• 제목/요약/키워드: CHANGES IN GROWTH

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마카 추출액을 첨가한 음료의 품질특성 및 저장 중 항산화성 평가 (Quality Characteristics of Drink with Maca (Lepidium meyenii) Extract and Evaluation of Its Antioxidant Activity during Storage)

  • 전인숙;강용수;정해정
    • 한국식품저장유통학회지
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    • 제18권5호
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    • pp.669-677
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    • 2011
  • 본 연구에서는 마카 열수 추출액을 다양한 수준(0%, 8%, 16%, 24% 및 32%)으로 첨가하여 음료를 제조한 후 품질 특성을 살펴보고 $4^{\circ}C$$37^{\circ}C$에서 4주간 저장하면서 항산화능의 변화를 분석하였다. 마카 음료의 pH는 마카 추출액 첨가군이 대조군보다 낮게 나타났고 $^{\circ}Brix$는 높게 나타났다. 색도측정 결과 마카 추출액 첨가량이 증가할수록 명도는 감소하였고 적색도는 증가하였다. 소비자 기호도 검사결과 대조군과 비교하여 24% 첨가군까지 전반적인 바람직성에서 유의적인 차이가 없는 것으로 나타났다. 마카음료의 총폴리페놀 함량은 마카 추출액 첨가농도가 증가할수록 높게 나타났고 저장 기간에 따라 감소하는 경향을 보였으며 $4^{\circ}C$에 저장한 경우가 $37^{\circ}C$에 저장한 경우보다 높은 함량을 나타내었다. DPPH radical 소거능, superoxide anion radical 소거능 및 tyrosinase 저해활성 역시 마카 추출액 첨가군이 대조군보다 높게 나타났으며 저장기간이 길어질수록 항산화능은 전반적으로 감소하는 경향을 나타내었으며 DPPH radical 소거능 및 tyrosinase 저해활성은 $4^{\circ}C$에 저장한 경우가 $37^{\circ}C$에 저장한 경우보다 대체로 높은 활성을 유지하는 것으로 나타났다. 저장 중 미생물학적 안전성 검사에서는 $80^{\circ}C$에서 10분간 살균으로 모든 시료에서 미생물이 검출되지 않아 저장 안전성을 유지하는 것으로 나타났다.

Myeloid-specific SIRT1 Deletion Aggravates Hepatic Inflammation and Steatosis in High-fat Diet-fed Mice

  • Kim, Kyung Eun;Kim, Hwajin;Heo, Rok Won;Shi, Hyun Joo;Yi, Chin-ok;Lee, Dong Hoon;Kim, Hyun Joon;Kang, Sang Soo;Cho, Gyeong Jae;Choi, Wan Sung;Roh, Gu Seob
    • The Korean Journal of Physiology and Pharmacology
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    • 제19권5호
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    • pp.451-460
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    • 2015
  • Sirtuin 1 (SIRT1) is a mammalian $NAD^+$-dependent protein deacetylase that regulates cellular metabolism and inflammatory response. The organ-specific deletion of SIRT1 induces local inflammation and insulin resistance in dietary and genetic obesity. Macrophage-mediated inflammation contributes to insulin resistance and metabolic syndrome, however, the macrophage-specific SIRT1 function in the context of obesity is largely unknown. C57/BL6 wild type (WT) or myeloid-specific SIRT1 knockout (KO) mice were fed a high-fat diet (HFD) or normal diet (ND) for 12 weeks. Metabolic parameters and markers of hepatic steatosis and inflammation in liver were compared in WT and KO mice. SIRT1 deletion enhanced HFD-induced changes on body and liver weight gain, and increased glucose and insulin resistance. In liver, SIRT1 deletion increased the acetylation, and enhanced HFD-induced nuclear translocation of nuclear factor kappa B (NF-${\kappa}B$), hepatic inflammation and macrophage infiltration. HFD-fed KO mice showed severe hepatic steatosis by activating lipogenic pathway through sterol regulatory element-binding protein 1 (SREBP-1), and hepatic fibrogenesis, as indicated by induction of connective tissue growth factor (CTGF), alpha-smooth muscle actin (${\alpha}$-SMA), and collagen secretion. Myeloid-specific deletion of SIRT1 stimulates obesity-induced inflammation and increases the risk of hepatic fibrosis. Targeted induction of macrophage SIRT1 may be a good therapy for alleviating inflammation-associated metabolic syndrome.

Effect of Light with Different Wavelengths on Nostoc flagelliforme Cells in Liquid Culture

  • Dai, Yu-Jie;Li, Jing;Wei, Shu-Mei;Chen, Nan;Xiao, Yu-Peng;Tan, Zhi-Lei;Jia, Shi-Ru;Yuan, Nan-Nan;Tan, Ning;Song, Yi-Jie
    • Journal of Microbiology and Biotechnology
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    • 제23권4호
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    • pp.534-538
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    • 2013
  • The effects of lights with different wavelengths on the growth and the yield of extracellular polysaccharides of Nostoc flagelliforme cells were investigated in a liquid cultivation. N. flagelliforme cells were cultured for 16 days in 500 ml conical flasks containing BG11 culture medium under $27{\mu}mol{\cdot}m^{-2}{\cdot}s^{-1}$ of light intensity and $25^{\circ}C$ on a rotary shaker (140 rpm). The chlorophyll a, phycocyanin, allophycocyanin, and phycoerythrin contents in N. flagelliforme cells under the lights of different wavelengths were also measured. It was found that the cell biomass and the yield of polysaccharide changed with different wavelengths of light. The biomass and the yield of extracellular polysaccharides under the red or violet light were higher than those under other light colors. Chlorophyll a, phycocyanin, and allophycocyanin are the main pigments in N. flagelliforme cells. The results showed that N. flagelliforme, like other cyanobacteria, has the ability of adjusting the contents and relative ratio of its pigments with the light quality. As a conclusion, N. flagelliforme cells favor red and violet lights and perform the complementary chromatic adaptation ability to acclimate to the changes of the light quality in the environment.

공급사슬 내에서 품질지향적 기업문화가 지속가능경영성과에 미치는 영향에 관한 실증연구 (An Empirical Study on the Impact of Quality Oriented Corporate Culture on Sustainability Management Performances)

  • 우무진;박종우;정병영
    • 유통과학연구
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    • 제12권6호
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    • pp.31-39
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    • 2014
  • Purpose - Environmental issues, climatic changes, and greenhouse gases are problems to be solved at a global level. With an increased emphasis on the environmental and social responsibility of the management of companies, the manner in which companies approach quality-oriented culture and their individual sustainability management are being discussed as truly important issues to help them secure their competitiveness and growth strategies. This study proposes strategic directions to help manufacturers not only in expanding their competitive quality-oriented company culture but also in strengthening their sustainability management abilities. This study conducts a literature review and empirical research to examine how significantly the variables of a quality-oriented company culture, customer-centered management, and process-centered and supply chain management-centered cooperation affect sustainability management performance in relation to economic profitability, environmental integrity, and social responsibility. Research design, data, and methodology - To verify research models and hypotheses, the study examined 170 companies using a questionnaire survey conducted over six weeks, and involved the performance of data analysis on 146 samples. Questionnaire responses were calibrated based on a Likert scale. The study used the Smart PLS 2.0 program designed for PLS (partial least squares), an analysis instrument of SEM (structural equation modeling). The study then verified empirical research hypotheses working on reliability analysis, validity analysis, factorial analysis, and path analysis. Results - Among the nine hypotheses, four are accepted and the rest are rejected. A quality-oriented company culture focusing on customer-centered management significantly influenced the maintainability management performance of environmental integrity and social responsibility, while economic profitability was dismissed. A process-focused quality-oriented company culture was significantly concerned with economic profitability but not with environmental integrity or social responsibility. A supply-chain cooperative company culture had a significant effect on economic profitability but not on environmental integrity or social responsibility. Conclusion - This study proposes strategic directions to help manufacturers expand their competitive quality-oriented company culture as well as strengthen abilities with sustainability management. It conducts a literature review and empirical research to examine how significantly the variables of quality-oriented company culture, customer-centered management, and process-centered and supply chain management-centered cooperation affect sustainability management performance in relation to economic profitability, environmental integrity, and social responsibility. There are two main conclusions. First, companies should consider the need for social responsibility management and environmental transparent management-focused maintainability management as avenues to create new markets and business, thereby helping the companies secure a reputation for having a customer and process-centered quality-oriented company culture by creating shared values between supply chains and enabling win-win situations through cooperation. Second, we are marching towards a creative win-win era from a society of conflicts and ruptures. Companies should understand that social responsibility management and supply chain management (SCM)-focused cooperation are the foundations of sustainable development, as they try to improve their culture while pursuing both win-win relationships with interested parties and equity in various conflictive relations.

청년창업기업의 창업초기 생존전략 : 중진공 청년전용자금 활용기업 사례 (Youth Startup Firms: A Case Study on the Survival Strategy for Creating Business Performance)

  • 이승창;임원호;서응교
    • 유통과학연구
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    • 제12권6호
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    • pp.81-88
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    • 2014
  • Purpose - Entrepreneurship promotion is emerging as an important economic growth agenda. However, in Korea, entrepreneurship has weakened because of the collapse of the venture bubbles of the 2000s and the global economic recession in 2008, which have induced the business community to choose stability over risk. The Korean government has been implementing several support projects to inspire and promote youth entrepreneurship through various means including financial assistance; however, the perpetuation rate of young entrepreneurship is still low as compared to advanced economies such as the US and EU. This case study focuses on the Youth Start-Up Business Support Program of the Small & Medium Business Corporation, and explores practical alternatives. Further, it aims to suggest managerial factors and a conceptual model for change management factors affecting the business performance creation of a startup company, based on the Small and medium Business Corporation's young venture startup fund. Research design, data, and methodology - Many studies examine the current progress and issues of startup firms, for example, a lack of systematic cultivation of entrepreneurship and startup business training, lack of commercialization funding for youth startup businesses, lack of mentoring, and inadequate infrastructure. From prior research, we address four factors, namely, personal managerial capabilities, innovative business model, sufficient cash flow, and social network, affecting startup companies' business performance. This study involved a sample survey of 200 young entrepreneurs to investigate casual relations between the four factors and business performance. A regression analysis was used to verify the hypotheses. Results - First, in relation to differences in the founder's personal characteristics, age, sales amount, and number of employees significantly impact business performance. Second, regarding the causal relation between the four factors for creating business performance, an innovative business model and social networking have supported the hypotheses, revealing that the more that a start-up founder has an innovative business model and social networking, the more the start-up firms are likely to have better performance (e.g., sales volume, employment, ROE, ROI, etc.). Although the founder's competency and sufficient cash flow have no significant relationship with business performance, the mean value was higher performance for high founder's competency and sufficient cash flow. Conclusions - This study provides basic data on policy support strategies of the Small and Medium Business Corporation, to help young entrepreneurs achieve their start-up business goals. It shows that young entrepreneurship startup firms should strive to explore ideas to satisfy customers' needs, and that changes in customer value and the continuous innovation of business model differentiation are required to actively respond to change management. Moreover, at the infant startup stage, they should activate social network programs to share information, thereby offsetting resource scarcity and managing business risk. Further, the establishment of a long-term vision and the implementation of training programs in related specific fields should be supported to strengthen founders' personal capabilities.

통합 토지이용 교통모형을 이용한 교통정책평가에 관한 연구 I: 기존사례연구를 중심으로 (Study on Transport Policy Assessment Using the Integrated Land Use Transport Model)

  • 이승재;손지언
    • 한국ITS학회 논문지
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    • 제9권1호
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    • pp.111-120
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    • 2010
  • 도로교통 장려정책은 1970년대부터 산업성장에 기반이 되어 국가전반에 순기능을 발휘하였으나, 점차 수도권에 집중 된 토지개발정책과 맞물려 역기능이 나타나기 시작했다. 승용차보유대수가 폭발적으로 증가하였던 시기는 정부의 적극적인 도시개발이 진행되어온 시기와 맞물린다고 볼 수 있다. 교통은 통행목적 및 활동에 기반하는 파생적 수요이기 때문에 교통수요를 정확히 추정하고, 이를 통해 정책평가를 도출하기 위해서는 토지이용에 대한 특성파악이 선행되어야 한다. 본 연구에서는 기존에 연구된 교통과 토지이용에 관한 통합모델을 고찰하여, 교통수요추정의 정확성 확보를 위한 정책평가 기반을 마련하는데 연구의 목적이 있다. 따라서 교통-토지이용모델의 이론적 배경이 되고 있는 Predictive model과 Optimizing model에 대해서 고찰하고, 해외사례를 통하여 사용된 모델에 대한 평가 및 장단점에 대해 살펴보았다. 본 연구는 이미 시행되고 있거나, 계획되고 있는 다양한 도시정책을 평가하기 위한 준거를 제시하기 위한 사전단계임으로 이를 기반으로 향후에 서울 및 수도권을 대상으로 하는 통합토지이용모델을 개발할 수 있을 것이다. 또한 기술의 발달로 인한 U-Society환경이 교통패턴에 미치는 영향, 즉 이동 중에 다양한 활동을 할 수 있는 U-Transportation 현상이 통행패턴에 미치는 영향을 파악함으로 ITS 사업 추진에 중요한 기반으로 활용될 수 있을 것이다.

소프트웨어 저작권 침해사례와 분쟁해결에 관한 연구 (A Study on Infringement Cases of Software Copyright and the Dispute Settlement)

  • 장병윤
    • 한국중재학회지:중재연구
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    • 제13권2호
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    • pp.547-584
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    • 2004
  • Information technology(IT) is changing rapidly based on growth of internet and computer businesses. Therefore, computer programs and softwares are distributed to computer users promptly for their productivity increase and efficient work. So, in the distribution, the softwares will be copied or released through network or other methods which are not authorized by the program owners. In that case, copyright dispute is incurred and various issues are come out due to infringement of the software copyright. Thus, the purpose of this study is to research infringement cases of the software copyright and how to settle the dispute which is related with software programs. To achieve the purpose of this study, this research consisted of 5 chapters. At chapter 1 introduction, it mentioned necessity of this study, purpose and how to research this study, and at chapter 2 dispute factors indicated and summarized for technical resolution. At chapter 3, infringement cases of software copyright analyzed and studied upon intellectual property(IP) related laws. And methods of dispute settlement discussed and suggested to chapter 4 for copyright and intellectual property protection. Also, it emphasized importance of arbitration to resolve the issues timely and avoid time and economical consumption. Of course, arbitration law has to be matched with the trend of technology development for effective settlement. At chapter 5 conclusion, it summarized this research and suggested further research for empirical test of economic value of the software copyright upon the aspect of business, law, and engineering. In this study, the results are 1) IP related laws have to be enacted or revised to meet technical changes for the protection of software copyright on time. The enactment or the revision of law takes a long time, therefore, to deal the dispute effectively, 2) arbitration law has to be utilized efficiently in order to resolve issues and settle the dispute promptly. It is suggested the dispute settlement through arbitration to save time and economic matters for legislation, and to harmony with the technology trends. 3) Recognition of software copyright is to be improved by users and enterprises for development of software related industries and intellectual property protection. In conclusion, the protection of software copyright is important than any other things in the field of IT because of the development of industry and intellectual property related laws. The development is for areas of business, law and engineering, so research and practices are to be combined with the areas so that it could resolve the dispute settlement and IP protection effectively.

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PPG 2차 미분을 이용한 정상인과 당뇨병 환자의 말초혈관 탄성도 비교 (Comparison of peripheral vascular compliance between normal and diabetic groups using the second derivative of photoplethysmogram)

  • 김성우;이주형;남기창;김수찬;차은종;김덕원
    • 전자공학회논문지SC
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    • 제44권4호통권316호
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    • pp.15-20
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    • 2007
  • 현재, 우리나라 당뇨병의 유병률은 빠른 속도로 증가하고 있으며 당뇨병의 유병기간이 길수록 각종 합병증이 발생하여 더욱 심각한 증상을 나타내는데, 그 중 비만 및 고혈당, 당대사장애로 인한 당뇨병성 혈관합병증과 말초 혈관 경화증이 많이 발병하고 있는 실정이다. 따라서 본 연구에서는 광혈류량 측정법(Photoplethysmography)으로 손가락 및 발가락에서 얻어진 맥파의 2차 미분분석을 통해 연령이 비슷한 정상인 50명과 당뇨병으로 확진된 50명의 말초 혈관 탄성도를 객관적으로 비교하고자 하였다. PPG 파형의 2차 미분 분석에 사용되는 평가 인자는 a, b, c, d, e 이고, b/a는 혈관의 탄성도를 의미하며 탄성도가 떨어질수록 b/a의 절대 값은 감소하게 된다. 정상인 50명의 PPG 2차 미분 b/a값은 $-1.09{\pm}0.14$, 당뇨병 환자 50명의 PPG 2차 미분 b/a값은 $-0.81{\pm}0.09$로 정상인에 비해 당뇨병 환장의 말초혈관 탄성도가 감소하였으며, Independent t-test 검정 결과 통계적으로 유의한 차이를 보였다(p<0.05). 본 연구에서는 PPG 파형의 2차 미분 분석을 통하여 정상인과 혈관합병증 발병율이 높은 당뇨병 환자의 말초혈관 탄성도를 비교하였으며, 향후 비침습적이고 간단한 방법으로 당뇨병 환자의 말초혈관 탄성도와 혈관 경화정도를 객관적으로 평가하고 진단함으로써 당뇨병 환자들의 심혈관계질환 사전예방과 치료효과 판정에 도움을 줄 것으로 기대한다.

부재료를 달리하여 제조한 김치의 발효특성 (Fermentative Characteristics of Kimchi Prepared by Addition of Different Kinds of Minor Ingredients)

  • 이진희;조영;황인경
    • 한국식품조리과학회지
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    • 제14권1호
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    • pp.1-8
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    • 1998
  • 부재료를 달리하여 제조한 김치의 발효속도특성 및 미생물학적 발효양상을 조사하였다. 발효 진행에 따라 김치 시료들의 pH는 감소하고 총산도는 증가하였고, 산화환원전위는 감소되다가 다시 증가하는 현상을 보였고 발효 최적기에 가장 낮은 값을 나타내었다. 또한 전 발효 기간 동안 생강, 고추가루 및 혼합시료에서 총생균수와 젖산균수가 많았으며, Leu. mensenteroides의 수는 생강과 고추가루 시료에 많았다. 김치의 적숙기에 젖산균 및 Leu. mensenteroides의 수가 최대이었고 Leu. mensenteroides가 감소하는 시기에 Lac. plantarum이 생기기 시작하였다. 이러한 발효속도 및 미생물 특성의 경시적 변화가 마늘 시료에서는 느리게 적생고추 시료에서는 빠르게 진행되었다. 따라서, 마늘은 젖산균 발효를 비교적 낮은 수준으로 오래 지속되게 하여 김치의 가식일수를 늘이는 저장성 향상에 필요한 부재료이고, 생강과 고추가루는 젖산균과 그 중 Leu. mensenteroides의 생육을 촉진하여김치 맛을 좋게하는데 도움이 되는 부재료라고 생각된다. 그리고, 산화환원전위가 김치의 발효 최적기를 찾는데 유용한 지표가 됨을 알 수 있었다.

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Cook-Chill 및 Sous Vide 방법에 의한 시금치 식자재의 가공 및 저장 (Processing and Storage of Spinach Products Using Cook-chill and Sous Vide Methods)

  • 김기태;구경모;백현동;류은순;이동선
    • 한국식품영양과학회지
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    • 제30권6호
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    • pp.1095-1101
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    • 2001
  • 시금치를 한국 식단의 나물무침용 식자재로 사용하기 위하여 cook-chill 가공과 sous vide 포장처리하였다 시금치를 데치기하여 500 g씩 차단성 플라스틱 봉지에 진공포장하고 9$0^{\circ}C$의 열탕에서 살균하고, 3$^{\circ}C$냉수에서 급속히 냉각한 다 음, 3$^{\circ}C$및 1$0^{\circ}C$에서 저장하면서 품질을 측정하였다. 저온살균 조건으로는 Listeria monocytogenes의 6D 사멸조건과 streptococcus faecalis의 13D 사멸조건을 비교하였다. 조직의 연화를 위한 10$0^{\circ}C$ 스팀에서의 데치기 공정은 6분이 적절하였으며, 열침투특성과 냉각특성의 측정으로부터 얻은 저온살균조건으로는 L.monocytogenes 사멸과 S. faecalis 사멸의 목표시에 각각 22.8분 및 30.0분의 가열 시간으로 얻어졌다 초기 물리화학적 품질에서 L.monocytogenes 사멸조건으로 열처리 된 시금치가 S. faecalis 사멸조건으로 가공된 것에 비해 약간 양호하였고, 이러한 효과는 이 후 저장시 품질 보존에서도 지속되었다. 저장 중 호기성 총균수, 저온성 세균수, 혐기성 세균수로 나타난 미생물적 품질에서는 두 가지 살균처리 모두에서 1$0^{\circ}C$에서 저장 8일까지는 미생물의 수가 거의 증가하지 않았고, 3$^{\circ}C$에서는 14일까지 미생물증식이 거의 없어서 안전한 저장성을 나타내었다. L. monocytogenes 사멸조건으로 열처리된 시금치 제품의 경우 물리화학적 품질에 기준한 저장기간은 미생물학적 품질에 기준한 것보다는 길었다. 시금치 제품의 나물무침으로서의 관능적 품질은 바로 데쳐서 조리한 것에 비해서 열등하여서 공정의 개선에 의하여 보다 높은 품질향상이 필요한 것으로 나타났다

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