• 한국산학기술학회논문지
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• 제10권3호
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• pp.677-683
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• 2009

중소기업청의 정책자금 융자업체 결정과 관련하여 본 평가가 비계무적 측면을 토대로 이루어지고 있기 때문에 재무적 측면을 반영할 필요성이 있다. 이에 본 연구는 정책자금을 받은 IT 업종에 속해 있는 기업들을 대상으로 DEA와 맘퀴스트 지수를 이용, 이들 기업들의 상대적 효율성 및 생산성 변화를 파악하였다. 본 연구결과는 첫째, 2006년의 경우 CCR 효율성이 1인 기업은 28개 기업 가운데 6개 기업이며, 이 가운데 외감과 코스닥이 각각 3개 기업으로 나타났다. 2007년의 경우 CCR 효율성이 1인 기업은 28개 기업 가운데 6개 기업이며, 이 가운데 외감이 5개 기업, 코스닥이 1개 기업으로 나타났다. 둘째, 2006년의 경우 BCC 효율성이 1인 28개 기업 가운데 11개 기업이며, 이 가운데 외감기업이 7개, 코스닥기업이 4개로 나타났다. 2007년의 경우 BCC 효율성이 1인 기업은 28개 기업 가운데 13개 기업이며, 이 가운데 외감이 9개 기업, 코스닥이 4개 기업으로 나타났다. 셋째, 규모의 수익가변과 관련하여 2006년의 경우 DRS는 15개, IRS는 2개로 나타났고, 2007년의 경우는 DRS는 14개, IRS는 1개로 나타났다. 넷째, Malmquist Index를 통한 생산성 변화를 살펴보면 정책자금을 받은 IT 외감 및 코스닥 기업들 모두 1보다 크므로 생산성 향상이 이루어 졌음을 알 수 있다. 본 연구결과를 통해 도출되는 표본기업들의 상대적 효율성 및 생산성 변화정도는 정책자금 융자업체를 결정하기 위한 본 평가 시 재무적 측면을 반영할 수 있는 시험적 시도라는 점에서 본 연구의 의의가 있다. 향후 정책자금 신청업체의 자료가 체계적으로 구축되면, 이들 자료들을 대상으로 상대적 효율성 및 생산성 변화정도를 파악하여 실질적으로 이를 정책자금 신청업체들의 본 평가에 반영함으로써 제도개선을 도모할 필요가 있다.

• 한국연초학회지
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• 제4권2호
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• pp.41-50
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• 1982

To investigate tile effects of growth characteristics on the yield, price per Kg, chemical contents and physical properties in Burley tobacco, ten varieties including Burley 21 were tested in this study. The results obtained are summarized as follows. 1 Forty to fifty days after transplanting, CCR (Crop Growth Rate) was the highest. RCR (Relative Growth Rate) increased up to 40 days, but decreased 50 days when maturation began. High- yielding varieties showed high CCR and RCR till 60 days. 2. Total alkaloid content of cured leaf increased about three times than that of topping stage, but the increased rates were some what different among varieties. 3. Leaf area, stalk diameter, stalk height and days to flower showed positive correlations to yield, whereas leaf thickness and weight per unit leaf area showed negative. 4 Varieties which are high in cured leaf weight ratio and weight per unit leaf thickeners showed relatively poor quality. 5 Nitrogen content was high in leafy and larger stalk diameter variety. 6. There are positive correlation between weight per unit leaf thickness and filling power. The time of combustion was positively correlated to leaf thickness and weight Per unit leaf. 7. It can be concluded that many characteristics are related to the yield, but not quality. It is, there fore, easy to Predict tile yield, but difficult to forecast the qualiffy.

• 한국산학기술학회:학술대회논문집
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• 한국산학기술학회 2011년도 춘계학술논문집 2부
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• pp.765-768
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• 2011

최근 건설경기의 난국 속에서 많은 건설기업들이 경영상의 어려움에 처해 있다. 본 연구에서는 코스피 코스닥 상장 건설기업들을 대상으로 ANP와 DEA 결합 모델을 이용하여 기업의 경영 효율성 분석을 실시한다. DEA 모형에 쓰이는 투입 및 산출 요소의 결정은 ANP 모형의 중요도 분석을 통하여 결정함으로써 기존의 방법보다 효율성 분석 결과의 신뢰도를 제고하였는데, 효율성 분석결과 비효율적 그룹에 대해서는 효율적 그룹으로의 이동을 위한 벤치마킹 대상과 개선을 위한 효율성 수치를 제공한다. 또한 연구의 결과로 나온 기업별 효율성과 주가와의 상관관계를 분석한다. 본 연구에서는 코스피 상장 건설기업 36곳과 코스닥에 상장된 건설기업 21곳인 총57개 기업을 대상으로 기업의 효율성을 평가하였는데, 효율성 분석결과 CCR 효율성이 1인 기업은 4개 기업, BCC 효율성이 1인 기업은 7개 기업, 규모의 효율성이 1인 기업은 4개 기업 이었으며 각각의 효율적 그룹군 기업과 주가와의 상관관계는 CCR, BCC 모형 모두에서 0.7 이상의 강한 양의 상관관계를 나타냈다.

• 동의생리병리학회지
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• 제21권5호
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• pp.1099-1107
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• 2007

This study was investigated the anti-allergic effect of SJSBT on DNCB induced atopic dermatitis in NC/Nga mice. We summerized as the follow. SJSBT significantly decreased the clinical manifestations of atopic dermatitis including itching, dryness, edema, hemorrhage, and lichenification in dose dependent manner. SJSBT markedly suppressed invasion and edema of leukocytes and mast cell in dorsal skin and ear tissue. SJSBT significantly reduced the number of CD11b+/Gr-1 cell compared with positive control, but it had no affect the number of CD3+ and CCR3+/CD3+ cell. SJSBT markedly suppressed the expression of cytokine and chemokine such as IL-6, $TNF-{\alpha}$, eotaxin and CCR3 compared with positive control group. SJSBT significantly decreased the invasion of CD4+ and CCR3+ cell in ear and dorsal skin tissue compared with positive control group by using immunohistochemical staining. Taken together, these findings suggested that SJSBT has an anti-allergic activity and this might be useful for the clinical application to treat allergic diseases such as atopic dermatitis.

• 대한한방소아과학회지
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• 제22권3호
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• pp.105-137
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• 2008

Objectives : The purpose of this study is to investigate the effect of Gupoongjeseuptang (GPJST) on atopic dermatitis by in vivo experiment using NC/Nga atopic dermatitis mouse, which has histological and clinical similarities to the atopic dermatitis of human. Methods : To investigate the effect of GPJST on atopic dermatifis, we evaluated atopic dermatitis-like skin lesions by clinical skin index and analyzed immunological parameters in peripheral blood mononuclear cells (PBMCs), splenocytes, draining lymph node (DLN) and performed skin histology in ears and dorsal skin of atopic dermatitis-like skin NC/Nga mouse in vivo. Results : In vivo, clinical skin severity score were significantly lower in GPJST group than control group. IgE, IL-6, $TNF-{\alpha}$, IgG1, IgM, IgG2a and IgG2b levels in serum decreased remarkably in GPJST group than control group. Also, total absolute number of $CD3^+CD69^+$, and $CCR3^+$ cells recovered as normal in PBMCs and $CD3^+$, $CD3^+CD69^+$ decreased significantly compared with control group in isolated DLN from NC/Nga mouse and total absolute number of $CD11b^+Gr-1^+$, $CCR3^+CD3^+$ in dorsal skin of NC/Nga mouse decreased by GPJST. We analyzed ear and neck-back skin after biopsy and dyeing by hematoxyline/eosin (H&E) and toluidine staining (mast cells marker) and obtained results that GPJST are very effective to histological symptoms (dermal and epidermal thickening, hyperkeratosis and inflammatory cell (CD4, $CCR3^+$) infiltration). Conclusions : This study demonstrates immunological activity of GPJST on atopic dermatitis-like model mice.

• 한국항만경제학회지
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• 제26권1호
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• pp.131-143
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• 2010

본 논문은 세계 주요 컨테이너 항만의 효율성을 분석하기 위해 Containerisation International Yearbook에 수록된 컨테이너 항만 가운데 컨테이너 물동량 처리기준(2007년)으로 20대 항만을 선정하여 DEA(CCR, BCC, 규모효율성)분석을 실시하였다. 항만의 효율성에 영향을 미칠 수 있는 변수를 국내외 기존 연구를 참고하여 선정하였다. 투입변수는 선석수, 수심, 크레인수, 총면적을, 산출변수는 컨테이너 화물처리량을 선정하였다. 분석결과를 요약하면, 첫째, DEA-CCR효율성은 선전항(중국)이 1.0으로서 분석대상 항만 중 가장 효율적인 항만으로 분석되었다. 둘째, DEA-BCC효율성을 분석한 결과 싱가포르, 선전항(중국), 닝보(중국), 탄중펠레파스(말레이시아)가 효율성 1.0으로서 분석대상 항만 중 효율적인 항만으로 분석되었다. 셋째, 규모의 효율성 분석결과는 선전항(중국) 만이 2004년부터 2007년까지 4년 연속효율성 1.0으로서 분석대상 항만 중 가장 효율적인 항만으로 분석되었다.

• 대한한방소아과학회지
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• 제23권3호
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• pp.263-291
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• 2009

Objectives The purpose of this study is to investigate the effect of YHJST on atopic dermatitis in an experiment using an NC/Nga mice induced by DNCB, which has histological and clinical similarities to the condition in humans. Methods To investigate the effect of YHJST on atopic dermatitis(AD), we evaluated atopic dermatitis-like skin lesions by clinical skin index and analyzed immunological parameters in peripheral blood mononuclear cells(PBMCs) and performed skin histology in ears and dorsal skin of NC/Nga ato-mouse. Results YHJST medicines decreased Serum level of IgE, IL-6, TNF-$\alpha$. Also total number of $CD69^+$, $CD3^+$ in PBMCs, absolute cell number of $CCR3^+CD3^+$, $CD11b^+Gr-1^+$ in Dorsal skin tissue, Serum IgG1, IgM, IgG2a and IgG2b decreased significantly. Furthermore YHJST is extremely effective to histological symptoms; dermal and epidermal thickening, hyperkeratosis and inflammatory cell infiltration and suppressed histologic infiltration of $CD4^+$ & $CCR3^+$ in ear and dorsal skin lesions significantly. YHJST decreased gene-expression of IL-6, TNF-$\alpha$, CCR3, Eotaxin mRNA than that of control group. Conclusions YHJST on atopic dermatitis to atopic dermatitis NC/Nga mouse induced DNCB was incredibly effective.

• Bulletin of the Korean Chemical Society
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• 제31권10호
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• pp.2761-2770
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• 2010

In this study, we have developed QSAR models for a series of 38 piperidine-4-carboxamide CCR5 antagonists using CoMFA, CoMSIA and HQSAR methods. Developed models showed good statistics in terms of $q^2$ and $r^2$ values. Best predictions obtained with standard CoMFA model ($r^2$ = 0.888, $q^2$ = 0.651) and combined CoMSIA model ($r^2$ = 0.892, $q^2$ = 0.665) with electrostatics and H-bond acceptor parameter. The validity of developed models was assessed by test set of 9 compounds, which showed good predictive correlation coefficient for CoMFA (0.804) and CoMSIA (0.844). Bootstrapped analysis showed statistically significant and robust CoMFA (0.968) and CoMSIA (0.936) models. Best HQSAR model was obtained with a $q^2$ of 0.662 and $r^2$ of 0.936 using atom, connection, hydrogen, donor and acceptor as parameters and fragment size (7-10) with optimum number of 6 components. Predictive power of developed HQSAR model was proved by test set and it was found to be 0.728.

• 혜화의학회지
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• 제16권2호
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• pp.171-190
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• 2007

Atopic dermatitis is a chronic inflammatory skin disease characterized by pruritic and erythromatous skin lesions. In this study we examined the suppressive effects of SJJY on der f induced atopic dermatitis in NC/Nga mic, and concluded as follows: Oral administration of SJJY significantly decreased the severity score in the skin lesions at the dosage of 6.6 mg/25g/day for 8 weeks. SJJY significantly suppressed the infiltration of inflammatory cells into skin compared with control, and decreased the expression of CD4, CD8, CD20 and CCR3 in the skin lesions. SJJY significantly decreased the level of IgE in the serum compared with control, and the levels of IgM, IgG2a and IgG2b were also decreased. SJJY significantly decreased the levels of IL-6, but not TNF-a, in the serum compared with control. The levels of IFN-$\gamma$ was significantly increased in the supernatant of CD3/CD28 activated cultured splenocytes from the SJJY treated mice. The levels of IL-4 and IFN-$\gamma$ in the supernatants was much less in the der f activated splenocytes from SJJY treated mice than control. SJJY significantly increased the total number of cells in lymph node, while decreased the total number of skin compared with control. SJJY increased the number of CD3+ and CD4+ cell compared with control, while decreased the number of CD4+/CD25+ and CCR3+ cells in the PBMC. SJJY increased the number of CD3+, CD4+, CD8+, CD4+/CD25+, NKT+, CD3+/CD69+ cells compared with control, while decreased the number of B220+/IgE+, B220+/CD23+ cells in the lymph node. SJJY significantly decreased the number of CD3+/CD69+, CCR3+, B220+/IgE+, CD11b+/Gr-1+ compared with control in the skin lesions. Taken together, these results suggested that SJJY has suppressive effects on atopic dermatitis by the regulation of immune system and has potential as a therapeutics for atopic dermatitis. Further studies on molecular mechanisms on immune regulation are needed.

• Animal Bioscience
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• 제34권10호
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• pp.1590-1599
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• 2021

Objective: This study investigates the expression patterns of toll-like receptors (TLRs) and intracellular mediators in horse muscle cells after exercise, and the relationship between TLRS expression in stressed horse muscle cells and immune cell migration toward them. Methods: The expression patterns of the TLRs (TLR2, TLR4, and TLR8) and downstream signaling pathway-related genes (myeloid differentiation primary response 88 [MYD88]; activating transcription factor 3 [ATF3]) are examined in horse tissues, and horse peripheral blood mononuclear cells (PBMCs), polymorphonuclear cells (PMNs) and muscles in response to exercise, using the quantitative reverse transcription-polymerase chain reaction (qPCR). Expressions of chemokine receptor genes, i.e., C-X-C motif chemokine receptor 2 (CXCR2) and C-C motif chemokine receptor 5 (CCR5), are studied in PBMCs and PMNs. A horse muscle cell line is developed by transfecting SV-T antigen into fetal muscle cells, followed by examination of muscle-specific genes. Horse muscle cells are treated with stressors, i.e., cortisol, hydrogen peroxide (H₂O₂), and heat, to mimic stress conditions in vitro, and the expression of TLR4 and TLR8 are examined in stressed muscle cells, in addition to migration activity of PBMCs toward stressed muscle cells. Results: The qPCR revealed that TLR4 message was expressed in cerebrum, cerebellum, thymus, lung, liver, kidney, and muscle, whereas TLR8 expressed in thymus, lung, and kidney, while TLR2 expressed in thymus, lung, and kidney. Expressions of TLRs, i.e., TLR4 and TLR8, and mediators, i.e., MYD88 and ATF3, were upregulated in muscle, PBMCs and PMNs in response to exercise. Expressions of CXCR2 and CCR5 were also upregulated in PBMCs and PMNs after exercise. In the muscle cell line, TLR4 and TLR8 expressions were upregulated when cells were treated with stressors such as cortisol, H₂O₂, and heat. Migration of PBMCs toward stressed muscle cells was increased by exercise and oxidative stresses, and combinations of these. Treatment with methylsulfonylmethane (MSM), an antioxidant on stressed muscle cells, reduced migration of PBMCs toward stressed muscle cells. Conclusion: In this study, we have successfully cultured horse skeletal muscle cells, isolated horse PBMCs, and established an in vitro system for studying stress-related gene expressions and function. Expression of TLR4, TLR8, CXCR2, and CCR5 in horse muscle cells was higher in response to stressors such as cortisol, H₂O₂, and heat, or combinations of these. In addition, migration of PBMCs toward muscle cells was increased when muscle cells were under stress, but inhibition of reactive oxygen species by MSM modulated migratory activity of PBMCs to stressed muscle cells. Further study is necessary to investigate the biological function(s) of the TLR gene family in horse muscle cells.