• Journal of the Korean Applied Science and Technology
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• v.3 no.2
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• pp.41-47
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• 1986

The transesterification reaction between diethanolamine and methyl-methacrylate was kinetically investigated in the presence of various metal acetate catalysts at $120^{\circ}C$. The quantity of methylmethacrylate reacted in the reaction flask was measured by gas chromatography and liquid chromatography, and the reaction rate was investigated by measuring of the quantity of products and reactnts under various catalysts. The transesterification reaction was carried out in the first order reaction kinetics with respect to the concentration of diethanolamine and methylmethacrylate, respectively. The apparent rate constant was found to obey first-order kinetics with respect to the concentration of catalyst. The linear relationship was shown between apparent rate constant and reciprocal absolute temperature, and by the Arrhenius plot, the activation energy has been calculated as 11.08 Kcal with zinc acetate catalyst, 17.99 Kcal without catalyst. The maximum reaction rate was appeared at the range of 1.4 to 1.6 of electronegativity of metal ions and instability constant of metal acetates.

• Molecules and Cells
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• v.28 no.2
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• pp.119-124
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• 2009

Anti cancer agent 5-FU (Fluoro Uracil) is a prodrug that can be metabolized and then activated to interfere with RNA and DNA homeostasis. However, the majority of administered 5-FU is known to be catabolized in vivo in the liver where Dihydropyrimidine dehydrogenase (DPD) is abundantly expressed to degrade 5-FU. The biological factors that correlate with the response to 5-FU-based chemotherapy have been proposed to include uridine phosphorylase (UPP), thymidine phosphorylase (TPP), p53 and microsatellite instability. Among these, the expression of UPP is known to be controlled by cytokines such as $TNF-{\alpha}$, IL1 and $IFN-{\gamma}$. Our preliminary study using a DNA microarray technique showed that basic fibroblast growth factor (bFGF) markedly induced the expression of UPP1 at the transcription level. In the present study, we investigated whether bFGF could modulate the expression of UPP1 in osteo-lineage cells and examined the sensitivity of these cells to 5-FU mediated apoptosis.

• Korean Journal of Remote Sensing
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• v.34 no.3
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• pp.465-480
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• 2018

On 20 January 2017, the fresh snow cover which is more than 20 cm, accompaning with lightning occurred over Yeongdong coastal region for the first 3-hour of the heavy snowfall event. This study analyzed sounding observations in the heavy snow period which were including the measurements of wind profiler, radiometer and rawinsonde. The features examined from the vertical wind and temperature data at the two adjacent stations, Bukgangneung and Gangneung-Wonju National University, are summarized as follows: 1) The strong (30-40 kts) north-east winds were observed in the level from 2 to 6 km. The Strong atmospheric instability was found from 4 to 6 km, in which the lapse rate of temperature was about $-18^{\circ}C\;km^{-1}$. These features indicate that the deep convective cloud develops up to the height of 6 km in the heavy snowfall period, which is shown in the satellite infrared images. 2) The cooling was observed in the level below 1 km. At this time, the surface air temperature at Bukgangneung station decreased by $4^{\circ}C$. The narrow cooling zone estimated from AWS and buoy data was located in east-west direction. These are the features observed in the cold front of extratropical cyclone. The distributions of radar echo and lightning also show the same shape in east-west direction. Therefore, the results indicate that the Yeongdong thundersnow event was the combined precipitation system of deep convective cloud and cold frontal precipitation.

• Journal of the Korean Geotechnical Society
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• v.25 no.1
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• pp.65-76
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• 2009

The unsaturated characteristics of Korean weathered granite soils have been studied to investigate the influence of saturated permeability, rainfall intensity and soil-water characteristic curve (SWCC) on the slope stability. The upper, average and lower SWCCs were estimated from the publication and experimental results using the statistical concept. The roughly estimated SWCC can be used for the soils without experimental results by relating SWCC with the particle size distribution curve. An appropriate ratio between the saturated permeability and the rainfall intensity ($k_s$/i) was also suggested for practical use in designing the slopes by investigating the time-dependent variation of slope instability during the rainfall. The slope stability was deteriorated from the initiation of rainfall and recovered again after the factor of safety reached the critical value. The FS of the slope decreased at first and then increased after reaching the critical value during the rainfall. As a result, the slope instability was not related with an absolute rainfall intensity but with the ratio between the saturated permeability and the rainfall intensity. In case of the upper SWCC, the critical condition occurred when the ratio between the saturated permeability and the rainfall intensity was in the range of $1.0{\sim}2.0$.

• Economic and Environmental Geology
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• v.34 no.2
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• pp.217-226
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• 2001

Stable isotope, paleoceanographic and sedimentological analyses were carried out along the core Ml5612 from the Mid-Atlantic Ridge. Distinct negative ${\delta}^{18}O anomalies punctuate the planktonic isotope records and correlate with the Heinrich-IRD cvents. The IRD layer in the corc contains varying amounts of quartz, K-feldspar, plagioclase, calcite, dolomite and mica, in which detrital carbonate contributes between I and 13% (except H3 and H6). Anomalies are strongest in the N. pachydenna (sin.) isotope record. Systematic changes in the ${\delta}^{18}O offset of G. hul/aides and G. inJlata signify variations in mid-latitude thermocline structure. In conjunction with negative benthic ${\delta}^{13}C anomalies, the data document a stronger contribution of a ${\delta}^{13}C depleted, nutrient-rich water mass during the IRD events. The ${\delta}^{13}C amplitude of > 1 $\textperthousand$ between 25 and 57 ka indicates changes between northern source (NADW) and southern source (AABW) water masses at this site. The IRD layers in the core Ml56l2 are correlative with those from the core S075-26KL and DSDP 609. The IRD layers from the Portuguese margin arc coeval with HI, H2 and H4 of the open North Atlantic. This similarity (and/or synchronicity in both regions may have been resulted from common changes in a North Atlantic thermohaline switch.

• The Korean Journal of Ecology
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• v.25 no.1
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• pp.45-49
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• 2002

Pollen analyses and $^{14}$ C dating of the sediments of the Akindonuma moor, which is situated in a closed depression of an old landslide, were peformed in order to study the vegetation history of the montane zone of the Miyagi Prefecture, Northeast Japan. The main results are as follows: Two forest zones have been distinguished: 1) the A-I zone, or the Fagus-Quercus-Betula forest (R I stage, before about 11,700 yrs B.P.), and 2) the A-II zone, or the Fagus-Quercus forest (R II stage, after about 11,700 yrs B.P.). By comparing the geological section with the pollen diagram of the moor, it is assumed that the deposit environment of the Middle Part, which mostly consists of peat layers, is very stable. During the period, the Ulmus/Zelfkova pollen ratio was very low and small peak was not recognized. According to the preceding research, theme is a close relationship between the fluctuation of the Ulmus/Zelkova pollen ratio and the general trend of hillslope instability in the changing balance of temporature and precipitation Actually, Zelkova serrata tends to cover the footslope and the lower sideslope. Ulmus davidiana covers the footslope and the alluvial cone. Therefore, the fact that the Ulmus/Zeikova pollen ratio was very low and small peak was not recognized, is believed to reflect the stability of the earth's surface environment, which was estimated from the geological section.

• Geomechanics and Engineering
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• v.17 no.2
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• pp.181-194
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• 2019

Due to the seepage of groundwater, the resisting force of slopes decreases and the sliding force increases, resulting in significantly reduced slope stability. The instability of most natural slopes is closely related to the influence of groundwater. Therefore, it is important to study slope stability under groundwater seepage conditions. Thus, using a simplified seepage model of groundwater combined with the analysis of stresses on the slip surface, the limit equilibrium (LE) analytical solutions for two- and three-dimensional slope stability under groundwater seepage are deduced in this work. Meanwhile, the general nonlinear Mohr-Coulomb (M-C) strength criterion is adopted to describe the shear failure of a slope. By comparing the results with the traditional LE methods on slope examples, the feasibility of the proposed method is verified. In contrast to traditional LE methods, the proposed method is more suitable for analyzing slope stability under complex conditions. In addition, to facilitate the optimization of drainage design in the slope, stability charts are drawn for slopes with different groundwater tables. Furthermore, the study concluded that: (1) when the hydraulic gradient of groundwater is small, the effect on slope stability is also small for a change in the groundwater table; and (2) compared with a slope without a groundwater table, a slope with a groundwater table has a larger failure range under groundwater seepage.

• Journal of Gastric Cancer
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• v.23 no.1
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• pp.224-249
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• 2023

Gastric cancer is heterogeneous in morphology, biology, genomics, and treatment response. Alterations in human epidermal growth factor receptor 2 (HER2) overexpression, microsatellite instability (MSI) status, programmed death-ligand 1 (PD-L1) levels, and fibroblast growth factor receptor 2 (FGFR2) can be used as biomarkers. Since the combination of fluoropyrimidine/platinum plus trastuzumab that was investigated in the ToGA trial was approved as a standard of care in HER2-positive patients in 2010, no other agents showed efficacy in the first- (HELOISE, LOGiC, JACOB trials) and second- (TyTAN, GATSBY, T-ACT trials) line treatments. Despite the success in treating breast cancer, various anti-HER2 agents, including a monoclonal antibody (pertuzumab), an antibody-drug conjugate (ADC; trastuzumab emtansine [T-DM1]), and a small molecule (lapatinib) failed to translate into clinical benefits until the KEYNOTE-811 (first-line) and DESTINY-Gastri01 (≥second-line) trials were conducted. The incorporation of HER2-directed treatment with immune checkpoint inhibitors in the form of a monoclonal antibody or ADC is now approved as a standard treatment. Despite the promising results of new agents (engineered monoclonal antibodies, bi-specific antibodies, fusion proteins, and small molecules) in the early phase of development, the management of HER2-positive gastric cancer requires further optimization to achieve precision medicine with a chemotherapeutic backbone. Treatment resistance is a complex process that can be overcome using a combination of chemotherapy, targeted agents, and immune checkpoint inhibitors, including novel agents. HER2 status must be reassessed in patients undergoing anti-HER2 treatment with disease progression after the first-line treatment. As a general guideline, patients who need systemic treatment should receive chemotherapy plus targeted agents, anti-angiogenic agents, immune checkpoint inhibitors, or their combinations.

• Journal of Pharmaceutical Investigation
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• v.34 no.2
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• pp.107-114
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• 2004

External lyogels containing prostaglandin $E_1$ ethyl ester $(PGE_1-EE)$, a prodrug of prostaglandin $E_1\;(PGE_1)$ as a therapeutic agent for erectile dysfunction, were formulated to overcome the aqueous instability and enhance the percutaneous absorption. Lyogels of $PGE_1-EE$ were prepared with ethanol (EtOH)/proplyene glycol (PG) cosolvent system as a vehicle, cineol as an enhancer, and hydroxypropylcellusose as a gelling agent. In vitro percutaneous absorption studies were performed to determine the rate of $PGE_1$ absorption through rat or hairless mouse skin. The permeability of $PGE_1-EE$ lyogel with enhancer was 16-fold greater than that of lyogel without enhancer. Cosolvent produced 9-fold increase in percutaneous absorption. Pharmacodynamic effects of lyogels were evaluated in mature male cats in terms of intracavernosal pressure (ICP). Lyogels containing 0.1 % of $PGE_1-EE$ showed higher ICP compared to intraurethral preparation of $PGE_1$ (1 %) and enhancer-free control lyogel. The shelf-life $(t_{10%})$ of lyogel at refrigerated condition $(4^{\circ}C)$ was calculated as 928 days, which is 4.2 times longer than that of control hydrogel. As a result, $PGE_1-EE$ was formulated successfully to a lyogel system with a selective enhancer and cosolvent system for the topical delivery of $PGE_1$.

• Journal of Veterinary Clinics
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• v.26 no.3
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• pp.273-275
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• 2009

A 6-year-old castrated male Shih-tzu was presented because of a 1-month history of progressive tetraplegia. On the basis of the findings of neurological examination, radiographs and magnetic resonance imaging, herniated intervertebral disc of C4-C5, C5-C6 and C6-C7 compressed spinal cord. The oxygen-ozone was intra-operatively injected into the C4-C5 and C6-C7 intervertebral disc and a ventral decompression performed at C5-C6 intervertebral space. Immediately after the surgery, neck pain was disappeared and three weeks after surgery, there was complete resolution of the neurological deficits with normal gaits. On magnetic resonance images at 2-month after surgery, herniated disc materials of C5-C6 and C6-C7 were completely removed and that of C4-C5 remarkably reduced. Consequently decompression which was performed at all of the three lesions resulted in good clinical outcome without additional internal fixation for minimizing postoperative instability.