• International Journal of Oral Biology
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• 제36권3호
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• pp.143-148
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• 2011

The present study investigated the role of peripheral P2X receptors in inflammatory pain transmission in the orofacial area in rats. Experiments were carried out on male Sprague-Dawley rats weighing 220 to 280 g. Formalin (5%, 50 ${\mu}L$) and complete Freund's adjuvant (CFA, 25 ${\mu}L$) was applied subcutaneously to the vibrissa pad to produce inflammatory pain. TNP-ATP, a $P2X_{2,2/3,4}$ receptor antagonist, or OX-ATP, a $P2X_7$ receptor antagonist, was then injected subcutaneously at 20 minutes prior to formalin injection. One of the antagonists was administered subcutaneously at three days after CFA injection. The subcutaneous injection of formalin produced a biphasic nociceptive behavioral response. Subcutaneous pretreatment with TNP-ATP (80, 160 or 240 ${\mu}g$) significantly suppressed the number of scratches in the second phase produced by formalin injection. The subcutaneous injection of 50 ${\mu}g$ of OX-ATP also produced significant antinociceptive effects in the second phase. Subcutaneous injections of CFA produced increases in mechanical and thermal hypersensitivity. Both TNP-ATP (480 ${\mu}g$) and OX-ATP (100 ${\mu}g$) produced an attenuation of mechanical hypersensitivity. However, no change was observed in thermal hypersensitivity after the injection of either chemical. These results suggest that the blockade of peripheral P2X receptors is a potential therapeutic approach to the onset of inflammatory pain in the orofacial area.

• The Korean Journal of Physiology and Pharmacology
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• 제24권6호
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• pp.453-462
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• 2020

Chronic joint pain due to loss of cartilage function, degradation of subchondral bone, and related conditions are common plights of an arthritis patient. Antioxidant compounds could solve the problems in arthritic condition. The objective of this study was to evaluate the anti-arthritic activity of D-carvone against complete Freund's adjuvant (CFA)-induced arthritis in rats. D-carvone was orally administered for 25 days at the doses of 30 and 60 mg/kg against CFA-induced arthritic rats. Changes in body weight, paw swelling, organ index, hematological parameters, oxidative stress markers, inflammatory cytokines, and histopathology were recorded. Oral treatment of D-carvone significantly improved the body weight, reduced the paw swelling, edema formation, and organ index in arthritic rats. The levels of white blood cells were reduced, red blood cells and hemoglobin levels were improved in D-carvone treated arthritic rats. Lipid peroxidation levels were lowered whereas enzymatic and non-enzymatic antioxidants were significantly elevated by D-carvone administration against arthritic rats. D-carvone significantly modulated inflammatory cytokine levels and improved the ankle joint pathology against CFA-induced arthritic inflammation. In conclusion, D-carvone proved significant anti-arthritic activity against CFA-induced arthritis in rats.

• 디지털융복합연구
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• 제6권2호
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• pp.41-53
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• 2008

This research is to redefine the concept of Good School and to validate an effective Good Secondary School Scale in Kyung-gi Province and Seoul. As statistical methods, SPSS 13.0 and AMOS 5.0 were used. Item Analysis and Exploratory Factor Analysis(EFA) were conducted to test the reliability of items and the factor structure. And Confirmatory Factor Analysis(CFA) was conducted to test the validity and fitness of the Good School Scale. The outcomes are as follows: First, six factors(school environment, curriculum, teacher, school-based management system, director) will increase the good schooling effectiveness. Second, As a result of Confirmatory Factor Analysis(CFA), the goodness of fit indices(GFI AGFI, CFI, RMSEA) demonstrate statistically significance and fitness of the model. The final Good School Scale supports 6 Good School Factors obtained in main test. Therefore, we can say that this scale can be used as a valid instrument to measure a real Good Schooling Effectiveness at the secondary school situation in Korea.

• 한국정보통신학회논문지
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• 제14권7호
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• pp.1581-1588
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• 2010

대부분의 디지털 촬영 장치는 비용 및 속도 상의 이점을 위해 Color Filter Array(CFA)를 포함하고 있는 단일 이미지 센서를 사용한다. 따라서 완전한 컬러 영상으로 복원하기 위하여 다양한 컬러 보간 방법이 개발되고 있다. 본 논문은 이러한 컬러 보간 방법 중, 방향성 필터를 이용하여 수직, 수평, 대각선 방향의 에지를 고려한 컬러 보간 방법에 관한 것이다. 하드웨어 구현을 위해 하드웨어 자원의 효율성을 고려하였다. Kodak 테스트 영상 24장으로 실험하여 기존 방법과 비교함으로써 제안한 방법의 성능을 확인하였다. Verilog HDL로 구현하였으며, Virtex4 FPGA 보드와 CMOS 이미지 센서를 이용하여 검증하였다.

• 약학회지
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• 제59권4호
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• pp.170-176
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• 2015

In vaccine development, the major points may be induction of effective and increased levels of antibody production. This is especially the case when the antigenic sources are carbohydrates. For many years, thus, we have researched various types of formulations such as liposomal and conjugate vaccines. However, the fastidious formulation process and high costs are a problem. For this reason, there is currently a focus on utilizing immunoadjuvants. In this present study, we tested if platycodin D (PLD) from Platycodon Radix have immunoadjuvant activity against the cell wall of Candida albicans (CACW). The resulting data showed that in the murine model of antibody production, CACW combined with PLD [CACW/PLD/IFA] increased the production of antibodies specific to C. albicans when compared to the antibody production by [CACW/IFA]-induction, which was used as a negative control (P<0.05). In the case of [CACW/PLD/IFA], the antibody production was 1.4 times as that of the CFA. In addition, formulations containing either had a prolonged antibody inducing activity maintaining the initial titers of antibody as compared to the CFA formula. Cytokine profiling with the antisera displayed that the PLD produced both Th1 and Th2 immunoresponses, but Th1 dominant was much greater (P<0.05). Furthermore, [CACW/PLD/IFA] formula enhanced resistance of mice against disseminated candidiasis, whereas the CFA had no such effect. In conclusion, PLD has an immunologic activity, which is protective against the disease. Thus, PLD can be a goof candidate for a new immunoadjuvant in development of the fungal vaccine.

• 한방안이비인후피부과학회지
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• 제16권2호
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• pp.138-151
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• 2003

Although the use of acupuncture for pain has increased in recent years, the mechanisms of acupuncture analgesia (AA) remains obscure. The lack of suitable experimental animal models for persistent pain, which show clear AA, has been the major stumbling block in the investigation of the physiological mechanisms of AA. In the present study, we test AA in two knee arthritis model induced by injection of CFA or carrageenan as a chronic pain model. After induction of arthritis, the rat subsequently showed a reduced stepping force of the affected limb for the next several days. Electroacupuncture (EA) was applied to an acupuncture point each on the contralateral forelimb for 30 minutes under enflurane anesthesia. After the termination of EA, behavioral tests measuring stepping force were periodically conducted during the next several hours. EA produced a significant improvement of stepping force of the foot lasting for at least 2 hours when applied to LR2 In CFA model, and applied to ST36 in carrageenan model, but both points did not produce any significant effects in each other model. These data suggest that EA produce analgesic effect in knee arthritic pain and the analgesic effect is specific to the acupuncture point.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제26권3호
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• pp.226-235
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• 2015

Objectives : The purpose of this study was to examine the factor structure of the Adolescent Personality Assessment Inventory (PAI-A) in a standardized adolescent sample using exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). Methods : For this purpose, three models about factor structure of the PAI-A were explored with EFA in 490 adolescents and then were evaluated with CFA in 268 young offenders. Results : The results showed that the five factor model was considered to be most appropriate for factor structures of the PAI-A in EFA. However, none of the factor models were appropriate for the factor structures of the PAI-A in CFA. Conclusion : These findings suggest that the "five factor model" is thought to explain the PAI-A the best, but further studies are needed.

• 대한의용생체공학회:의공학회지
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• 제39권6호
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• pp.278-283
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• 2018

Nowdays, many people suffer from the neck pain due to forward head posture(FHP) and text neck(TN). To assess the severity of the FHP and TN the craniovertebral angle(CVA) is used in clinincs. However, it is difficult to monitor the neck posture using the CVA in daily life. We propose a new method using the cervical flexion angle(CFA) obtained from a wearable sensor to monitor neck posture in daily life. 15 participants were requested to pose FHP and TN. The CFA from the wearable sensor was compared with the CVA observed from a 3D motion camera system to analyze their correlation. The determination coefficients between CFA and CVA were 0.80 in TN and 0.57 in FHP, and 0.69 in TN and FHP. From the monitoring the neck posture while using laptop computer for 20 minutes, this wearable sensor can estimate the CVA with the mean squared error of 2.1 degree.

• 대한간호학회지
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• 제53권5호
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• pp.525-537
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• 2023

Purpose: This study aimed to develop and test a reward scale for hospital nurses. Methods: The initial items were identified through a literature review and focus group interviews with ten hospital nurses. The content validity of the items was evaluated by ten experts. Fifty-one items were derived from the pilot survey. Four hundred eighty-eight nurses participated in the study: 248 for exploratory factor analysis (EFA) and 240 confirmatory factor analysis (CFA). Data were analyzed using item analysis, EFA, CFA, convergent validity, known-group validity, and internal consistency using IBM SPSS Statistics 29.0 and IBM SPSS AMOS 29.0. Results: The final scale consisted of 31 items and eight factors (decent wage, opportunity to grow and develop, support for special situations, various benefits, flexibility of work, job-related achievement, reflecting career and performance, and recognition), which explained 67.3% of the total variance. The eight-subscale model was validated by CFA. Convergent validity was evaluated by analyzing correlation with intention to leave (r = - .63, p < .001) and job satisfaction (r = .54, p < .001). The known-group validity was evaluated by comparing the reward scales according to age, clinical career, income level and hospital type. The scale was found to be reliable with a Cronbach's α of .89. Conclusion: Both the validity and reliability of the reward scale for hospital nurses are verified, which can enhance the understanding of the range of rewards and may assist nurse managers in establishing an effective reward system.

• 한국지반환경공학회 논문집
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• 제11권1호
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• pp.19-26
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• 2010

본 연구는 석탄회의 카드뮴에 대한 흡착특성을 조사하기 위하여 회분식 실험과 반응표면분석을 실시하였다. Langmuir model과 Chapman-Richards model로 산정된 석탄회의 카드뮴의 최대 제거량은 12.95mg/g와 12.99mg/g로 조사되었다. 또한 초기 pH 4에서 9까지의 카드뮴의 제거특성은 초기 pH에 따라 서로 다른 양상을 나타내었으며, pH가 증가 할수록 카드뮴의 제거량은 흡착과 침전에 의한 영향으로 증가하는 것으로 나타났다. 또한, pH에서 카드뮴의 제거량의 감소에 대한 결과는 $H^+$이온의 증가에 따른 카드뮴이온과의 경쟁적 반응에 의한 것으로 사료된다. 반응표면분석법 중 Box-Behnken법을 이용하여 초기 카드뮴 농도($X_1$), 초기 pH($X_2$), 그리고 초기 석탄회의 주입량($X_3$)을 독립변수로 선정하였으며, 종속변수인 석탄회의 카드뮴의 흡착특성을 수학적 모델로 도출하였다. 경험적 모델인 반응표면분석법을 이용하여 실험적 요인과 반응변수에 대한 관계를 도출하도록 반응모델식을 개발하였다. 통계학적 분석결과, 1차 선형효과(주효과)에서 초기 카드뮴 농도, 초기 pH, 초기 석탄회의 주입량과, 2차 비선형 효과(교호작용, 상호효과)에 대하여 유의한 것으로 조사되었다. 도출된 반응모델은 수정 결정계수가 0.928으로 1에 근사한 값을 갖는 것으로 나타났으며, 도출된 반응모델은 카드뮴 제거율에 매우 근접하게 결과를 도출할 수 있었다. 또한, 통계학적 분석결과 카드뮴 제거에 미치는 영향은 초기 pH > 초기 카드뮴 농도 > 초기 석탄회의 주입량 순으로 나타났다.