• Nutritional Sciences
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• 제6권2호
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• pp.100-105
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• 2003

Small dense LDL(LDL III) is emerging as a major risk factor for coronary artery disease. LDL III generation is associated with high triglyceride concentration, high hepatic lipase activity, and high cholesterol ester transfer protein (CETP) levels. CETP polymorphisms have been reported to be associated with coronary artery disease. In this study, we investigated the relationship between CETP polymorphism and LDL III generation. VLDL1, VLDL2, IDL and LDL subfractions were measured in 87 normal healthy Korean subjects who had been SNP genotyped for Taq1B, I405v and A629C. We found no differences in LDL subfractions and lipoprotein composition between homozygotes for Taq1B2B2, and those for Taq1B1B1 and Taq1B1B2. There were no differences in LDL subfractions and lipoprotein composition between homozygotes for 629AA, and those for 629AC and -629CC. However, homozygotes for 405VV had a significantly lower LDL III concentration and proportion than those for 405II and 405IV. We concluded that, among the Taq1B, I405V and A629C polymorphisms, only the 1405V polymorphism was associated with the concentration and proportion of LDL III.

• Smart Structures and Systems
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• 제10권1호
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• pp.1-14
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• 2012

Given an object, its positioning in the space is a main concern in structural monitoring and a required feedback in structural health monitoring, structural control and robotics. In addition, to make the sensor unit wireless is a crucial issue for advanced applications. This paper deals with the exploitation of wireless transmission technology to long-term monitoring GPS (Global Positioning System) receivers - like the Leica GMX 902 and the Leica GRX 1200-pro. These GPS receivers consist of five parts: antenna, receiver, user client computer, interface and power supply. The antenna is mounted on the object to be monitored and is connected with the receiver by a coaxial-cable through which the radio frequency signals are transmitted. The receiver unit acquires, tracks and demodulates the satellite signals and provides, through an interface which in this paper is made wireless, the resulting GPS raw data to the user client computer for being further processed by a suitable positioning algorithm. The power supply reaches the computer by a wired link, while the other modules rely on batteries re-charged by power harvesting devices. Two wireless transmission systems, the 24XStream and the CC1110, are applied to replace the cable transmission between the receiver and the user client computer which up to now was the only market offer. To verify the performance and the reliability of this wireless transmission system, some experiments are conducted. The results show a successful cable replacement.

• Asian Pacific Journal of Cancer Prevention
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• 제16권11호
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• pp.4525-4530
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• 2015

Background: The MTHFR C677T polymorphism is a genetic alteration affecting an enzyme involved in folate metabolism, but its relationship to host susceptibility to prostate cancer remains uncertain. The aim of this study was to investigate the association between MTHFR C677T polymorphism and prostate cancer by performing a meta-analysis. Materials and Methods: Pubmed and Web of Science databases were searched for case-control studies investigating the association between MTHFR C677T polymorphism and prostate cancer. Odds ratios (OR) and 95% confidence intervals (95%CI) were used to assess any link. Results: A total of 22 independent studies were identified, including 10,832 cases and 11,993 controls. Meta-analysis showed that there was no obvious association between MTHFR C677T polymorphism and risk of prostate cancer under all five genetic models. There was also no obvious association between MTHFR C677T polymorphism and risk of prostate cancer in the subgroup analyses of Caucasians. In contrast, MTHFR C677T polymorphism was associated with increased risk for prostate cancer in Asians with the allele model (C vs G: OR=1.299, 95 %CI =1.121-1.506, P=0.001, $P_{heterogeneity}=0.120$, $I^2=45%$), additive genetic model (CC vs TT: OR =1.925, 95 % CI= 1.340-2.265, P=0.00, $P_{heterogeneity}=0.587$, $I^2=0.00%$), recessive model (CC vs TT+TC: OR= 1.708, 95 % CI=1.233-2.367, P=0.001, $P_{heterogeneity}=0.716$, $I^2=0.00%$), and heterozygote genetic model (CT vs TT: OR=2.193, 95 % CI =1.510-3.186, P=0.000, $P_{heterogeneity}=0.462$, $I^2=0.00%$). Conclusions: These results suggest that the MTHFR C677T polymorphism does not contribute to the risk of prostate cancer from currently available evidence in populations overall and Caucasians. However, the meta analysis indicates that it may play a role in prostate cancer development in Asians.

• 한국실천공학교육학회논문지
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• 제3권2호
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• pp.136-141
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• 2011

제조현장에서 활용되는 생산 장비들의 시스템 발전 및 변화 추세는 PLC, DCS, SCADA 등 기존 시스템의 특성화된 영역들과 함께하고 있고 일부에서만 특성화된 영역이 고유의 영역으로 위치를 지키고 있다. 특히 시스템 간 통합, 감시제어시스템과 생산관리시스템, 경영정보시스템이 서로 연계 되어 가고 있으며 이러한 연계는 Open System을 요구하고 있는 현실이다. 이에 맞추어 최근 산업현장에서의 생산 자동화장비들은 단위기계의 자동화 단계를 벗어나 전체 공정의 흐름을 연계하여 생산하는 단계로 변해가고 있으며 급격히 융복합화된 기능과 성능을 요구하고 있지만 대부분의 학부 교육은 현장의 교육 요구 사항을 만족하지 못하고 있는 것이 현실이다. 본 연구에서는 이러한 문제점들을 해결할 수 있도록 관련 학부 교육과 재직자 교육을 연계하여 보다 현장감 있는 교육을 실시할 수 있도록 설계한 장비와 교육과정을 제안한다.

• 대한조선학회논문집
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• 제58권3호
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• pp.137-143
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• 2021

In this study, the fracture strength of Flexible Secondary Barrier (FSB) composites was standardized by conducting a distribution analysis of the fracture probability, considering that the fracture strength of FSB composites such as glass fiber reinforced composites is relatively large. As the mechanical performance of FSB composites varies with the fiber direction, 20 replicate uniaxial tensile tests were performed for different temperatures ranging from the ambient to cryogenic conditions, considering the actual operating environment of liquefied natural gas. For the probability statistical analysis, the Weibull distribution analysis derived from the weakest link theory was used, considering the large variance in the fracture strength and brittle fracture behavior. The results of the Weibull distribution analysis were used to calculate the standard fracture strength of the FSB composites for different fiber directions. The findings can help ensure the reliability of the FSB mechanical properties in different fiber directions in the design of the secondary barrier and structural analyses.

• Asian Pacific Journal of Cancer Prevention
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• 제14권4호
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• pp.2577-2582
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• 2013

Objectives: Interleukin (IL) -10 is a potent cytokine with a dual ability to immunosuppress or immunostimulate. We aimed to explore the association of IL10 promoter polymorphisms with risk of gastric cancer (GC) in a Han population in Southwestern China. Methods: We enrolled 308 pairs of GC and control subjects from four hospitals and a community between October 2010 and August 2011 in a 1:1 matched case-control design. Demographic information was collected using a designed questionnaire. IL10-592 A>C and IL10-1082 A>G polymorphisms were determined by Sequenom MassARRAY analysis. Results: Patients with GC reported statistically higher proportions of family history of cancer (29.9% versus 10.7%, P<0.01) and alcohol drinking (54.6% versus 43.2%, P<0.01) than did controls. Similar results were observed in comparison between non-cardia GC patients and controls (P<0.01 and P=0.03). Variant genotypes of IL10-592 A>C and IL10-1082 A>G were not associated with overall GC risk (adjusted OR, 0.94, 95% CI, 0.66-1.33; adjusted OR, 1.00, 95% CI, 0.62-1.60). Sub-analysis showed that the IL10-592 AC/CC variant genotype was associated with decreased non-cardia GC risk (adjusted OR, 0.58; 95% CI, 0.36-0.95). No association was found between any of the IL10 haplotypes established from two polymorphisms and risk of non-cardia GC. Conclusions: In conclusion, our data do not link the two SNPs of IL10-592 and IL10-1082 with overall GC risk. We demonstrate that IL10-592 polymorphism is associated with protective effect against non-cardia GC. Our findings may offer insight into risk associated with the development of GC in this region.