• Transactions of the Korean Society of Mechanical Engineers B
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• v.30 no.5 s.248
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• pp.446-456
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• 2006

The effect of relative position of the stationary turbine blade for the fixed vane has been investigated on blade tip and shroud heat transfer. The local mass transfer coefficients were measured on the tip and shroud fur the blade fixed at six different positions within a pitch. A low speed stationary annular cascade with a single turbine stage was used. The chord length of the tested blade is 150 mm and the mean tip clearance of the blade having flat tip is 2.5% of the blade chord. A naphthalene sublimation technique was used for the detailed mass transfer measurements on the tip and the shroud. The inlet flow Reynolds number based on chord length and incoming flow velocity is fixed to $1.5{\times}10^5$. The results show that the incoming flow condition and heat transfer characteristics significantly change when the relative position of the blade changes. On the tip, the size of high heat/mass transfer region along the pressure side varies in the axial direction and the difference of heat transfer coefficient is up to 40% in the upstream region of the tip because the position of flow reattachment changes. On shroud, the effect of tip leakage vortex on the shroud as well as tip gap entering flow changes as the blade position changes. Thus, significantly different heat transfer patterns are observed with various blade positions and the periodic variation of heat transfer is expected with the blade rotation.

• Journal of Advanced Marine Engineering and Technology
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• v.29 no.2
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• pp.185-193
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• 2005

The present study composed a diesel-atkinson cycle of high expansion as a method of achieving high efficiency in diesel cycle engines. It also interpreted the cycle engine thermodynamically analysis to determine the possibility of the improvement of thermal efficiency and clarified the characteristics of several factors . According to the result of theoretical analysis, heat efficiency was highest when expansion-compression ratio Reど:1. In addition. diesel engines with high apparent compression ratio had higher expansion-compression ratio than otto engines and consequently their effect of high expansion was high. which in turn enhanced thermal efficiency. When the atkinson cycle was implemented in a real diesel engine by applying the miller cycle through the variation of the closing time of the intake valve, the effective compression ratio and the quantify of intake air decreased and as a result, the effect of high expansion was not observed. Accordingly. the atkinson cycle can be implemented when the quantity of intake air is compensated by supercharge and the effective compression ratio is maintained at its initial level through the reduction of the clearance volume. In this case. heat efficiency increased by $4.1\%$ at the same expansion-compression ratio when the apparent compression ratio was 20 and the fuel cut off ratio was 2. As explained above, when the atkinson cycle was used for diesel cycle. heat efficiency was improved. In order to realize high expansion through retarding the intake value closing time, the engine needs to be equipped with variable valve timing equipment, variable compression ratio equipment and supercharged Pressure equipment. Then a diesel-atkinson cycle engine is realized.

• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.1
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• pp.181-186
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• 2006

A pharmacological inhibition of nitric oxide synthase (NOS) in rats produces vasoconstriction, renal dysfunction, and hypertension. The present study was aimed at investigating whether the methanol extract of Serous commixta cortex (MSC) ameliorates $N^G$-nitro-L-arginine methylester (L-NAME) induced hypertension in rats. Treatment of rats with L-NAME (10 mg/kg/day in drinking water, 5 weeks) caused a sustained increase in systolic blood pressure (SBP). Administration of MSC (100 or 200 mg/kg/day, p.o) significantly lowered the SBP in the L-NAME-treated rats and this effect was maintained throughout the whole experimental period. Moreover, ecNOS expression in aorta and kidney tissue from L-NAME treated rats was significantly restored dy administration of MSC. Furthermore, the impairment of acetylcholine (ACh)-induced relaxation of aortic rings in the L-NAME treated rats was reversed dy administering of MSC. The renal functional parameters including urinary volume, sodium excretion, and creatinine clearance (Ccr) were also restored by administering MSC. Taken together, the present study suggeststhat MSC prevents the increase in SBP in rats with L-NAME-induced hypertension, which may result from the up-regulation of the vascular and renal ecNOS/No system.

• Biomolecules & Therapeutics
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• v.2 no.4
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• pp.310-315
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• 1994

The pharmacokinetics and tissue distribution of DA-3030 (recombinant human granulocyte colony-stimulating factor, rhG-CSF, recently manufactured by Dong-A research laboratory of Dong-A Pharmaceutical Company) were compared with reported data in the literature. After intravenous(i.v.) administration of DA-3030, at dose of 5, 10 and 100 $\mu\textrm{g}$/kg to rats, some pharmacokinetic parameters, such as terminal half-lives(1.05, 1.19 and 1.83 hr, respectively) and clearance (84.0, 54.8 and 45.5 mι/hr/kg, repectively), were dose-dependent. This could be due to the saturable metabolism of DA-3030 in rats. Similar results were also reported. After subcutaneous(s.c.) and intramuscular(i.m.) administrations of DA-3030, 10 $\mu\textrm{g}$/kg to rats, the extent of bioavailability(absolute bioavailability) were incomplete; the values were 23.3 and 18.2% after s.c. and i.m. injections, respectively, due to the degradation of DA-3030 by protease. After 7-consecutive day i.v. administrations of DA-3030, 10 $\mu\textrm{g}$/kg/day, to rats, the plasma concentrations and pharmacokinetic parameters of DA-3030 were not significantly different from those in single administration. In mice and dogs at DA-3030 dose of 10 $\mu\textrm{g}$/kg, the plasma concentrations of DA-3030 were also declined rapidly with terminal half-lives of 1.31 and 1.15 hr, respectively. DA-3030 was highly concentrated in the kidney after i.v. administration of DA-3030, 10 $\mu\textrm{g}$/kg, to rats, and the results were similar to those obtained using radiolabelled rhG-CSF in the literature. Above data indicate that DA-3030 has similar properties to rhG-CSF manufactured by other companies in view of pharmacokinetics.

• Biomolecules & Therapeutics
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• v.6 no.2
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• pp.130-138
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• 1998

In this study, the effect of verapamil (VER) on cyclosporin A (CsA)-induced nephrotoxicity was investigated in uninephrectomized rats. Male Wistar rats were administered CsA (50 mg/kg/day, p.o.) or VER (0.5 mg/kg/day, i.p.) with CsA (50 mg/kg/day, p.o.) for 20 days. The urinary N-acetyl-$\beta$-D-glucosaminidase (NAG) activity along with BUN, serum creatinine, creatinine clearance (CLcr), body weight, and 24 hr-urine output were measured and histopathologic changes of kidney were evaluated by light and electron microscopy. The results obtained from this study can be summarized as follows: While NAG activity, BUN and serum creatinine was progressively increased and CLcr significantly decreased in CsA group, VER almost signifi-cantly (p<0.05) suppressed and normalized CsA-induced changes in VER+CSA group. While urine output increased until 12th days and thereafter progressively decreased in CsA group, it gradually increased in control and VER+CSA group. While body weight progressively made a gain in control and VER+CSA groups, it significantly (p<0.05) lost in CsA group. On light microscopy, the glomerular hyperemia and proximal convoluted tubular (PCT) dilatation, focal tubular cell vacuolation and necrosis were clearly evident in CsA group, but, were not seen in other groups. Ultrastructural studies revealed thickened glomerular endothelium and basal lamina of capillary, irregular shaped pedicels of podocytes, indistinct slit pores and narrowed bowman's space. The large oval vacuoles with dense debris and phagosome were distributed in apical zone and deformed microvilli and mitochondria were seen in the PCT cell of CsA group. But, glomeruli and PCT cell were relatively preserved in normal apperance in other groups. In conclusion, it is suggested that verapamil has a protective effect on cyclosporine-induced nephrotoxicity in uninephrectomized rats.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.29 no.4 s.235
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• pp.495-503
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• 2005

Experiments were conducted in a low speed stationary annular cascade to investigate local heat transfer characteristics on the tip and shroud and the effect of inlet Reynolds number on the tip and shroud heat transfer. Detailed mass transfer coefficients on the blade tip and the shroud were obtained using a naphthalene sublimation technique. The turbine test section has a single stage composed of sixteen guide vanes and blades. The chord length and the height of the tested blade are 150 mm and about 125 mm, respectively. The blade has flat tip geometry and the mean tip clearance is about $2.5{\%}$of the blade chord. The inlet flow Reynolds number based on chord length and incoming flow velocity is changed from $1.0{\times}10^{5}\;to\;2.3{\times}10^{5}.$ to investigate the effect of Reynolds number. Flow reattachment after the recirculation near the pressure side edge dominates the heat transfer on the tip surface. Shroud surface has very intricate heat/mass transfer distributions due to complex flow patterns such as acceleration, relaminarization, transition to turbulent flow and tip leakage vortex. Heat/mass transfer coefficient on the blade tip is about 1.7 times as high as that on the shroud or blade surface. Overall averaged heat/mass transfer coefficients on the tip and shroud are proportional to $Re_{c}^{0.65}\;and\;Re_{c}^{0.71},$ respectively.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.29 no.4 s.235
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• pp.485-494
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• 2005

For the extensive investigation of local heat/mass transfer on the near-tip surface of turbine blade, experiments were conducted in a low speed stationary annular cascade. The turbine test section has a single stage composed of sixteen guide vanes and blades. The chord length and the height of the tested blade are 150 mm and about 125 mm, respectively. The blade has flat tip geometry and the mean tip clearance is about $2.5{\%}$ of the blade chord. Detailed mass transfer coefficient on the blade near-tip surface was obtained using a naphthalene sublimation technique. The inlet flow Reynolds number based on chord length and incoming flow velocity is changed from $1.0{\times}10^{5}\;to\;2.3{\times}10^{5}.$ Extremely complex heat transfer characteristics are observed on the blade surface due, to complicated flow patterns, such as flow acceleration, laminarization, transition, separation bubble and tip leakage flow. Especially, the suction side surface of the blade has higher heat/mass transfer coefficients and more complex distribution than the pressure side surface, which is related to the leakage flow. For all the tested Reynolds numbers, the heat/mass transfer characteristics on the turbine blade are the similar. The overall averaged $Sh_{c}$ values are proportional to $Re_{c}^{0.5}$ on the stagnation region and the laminar flow region such as the pressure side surface. However, since the flow is fully turbulent in the near-tip region, the heat/mass transfer coefficients are proportional to $Re_{c}^{0.8}.$

• Journal of Fashion Business
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• v.12 no.5
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• pp.111-125
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• 2008

The purpose of this study is in the investigation to relieve into the clothing inconvenience levels and to need by arthritis patients who experience clothing difficulties in daily living even without showing conspicuous physical disabilities. For this study, personal interviews were carried out with 151 female arthritis patients, using a questionnaire form consisting of a total of 206 items. Data analysis were done with spss 12.0 for the frequency analysis, cross tab analysis, t-test, and ANOVA. The findings are as follows. 1. The survey subjects were diverse in their age from 20s to 60s and 18.5% of them have need of other's assistance at the time of getting dressed or undressed of clothing. The knee part was felt to be the most uncomfortable, causing the inconveniences in wearing pants or panties. 2. The investigation into the inconvenience levels at the time of dressing or undressing of clothing was indicated that the wearing of pants was the hardest movement to arthritis patients, as the items relating to the movements for putting feet into or pulling them out of pants and those for raising pants over the hip were also accompanied by the feeling of pains. In addition, the aged arthritis patients felt the clothes-wearing movements more difficult. 3. The survey on the kind and inconvenience levels for the clothes currently being worn showed the highest wearing ratio for the pants, which were pointed out to be the most inconvenient. 4. As for the clothing improvement, the needs were located as a whole in the sufficiency in measures of pants crotch and circumference items, the flexibility in materials, the short length of pants, or the front clearance.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.25 no.1
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• pp.24-28
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• 1989

This paper describes a fundamental method to suppress vibration of a structure under excitation by attaching a impact absorber. The influence of the shape of impact absorber, such as weight of add mass, impact clearance, contacting area and the exciting frequency on suppressing vibrations of the structure is investigated. The effectiveness of the proposed vibration absorber is demonstrated experimentally.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.6
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• pp.742-752
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• 2017

The bridge type of steel concrete composite rahmen or pre-flex has been applied where a lower depth girder is required due to vertical clearance restrictions caused by the crossing of rivers and roads. On the other hand, because these types are not only complicated to manufacture and construct, but also expensive, void slab bridges may be an alternative. In this study, prefabricated PSC-I shape girder was used to make a void slab and all procedures for bridge development, such as analysis, design, fabrication, and real-scale test, were included in the scope of research. The results of this study will provide sufficient background data to be applied to the field and the structural safety has been verified through experiments.