 개발에 있어서 뇌 안에서 일어나는 분자수준의 변화를 실시간으로 모니터링함으로써 관련연구에 크게 기여할 것으로 기대된다.