• Title/Summary/Keyword: CCl$^4$

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Plants with Liver Protective Activities (V) -Liver protective activities of Atractylodes japonica (alba) and Gentiana scabra- (강간제(强肝劑)로 사용(使用)된 생약(生藥)의 조사연구(調査硏究) (V) -백출(白朮) 및 용담(龍膽)의 강간효과(强肝效果)에 관(關)한 연구(硏究)-)

  • YunChoi, Hye-Sook;Yu, Jae-Chun;Chang, Il-Moo
    • Korean Journal of Pharmacognosy
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    • v.12 no.1
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    • pp.23-25
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    • 1981
  • Methanol extracts of the roots of Atractylodes japonica (alba) (Compositae) and Gentiana scabra (Gentianaceae) were further fractionated with n-butanol, chloroform, n-hexane and water. Then each fraction was p.o. administered to an animal model of hepatitis caused by $CCl_4$ intoxication. Measurements of sleeping time of mice induced by hexobarbital administration indicated that n-butanol and chloroform fractions of Atractylodes japonica (alba), and chloroform and n-hexane fractions of Gentiana scabra showed significant liver protective activities. Measurements of the activities of serum transaminase, S-GOT and S-GPT appeared to support these results.

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Study on the Chlorination reaction of Pyrochlore with Carbon Tetrachloride gas (사염화탄소에 의한 복합광(Pyrochlore)의 염화반응 연구)

  • Nam, Chul-Woo;Choi, Young-Yoon;Kim, Byung-Su
    • Proceedings of the Korean Institute of Resources Recycling Conference
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    • 2005.10a
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    • pp.266-270
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    • 2005
  • 본 연구는 Ta, Nb, Zr, 및 희토류 등을 복합적으로 함유한 복합광을 대상으로 사염화탄소에 의한 염화반응을 알아보기 위한 기초연구로서 각 산화물의 염화반응 특성을 알아보고 이를 토대로 복합광의 염화반응을 비교하여 보았다. 실험결과 산화물 상태의 Nb, Ta 및 Zr은 비교적 낮은 온도에서 염화반응이 일어나고 염화물이 휘발됨을 알 수 있었다. 복합광을 반응 온도 $400^{\circ}C,\;CCl_4$ 분압 0.28 일때 반응시간이 10분에서 60분으로 변함에 따라 니오븀 및 탄탈륨은 $91%{\sim}99%$의 높은 회수율을 나타내었으나 지르코늄은 각각 16.5%에서 27.5%로 약간 증가하는 경향을 나타내었다. 희토류의 경우 세륨은 반응율이 71.7에서 73% 정도였고 란타늄은 51%에서 54% 정도의 반응율을 나타내었다.

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The protective and antioxidant effect of Solanum lycopersicum extract in liver fibrosis induced rats

  • Oh, Se-Mi;Park, Jun-Ho;Lee, Sang-Hee;Kim, Hee-Seok;Kim, Ki-Young;Andrea, Mattes
    • Proceedings of the PSK Conference
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    • 2003.04a
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    • pp.155.2-156
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    • 2003
  • The adducts of lipid peroxidation and related aldehydic end are mediators of chronic poisoning and affect the development of chronic liver damage leading to fibrosis and cirrhosis. Substances delayed or suppresed lipid peroxidation could have an antioxidant and protective effect in liver disease. In this study, it was attempted to find out above mentioned effect of Solanum lycopersicum investigated in CCl4 induce liver fibrosis model. (omitted)

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Screening of Momordica dioica for Hepatoprotective, Antioxidant, and Antiinflammatory Activities

  • Shreedhara, C.S.;Vaidya, V.P.
    • Natural Product Sciences
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    • v.12 no.3
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    • pp.157-161
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    • 2006
  • The alcoholic extract of Momordica dioica roots significantly reduced $CCl_4$ induced hepatotoxicity in rats upon oral administration (200 mg/kg), as judged from the serum enzyme levels [serum glutamate oxaloacetate transaminases (SGOT), serum glutamate pyruvate transminases (SGPT), and alkaline phosphatase (ALP)]. These results were comparable with sylimarin (1.25 mg/kg, p.o.). The alcoholic extract inhibited the formation of oxyten derived free radicals (ODFR) in vitro with $4000\;{\mu}g/ml$ ascorbic system. The alcoholic extract also significantly reduced carrageenan-induced paw edema when administered orally (200 mg/kg) and the activity was comparable with ibuprofen(200 mg/kg, p.o.).

Effects of Zanthoxylum schinifolium and Its Active Principle on Serum Lipid Levels in Carbon Tetrachlotide-Treated Mice (산초 및 그 활성성분이 사염화탄소를 투여한 Mouse의 혈청지질성분에 미치는 효과)

  • 문숙임
    • The Korean Journal of Food And Nutrition
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    • v.13 no.3
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    • pp.249-254
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    • 2000
  • 산초종피 메탄올 추출물과 heperoside의 사전투여가 사염화탄소에 의해 예상되는 혈청지질설분의 농도 변화에 미치는 효과를 밝히기 위해 ICR계 mouse를 대상으로 실험한 결과는 다음과 같다. 사엽화탄소로 혈청 총콜레스테롤 농도가 유의적으로 증가되었으나, 산초 메탄올 추출물과 hyperoside의 사전투여는 사염화탄소에 의한 이의 증가를 유의적으로 억게시켰으며, 20mg/kg hyperoside투여군에서 그 효과가 가장 높았다. 사염화탄소로 혈청 HDL-cholesterol농도가 유의적으로 감소되었으나, 산초 메탄올 추출물과 hy-peroside의 사전투여는 사염화탄소에 의한 이의 감소를 유의적으로 억제시켰으며, 20mg/kg hyperoside투여군에서 그 효과가 가장 높았다. 사염화탄소로 혈청 LDL-cholesterol농도가 유의적으로 증가되었으나, 산초 메탄올 추출물과 hyperoside의 사전투여는 사염화탄소에 의한 이의 증가를 유의적으로 억제시켰으며, 20mg/kg hyperoside 투여군에서 그 효과가 가장 높았다. 사염화탄소로 혈청 triglyceride 농도가 유의적으로 증가되었으나, 산초 메탄올 추출물과 hyperoside의 사전투여는 사염화탄소에 의한 이의 증가를 유의적으로 억제시켰다.

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Preparation of Chemical Solution for the Provisional Cement Remnant Cleaning in Dental Crown (치과 보철용 크라운에 잔존하는 임시 시멘트의 용해액의 개발)

  • Yi, Yong-Hyun;Kim, Byung-Jin;Lee, Kwang-Rae
    • Journal of Industrial Technology
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    • v.37 no.1
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    • pp.12-15
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    • 2017
  • It is important in dentistry that the provisional cement should be cleaned thoroughly from the crown before definitive cementation. The provisional cement has been removed by physical means such as curette, scaler, pumice, or sand-blasting with alumina particles, which is time-consuming, irritating, tedious, even causing crack. To avoid such troubles occurring through such physical cleaning means, the chemical solutions for dissolving the provisional cement remaining in dental crown were prepared, and solubilizing power of the solutions was measured and compared. The solution composed of MEA, NaOH, chloride chemicals ($CHCl_3$, $CCl_4$, $CH_2Cl_2$), surfactants (Igepal, Tween20), chelating agent (EDTA), and Ethyl cellosolve was most effective for dissolving the provisional cement.

Studies on the Concurrent Administrations of Sosiho-Tang Extract and Methionine-Effects on the Liver Lesion Induced by Carbon Tetrachloride in Rats-

  • Kim, Jeong-Soo;Kim, Gi-Hyung;Kim, Il-Hyuk
    • Korean Journal of Pharmacognosy
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    • v.17 no.2
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    • pp.148-152
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    • 1986
  • The preventive effect of Sosiho-Tang extract administered concurrently with methionine on hepatotoxicity induced by carbon tetrachoride (20% $CCl_4$ in olive oil, 5 ml/kg) in rats was studied. S-GOT values were decreased significantly by the concurrent administration of Sosiho-Tang extract 100 mg/kg with methionine 100 mg/kg and also Sosiho-Tang 200 mg/kg with methionine 100 mg/kg. S-GPT values were decreased remarkably by the concurrent administration of Sosiho-Tang extract 200 mg/kg with methionine 100 mg/kg. In histological observations, the pattern of the contrast group indicated the marked necrosis of the parenchymatous cells around the centrilobular area and the fatty changes of the hepatic cells around the midzonal area, but the concurrent administration of Sosiho-Tang extract 200 mg/kg and methionine 100 mg/kg revealed better improvements than their respective single administration in all pathological aspects.

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IR Edge and Oxide Impurity Absorption in Heavy Metal Fluoride Glasses (플루오르화중금속 유리의 적외선에지 및 산화물(불수물) 흡수)

  • 정기호
    • Journal of the Korean Ceramic Society
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    • v.22 no.3
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    • pp.29-34
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    • 1985
  • The IR spectra of he heavy metal fluoride glasses showed peaks at $1, 400cm^{-1}$ or $1, 100cm^{-1}$ due to metal oxyfluoride impurities. The intensity of this band and hence the oxide impurity content of the glass could be reduced considerably by the use of reactive atmosphere melting under $CCl_4$ In comparison with the fundamental IR absorption band of heavy metal oxides the oxide impurity bands observed in the heavy metal fluoride glasses are multiphonon bands due to a 2-phonon absorption process. The envelope of the a vs. v curve beyond thue fundamental region shows the exponential fall off of a with increasing v-typical of intrinsic multiphonon absorption. In the multiphonon region the amount of structure is intermediate between that observed for covalent solids and that for ionic solids.

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Focus on Anti-Oxidative and Free Radical Scavenging Activity of Ganoderma lucidum

  • Lin, Zhi-Bin
    • Biomolecules & Therapeutics
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    • v.12 no.3
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    • pp.133-137
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    • 2004
  • Present review is built on base of research work on Ganoderma lucidum in our laboratory. A great deal of experimental evidence has suggested that the pharmacological activities of Ganoderma lucidum (Lingzhi) are related to anti-oxidative and free radical scavenging activity. The anti-oxidative and free radical scavenging effects of polysaccharides and triterpenoids isolated from Ganoderma lucidum in different oxidative injury models including tert-butylhydroperoxide (tBOOH)- damaged mice peritoneal macrophages, alloxan-induced diabetes, experimental liver injury models induced by carbon tetrachloride (CCl4), D-galactosamine (DGal) and Bacillus Calmette-Guerin (BCG) plus lipopolysaccharides (LPS) were investigated. It is also demonstrated that Lugu lingzhi, one of Ganoderma product, significantly inhibited LDL oxidation mediated by endothelial cells and decreased monocyte adhesion to endothelial cell (EC) induced by Oxidative low-density lipoprotein (ox-LDL) and advanced glycation endproducts (AGE). Lugulingzhi-treated serum could markedly inhibit the expression of intercellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-l) induced by ox-LDL and AGE.

Screening of the Hepatoprotective Drugs from Folk Medicines (간 보호 효과를 지닌 자원 생약의 검색)

  • Park, Jong-Hee;Moon, Jeon-Ok
    • Korean Journal of Pharmacognosy
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    • v.28 no.3
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    • pp.156-161
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    • 1997
  • For the search of hepatoprotective compounds from the folk medicines, 14 natural products which have been traditionally used as hepatoprotective drugs in Korea were extracted with methanol. The extracts were screened for the antioxidant activity on lipid peroxidation induced by Fenton reaction in rat homogenate and Ac2F cell toxicity by t-hydroperoxide. Dendrobium moniliforme and Castanea crenata were chosen for the further investigation and its therapeutic effects on the liver damage induced by carbon tetrachloride in rats were evaluated. Oral administration of the extracts reduced the aspartate aminotransferase(AST) and alanine aminotransferase(ALT) activities in the serum of the carbon tetrachloride intoxicated rat. And the treatment of the extracts prevented the decrease of aminopyrine N-demethylation and aniline hydroxylation activities of the carbon tetrachloride-intoxicated rat liver. These results suggest that oral administration of Dendrobium moniliforme and Castanea crenata is effective in recovering the liver function in $CCl_4-treated$ rats.

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