• Title/Summary/Keyword: CK2

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Anaphylactoid Reaction Induced by Administration Dirofilaria immitis Extracts (개 심장사상충 추출액 투여에 의한 Anaphylactoid Reaction)

  • Lee, Jee-young;Song, Kun-ho;Kwon, Hyun-ju;Kim, Myung-cheol;Yun, Hyo-in;Kim, Duek-hwan
    • Korean Journal of Veterinary Research
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    • v.43 no.3
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    • pp.507-516
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    • 2003
  • This study was performed to clarify the induction possibility of anaphylactoid reactions by the administration with the heartworm extracts, and, if any, to elucidate different virulences in terms of the protein concentrdtions and sexes of Dirofilaria immitis. Twenty three clinically healthy D. immitis-free adult dogs were used in the present study. The experimental animals were divided into 5 groups. Group A (5 heads) was administered with an female heartworm extract containing 0.1 g/dl protein concentration. Group B (4 heads) was administered with an male heartworm extract containing 0.1g/dl protein concentration. Group C (5 heads) was administered with an female heartworm extract containing 0.2 g/dl protein concentration. Group D (4 heads) was administered with an male heartworm extract containing 0.2 g/dl protein concentration. Group E (5 heads) was administered with an female heartworm extract containing 0.4 g/dl protein concentration. The changes of clinical symptoms and vital signs (body temperature, heart rate and respiration rate) were examined before and 5 minutes, 15 minutes, 30 minutes, 1 hour, 2 hours and 24 hours after injection with the extracts, respectively. In addition, the changes of hematological values (RBC, PCV and total leukocytes counts), serum chemical values (ALP and CK) were determined. It was considered that heartworm extract could induce anaphylactoid reaction and adult female heartworm extract was more affective than those of adult male heartworm extract in the changes of clinical symptoms, vital signs, hematological values and serum chemical values.

The study on dose variation due to exchange of Upper and Lower jaw in the linear accelerator (선형가속기에서 상위조리개와 하위조리개의 교환에 의한 선량 변화의 고찰)

  • Lim CK.;Kim HN.;Song KW.
    • The Journal of Korean Society for Radiation Therapy
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    • v.11 no.1
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    • pp.6-10
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    • 1999
  • The field size can be beam output, therefore MonitorUnit can be varied due to field size dependence The purpose of this study is to evaluate and compare the dose variation according to exchange of collimator The measurements were perfomed with Wellhofer dosimetry system(water phantom. ion chamber. electrometer. system controller. build up cap. etc)and two types of linear accerlerator (Mevatron KD, MevatronMX) Scatter can be affected to field size dependence and scatter correction is separated into collimator and phantom components, scatter components can affect by exchanging of collimator Measurements of collimator scatter factor(Sc) was done in air with build up cap. 1)Square field (5cm2 to 40cm2) was measured 2)and then keeping the upper jaw constant at loom and varing lower jaw from 5cm to 40cm, 3)keeping the lower jaw constant at 10cm and varing upper jaw from 5cm to 40cm Measurements of total scatter factor(Scp) was done in water at Dmax as the procedure of collimator scatter factor measurements in water Dmax The total scatter factors were obtained to the following equation(Sp=Scp/Sc) The measured data is normalized to the data of reference field size($10{\times}10$), rectangular field is inverted to equivalent field to compare three field size data As the collimator setting is varied, the output was changed In conclusion, the error was obtained small but it must be eliminated if we intend to reach the common stated goal of $5\%$ overall uncertainty in dose determination

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A Case of Trichoblastic Fibroma at the Cheek (뺨에 발생한 모낭모세포성 섬유종의 치험례)

  • Oh, Hyeon Bae;Lee, Ki Ho;Lee, Seung Ryul;Kang, Nak Heon;Suh, Kwang Sun
    • Archives of Plastic Surgery
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    • v.33 no.4
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    • pp.495-498
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    • 2006
  • Purpose: Trichoblastic fibroma originates from hair germ layer tumor which is a benign tumor mixture of epidermal and mesodermal factor. Trichoblastic fibroma was found only in adults and showed equal occurrence rate between men and women. Since it is a rare tumor, we report a case of a trichoblastic fibroma which developed on the right cheek. Methods: A 72 year-old male was treated with excisional operation 17 years ago due to a solitary tumor that developed on the same site. He returned to the hospital with an asymptomatic mass which have been increasing in size for the last 3 months. Results: In computerized tomography, a size of $2.7{\times}2.3{\times}0.8cm$ tumor was found in the subcutaneous tissue layer. Grossly, the mass was well-circumscribed, smooth-surfaced and flesh colored, and was lobulated and fragile. Pathologic observation showed diverse shaped and sized tumor cell nests and fibrocellular stroma consisting basophilic cells in dermal and subdermal layers. Immunohistopathologic staining showed positive reaction on pancytokeratin, CK-5/6, and bcl-2. Conclusion: By having no connection to the epidermis, and being positioned in the dermal and epidermal layers, typical pathologic findings make it possible to differentiate this tumor with basal cell carcinoma. This lesion is not clear whether it is a local recurrence or not, and it is necessary to observe a new recurrence in the future.

The Analysis of Preservice Teachers' Perception of TPACK (TPACK에 대한 예비 교사의 인식 분석)

  • Jang, Bong Seok
    • Journal of Practical Engineering Education
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    • v.13 no.2
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    • pp.293-300
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    • 2021
  • The aim of this study was to measure preservice teachers' perceptions of Technological Pedagogical Content Knowledge (TPACK). The researcher analyzed responses on the TPACK scale of 307 students in A University located in Chungcheongbuk-do. During the statistical analysis, IBM SPSS 21 program was used to implement Independent Samples T-test, One-way Analysis of Variance, and Multiple Regression Analysis (Enter method). The results are as follows. First, for the mean difference by gender, the mean of female students was higher than that of male students in Pedagogical Knowledge, Pedagogical Content Knowledge, Technological Pedagogical Knowledge, and Technological Pedagogical Content Knowledge. Second, for the mean difference by grade level, the mean of the 1st, 3rd and 4th graders was higher than that of the 2nd graders in the Content Knowledge at a statistically significant level. Third, toward Technological Pedagogical Content Knowledge, Pedagogical Knowledge of .11 beta value, Pedagogical Content Knowledge of .11 beta value, and Technological Pedagogical Knowledge of .715 beta value were found to be statistically significant predictors. Finally, the researcher discussed development of the TPACK implementation manual and workbook and provision of various technology practice opportunities.

A Study on Music Summarization (음악요약 생성에 관한 연구)

  • Kim Sung-Tak;Kim Sang-Ho;Kim Hoi-Rin;Choi Ji-Hoon;Lee Han-Kyu;Hong Jin-Woo
    • Journal of Broadcast Engineering
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    • v.11 no.1 s.30
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    • pp.3-14
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    • 2006
  • Music summarization means a technique which automatically generates the most importantand representative a part or parts ill music content. The techniques of music summarization have been studied with two categories according to summary characteristics. The first one is that the repeated part is provided as music summary and the second provides the combined segments which consist of segments with different characteristics as music summary in music content In this paper, we propose and evaluate two kinds of music summarization techniques. The algorithm using multi-level vector quantization which provides a repeated part as music summary gives fixed-length music summary is evaluated by overlapping ration between hand-made repeated parts and automatically generated summary. As results, the overlapping ratios of conventional methods are 42.2% and 47.4%, but that of proposed method with fixed-length summary is 67.1%. Optimal length music summary is evaluated by the portion of overlapping between summary and repeated part which is different length according to music content and the result shows that automatically-generated summary expresses more effective part than fixed-length summary with optimal length. The cluster-based algorithm using 2-D similarity matrix and k-means algorithm provides the combined segments as music summary. In order to evaluate this algorithm, we use MOS test consisting of two questions(How many similar segments are in summarized music? How many segments are included in same structure?) and the results show good performance.

The Relation between Collateral Circulation and $^{99m}Tc$-MIBI Heart SPECT (심근경색에서 측부순환 유무에 따른 $^{99m}Tc$-MIBI 심근 SPECT 소견)

  • Kim, Jae-Man;Na, Deug-Young;Park, Eun-Kyung;Yang, Hyung-In;Kim, Deog-Yoon;Kang, Heung-Sun;Choue, Chung-Whee;Kim, Kwon-Sam;Kim, Myung-Shick;Song, Jung-Sang;Bae, Jong-Hoa
    • The Korean Journal of Nuclear Medicine
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    • v.28 no.1
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    • pp.37-43
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    • 1994
  • The coronary collateral vessels have revealed their significance in terms of reduction of infarct size, preservation left ventricular function, and prevention of left ventricular aneurysm in patients with myocardial infarction. The purpose of this study were to evaluated the relation between collateral circulation and $^{99m}Tc$-MIBI Heart SPECT in patient with acute myocardial infarction and their clinical significance. The fifty six MI patients with antegrade TIMI perfusion grade 0 and 1 were studied. The patients were classified into two groups; Group I inclueded 30 patients with grade 2, 3 Collateral flow. Group II inclueded 26 patients with grade 0, 1 Collateral flow. Collateral filling were graded from 0 to 3: 0- none, 1- Filling of side branch only, 2- Partial filling of the epicardial segment, 3- Complete filling of epicardial segment. Clinical variables, left ventricular function, $^{99m}Tc$-MIBI Heart SPECT were analyzed with angiographic finding. Results were following: 1) Collateral visualization was found to be greater in patient with involvement of right coronary artery (RCA). The collateral development site of infarct related artery was RCA 15 cases, left anterior descending artery (LAD) 10 cases, left circumflex artery (LCX) 5 cases, and the collateral circulation from LAD to RCA was 13 cases (40.6%). 2) There was a tendency to be decreased in peak CK activity with group I. 3) The presence of good collateral channels was more frequently $^{99m}Tc$-MIBI reversible perfusion defect (83.4% vs 15.3%, p<0.05). 4) No differences of left ventricular end diastolic volume (LVEDV), left ventricular end systolic volume (LVESV), ejection fraction (EF) were noted between group I and group II. The presence of good collateral channels did affect the frequency of occurrence of $^{99m}Tc$-MIBI reversible perfusion defect.

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Long-term Cryopreservation of Mesenchymal Stem Cells Derived from Human Eyelid Adipose and Amniotic Membrane: Maintenance of Stem Cell Characteristics

  • Song, Yeon-Hwa;Park, Se-Ah;Yun, Su-Jin;Yang, Hye-Jin;Yoon, A-Young;Kim, Haek-Won
    • Development and Reproduction
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    • v.15 no.4
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    • pp.339-347
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    • 2011
  • Human eyelid adipose-derived stem cells (hEAs) and amniotic mesenchymal stem cells (hAMs) are very valuable sources for the cell therapeutics. Both types of cells have a great proliferating ability in vitro and a multipotency to differentiate into adipocytes, osteoblasts and chondrocytes. In the present study, we evaluated their stem cell characteristics after long-time cryopreservation for 6, 12 and 24 months. When frozen-thawed cells were cultivated in vitro, their cumulative cell number and doubling time were similar to freshly prepared cells. Also they expressed stem cell-related genes of SCF, NANOG, OCT4, and TERT, ectoderm-related genes of NCAM and FGF5, mesoderm/endoderm-related genes of CK18 and VIM, and immune-related genes of HLA-ABC and ${\beta}$2M. Following differentiation culture in appropriate culture media for 2-3 weeks, both types of cells exhibited well differentiation into adipocyte, osteoblast, and chondrocyte, as revealed by adipogenic, osteogenic or chondrogenic-specific staining and related genes, respectively. In conclusion, even after long-term storage hEAs and hAMs could maintain their stem cell characteristics, suggesting that they might be suitable for clinical application based on stem cell therapy.

Anti-Seismic Performance Evaluation of Circular Pier By Interval Reinforcement (보강간격에 따른 원형 기둥부재의 내진 성능 평가)

  • Jang, Il-Young;Kim, Seong-Kyum;Park, Jun-Young;Yang, Jae-Yeol
    • 한국방재학회:학술대회논문집
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    • 2011.02a
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    • pp.165-165
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    • 2011
  • 내진 설계규정이 적용되기 이전에 시공되어 사용 중인 교량의 경우 지진 발생시 교각의 파괴 또는 구조적 피해는 교량 전체 시스템의 붕괴를 초래하므로 지진하중에 대하여 피해를 최소화해야 한다. 이를 위해 내진설계규정이 적용되기 이전의 교량 또는 지진취약지역으로 분류된 곳의 교량, 사회적 중요도가 높은 교량에 대해 교각의 내진성능보강을 실시하고 있다. 2007년 말 국토해양부가 관리하고 있는 11,940개 교량 중 지진 발생시 피해가 우려되는 1,342개(일반국도 682개, 고속국도 600개) 교량에 대해 2006년부터 내진보강이 착수되었고 2009년에는 확대 추진하여 일반국도 80개교, 고속국도 100개교에 대한 보강을 실시하였다. 이와 같이 확대 추진되고 있는 정책에 반해, 내진보강 기술 및 제품이 부족하고 새로운 내진보강재 개발이 불가피해지고 있는 것이 현실이다. 소성영역에서의 횡방향 철근은 지진 시 종방향 철근의 좌굴과 콘크리트의 압축강도저하를 방지하며, 전단보강철근으로도 중요한 역할을 하여 교각의 전단강도를 증가시킨다. 그러나 이러한 횡방향 철근은 초기 설계에 의한 시공이 종료된 후 기존의 성능을 증가시키기 위하여 철근량을 증가하거나 단면의 변화를 주기에는 매우 어려운 일이다. 따라서 내진성능을 위한 단면력 증가를 위하여 다양한 재료의 보강재와 형식이 사용되고 있다. 본 연구에서는 원형교각 모델의 구조해석을 이용해 내진성능평가를 선행한 후 실험체를 제작, Helical Bar를 보강하여 준정적 실험을 통해 내진보강성능을 평가하였다. 압축설계강도 $f_{ck}=240kgf/cm^2$를 기준으로 교량등급 2등교인 일반적인 도로교의 1/4축소모형을 설계, 기초부는 $1,200{\times}600{\times}600$ (mm)으로 철근과 콘크리트로 구성하였으며, 기둥부는 직경 400mm, 높이 1,250mm 크기의 철근콘크리트 원형 교각 실험체를 제작하였다. 제작된 실험체는 총 3개로, 분류는 무보강 일반 실험체, Helical Bar 직경에 따른 분류, 보강간격에 따른 분류로 나누어진다.

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Effect of different exercise intensities on biomarkers of oxidant-antioxidant balance, inflammation, and muscle damage

  • Roh, Hee-Tae;Ha, Hyoung Zoo;Woo, Jin-Hee;Lee, Yul-Hyo;Ko, Kangeun;Bae, Ju-Yong
    • Journal of the Korean Applied Science and Technology
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    • v.35 no.3
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    • pp.778-786
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    • 2018
  • We investigated the effect of different exercise intensities on biomarkers of oxidant-antioxidant balance, inflammation, and muscle damage. Eighteen healthy and untrained male subjects were enrolled.Subjects were randomly and equally assigned to a moderate-intensityexercise(MIE, $65%VO_2max$) group(n=9) or a high-intensity exercise(HIE, $85%VO_2max$) group(n=9).Blood samples were collectedimmediately pre-exercise, post-exercise, and 60min post-exercisetoexamine oxidant-antioxidant balance(d-ROMs; BAP), inflammation(CRP; fibrinogen), muscle damage(CK; LDH), and lactate. Serum d-ROMs and BAP levels were significantly increased post-exercise compared with pre-exercise levels in HIE group(p<0.05). Lactate levels were significantly increased post-exercise compared pre-exercise levels in both the MIE and HIE groups(p<0.05). In addition, post-exercise serum d-ROMs and plasma lactate levels were significantly higher in the HIE group than in the MIE group(p<0.05). These results suggest that although relatively high-intensity exercises may increase oxidative stress levels in the body, they do not produce inflammatory response and/or muscle damage.

Impact of wilting and additives on fermentation quality and carbohydrate composition of mulberry silage

  • Zhang, Ying Chao;Wang, Xue Kai;Li, Dong Xia;Lin, Yan Li;Yang, Fu Yu;Ni, Kui Kui
    • Asian-Australasian Journal of Animal Sciences
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    • v.33 no.2
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    • pp.254-263
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    • 2020
  • Objective: The objective of this study was to investigate the effects of wilting and additives on the fermentation quality, structural and non-structural carbohydrate composition of mulberry silages. Methods: The selected lactic acid bacteria strains Lactobacillus plantarum 'LC279063' (L1), commercial inoculant Gaofuji (GF), and Trichoderma viride cellulase (CE) were used as additives for silage preparation. Silage treatments were designed as control (CK), L1, GF, or CE under three wilting rates, that is wilting for 0, 2, or 4 hours (h). After ensiling for 30 days, the silages were analyzed for the chemical and fermentation characteristics. Results: The results showed that wilting had superior effects on increasing the non-structural carbohydrate concentration and degrading the structural carbohydrate. After ensiling for 30 days, L1 generally had a higher fermentation quality than other treatments, indicated by the lower pH value, acetic acid, propionic acid and ammonia nitrogen (NH3-N) content, and the higher lactic acid, water soluble carbohydrate, glucose, galactose, sucrose, and cellobiose concentration (p<0.05) at any wilting rate. Wilting could increase the ratio of lactic acid/acetic acid and decrease the content of NH3-N. Conclusion: The results confirmed that wilting degraded the structural carbohydrate and increased the non-structural carbohydrate; and L1 exhibited better properties in improving fermentation quality and maintaining a high non-structural carbohydrates composition compared with the other treatments.