• Ocean and Polar Research
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• 제26권4호
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• pp.551-557
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• 2004

Polymorphism of the lipoprotein lipase (LPL) gene which plays an important role in regulation of lipid deposition was analysed in two red seabream (pagrus major) populations (KF4, cultured KORDI line, n=100 : JPN, imported from Japan, n=100). We amplified a DNA fragment (1,091 bp) including the exon 2 region of the LPL gene, and conducted PCR-RFLP analysis using MspI and AluI. The PCR products were also sequenced. Two alleles (A and B) were found in MspI digestion and Sve alleles (A, B, C, D and E) in AluI digestion. The sequenced data revealed four nucleotide substitutions including one transversion at the MspI recognition site (nt 2,235, $C{\rightarrow}10$) and three transitions at the AluI recognition sites (nt 1,721, $A{\rightarrow}G;$ nt 2,319, $C{\rightarrow}T;$ nt 2,319, $T{\rightarrow}C$). Among them, substitutions at the nt 2,235 and 2,319 sites which are located in the exon 2 were proved to be silent point mutations. MspI polymorphism resulted in 3 genotypes, and the allele frequency was significantly different between the two fish populations, KF4 and JPN. In the case of AluI polymorphism, the 5 alleles (A, B, C, D, E) comprised 12 genotypes of the 5 alleles. KF4 population, alleles D and I were specific to the LPL gene Polymorphisms would be useful DNA markers for red seabream population.

• Bulletin of the Korean Chemical Society
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• 제20권4호
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• pp.422-426
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• 1999

The Grignard reactions of bis(chloromethyl)dimethylsilane (1) with trimethylchlorosilane (2) in THF give both the intermolecular C-Si coupling and intramolecular C-C coupling products. At beginning stage, 1 reacts with Mg to give the mono-Grignard reagent ClCH2Me2SiCH2MgCl (1) which undergoes the C-Si coupling reaction to give MC2Si(CH2SiMe3)2 3, or C-C coupling to a mixture of formula Me3SiCH2(SiMe2CH2CH2)nR1 (n = 1, 2, 3, ..; 4a, R1I = H: 4b, R1 = SiMe3). In the reaction, two reaction pathways are involved: a) Ⅰ reacts with 2 to give Me3SiCH2SiMe2CH2Cl 6 which further reacts with Mg to afford a Me2SiCH2Mel-SiCH2MgCl (Ⅱ) or b) I cyclizes intramolecularly to a silacyclopropane intermediate A, which undergoes a ring-opening polymerization by the nucleophilic attack of the intermediates I or Ⅱ, followed by the termination reaction with H2O and 2, to give 4a and 4b, respectively. As the mole ratio of 2/1 increased from 2 to 16 folds, the formation of product 3 increased from 16% to 47% while the formation of polymeric products 4 was reduced from 60% to 40%. The intermolecular C-Si coupling reaction of the pathway a becomes more favorable than the intramolecular C-C coupling reaction of the pathways b at the higher mole ratio of 2/1.

• Bulletin of the Korean Chemical Society
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• 제30권8호
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• pp.1729-1732
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• 2009

Bioactivity-guided fractionation led to the isolation of two new phenylpropanoids, 3-O-p-coumaroyl-1-(4-hydroxy- 3,5-dimethoxyphenyl)-1-propanone (1) and 3-O-p-coumaroyl-1-(4-hydroxy-3,5-dimethoxyphenyl)-1-O-$\beta$-gulcopyranosylpropanol (2), together with three known compounds, N-p-coumaroylserotonin (3), N-feruloylserotonin (4) and p-coumaric acid (5) from the leaves of Sasa quelpaertensis Nakai. Their structures were elucidated by spectroscopic methods including 1D and 2D-NMR. Compared to arbutin (I$C_{50}$ 0.048 mM) as a control, compounds 3 and 4 exhibited stronger tyrosinase inhibition activities with an I$C_{50}$ values of 0.027 mM and 0.026 mM, respectively. Compounds 1 (I$C_{50}$ 0.055 mM) and 2 (I$C_{50}$ 0.053 mM) also showed strong activities.

• 한국군사과학기술학회지
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• 제13권6호
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• pp.1080-1090
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• 2010

A study for improvement of credibility on test & evaluation result of interoperability in battle management information system which focused in C4I systems is very essential in rapid change of battle field environment. Realization of effective operation process with integration of developed IT also core factor for reducing of operational response time such as information gathering from sensor to shooter, time for commander's decision making. Therefore, by required to meet of high technical T&E, meet of complex software's user requirement, long-term system development period, system integration ability's request by various linkage of systems, it is high a M&S dependency to optimal performance, interpoerability's guarantee. Especially credibility on test & evaluation using M&S is very important. This paper will propse a VV&A applied methods using other VV&A case to improve credibility of M&S on test & evaluation.

• 정보보호학회지
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• 제32권5호
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• pp.67-73
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• 2022

DevOps는 개발과 운영을 배포 기간을 최소화함과 동시에 안정적인 운영을 목표로 하는 현재 가장 진보된 개발 문화이자 방법론이다. DevOps는 수많은 IT 기업에서 활용되고 있으며, 국방 분야도 마찬가지로 소프트웨어 전력 우위를 선점하기 위하여 DevOps 도입을 고려해왔다. 그러나 사이버 위협의 대응이 부족한 DevOps을 국방 소프트웨어에 적용하기가 쉽지 않다. 이에 미 국방부(Department of Defense, 이하 DoD)는 미래의 사이버 위협으로부터 국방 소프트웨어의 피해를 최소화하고자 DevOps 전 단계에 사이버 보안을 결합한 DevSecOps를 채택하여 개발 및 시범운영 중에 있다. 본 연구에서는 DevOps와 DevSecOps의 개념을 소개하고 국방 소프트웨어 분야의 적용 사례를 살펴본다. 그 중 DoD의 DevSecOps의구조, 구축 사례, 공급망 보안 방안을 분석하고 이를 바탕으로 우리 군의 DevSecOps 적용 가능성에 대해 논의하고자 한다.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1994년도 춘계학술대회 and 제3회 신약개발 연구발표회
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• pp.339-339
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• 1994

It has been reported that Indole-3-carbinol (I3C), a naturally occurring compound In cruclferous vegetables, exerts anticarcinogenic activity In several organs In rodents. The modifying effects of I3C were therefore assessed uging a rat multi-organ carcinogenesis model. A total of 100 male Sprague-Dawley rats were divided Into 3 groups. Animals of groups 1 and 2 were sequentially treated with diethylnitrosamine (DEN; 100 mg/kg b.w., i.p.), N-methylnitrosourea (NNU; 20 mg/kg b.w., 4 times for 2 weeks, i.p), and dihydroxy-di-N-propylnitrosauine (DHPN; 0.1% In d.w. for 2 weeks) for 4 weeks (DMD treatment). Animals of groups 1 and 3 were given the diet of 0.25% I3C for 20 weeks after DMD initiation and then were given basal diet for 28 weeks. All animals were sacrificed at week 24 and 52, respectively. I3C has been clearly demonstrated promoting effects on the development of glutathione S-transferase placental form (GST-P) positive hepatic foci at 24 weeks of the experiment. And I3C also exerted promoting potential In the hepatocellular adenoma (4/14; 29%) and the adenoma (7/14; 50%) of the thyroid gland at 52 weeks of the experiment. Therefore, I3C may promote hepatocarcinogenesis and thyroid tumorigenesis in the rat multi-organ carcinogenesis model.

• 대한한의학회지
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• 제18권2호
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• pp.316-325
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• 1997

In a 36-month period, 23 selected Patients with Acute Cerebral Infarction were studied utilizing Computerized Tomography, Barthel Index in an attempt to correlate Brain Computerized Tomography findings with 1week, 4weeks rehabilitation and evaluate the influences of the size and location of the lesion. The study suggested that the size of the lesion had impact on 4 weeks rehabilitation. There was significant different between the patients with Middle Cerebral Artery Pial Territory Infarction(I.P.B.M.C.A.) lesion and the patients with Lacunar Infarction(L.I.), Striatocapsular Infarction(S.C.I.), Internal Watershed Infarction(I.W.I.) lesion, but there was no significant difference between the patients with L.I. lesion and the patients with S.C.I. lesion and the patients with I.W.I. lesion. The size and location of the lesion should be considered together in predicting the functional outcomes of Acute Cerebral Infarction.

• Progress in Superconductivity
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• 제3권1호
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• pp.1-4
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• 2001

Interface-engineered junctions with $YbBa_2$$Cu_3$$O_{7}$ as the counter electrode were demonstrated. The junctions exhibited excellent Josephson characteristics with a Josephson critical current ($I_{c}$) ranging from 0.1 mA to 8 mA and a magnetic field modulation of the $I_{c}$ exceeding 80% at 4.2 K while maintaining complete c-axis orientation of the counter-electrode layer. The$ 1\sigma$ spreads in $I_{c}$ for junctions with an average $I_{c}$ of 1-2 mA were 5-8% for 16 junctions within a chip, and 9.3% for a 100-junction array. Our dI/dV measurements suggest that a theoretical approach taking into account both a highly transparent barrier and the proximity effect is required to fully understand the Junction characteristics.ristics.

• 폴리머
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• 제38권4호
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• pp.425-433
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• 2014

In this study, microstructure and gel content (C-C) of polybutadiene rubber (PBR) were investigated using various techniques including ASTM D 3616, attenuated total reflectance Fourier transform infrared spectrometry (ATR FTIR), differential scanning calorimetry (DSC) and nuclear magnetic resonance spectroscopy (NMR). The ATR FTIR spectra of the samples were investigated to determine the cis, trans, 1, 2-vinyl and the C-C gel content in PBR. The absorbance ratios of specific peaks in different grades of PBR were correlated with the C-C gel content measured by the ATR FTIR techniques. Physico-mechanical and rheological properties of rubber compounds based on BR with various amounts of gel were determined. The results showed that there is an acceptable correlation between these properties and the C-C gel content of PBR.

• 대한화학회지
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• 제18권4호
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• pp.244-250
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• 1974

Galvanostatic double pulse 방법으로 백금전극을 사용해서 염소산이온의 전극반응기구를 조사하였다. double current pulse(음극펄스를 먼저 주고 다음에 양극펄스를 주었을 때)를 주었을 때 전류밀도 20∼25ma/$cm^2$ 범위에서 염소산이온의 전극반응기구가 다음과 같이 가정되었다. 더 높은 전류밀도 40∼90ma/$cm^2$ 범위에서, 염소산이온의 전극반응기구는 다음과 같이 가정되었다.$CIO_3^-\;{\longrightarrow^{I}_{n_{1c}}\;CIO_2^-\;{\longrightarrow^{II}_{n_{2a}}\;CIO^-\;{\longrightarrow^{I'}_{n_{1a}}\;CIO_2^-\;{\longrightarrow^{II'}_{n_{2a}}\;CIO_4^-$ 더 높은 전류밀도 40~90ma/$cm^2$ 범위에서, 염소산 이온의 전극 반응 기구는 다음과 같이 가정되었다.$CIO_3^-\;{\longrightarrow^{III}_{n_c}}\;CIO^-\;{\longrightarrow^{I'}_{n_{1a}}\;CIO_2^-\;{\longrightarrow^{II'}_{n_{2a}}\;CIO_4^-$ 혹은 $CIO_3^-\;{\longrightarrow_{n_c}}\;CIO^-\;{\longrightarrow_{n_a}}\;CIO_4^-$