• Title/Summary/Keyword: C1-generic

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Synopsis of Dragonet Fish, Family Callionymidae (Pisces, Perciformes) form Korea (한국산(韓國産) 돛양태과(科)(농어목(目)) 어류(魚類)의 분류(分類))

  • Lee, Chung-Lyul;Kim, Ik-Soo
    • Korean Journal of Ichthyology
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    • v.5 no.1
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    • pp.1-40
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    • 1993
  • Fourteen species and four genera of the family Callionymidae from Korea were reviewed and provided a tentative the key to species and genera. The taxonomic position and scientific name of the family Callionymidae were recheked together with states of their distribution. Among them, two species Callionymus kitaharai and C. doryssus previously described by Chyung(1977), were found to be the same species under synonym of Repomucenus huguenini. On the other hand, two species Repomucenus leucopoecilus and Repomucenus sp. were newly added. Seven species, previously reported as the family Callionymidae from Korea, were transferred into another generic name or specific name Draculo mirabilis into Eleucherochir mirabilis, Callionymus joponicus into Callurichthys japonics, Callionymus altivelis into Synchiropus altivelis, Callionymus kitaharai into Repomucenus huguenini, Callionymus richardsoni into Repomucenus curvicornis, Callionymus lunatus into Repomucenus lunatus, Callionymus flagris into Repomucenus oalenciennei. The species of Calliurichthys japonicus, Repomucenus lunatus, Repomucenus curvicornis, Repomucenus huguenini, Repomucenus ualenciennei and Synchiropus altivelis were mainly distributed in the South Sea, while the other species of the family were mainly distributed in the Yellow Sea of Korea.

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Improved Dissolution Characteristics of Ibuprofen Employing Self-Microemulsifying Drug Delivery System and Their Bioavailability in Rats (자가유화 약물전달시스템을 이용한 이부프로펜의 용출개선 및 흰쥐에서의 생체이용률 평가)

  • Kim, Hyung-Soo;Lee, Sang-Kil;Choi, Sung-Up;Park, Hye-Sook;Jeon, Hyun-Joo;Choi, Young-Wook
    • Journal of Pharmaceutical Investigation
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    • v.32 no.1
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    • pp.27-33
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    • 2002
  • A self-microemulsifying drug delivery system(SMEDDS) composed of Cremophor $EL^{\circledR},\;Labrasol^{circledR}$, and Lauroglycol $FCC^{circledR}$ was prepared for the enhancement of solubility, dissolution rate and bioavailability of ibuprofen(IBP), which is water-insoluble but soluble in oils and surfactants. Phase diagram with various regions including microemulsion area was depicted. The SMEDDS was encapsulated in soft gelatin capsules and their dissolution characteristics in various media were observed in comparison to the generic products commercially available in the market. Soft capsules of SMEDDS formulation showed better dissolution profiles, especially in acidic condition, than the others. For the period of 1 hr dissolution in pH 1.2 medium, it reached over 70% dissolution from soft capsules, compared to less than 40% dissolution from commercial reference tablets. On the other hand, in vivo pharmacokinetic parameters were obtained after oral administrations of different IBP preparations to Sprague Dawley rats. SMEDDS formulation showed higher $C_{max}$ and greater $AUC_{0-5hr}$ than the suspension of reference tablet or IBP powder. Therefore, it is possible to conclude that a newly developed soft capsules employing SMEDDS provides an alternative preparation to improve oral bioavailability of IBP.

A Study on the Clearance Level(draft) for the Steel Scrap from the KRR-1 & 2 Decommissioning (연구로 1,2호기 해체 철재폐기물의 규제해제농도기준(안) 도출을 위한 연구)

  • 홍상범;이봉재;정운수
    • Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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    • v.2 no.1
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    • pp.60-67
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    • 2004
  • The exposure dose form recycling of a large amount of the steel scrap from the KRR-1&2 decommissioning activities was evaluated, and also the clearance level(draft) was derived. The maximum individual dose and collective dose were evaluated by modifying internal dose conversion factor which was based on the concept of effective dose in ICRP 60, applied to the RESRAD-RECYCLE ver 3.06 computing code, IAEA Safety Series 111-P-1.1 and NUREG-1640 as the assessment tool. The result of assessment for individual dose and collective dose is 23.9 $\mu$Sv per year and 0.11 man$.$Sv per year respectively. The clearance levels were ultimately determined by extracting the most conservative value form the results of the generic assessment and specific assessment methodologies. The result of clearance level for radionuclides( $Co^{60}$ , C $s^{l37}$) is less than 1.14${\times}$10$^{-1}$ Bq/g to comply with the clearance criterion(maximum individual dose : 10 $\mu$Sv per year, collective dose : 1 man$.$Sv per year) provided for Korea Atomic Energy Act and relevant regulations.s.

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Taxonomic Revision of the Family Sciaenidae (Pisces, Perciformes) from Korea (한국산(韓國産) 민어과(科)(농어목(目)) 어류(魚類)의 분류학적(分類學的) 재검토(再檢詞))

  • Lee, Chung-Lyul;Park, Mi-Hye
    • Korean Journal of Ichthyology
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    • v.4 no.1
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    • pp.29-53
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    • 1992
  • The taxonomic revision of the family Sciaenidae was made based on the specimens collected from the south-western coasts of the Korea from 1989 to May 1992. The family Sciaenidae from Korea was classified into 12 species belong to 8 genera : Pseudosciaena crocea, Pseudosciaena polyactis, Collichthys lucidus, Collichthys niveatus, Larimichthys rathbunae, Johnius grypotus ; Nibea albiflora, Nibea mitsukurii, Nibea diacanthus, Miichthys miiuy, Argyrosomus argentatus and Atrobucca nibe. Six species, previonsely reported as the family Sciaenidae from Korea, were transferred into different generic name or specific name : Pseudosciaena manchurica into P. polyactis ; Nibea goma into N. diacanthus ; into Miichthys miiuy ; Nibea argentatus into Argyrosomus argentatus ; Nibea nibe into Atrobucca nibe and Johnius belengerii into J. grypotus. The species Collichthys fragilis was identified as the same species of C. lucidus, based on the number of light organs just above abdominal midline, the shape of occipital crest and first spine of anal fin. Keys to genera and species are provided together with description and distributional data.

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Study on Underwater Object Tracking Based on Real-Time Recurrent Regression Networks Using Multi-beam Sonar Images (실시간 순환 신경망 기반의 멀티빔 소나 이미지를 이용한 수중 물체의 추적에 관한 연구)

  • Lee, Eon-ho;Lee, Yeongjun;Choi, Jinwoo;Lee, Sejin
    • The Journal of Korea Robotics Society
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    • v.15 no.1
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    • pp.8-15
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    • 2020
  • This research is a case study of underwater object tracking based on real-time recurrent regression networks (Re3). Re3 has the concept of generic object tracking. Because of these characteristics, it is very effective to apply this model to unclear underwater sonar images. The model also an pursues object tracking method, thus it solves the problem of calculating load that may be limited when object detection models are used, unlike the tracking models. The model is also highly intuitive, so it has excellent continuity of tracking even if the object being tracked temporarily becomes partially occluded or faded. There are 4 types of the dataset using multi-beam sonar images: including (a) dummy object floated at the testbed; (b) dummy object settled at the bottom of the sea; (c) tire object settled at the bottom of the testbed; (d) multi-objects settled at the bottom of the testbed. For this study, the experiments were conducted to obtain underwater sonar images from the sea and underwater testbed, and the validity of using noisy underwater sonar images was tested to be able to track objects robustly.

Bioequivalence Evaluation of Lovastatin Tablets (로바스타틴 정제의 생물학적 동등성 평가)

  • Bok, Hae Sook;Kim, Myoung Min;Choi, Kyung Eob
    • Korean Journal of Clinical Pharmacy
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    • v.8 no.2
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    • pp.107-112
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    • 1998
  • Lovastatin is a lipid lowering agent for the treatment of hypercholesterolemia and belongs to a new class of pharmacologic compounds called the 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors. By competitively inhibiting HMG CoA reductase, lovastatin disrupts the biosynthesis of cholesterol in hepatic and peripheral cells and increases the synthesis of high-density-lipoprotein HDL) receptors. Following oral administration, the lactone ring of lovastatin is hydrolysed to the active inhibitor of HMG CoA reductase, lovastatin acid. Lovastatin is known to have poor oral absorption and wide individual variation. In this study, bioequivalence test of two lovastatin formulations, the test drug ($Lovaload^{TM}$, Chong Kun Dang Pharmaceutical Co.) and the reference drug ($Mevacor^{TM}$, Chung Wae Pharmaceutical Co.) were conducted according to the guidelines of Korea Food and Drug Administration (KFDA). A total of 18 healthy male volunteers, $31.90\pm3.60$ years old and $72.17\;7.88$ kg of body weight in average, were evaluated in a randomized crossover manner with a 2-week washout period. Concentrations of lovastatin acid in plasma were measured upto 12 hours following a single oral administration of eight tablets (20 mg of lovastatin per tablet) by high-performance liquid chromatography with UV detection at 238 nm. The area under the concentration-vs-time curve from 0 to 12 hours $(AUC_{0-12h})$ was calculated by the trapezoidal summation method. The statistical analysis showed that there are no significant differences in $AUC_{0-12h),\;C_{max}\;and\;T_{max}$ between the two formulations ($6.72\%,\;1.52\%,\;and\;0.88\$, respectively). The least significant differences between the formulations at $\alpha$=0.05 were less than $20\%\;(11.65\%,\;19.73\%,\;and\;14.81\%\;for\;AUC_{0-12h},\;C_{max}\;and\;T_{max}$, respectively). The $90\%$ confidence intervals for these parameters were also within $\pm20\%\;(-1.50{\leq}{\delta}{\leq}15.00$, $-12.50{\leq}{\delta}{\leq}15.50,\;and\;-9.64{\leq}{\delta]{\leq}11.40{\leq}\;for\;\;AUC_{0-12h}$ ,$C_{max}\;and\;T_{max}$, respectively). In conclusion, the new generic product $Lovaload^{TM}$ was proven to be bioequivalent with the reference drug.

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The Distribution of Fish Larvae in the Korea Strait (대한해협의 자치어 분포상)

  • KIM Yong Uk
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.17 no.3
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    • pp.230-243
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    • 1984
  • Larvae of fishes were collected at 26 stations in the Korea Strait, by horizontal towings using the fish larval net (Norpac) in the surface layer and by oblique towings using Isaac-Kid mid-water trawl in the mid-water layer in summer (July) and in autumn (November), in 1983. The towing speed was 1.5 knots. Of the larval fish examined, 3,529 individuals were identified to generic and specific levels. They belong to 27 families, consisting of 38 species in 37 genera. Unidentified were 114 specimens. The most abundant species was Engraulis japonica which occupied $88.5\%$ of the whole 3,645 individuals. Diaphus sp. took the second place with 50 individuals ($l.3\%$). Seasonally abundant species were in the order of Engraulis japonica, a Gobid, Trichiurus lepturus, and Diaphus sp. in summer, and in the order of Diaphus sp., Engraxlis japonica, Bothus sp., and a Ophichthid in autumn. Of these larvae, Engraulis japonica and Diaphus sp. continuously appeared from summer to Autumn. Champsodon sp., Diaphus sp. and Synagrops philippinensis were unrecorded species in Korea.

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Rosenvingea orientalis (Scytosiphonaceae, Phaeophyceae) from Chiapas, Mexico: life history in culture and molecular phylogeny

  • West, John A.;Zuccarello, Giuseppe C.;Pedroche, Francisco F.;De Goer, Susan Loiseaux
    • ALGAE
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    • v.25 no.4
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    • pp.187-195
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    • 2010
  • The genus Rosenvingea is well known in the tropics. Four species have been reported from Pacific Mexico: R. floridana, R. antillarum, R. intricata and R. sanctae-crucis. We collected a plant (Boca del Cielo, Chiapas) that we identified as Rosenvingea orientalis, a species not previously reported from Pacific Mexico. We were able to characterize the life cycle of this species for the first time in laboratory culture. It reproduced exclusively by plurilocular sporangia (plurangia). The mature plants were up to 6 cm long with cylindrical to compressed fronds (to 2 mm wide) with dichotomous branches in the upper half of the thallus. The medulla was hollow with 2-3 layers of large inflated colourless cells at the periphery. The cortex was comprised of 1 layer of small cells, each with a single chloroplast and pyrenoid. Linear plurangial sori with phaeophycean hairs formed along the mature fronds. Zoospore germlings developed into prostrate filamentous systems, each with a single phaeophycean hair that gave rise to a single erect shoot with multiple hairs arising near the tip. Molecular phylogeny using the psaA gene placed this isolate within the Scytosiphonaceae. It does not confirm the exact identification of R. orientalis, although its placement close to other Rosenvingea sequences was confirmed and morphological evidence supports its placement in R. orientalis. Our culture investigations indicated that it has an asexual life cycle. Further collections are needed to resolve the full generic and specific relationships of Rosenvingea and related taxa, and their reproductive patterns.

Computational design of mould sprue for injection moulding thermoplastics

  • Lakkannan, Muralidhar;Mohan Kumar, G.C.;Kadoli, Ravikiran
    • Journal of Computational Design and Engineering
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    • v.3 no.1
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    • pp.37-52
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    • 2016
  • To injection mould polymers, designing mould is a key task involving several critical decisions with direct implications to yield quality, productivity and frugality. One prominent decision among them is specifying sprue-bush conduit expansion as it significantly influences overall injection moulding; abstruseness anguish in its design criteria deceives direct determination. Intuitively designers decide it wisely and then exasperate by optimising or manipulating processing parameters. To overwhelm that anomaly this research aims at proposing an ideal design criteria holistically for all polymeric materials also tend as a functional assessment metric towards perfection i.e., criteria to specify sprue conduit size before mould development. Accordingly, a priori analytical criterion was deduced quantitatively as expansion ratio from ubiquitous empirical relationships specifically a.k.a an exclusive expansion angle imperatively configured for injectant properties. Its computational intelligence advantage was leveraged to augment functionality of perfectly injecting into an impression gap, while synchronising both injector capacity and desired moulding features. For comprehensiveness, it was continuously sensitised over infinite scale as an explicit factor dependent on in-situ spatio-temporal injectant state perplexity with discrete slope and altitude for each polymeric character. In which congregant ranges of apparent viscosity and shear thinning index were conceived to characteristically assort most thermoplastics. Thereon results accorded aggressive conduit expansion widening for viscous incrust, while a very aggressive narrowing for shear thinning encrust; among them apparent viscosity had relative dominance. This important rationale would certainly form a priori design basis as well diagnose filling issues causing several defects. Like this the proposed generic design criteria, being simple would immensely benefit mould designers besides serve as an inexpensive preventive cliché to moulders. Its adaption ease to practice manifests a hope of injection moulding extremely alluring polymers. Therefore, we concluded that appreciating injectant's polymeric character to design exclusive sprue bush offers a definite a priori advantage.

Multi-FNN Identification Based on HCM Clustering and Evolutionary Fuzzy Granulation

  • Park, Ho-Sung;Oh, Sung-Kwun
    • International Journal of Control, Automation, and Systems
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    • v.1 no.2
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    • pp.194-202
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    • 2003
  • In this paper, we introduce a category of Multi-FNN (Fuzzy-Neural Networks) models, analyze the underlying architectures and propose a comprehensive identification framework. The proposed Multi-FNNs dwell on a concept of fuzzy rule-based FNNs based on HCM clustering and evolutionary fuzzy granulation, and exploit linear inference being treated as a generic inference mechanism. By this nature, this FNN model is geared toward capturing relationships between information granules known as fuzzy sets. The form of the information granules themselves (in particular their distribution and a type of membership function) becomes an important design feature of the FNN model contributing to its structural as well as parametric optimization. The identification environment uses clustering techniques (Hard C - Means, HCM) and exploits genetic optimization as a vehicle of global optimization. The global optimization is augmented by more refined gradient-based learning mechanisms such as standard back-propagation. The HCM algorithm, whose role is to carry out preprocessing of the process data for system modeling, is utilized to determine the structure of Multi-FNNs. The detailed parameters of the Multi-FNN (such as apexes of membership functions, learning rates and momentum coefficients) are adjusted using genetic algorithms. An aggregate performance index with a weighting factor is proposed in order to achieve a sound balance between approximation and generalization (predictive) abilities of the model. To evaluate the performance of the proposed model, two numeric data sets are experimented with. One is the numerical data coming from a description of a certain nonlinear function and the other is NOx emission process data from a gas turbine power plant.