• Proceedings of the Korea Society of Environmental Toocicology Conference
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• 2003.05a
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• pp.189-189
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• 2003

Sophoricoside was isolated as the inhibitor of IL-5 bioactivity from Sophora japonica (Leguminosae). To develope as novel anti-allergic drug, kinetic study was performed in rats. Serum concentration of sophoricoside was measured by gas chromatography-mass spectrometry (GC/MS) in male Sprague-Dawley rat (250${\pm}$10g, n=5) after oral administration of sophoricoside (100mg/kg). The recovery of sophoricoside after extraction and concentration was above 95 % from rat serum. Between-day precision(relative standard deviation 2.2-2.8%) and within-day precision(2.0-12.1%) were determined from replicate analysis of a spiked control and incurred serum sample. The detection limits of sophoricoside in this serum was approximately 0.1 ng/mL. The Pharmacokinetic parameters were derived from the noncompartmental analysis. The C$\_$max/(3.56${\pm}$0.34 $\mu\textrm{g}$/mL) value for sophoricoside in male rat was observed at 7.6 h. The elimination half-life(t$\_$1/2/) of sophoricoside was approximately 4.47 h, the mean residence time (MRT) averaged 10.75 h, the total body clearance (Cl) averaged 0.0042 mL/min/kg. and the area under the serum concentration-time curve (AUC$\_$0-$\infty$/) was 24.93 $\mu\textrm{g}$$.$hr/mL.

• Journal of Pharmaceutical Investigation
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• v.21 no.1
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• pp.43-50
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• 1991

The hepatic uptake of an anionic fluorescence probe, l-anilino-8-naphthalene sulfonate (ANS) was characterized using isolated rat hepatocytes. The initial uptake rate of ANS by isolated hepatocytes was determined. The uptake process of ANS was fitted well to the Michaelis-Menten equation with a saturable component. The $V_{max}$ and $K_m$ values were $2.9{\pm}0.1\;nmol/min/mg$ protein and $29.1{\pm}3.2\;{\mu}M$, respectively. The uptake clearance $(CL_{up})$ based on the ratio of $V_{max}$ to $K_m$ was 11.7 ml/min/g liver, revealing the good coincidence with that assessed from the analysis of the plasma disappearance curve in previous report. Furthermore, the effect of serum protein on the hepatic uptake of ANS into isolated hepatocytes was investigated. The permeability clearances $(PS_{inf})$ of ANS uptake were much higher than those predicted based on the unbound fractions in the presence of serum. These suggested that the hepatic uptake of extensively serum protein-bound ANS is mediated not only by the unbound form of ligand but also by the serum protein-mediated uptake mechanism.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.15 no.1
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• pp.45-63
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• 2017

The oldest commercial reactor in South Korea, Kori-1 Nuclear Power Plant (NPP), will be shut down in 2017. Proper treatment for decommissioning wastes is one of the key factors to decommission a plant successfully. Particularly important is the recycling of clearance level or very low level radioactively contaminated metallic wastes, which contributes to waste minimization and the reduction of disposal volume. The aim of this study is to introduce a conceptual design of a recycle system and to evaluate the doses incurred through defined work flows. The various architecture diagrams were organized to define operational procedures and tasks. Potential exposure scenarios were selected in accordance with the recycle system, and the doses were evaluated with the RESRAD-RECYCLE computer code. By using this tool, the important scenarios and radionuclides as well as impacts of radionuclide characteristics and partitioning factors are analyzed. Moreover, dose analysis can be used to provide information on the necessary decontamination, radiation protection process, and allowable concentration limits for exposure scenarios.

• Design & Manufacturing
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• v.14 no.2
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• pp.56-61
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• 2020

Recently, research for machining next-generation micro semiconductor processes and micro patterns has been actively conducted. In particular, it is applied to various industrial fields depending on the machining method in the case of FIB (Focused ion beam) milling. In this study, intends to deal with FIB milling machining technology for ultra-precision diamond tool fabrication technology. Ultra-precision diamond tools require nano-scale precision, and FIB milling is a useful method for nano-scale precision machining. However, FIB milling has a problem of Gaussian characteristics that are differently formed according to the beam current due to the input of an ion beam source, and there are process conditions to be considered, such as a side clearance angle problem of a diamond tool that is differently formed according to the tilting angle. A series of process steps for fabrication a ultra-precision diamond tool were studied and analyzed for each process. It was confirmed that the effect on the fabrication process was large depending on the spot size of the beam and the current of the beam as a result of the experimental analysis.

• The Korean Journal of Pharmacology
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• v.12 no.2 s.20
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• pp.43-49
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• 1976

The facts that $PGE_2$ produced diuresis in the rabbit when given into a lateral ventricle of the brain and that $PGF_{2{\alpha}}$ is abundantly found in the brain prompted us to investigate the effects of $PGF_{2{\alpha}}$ introduced directly into the ventricle on the renal function. $PGF_{2{\alpha}}$ given intraventriculary in doses of $10{\mu}g\;and\;100{\mu}g$ elicited prompt diuresis, 10-fold increase of sodium excretion and two-fold increment of potassium excretion. Free water reabsorption also increased along with the increased osmolar clearance. Neither renal plasma flow nor glomerular filtration rate did change significantly. This, along with the fact that the percentage of reabsorbed sodium filtered decreased from 99.5 to 93.9, indicates the tubular site of the diuretic and natriuretic action. Atropine pretreatment did not influence the renal effects of intraventricular $PGF_{2{\alpha}}$. Intravenously administered $PGF_{2{\alpha}}$ in doses of 30 to $100{\mu}g$ did not produce any significant change in renal function. Intraventricular $PGF_{2{\alpha}}$ had no effect on the systemic blood pressure, whereas intravenous administration brought about a transient hypotension. These observations suggest that $PGF_{2{\alpha}}$ induces diuresis and natriuresis via central mechanism, that the site of the action resides in renal tubules, and that the reabsorption of sodium is inhibited in the proximal tubule, possibly through mediation of certain humoral agent. Overall, it is suggested that $PGF_{2{\alpha}}$ might play a roll in regulating renal function through the center.

• The Transactions of the Korean Institute of Electrical Engineers P
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• v.60 no.2
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• pp.82-90
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• 2011

The small precision spindle motors in the high value-added products including the visible home appliances such as DLP projector require not only the energy conversion devices but also high efficiency, low vibration and sound operation. However, the spindle motors using the conventional ball bearing and sintered porous metal bearing have following problems, respectively: the vibration by the irregularity of balls and the short motor life cycle by the ball's abrasion and higher sound noises by dry contact between shaft and sleeve. In this paper, it is proposed that the spindle motor with a fluid dynamic bearing is suitable for the motor to drive the color wheel of the DLP(digital lightening processor) in the visible home appliances. The proposed spindle motor is composed of the fluid dynamic bearing with both the radial force and the thrust force. The fluid dynamic bearing is solved by the finite element analysis of the mechanical field with the Reynolds equations. The magnetic part of spindle motor, which is a type of Brushless DC Motor, is designed by the electro-magnetic field analysis coupled with the Maxwell equation. And the load capacity and the friction loss of fluid dynamic bearing are analyzed to bearing clearance variation by the fabrication error in designed motor. The design of the proposed motor is implemented by the load torque caused by the eccentricity and the unbalance of the fluid dynamic bearing when the motors are fabricated in error. The prototype of the motor with the fluid dynamic bearing is manufactured, and experiment results show the vibration, sound, and phase current at no load and color wheel load of the motors in comparison. The high performance characteristics with the low vibration, the low acoustic noise and the optimal mechanical structure are verified by the experimental results.

• Journal of the Korean Society of Safety
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• v.25 no.3
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• pp.7-14
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• 2010

In order to analyze the vibro-impacts in the torsional system, several clearance types of nonlinearities should be included with the analytical or numerical method. These kinds of nonlinear factors can cause the errors while the system is calculated specifically with the numerical method, also it might take too long to get right answers with the every nonlinearity in the original system. Therefore, there are several methods developed for the sake of overcoming the deficiency of the analysis with the original system and saving the calculating time. The original system can be reduced by keeping the system characteristics such as from 14 to 6 DOF. Especially, since the torque flow in the torsional system is connected with the specific gear ratios, the original system can be transferred into the simpler system corresponding to each gear ratio rather than the original system, which can also show the same system characteristics such as the natural frequencies and the mode shapes. By using the reduced system, the calculating time can be saved and the redundant nonlinear effects for the system analysis can be ignored without any numerical errors.

• THE INTERNATIONAL COMMERCE & LAW REVIEW
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• v.43
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• pp.423-453
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• 2009

Import Agency Service Mall, which provide customers not only with convenient shopping experiences but also with purchasing, warehousing, shipping, and customs clearance services, have been playing a significant role in rapidly transforming Korean consumers into global consumers. The consumers' great demand for foreign goods(services) created Import Agency Service Mall(referred to hereafter as IASM) as a new business model of distribution and consumption, which seems to grow rapidly. Accordingly, this study examined the e-Trust by analyzing the characteristics of IASM, determinants of trust, risk perception and its association with e-Trust in IASM, and finally applying the result to general internet shopping mall(referred to hereafter as GISM). The following results came out from the analysis: First, from the result of checking these two types of internet shopping mall consumers have different determinants of trust. Second, from the question if two types perceive different risk, purchasing the foreign goods, it came out that they showed critical difference in variable relevant to goods delivery and customer service. IASM perceived risk from those two variables more than GISM Third, from the review of the relationships between determinants of trust and risk perception variables, IASM showed interrelation among all the variables except between customer service and perceived risk. Fourth, the researcher examined how the risk perceived in the course of purchasing goods has an effect on consumers e-Trust. In case of IASM, risk perception relevant to customer service had an effect on consumer e-Trust. To the contrary, incase of GISM, risk perception didn't have any effect on e-Trust. Finally, from the review of interrelation between determinants of trust and consumer e-Trust, it came out that for IASM capability had an effect on consumer e-Trust and for GISM consumer service had an effect on consumer e-Trust.

• Journal of Korean Tunnelling and Underground Space Association
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• v.14 no.4
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• pp.309-320
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• 2012

Dynamic behaviors of the tunnel linings of curved tunnels with various curvatures are investigated to examine the effect of wind loads due to passing vehicles. In the case without backfill, the responses of the tunnel lining should be considered to examine the clearance of the lining. A steel tunnel lining is selected to see the influence of the wind load upon the tunnel lining more clearly. The wind pressure upon the lining is simplified into the pressure and suction while the vehicle passing the loading positions. As the radius of curvature decreases, the response decreases, showing that the strength against the deformation is found to increase since the asymmetry of the deformation shape is reduced. It is found that the responses increase as the passing vehicle speed increases.

• Journal of Korean Tunnelling and Underground Space Association
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• v.15 no.3
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• pp.253-270
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• 2013

This paper concerns the effect of orientation and geometric characteristics of a fracture zone on the tunnel behavior using a numerical investigation. A parametric study was executed on a number of drill and blast tunnelling cases representing different fracture and tunnelling conditions using two and three dimensional finite element analyses. The variables considered include the strike and dip angle of fracture zone relative to the longitudinal tunnel axis, the width and the clearance of the fracture zone, the tunnel depth, and the initial lateral stress coefficient. The results of the analyses were examined in terms of the tunnel deformation including crown settlement, convergence, and invert heave as well as shotcrete lining stresses. The results indicate that the tunnel deformation as well as the shotcrete lining stress are strongly influenced by the orientation of the fracture zone, and that such a trend becomes more pronounced for tunnels with greater depths.