• 제목/요약/키워드: CHA

검색결과 17,837건 처리시간 0.053초

Serum Periostin Is Negatively Correlated With Exposure to Formaldehyde and Volatile Organic Compounds in Children

  • Yon, Dong Keon;An, Jaewoo;Ha, Eun Kyo;Jee, Hye Mi;Izuhara, Kenji;Ono, Junya;Jung, Young-Ho;Lee, Kyung Suk;Sheen, Youn Ho;Baek, Heysung;Han, Man Yong
    • Allergy, Asthma & Immunology Research
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    • 제10권6호
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    • pp.716-721
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    • 2018
  • Epidemiological studies have shown that exposure to tobacco smoke causing irritation and inflammation in the airways tends to reduce serum periostin concentrations in adults. We now investigate prospective cross-sectional study on 135 Korean students aged 7 years in the first grade who were participating in the Seongnam Atopy Project for Children's Happiness 2016 ($SAP_{2016}$) cohort. To the best of our knowledge, this is the first study to show significant inverse correlations between serum periostin concentration and exposure to xylene and formaldehyde in children. Our findings suggested the need for caution in using the serum periostin level as a marker for allergic diseases, since exposure to volatile organic compounds and formaldehyde may confound the interpretation of these results.

A case of the rare variant of Klinefelter syndrome 47,XY,i(X)(q10)

  • Song, Seung-Hun;Won, Hyung Jae;Yoon, Tae Ki;Cha, Dong Hyun;Shim, Jeong Yun;Shim, Sung Han
    • Clinical and Experimental Reproductive Medicine
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    • 제40권4호
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    • pp.174-176
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    • 2013
  • Klinefelter syndrome is the most common genetic form of male hypogonadism, but the phenotype becomes evident only after puberty. It is characterized by infertility, small testes, sparse body and facial hair, increased body weight, gynecomastia, increased LH and FSH, and a low level of testosterone. Early recognition and treatment of Klinefelter syndrome can significantly improve the patient's quality of life and prevent serious consequences. Here, we report an infertile man with a rare variant of Klinefelter syndrome with a 47, XY, i(X)(q10) karyotype.

Clinical predictors of chest radiographic abnormalities in young children hospitalized with bronchiolitis: a single center study

  • Kim, Ga Ram;Na, Min Sun;Baek, Kyung Suk;Lee, Seung Jin;Lee, Kyung Suk;Jung, Young Ho;Jee, Hye Mi;Kwon, Tae Hee;Han, Man Yong;Sheen, Youn Ho
    • Clinical and Experimental Pediatrics
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    • 제59권12호
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    • pp.471-476
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    • 2016
  • Purpose: Chest radiography is often performed on patients hospitalized with typical clinical manifestations of bronchiolitis. We aimed to determine the proportion of subjects with pathologic chest radiographic findings and the clinical predictors associated with pathologic chest radiographic findings in young children admitted with the typical presentation of bronchiolitis. Methods: We obtained the following data at admission: sex, age, neonatal history, past history of hospitalization for respiratory illnesses, heart rate, respiratory rate, the presence of fever, total duration of fever, oxygen saturation, laboratory parameters (i.e., complete blood cell count, high-sensitivity C-reactive protein [hs-CRP], etc.), and chest radiography. Results: The study comprised 279 young children. Of these, 26 had a chest radiograph revealing opacity (n=24) or atelectasis (n=2). Multivariate logistic regression analysis showed that after adjustment for confounding factors, the clinical predictors associated with pathologic chest radiographic findings in young children admitted with bronchiolitis were elevated hs-CRP level (>0.3 mg/dL) and past history of hospitalization for respiratory illnesses (all P<0.05). Conclusion: The current study suggests that chest radiographs in young children with typical clinical manifestations of bronchiolitis have limited value. Nonetheless, young children with clinical factors such as high hs-CRP levels at admission or past history of hospitalization for respiratory illnesses may be more likely to have pathologic chest radiographic findings.