• 제목/요약/키워드: CInchona Alkaloid

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Cinchona 알칼로이드를 키랄 리간드로 이용한 비대칭 Reformatsky 반응 (Enantioselective Reformatsky Reaction Using Cinchona Alkaloids as Chiral Ligands)

  • 박두한;최호진;이상기
    • 대한화학회지
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    • 제47권6호
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    • pp.597-600
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    • 2003
  • Cinchona 알칼로이드(1-4)들을 비대칭 Reformatsky 반응에 키랄 리간드로 사용하였다. 알데히드, 리간드, Reformatsky 시약의 적가 순서에 따라 반응의 수율이 달라지며, Reformatsky 시약과 알데히드, 리간드와의 비율도 수율에 크게 영향을 주었다.

Osmylated Macroporous Cinchona Alkaloid Resins: Highly Efficient and Recyclable Catalysts for Asymmetric Dihydroxylation of Olefins

  • Park, Yil-Sung;Jo, Cheon-Hee;Choi, Han-Young;Kwon, Eun-Kyung;Song, Choong-Eui
    • Bulletin of the Korean Chemical Society
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    • 제25권11호
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    • pp.1671-1675
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    • 2004
  • A simple method for simultaneous recovery and reuse of $OsO_4$ and alkaloid ligand in the asymmetric dihydroxylation of olefins has been developed by using macroporous alkaloid resins bearing residual vinyl groups.

Highly efficient ortho-fluoro-dimeric cinchona-derived phase-transfer catalysts

  • Park, Hyeung-Geun;Jeong, Byeong-Seon;Lee, Jeong-Hee;Yoo, Mi-Sook;Jew, Sang-Sup
    • 대한약학회:학술대회논문집
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    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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    • pp.250.3-251
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    • 2003
  • A series of cinchona alkaloid-derived dimeric quaternary ammonium salts were prepared as chiral phase-transfer catalysts by the introduction of various functional groups on the phenyl ligand. Among them. the 2-F-substituted derivative 21 showed the highest enantioselectivity in the alkylation of the glycine anion equivalent 1 (97->99 % ee).

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Some pharmacological studies with Cycleanine, a diphenylbisbenzylisoquinoline alkaloid from Stephania hernandifolia

  • Maitra, Suparna;Seal, Tapan;Mallik, Sujit;Khasnobis, Arnab;Nandi, RP;Vedasiromoni, J. Rajan;Mukherjee, Biswapati
    • Advances in Traditional Medicine
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    • 제3권3호
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    • pp.123-128
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    • 2003
  • Stephania hernandifolia belonging to the family Menispermaceae is the biggest storehouse of diphenylbisbenzylisoquinoline (DBBI) alkaloids. Exhaustive chemical processing of the bulb of S. hernandifolia by the application of modern separation techniques yielded a DBBI alkaloid which was identified as cycleanine using spectroscopic methods (UV, IR, $^1HNMR$. $^{13}CNMR$, Mass). Cycleanine showed significant anti-inflammatory activity against carrageenin induced paw oedema, comparable to that produced by diclofenac sodium, used as standard drug. It exhibited potent analgesic effects against chemical and thermal noxious stimuli. It was also found to possess anticonvulsive activity in the strychnine induced convulsion model.