Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.250.3-251
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- 2003
Highly efficient ortho-fluoro-dimeric cinchona-derived phase-transfer catalysts
- Park, Hyeung-Geun (College of Pharmacy, Seoul National University) ;
- Jeong, Byeong-Seon (College of Pharmacy, Seoul National University) ;
- Lee, Jeong-Hee (College of Pharmacy, Seoul National University) ;
- Yoo, Mi-Sook (College of Pharmacy, Seoul National University) ;
- Jew, Sang-Sup (College of Pharmacy, Seoul National University)
- Published : 2003.04.01
Abstract
A series of cinchona alkaloid-derived dimeric quaternary ammonium salts were prepared as chiral phase-transfer catalysts by the introduction of various functional groups on the phenyl ligand. Among them. the 2-F-substituted derivative 21 showed the highest enantioselectivity in the alkylation of the glycine anion equivalent 1 (97->99 ％ ee).
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