• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.33 no.7
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• pp.18-25
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• 2005

In this study, the main focus is the simulation of acoustic wave scattering in trailing edge and the analysis of the generation mechanism of instability wave by the interaction of trailing edge, shear flow and initial disturbance. The numerical algorithm is based on CFD/CAA hybrid method with high-order computational aeroacoustic method. It is found that steady mean flow gradient terms play a crucial role on the generation of instability wave through the comparison of simulations of Simple Linearized Euler Equation and Full Linearized Euler Equation. Through the comparison with the results of Full Navier-Stokes Equation, it is reasonable and efficient to use the Full Linearized Euler Equation in the initial generation mechanism of the instability wave near the trailing edge.

• Archives of Pharmacal Research
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• v.18 no.5
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• pp.336-339
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• 1995

Ephedra distachya cultures have been known to accumulate two major $\rho-coumaroylamino$ acids (p-coumaroylgicine and $\rho-coumaroylamino$ -D-alanine) by D-Ala treament. When D-Ala was added together with serial concentrations of yeast-derived elicitor, the accumulation of $\rho-coumaroylamino$ -D-Ala $(\rho-CDA)$ was geatly increased in an additive manner. In feeding experiments, $[1-^14C]$-D-Ala was incorporated into $\rho-CDA$at a rate of 2.2% or 2.3% of added radioactivity, indicating that exogenous D-Ala served as a precursor of the conjugate. $[1-^14C]$-L-Ala wasalso incorporated into p-CDA (0.23%) in the elicitor treated cultures. This fact suggested that at least a part of $(\rho-CDA)$ was produced from active conversion of L-Ala by the elecitation. In order to investigate a possible role of D-Ala as an elicitor of $\rpo-coumaroylamino$ acids $(\rpo-CAA)$, cold D-Ala was added together with labeled L-Ala. Although L-Ala seemed to be incorporated into $\rho-CDA$ by this treatment, the incorporation ratio was too small (0.054%) to draw a clear conclusion. However, the amount of $\rpo-coumaroylglycine$, which did not use D-Ala as a substrate, was also sightly increased by D-Ala treatment irrespective of the presence of elicitor, suggesting that exogenous D-Ala might act as an elicitor of$\rpo-CAA$ as well as a precusor substrate of $\rho-CDA$.

• Preventive Nutrition and Food Science
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• v.19 no.1
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• pp.19-26
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• 2014

Increased consumption of fresh vegetables that are high in polyphenols has been associated with a reduced risk of oxidative stress-induced disease. The present study aimed to evaluate the antioxidant effects of spinach in vitro and in vivo in hyperlipidemic rats. For measurement of in vitro antioxidant activity, spinach was subjected to hot water extraction (WE) or ethanol extraction (EE) and examined for total polyphenol content (TPC), oxygen radical absorbance capacity (ORAC), cellular antioxidant activity (CAA), and antigenotoxic activity. The in vivo antioxidant activity of spinach was assessed using blood and liver lipid profiles and antioxidant status in rats fed a high fat-cholesterol diet (HFCD) for 6 weeks. The TPC of WE and EE were shown as $1.5{\pm}0.0$ and $0.5{\pm}0.0mg$ GAE/g, respectively. Increasing the concentration of the extracts resulted in increased ORAC value, CAA, and antigenotoxic activity for all extracts tested. HFCD-fed rats displayed hyperlipidemia and increased oxidative stress, as indicated by a significant rise in blood and liver lipid profiles, an increase in plasma conjugated diene concentration, an increase in liver thiobarbituric acid reactive substances (TBARS) level, and a significant decrease in manganese superoxide dismutase (Mn-SOD) activity compared with rats fed normal diet. However, administration of 5% spinach showed a beneficial effect in HFCD rats, as indicated by decreased liver TBARS level and DNA damage in leukocyte and increased plasma conjugated dienes and Mn-SOD activity. Thus, the antioxidant activity of spinach may be an effective way to ameliorate high fat and cholesterol diet-induced oxidative stress.

• Preventive Nutrition and Food Science
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• v.19 no.4
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• pp.291-298
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• 2014

The aim of this study was to investigate the antioxidant activity of orange (Citrus auranthium) flesh (OF) and peel (OP) extracted with acetone, ethanol, and methanol. Antioxidant potential was examined by measuring total phenolic content (TPC), 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity (RSA), total radical-trapping antioxidant potential (TRAP), oxygen radical absorbance capacity (ORAC), and cellular antioxidant activity (CAA). The comet assay was used to determine the protective effects of OF and OP against $H_2O_2$-induced DNA damage. TPC was highest in the acetone extracts of OF and OP. DPPH RSA was also higher in the acetone extracts than in the ethanol extracts. The DPPH RSA was highest in the acetone extracts of OF. The TRAP and ORAC values of the all extracts increased in a dose-dependent manner. In the TRAP assay, the acetone extracts of OF and OP had the lowest $IC_{50}$ values. In the CAA assay, the methanol and acetone extracts of OP had the lowest $IC_{50}$ values. All of the samples protected against $H_2O_2$-induced DNA damage in human leukocytes, as measured by the comet assay, but the acetone extracts of OP had the strongest effect. These results suggest that acetone is the best solvent for the extraction of antioxidant compounds from OF and OP. Furthermore, the high antioxidant activity of OP, which is a by-product of orange processing, suggests that it can be used in nutraceutical and functional foods.

• Journal of Information Processing Systems
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• v.10 no.1
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• pp.103-118
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• 2014

Over the last couple of years, traditional VANET (Vehicular Ad Hoc NETwork) evolved into VANET-based clouds. From the VANET standpoint, applications became richer by virtue of the boom in automotive telematics and infotainment technologies. Nevertheless, the research community and industries are concerned about the under-utilization of rich computation, communication, and storage resources in middle and high-end vehicles. This phenomenon became the driving force for the birth of VANET-based clouds. In this paper, we envision a novel application layer of VANET-based clouds based on the cooperation of the moving cars on the road, called CaaS (Cooperation as a Service). CaaS is divided into TIaaS (Traffic Information as a Service), WaaS (Warning as a Service), and IfaaS (Infotainment as a Service). Note, however, that this work focuses only on TIaaS and WaaS. TIaaS provides vehicular nodes, more precisely subscribers, with the fine-grained traffic information constructed by CDM (Cloud Decision Module) as a result of the cooperation of the vehicles on the roads in the form of mobility vectors. On the other hand, WaaS provides subscribers with potential warning messages in case of hazard situations on the road. Communication between the cloud infrastructure and the vehicles is done through GTs (Gateway Terminals), whereas GTs are physically realized through RSUs (Road-Side Units) and vehicles with 4G Internet access. These GTs forward the coarse-grained cooperation from vehicles to cloud and fine-grained traffic information and warnings from cloud to vehicles (subscribers) in a secure, privacy-aware fashion. In our proposed scheme, privacy is conditionally preserved wherein the location and the identity of the cooperators are preserved by leveraging the modified location-based encryption and, in case of any dispute, the node is subject to revocation. To the best of our knowledge, our proposed scheme is the first effort to offshore the extended traffic view construction function and warning messages dissemination function to the cloud.

• Journal of Aerospace System Engineering
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• v.15 no.5
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• pp.50-59
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• 2021

The need for risk based safety management has been highlighted in accordance with the growth of aviation industry and public interest in aviation safety. Maintenance, Repair and Overhaul (MRO) in aviation industry is defined to guarantee the safety and reliability. Therefore, state's Civil Airworthiness Authority (CAA) has established safety oversight system dedicated for the development of a healthy MRO industry. The study proposed a risk based oversight system considering Korean environment. Based on literature review including analysis of International Civil Aviation Organization guidance and advance system, we identified two organization risks. Organization complexity can be evaluated in accordance with how large the organization is and how complicated the service they provide are. Organization profile is the organization's characteristic related with safety. This study contributes to improving the process of identifying risk of organization and focusing surveillance capabilities on risk areas for efficient management of CAA's resources.

• Genomics & Informatics
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• v.19 no.4
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• pp.38.1-38.7
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• 2021

Kawasaki disease (KD) is an acute pediatric vasculitis that affects genetically susceptible infants and children. To identify coding variants that influence susceptibility to KD, we conducted whole exome sequencing of 159 patients with KD and 902 controls, and performed a replication study in an independent 586 cases and 732 controls. We identified five rare coding variants in five genes (FCRLA, PTGER4, IL17F, CARD11, and SIGLEC10) associated with KD (odds ratio [OR], 1.18 to 4.41; p = 0.0027-0.031). We also performed association analysis in 26 KD patients with coronary artery aneurysms (CAAs; diameter > 5 mm) and 124 patients without CAAs (diameter < 3 mm), and identified another five rare coding variants in five genes (FGFR4, IL31RA, FNDC1, MMP8, and FOXN1), which may be associated with CAA (OR, 3.89 to 37.3; p = 0.0058- 0.0261). These results provide insights into new candidate genes and genetic variants potentially involved in the development of KD and CAA.

• The Korean Journal of Pesticide Science
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• v.14 no.4
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• pp.463-472
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• 2010

It was conducted to investigate the control efficacy of carboxylic acid amide (CAA) fungicides, such as benthiavalicarb, iprovalicarb, dimethomorph and mandipropamid, against pepper Phytophthora blight caused by P. capsid in the laboratory and the field. The fungicides inhibited mycelial growth and direct sporangium germination of P. capsid strongly, while there was no activity of all fungicides against zoospore release from sporangium. In greenhouse test, they showed the good protective and curative effect against pepper Phytophthora blight. Benthiavalicarb applied at $100{\mu}g\;mL^{-1}$ 7 days before inoculation prevented pepper Phytophthora blight by 100%, even though the zoosporangiurn suspension of P. capsid adjusted to not only $5{\times}10^3$ zoosporangia $mL^{-1}$ but also $1{\times}10^5$ zoosporangia $mL^{-1}$ was inoculated by soil-drenching. Except for dimethomorph, the other fungicides showed an excellent control activity over 2 years from 2009 to 2010 in the field test. The control value of dimethomorph applied at $250{\mu}g\;mL^{-1}$ was low, 27.2% in 2009, but that of dimethomorph applied even at $125{\mu}g\;mL^{-1}$ was high, 89.5% in 2010. All the fungicides showed good inhibitory effect on the mycelial growth and the direct germination of zoosporangiurn, and controlled pepper Phytophthora blight preventively and curatively, can be used to establish the spray system for control1ing the pepper disease.

• Journal of Korean Institute of Industrial Engineers
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• v.29 no.2
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• pp.157-164
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• 2003

The amount of information increases rapidly when working in a distributed environment where multiple collaborative partners work together on a complex product. Today's PDM (product data management) systems provide good capabilities regarding the management of product data within a single company. However, taking into account the variety of systems used at partner sites in an engineering environment one can easily imagine problems regarding the interoperability and the data consistency. This paper presents a concept to improve the workflow management using the parameters network. It shows a parameter driven engineering workflow that is able to manage engineering task across company boarders. We introduce a mechanism of workflow management based on the engineering parameters and an architecture of the distributed workspace to apply it within a PDM system. For a parameter mapping between CAD and PDM system we developed an XML-based CATIA data interface module using CAA.

• Proceedings of the Acoustical Society of Korea Conference
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• autumn
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• pp.421-426
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• 1999

수중 프로펠러의 비공동 소음을 Ffowcs William-Hawkings 형태의 음향 상사 방정식을 시간영역에서 해석하였으며 전산공력음향학(CAA)과 경계 요소법(BIEM)등 수치적 방법을 통해 해석하였다. 덕트 없는 프로펠러와 덕트 프로펠러에 대해서 비균일 유입류 조건에 대해서 소음 강도와 방향성을 예측하였으며 이는 수중 프로펠러의 운용시 지배적인 소음원을 구별하고 그 특성을 파악하여 적절한 소음 제어 책을 마련하는 기반이 될 것이다.