• Title/Summary/Keyword: CD80

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A Study on $Ni_{0.8}Cd_{0.2}Fe_2O_4$ by Mossbauer spectroscopy (Mossbauer 분광법을 이용한 $Ni_{0.8}Cd_{0.2}Fe_2O_4$)

  • Baek, Seung-Do
    • Korean Journal of Materials Research
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    • v.6 no.11
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    • pp.1107-1112
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    • 1996
  • Ni를 Cd로 대치시켜 세라믹 소결법으로 합성한 Ni0.8Cd0.2Fe2O4 의 X-ray 회절선을 측정하여 구조를 확인하고, 형성된 결정체의 격자 상수를 조사하였다. 이 시료의 Mossbauer 스펙트럼을 80K-900K의 온도 영역에서 측정 분석하여 Mossbauer parameter의 온도 의존성과 Fe 이온에 대한 자료를 얻고, 이 자료를 토대로 Ni0.8Cd0.2Fe2O4 의 자기 전이 현상과 Curied 온도 Tc와 격자 비열 및 Debye 온도와 같은 물성을 조사하였다.

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Pathogenesis of Minimal Change Nephrotic Syndrome: A Review of the Underlying Molecular Mechanisms

  • Yang, Eun Mi
    • Childhood Kidney Diseases
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    • v.23 no.1
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    • pp.1-6
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    • 2019
  • Nephrotic syndrome (NS) is the most common glomerular disorder in childhood, and a vast majority of cases are idiopathic. The precise cause of this common childhood disease is not fully elucidated despite significant advancements in our understanding of podocyte biology. Idiopathic NS has been considered "a disorder of T-cell function" mediated by a circulating factor that alters podocyte function resulting in massive proteinuria since the last four decades. Several circulatory factors released from T-cells are considered to be involved in pathophysiology of NS; however, a single presumptive factor has not been defined yet. Extended evidence obtained by advances in the pathobiology of podocytes has implicated podocytes as critical regulator of glomerular protein filtration and podocytopathy. The candidate molecules as pathological mediators of steroid-dependent NS are CD80 (also known as B7-1), hemopexin, and angiopoietin-like 4. The "two-hit" hypothesis proposes that the expression of CD80 on podocytes and ineffective inhibition of podocyte CD80 due to regulatory T-cell dysfunction or impaired autoregulation by podocytes results in NS. Recent studies suggest that not only T cells but also other immune cells and podocytes are involved in the pathogenesis of MCNS.

Dependence of the Electrical and Optical Properties of CdS Thin Films on Substrate and Annealing Temperatures (기판온도 및 열처리온도에 대한 CdS 박막의 전기적 및 광학적 특성)

  • Park, Ki-Cheol;Shim, Ho-Seob;Kim, Jeong-Gyoo
    • Journal of Sensor Science and Technology
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    • v.6 no.2
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    • pp.163-171
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    • 1997
  • CdS thin films for window material of solar cell were prepared by close spaced vapor transport deposition system and annealed at different temperatures. The structural, electrical, and optical properties of as-deposited and annealed CdS films were investigated as functions of substrate and annealing temperatures. The CdS thin films were grown perpendicularly to the substrate along the (002)plane with hexagonal structure regardless of the preparation conditions The resistivity of the CdS film deposited was increased gradually from $60{\Omega}cm$ for $25^{\circ}C$ to $2{\times}10^{4}{\Omega}cm$ for $300^{\circ}C$. The optical transmittance at the substrate temperature of $25^{\circ}C$ was about 80% in the the visible spectrum. The resistivity increased monotonically, and the optical transmittance was decreased substantially with annealing temperature due to the increased defect density in the CdS film.

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The Fabrication and Design of Driving Circuit for LCD panel using the high efficiency LED (고 효율 LED를 이용한 LCD 패널 구동회로의 설계 및 제작)

  • Ryu, Jang-Ryeol
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.13 no.7
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    • pp.3146-3151
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    • 2012
  • For using them as a optical source of inspections equipment for LCD panel, the design ofexcellent backlight system, brightness uniformity and high power and good protection against heat is essential.In this paper, backlight system which is built in the 45 inch side emitting LCD backlight by LED arraystructure and driving circuit were designed and developed. After that, their performances were measured. Itshowed the luminance from 3,000 to 25,000[$cd/m^2$], the mean value x:0.3144, y:0.3076 of x-y chromaticity,dimming range of 27~515[$cd/m^2$], free flicker noise in the 80kHz and black level of 0.7~0.1[$cd/m^2$], thermaltest of cooling system in 20,000[$cd/m^2$] over values.

The Effect of Dietary Low Iron Levels on the Metabolism of Iron in Long Termm Cadmium Poisoned Rats (장기간의 철분 부족 식이가 카드뮴중독된 흰쥐의 철분대사에 미치는 영향)

  • 최미경;김애정;승정자
    • Journal of the East Asian Society of Dietary Life
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    • v.4 no.2
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    • pp.9-16
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    • 1994
  • This study was undertaken to investigate the effects of dietary low (Fe) levels on Fe metabolism of cadmium(Cd) poisoned rats. 40 male Sprague weaning Dawley rats weighing 80-90g were divided into 4 groups(LFe:low Fe, LFeCd:low Fe and Cd, AFe: adequate Fe, AFeCd: adequate Fe and Cd) according to Cd administration(0, 50ppm in drinking water) and Fe levels(Fe:6ppm, 40ppm in diet)for 12 weeks. The food intake and body weight gain of Cd group with low Fe(LFeCd) were significantly lower than those of without Cd group with adequate Fe(AFe)(p<0.01, P<0.05). But there was no significantly difference between Cd groups and without Cd groups in water intake. The blood levels of hemoglobin, hematocrit, and serum levels of Fe of LFeCd were significantly lower than those of AFe(p<0.01, p<0.05, p<0.001). The urinary and fecal excretion of Fe of LFeCd was significantly lower than that of AFe(p<0.05, p0.05). The levels of Fe of liver, spleen in LFeCd were lower than those of AFeCd(p<0.05, p<0.05). These results indicates that adequate iron supplementation to Cd pretreated rats induce protective effects on the reduction of Fe status by Cd poisoning.

Effects of Cadmium on the Degradation of Butachlor Pollutant by Microorganism (Cadmium이 토양미생물에 의한 Butachlor 오염물질 분야에 미치는 영향)

  • 허태웅;정문호
    • Journal of Environmental Health Sciences
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    • v.20 no.3
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    • pp.78-84
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    • 1994
  • The effects of heavy metal, Cd on the degradation of the herbicide butachlor (N-Butoxymethyl-2-chlor-2',6'-diethylacetanilide) in soils were examined the laboratory. The degradation of the herbicide in soil was greatly inhibited by the amendment of the heavy metal, Cd. The inhibited rate of Cd concentration was high in the order of 30 ppm>20 ppm> 10 ppm>0 ppm. And tile degradation rate of butachlor was high in order of 80 $\mu$M>40 $\mu$M>20 $\mu$M. The effects of Cd on the degradation of the butachlor in soil varied with concentration of heavy metal and butachlor.

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Differential expression of cell surface markers in response to 2,4-dinitrofluorobenzene in RAW 264.7 and primary immune cells

  • Kim, Dong-Bum;Park, Min-Chul;Park, Byoung-Kwon;Kwon, Sang-Hoon;Choi, Joon-Ho;Kim, Hyun-Jong;Choi, Soo-Young;Park, Jin-Seu;Lee, Young-Hee;Kwon, Hyung-Joo
    • BMB Reports
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    • v.45 no.9
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    • pp.538-543
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    • 2012
  • We evaluated the expression of the costimulatory molecules CD80 and CD83 and major histocompatibility (MHC) class II induced by 2,4-dinitrofluorobenzene (DNFB) in the RAW 264.7 macrophage cell line. In contrast to the previously reported effect of DNFB on dendritic cells, CD86 expression did not change. Furthermore, we observed that the CD83 expression level transiently increased and then decreased. Induction of CD80 and MHC class II molecule expression and a decrease in CD83 expression by DNFB in vitro were also confirmed in splenocytes of BALB/c and NC/Nga mice. However, DNFB did not influence CD83 expression in peritoneal $CD11b^+$ cells from BALB/c or NC/Nga mice. Detailed in vivo experiments and further studies on the possible contribution of $CD11b^+$ cells to induce atopic dermatitis (AD) would be helpful to attain a better understanding of AD pathogenesis.

Modulatory Effect of Kaempferitrin, a 3,7-Diglycosylflavone, on the LPS-Mediated Up-regulation of Surface Co-stimulatory Molecules and CD29-Mediated Cell-cell Adhesion in Monocytic- and Macrophage-like Cells (활성화된 단핵구 및 대식세포의 항원제시기능에 대한 Kaempferitrin의 조절 효과)

  • Kim, Byung-Hun;Cho, Dong-Ha;Cho, Jae-Youl
    • YAKHAK HOEJI
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    • v.51 no.6
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    • pp.482-489
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    • 2007
  • Kaempferitrin, isolated from Kenaf (Hibiscus cannabinus), was examined to evaluate its modulatory effects on antigen-presenting cell functions of macrophages/monocytes such as phagocytosis of foreign materials, up-regulation of costimulatory molecules (CD40, CD80 and CD86), adhesion molecule activation, and antigen processing and presentation. Kaempferitrin strongly blocked up-regulation of CD40, CD80 and CD86, but not pattern recognition receptor (PRR) (e.g., TLR2). It also suppressed functional activation of CD29 (${\beta}1$-integrins), as assessed by cell-cell adhesion assay, required for T cell-antigen-presenting cell (APC) interaction. Furthermore, this compound did not block a simple activation of CD29, as assessed by cell-fibronectin adhesion assay. However, the compound did not diminish phagocytic uptake, an initial step for antigen processing, and ROS generation in RAW264.7 cells. In particular, to understand molecular mechanism of kaempferitrin-mediated inhibition, the regulatory role of LPS-induced signaling events was examined using immunoblotting analysis. Interestingly, this compound dose dependently suppressed the phosphorylation of $I{\kappa}B{\alpha}$, Src, Akt and Syk, demonstrating that it can negatively modulate the activation of these signaling enzymes. Therefore, our data suggested that kaempferitrin may be involved in regulating APC function-relevant immune responses of macrophages and monocytes by regulating intracellular signaling.

Fabrication and characterization of ternary compound ZnCdS nanowires

  • Lee, Dong-Jin;Son, Moon-A;Kang, Tae-Won
    • Proceedings of the Korean Vacuum Society Conference
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    • 2010.02a
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    • pp.57-57
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    • 2010
  • Self assembled $Zn_{x-1}Cd_xS$ nanowires, synthesized on a Indium tin oxide coated glass substrate with low composition of Cd as x=0.09, were fabricated non-precursor via a co-evaporation method using of solid sources of CdS and ZnS. We studies that ZnCdS nanowires are dislocation-free and the single crystalline hexagonal wurtzite structure showed by transmission electron microscopy and selected area electron diffraction pattern. Cathode luminescence spectra showed an near band edge peak at 383nm originated from nanowires at 80K and 300K. Core level spectra of the Cd 3d, Zn 2p and S 2p in the ZnCdS nanorods were obtained by x-ray photoelectron spectroscopy. Prepared ZnCdS nanorods showed different shape with increase of substrate temperature at the growth.

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