• Korean journal of applied entomology
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• v.11 no.1
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• pp.31-35
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• 1972

1. Continuous light induced more conidia than alternating light and darkness treatment in isolate Chinju 1. Isolate Suwon 3 produced much more conidia on synthetic medium than Chinju 1 in light. Conidial formation in Suwon 3 increased remarkably with alternate light and darkness in 8 days incubation. 2. Light was essential for perithecial formation in Chinju 1. No matured perithecia were observed in Suwon 3 with any treatment. Abundant perithecia were produced in Chinju 1 but only perithecial initiation occurred in Suwon 3. Suwon 3 produced significantly more conidia than Chinju 1, while perithecial formation was reversed. 3. Conidial numbers in soil decreased significantly through the winter at 10, 30 and 50 per cent soil moisture, with the most striking decrease at 10 per cent levels, but the number recovered again beginning in March, regardless of the soil moisture. The above results provide us a useful clue to support the possbility the conidia may serve as a primary inoculum.

• Journal for History of Mathematics
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• v.22 no.3
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• pp.171-186
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• 2009

$Poincar\acute{e}$ is mathematician and the episodes in his mathematical invention process give suggestions to scholars who have interest in how mathematical invention happens. He emphasizes the value of unconscious activity. Furthermore, $Poincar\acute{e}$ points the complementary relation between unconscious activity and conscious activity. Also, $Poincar\acute{e}$ emphasizes the value of intuition and logic. In general, intuition is tool of invention and gives the clue of mathematical problem solving. But logic gives the certainty. $Poincar\acute{e}$ points the complementary relation between intuition and logic at the same reasons. In spite of the importance of relation between intuition and logic, school mathematics emphasized the logic. So students don't reveal and use the intuitive thinking in mathematical problem solving. So, we have to search the methods to use the complementary relation between intuition and logic in mathematics education.

• Biomolecules & Therapeutics
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• v.21 no.6
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• pp.476-480
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• 2013

Obesity is one of the most serious health problems in developed countries. It negatively affects diverse aspects of human wellbeing. Of these, a relationship between obesity and depression is widely recognized but biomarkers for assessment of obesity-associated mood changes in animal obesity models are rarely known. Here we explored the link between obesity and the plasma levels of monoamine neurotransmitters involved in mood control using a sensitive UPLC/MSMS technique in high fat diet (HFD)-induced obesity model in male C57BL/6 mice to explore the potential utility of plasma tests for obesity-associated mood change. HFD (60% of total calories, 8 weeks) induced significantly higher weight gains in body (+37.8%) and fat tissue (+306%) in male C57BL/6 mice. Bioanalysis of serotonin, dopamine and norepinephrine in plasma at 8 weeks of HFD revealed that serotonin decreased significantly in the obese mice when compared to normal diet-fed mice ($2.7{\pm}0.6$ vs $4.3{\pm}2.0ng/ml$, N=8). Notably, a negative correlation was found between the levels of serotonin and body weight gains. Furthermore, principal component analysis (PCA) with the individual levels of neurotransmitters revealed that plasma levels of dopamine and serotonin could apparently differentiate the obese mice from lean ones. Our study demonstrated that blood plasma levels of neurotransmitters can be employed to evaluate the mood changes associated with obesity and more importantly, provided an important clue for understanding of the relationship between obesity and mood disorders.

• Molecular & Cellular Toxicology
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• v.5 no.3
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• pp.179-186
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• 2009

Hexachlorobenzene (HCB) is a bioaccumulative, persistent, and toxic pollutant. HCB is one of the 12 priority of Persistent Organic Pollutants (POPs) intended for global action by the United Nations Environment Program (UNEP) Governing Council. POPs are organic compounds that are resistant to environmental degradation through chemical, biological, and photolytic processes. Some of HCB is ubiquitous in air, water, soil, and biological matrices, as well as in major environmental compartments. HCB has effects on various organs such as thyroid, bone, skin, kidneys and blood cells and especially, revealed strong toxicity to liver. In this study, we identified genes related to hepatotoxiciy induced by HCB in human hepatocellular carcinoma (HepG2) cells using microarray and gene ontology (GO) analysis. Through microarray analysis, we identified 96 up- and 617 down-regulated genes changed by more than 1.5-fold by HCB. And after GO analysis, we determined several key pathways which known as related to hepatotoxicity such as metabolism of xenobiotics by cytochrome P450, complement and coagulation cascades, and tight junction. Thus, our present study suggests that genes expressed by HCB may provide a clue for hepatotoxic mechanism of HCB and gene expression profiling by toxicogenomic analysis also affords promising opportunities to reveal potential new mechanistic markers of toxicity.

• Journal of Food Hygiene and Safety
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• v.19 no.4
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• pp.185-192
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• 2004

Generic HACCP models for bakery products may help HACCP implementation at the wholesale bakery production lines easier. When baking, the internal temperature of bakery products went up to $85^{\circ}C$, which resulted in gelatinization of starch. Considering the characteristics of bakery products, general sanitation control procedures are the main target tool to keep bakery products safe. Monitoring of pathogenic microorganisms at bakery plant environment including production lines was carried out. At the wholesale bakery environment pathogenic microorganisms were detected. It gave a clue that general sanitation control procedures should be implemented for safe bakery products supply. Hazard analysis of raw materials and processing of bakery products, and determination of critical control points and critical limits at the wholesale bakeries lead to present generic model of bakery product HACCP plan. CCPs for the wholesale bakery products may be applied and modified for the implementation of HACCP plan at the wholesale bakery plant.

• Phonetics and Speech Sciences
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• v.9 no.3
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• pp.75-83
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• 2017

The purpose of this study is to find clues to the risk of voice disorders in soprano students. The subjects of the study were 17 soprano students and 18 general students (women). The phonation of vowels /a/, /i/, and /u/ with C4 and F4 notes in each group were recorded. Then, only soprano students were made to record their classical vocalization containing vibrato. Formant, formant energy, bandwidth, VAI (vowel area index), VSA (vowel space area) and L/H ratio were analyzed. There was significant difference in F3 such that the singers' note was measured around 3 kHz which seems to be 400 Hz higher than one from general students. But, There was no significant difference in L/H ratio between soprano student and the general student. There was a significant difference in F3 in the comparison of the soprano students' two vocalization methods. Classical vocalization was measured at 200Hz higher than sustained phonation in F3. Vocal tract adjustment was made and vowel space changed, but there was no significant difference in F3 energy, which is the index of singers' formant according to the phonation method. The L/H ratio, which can be a direct indicator of vocal effort, has no difference in phonation method and is lowered in all phonation methods as the pitch increases. C4 and F4 pitches are lower than the singing range of the soprano. When the pitch changes, vocal effort increases like a general student which will be an indicator of the risk of vocalization. This will be a clue to the vocalization of the immature soprano student.

• Journal of the Korean GEO-environmental Society
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• v.8 no.5
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• pp.23-29
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• 2007

The performance of the improved soil against liquefaction depends upon the chemical density, and it has been decided on the basis of the unconfined compressive strength of the improved soil up to date. On the other hand, several authors have proposed that the stiffness degradation could be treated as the clue for the judgment of the possibility of liquefaction. In this study, therefore, the stiffness degradation of the improved soil was estimated as the resistance against liquefaction by using the strain controlled cyclic triaxial test equipment. Based on the test results, it is concluded that the chemically treated sand can resist against the liquefaction in aspect of the reduction in effective stress and in the stiffness. Furthermore, even in the case of low chemical density, such as 2% in this study, has enough liquefaction resistance when compared with the 5~6% which often used in practical design. Considering this fact, the design of chemical density based on the unconfined strength can lead the overestimation in chemical density, and chemical density can be reduced when considering the stiffness reduction shown in this study.

• Annals of Clinical Neurophysiology
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• v.4 no.1
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• pp.44-50
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• 2002

Introduction : Orthostatic tremor develops in the legs while standing up with no weakness, pain or imbalance in the leg and the tremor is characteristically not observed when walking. However there have been some confusions about orthostatic tremor in several aspects. For the past ten years, we have observed 4 patients with orthostatic tremor. In each case tests were performed to investigate the following three important areas of inquiry about orthostatic tremor. Firstly, whether this disorder is an independent diagnostic entity or a variant of essential tremor. Secondly, whether the progress of this disorder is specifically related with standing posture. Lastly, the nature of the pathophysiologic mechanism behind the appearance of the tremor when standing after the lapse of a certain latent period and its disappearance upon the commencement of walking. Methods : Our 4 cases of orthostatic tremor were studied clinically, electrophysiologically, and pharmacologically. Electrophysiological tests included tremor spectrum test and electromyography. Results : We observed the presence of this tremor in several other tonic postures, as well as its absence, in a vertically lifted position from all our cases. Our cases registered a variable tremor frequency between 5 and 12 Hz according to the tremor spectrum test and EMG. Furthermore all our 4 cases demonstrated patterns of both synchronous EMG activity and alternating EMG activity at various times in homologous muscles of both legs. Orthostatic tremor was improved significantly with propranolol as well as clonazepam. Conclusions : From the results of our study we drew the following conclusions. It is probable that orthostatic tremor is simply a variant of essential tremor rather than being an independent diagnostic entity and that in most cases its development is specifically related with muscle contraction rather than merely with the act of standing. Furthermore we discovered a clue in the previously described neural control mechanism that the nuclear bag fibers in the muscle spindle have lag time of several seconds in their response to muscle strength and that their baseline does not reset fully in rapidly moving muscle. This neural control mechanism could offer sufficient explanation for the phenomena of tremor appearance when standing and disappearance when walking in orthostatic tremor.

• Journal of the Korean School Mathematics Society
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• v.18 no.3
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• pp.241-258
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• 2015

The purpose of this paper is to examine the students' mathematics problem solving process in the intuitive stages. For this, researcher developed the questionnaire which consisted of problems in relation to intuitive and algorithmic problem solving. 73 fifth grade and 66 sixth grade elementary students participated in this study. I got the conclusion as follows: Elementary students' intuitive problem solving ability is very low. The rate of algorithmic problem solving is higher than that of intuitive problem solving in number and operation areas. The rate of intuitive problem solving is higher in figure and measurement areas. Students inclined to solve the problem intuitively in that case there is no clue for algorithmic solution. So, I suggest the development of problems which can be solved in the intuitive stage and the preparation of the methods to experience the insight and intuition.

• Korean Journal of Cognitive Science
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• v.19 no.4
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• pp.477-497
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• 2008

Mood classification of blog text is an interesting problem, with a potential for a variety of services involving the Web. This paper introduces an approach to mood classification enhancements through the normalized negation n-grams which contain mood clues and corpus-specific term weighting(CSTW). We've done experiments on blog texts with two different classification methods: Enhanced Mood Flow Analysis(EMFA) and Support Vector Machine based Mood Classification(SVMMC). It proves that the normalized negation n-gram method is quite effective in dealing with negations and gave gradual improvements in mood classification with EMF A. From the selection of CSTW, we noticed that the appropriate weighting scheme is important for supporting adequate levels of mood classification performance because it outperforms the result of TF*IDF and TF.