Acknowledgement
Supported by : Korea Science and Engineering Foundation (KOSEF), Chungbuk National University
References
- Al Safarjalani, O.N., Zhou, X.J., Rais, R.H., Shi, J., Schinazi, R.F., Naguib, F.N., and El Kouni, M.H. (2005). 5-(Phenylthio) acyclouridine: a powerful enhancer of oral uridine bioavailability: relevance to chemotherapy with 5-fluorouracil and other uridine rescue regimens. Cancer Chemother. Pharmacol. 55, 541-551 https://doi.org/10.1007/s00280-004-0967-y
- Baynes, J.W., and Dominiczak, M.H. (2005). Medical biochem-mistry (Elsevier Mosby), pp.417-423
- Cao, D., and Pizzorno, G. (2004). Uridine phosophorylase: an important enzyme in pyrimidine metabolism and fluoropyrimidine activation. Drugs Today (Barc.) 40, 431-443 https://doi.org/10.1358/dot.2004.40.5.850491
- Diasio, R.B., and Harris, B.E. (1989). Clinical pharmacology of 5- fluorouracil. Clin. Pharmacokinet. 16, 215-237 https://doi.org/10.2165/00003088-198916040-00002
- Douillard, J.Y., Cunningham, D., Roth, A.D., Navarro, M., James, R.D., Karasek, P., Jandik, P., Iveson, T., Carmichael, J., Alakl, M., et al. (2000). Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial. Lancet 355,1041-1047 https://doi.org/10.1016/S0140-6736(00)02034-1
- el Kouni, M.H., Naguib, F.N., Park, K.S., Cha, S., Darnowski, J.W., and Soong, S.J. (1990). Circadian rhythm of hepatic uridine phosphorylase activity and plasma concentration of uridine in mice. Biochem. Pharmacol. 40, 2479-2485 https://doi.org/10.1016/0006-2952(90)90089-4
- Geng, Y., Gheuens, E., and de Bruijn, E.A. (1991). Activation and cytotoxicity of 5'-deoxy-5-fluorouridine in c-H-ras transformed NIH 3T3 cells. Biochem. Pharmacol. 41, 301-303 https://doi.org/10.1016/0006-2952(91)90490-V
- Giacchetti, S., Perpoint, B., Zidani, R., Le, B.N., Faggiuolo, R., Focan, C., Chollet, P., Llory, J.F., Letourneau, Y., Coudert, B., et al. (2000). Phase III multicenter randomized trial of oxaliplatin added to chronomodulated fluorouracil-leucovorin as first-line treatment of metastatic colorectal cancer. J. Clin. Oncol. 18,136-147
- Greco, F.A., Figlin, R., York, M., Einhorn, L., Schilsky, R., Marshall, E.M., Buys, S.S., Froimtchuk, M.J., Schuller, J., Schuchter, L., et al. (1996). Phase III randomized study to compare interferon alfa-2a in combination with fluorouracil versus fluorouracil alone in patients with advanced colorectal cancer. J. Clin. Oncol. 14, 2674-2681 https://doi.org/10.1200/JCO.1996.14.10.2674
- Johnston, P.G., and Kaye, S. (2001). Capecitabine: a novel agent for the treatment of solid tumors. Anticancer Drugs 12, 639-646 https://doi.org/10.1097/00001813-200109000-00001
- Kim, S., Park, D.H., and Shim, J. (2008). Thymidylate synthase and dihydropyrimidine dehydrogenase levels are associated with response to 5-fluorouracil in Caenorhabditis elegans. Mol. Cells 26, 344-349
- Lee, S.J., Lee, H.K., Cho, S.Y., Choi, J.K., Shin, H.K., Kwak, E.J., Cho, M.R., Kim, H.R., Kim, S.R., Kim, Y.M., et al. (2008). Identification of osteogenic purmorphamine deriva-tives. Mol. Cells 26, 380-386
- Longley, D.B., Harkin, D.P., and Johnston, P.G. (2003). 5-fluorouracil: mechanisms of action and clinical strategies. Nat. Rev. Cancer 3, 330-338 https://doi.org/10.1038/nrc1074
- Moyer, J.D., Oliver, J.T., and Handschumacher, R.E. (1981). Salvage of circulating pyrimidine nucleosides in the rat. Cancer Res. 41, 3010-3017
- Schwartz, E.L., Wan, E., Wang, F.S., and Baptiste, N. (1998). Regulation of expression of thymidine phosphorylase/plateletderived endothelial cell growth factor in human colon carcinoma cells. Cancer Res. 58, 1551-1557
- Seymour, M.T., Slevin, M.L., Kerr, D.J., Cunningham, D., James, R.D., Ledermann, J.A., Perren, T.J., McAdam, W.A., Harper, P.G., Neoptolemos, J.P., et al. (1996). Randomized trial assessing the addition of interferon alpha-2a to fluorouracil and leucovorin in advanced colorectal cancer. Colorectal Cancer Working Party of the United Kingdom Medical Research Council. J. Clin. Oncol. 14, 2280-2288 https://doi.org/10.1200/JCO.1996.14.8.2280
- Voboril, R., Hochwald, S.N., Li, J., Brank, A., Weberova, J., Wessels, F., Moldawer, L.L., Camp, E.R., and MacKay, S.L. (2004). Inhibition of NF-kappa B augments sensitivity to 5- fluorouracil/folinic acid in colon cancer. J. Surg. Res. 120, 178-188 https://doi.org/10.1016/j.jss.2003.11.023
- Wan, L., Cao, D., Zeng, J., Yan, R., and Pizzorno, G. (2006). Modulation of uridine phosphorylase gene expression by tumor necrosis factor-alpha enhances the antiproliferative activity of the capecitabine intermediate 5′-deoxy-5-fluorouridine in breast cancer cells. Mol. Pharmacol. 69, 1389-1395 https://doi.org/10.1124/mol.105.018515
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