• Bulletin of the Korean Mathematical Society
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• v.50 no.3
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• pp.839-865
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• 2013

We deal with the existence of positive radial solutions concentrating on spheres for the following class of elliptic system $$\large(S) \hfill{400} \{\array{-{\varepsilon}^2{\Delta}u+V_1(x)u=K(x)Q_u(u,v)\;in\;\mathbb{R}^N,\\-{\varepsilon}^2{\Delta}v+V_2(x)v=K(x)Q_v(u,v)\;in\;\mathbb{R}^N,\\u,v{\in}W^{1,2}(\mathbb{R}^N),\;u,v&gt;0\;in\;\mathbb{R}^N,}$$ where ${\varepsilon}$ is a small positive parameter; $V_1$, $V_2{\in}C^0(\mathbb{R}^N,[0,{\infty}))$ and $K{\in}C^0(\mathbb{R}^N,[0,{\infty}))$ are radially symmetric potentials; Q is a $(p+1)$-homogeneous function and p is subcritical, that is, 1 < $p$ < $2^*-1$, where $2^*=2N/(N-2)$ is the critical Sobolev exponent for $N{\geq}3$.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.8 no.4
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• pp.75-88
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• 2008

This paper presents a spatial-level nonparametric multi-focus image fusion technique based on kernel estimates of input image blocks' underlying class-conditional probability density functions. Image fusion is approached as a classification task whose posterior class probabilities, P($wi{\mid}Bikl$), are calculated with likelihood density functions that are estimated from the training patterns. For each of the C input images Ii, the proposed method defines i classes wi and forms the fused image Z(k,l) from a decision map represented by a set of $P{\times}Q$ blocks Bikl whose features maximize the discriminant function based on the Bayesian decision principle. Performance of the proposed technique is evaluated in terms of RMSE and Mutual Information (MI) as the output quality measures. The width of the kernel functions, ${\sigma}$, were made to vary, and different kernels and block sizes were applied in performance evaluation. The proposed scheme is tested with C=2 and C=3 input images and results exhibited good performance.

• Mycobiology
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• v.38 no.3
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• pp.215-218
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• 2010

Azoles are currently the most widely used class of antifungal drugs clinically, and are effective for treating fungal infections. Target site of azoles is ergosterol biosynthesis in fungal cell membrane, which is absent in the mammalian host. However, the development of resistance to azole treatments in the fungal pathogen has become a significant challenge. Here, we report the identification and functional characterization of a UPC2 homolog in the human pathogen Cryptococcus neoformans. UPC2 plays roles in ergosterol biosynthesis, which is also affected by the availability of iron in Saccharomyces cerevisiae and Candida albicans. C. neoformans mutants lacking UPC2 were constructed, and a number of phenotypic characteristics, including antifungal susceptibility and iron utilization, were analyzed. No differences were found between the mutant phenotypes and wild type, suggesting that the role of C. neoformans UPC2 homolog may be different from those in S. cerevisiae and C. albicans, and that the gene may have a yet unknown function.

• 제어로봇시스템학회:학술대회논문집
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• 2005.06a
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• pp.990-993
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• 2005

This paper presents new results on designing a robust adaptive direct controller for a class of non-linear first order systems. The designing method based on the use of dead zone in the parameters' update law. It is shown that the size of the dead zone does not depend on the upper bounds of the disturbances. That means that even if the bounds are large, the tracking error will always converge to a set of the dead zone size. However, in the ideal case, when the exogenous signal functions and the function represents un-modeled dynamics of the systems equal to zero, the proposed controller does nt mean the convergence to zero of the tracking error. Computer simulation results show the effectiveness of the controller in dealing with the stated problems.

• Journal of the Korean Mathematical Society
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• v.35 no.3
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• pp.583-611
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• 1998

We consider a general class of real-valued Levy processes {X(t), $t\geq0$}, and obtain suitable large deviation results for the empiricals L(t, A) defined by $t^{-1}{\int^t}_01_A$(X(s)ds for t > 0 and a Borel subset A of R. These results are used to obtain the asymptotic behavior of P{Z(t) < a}, where Z(t) = $sup_{u\leqt}\midx(u)\mid$ as $t\longrightarrow\infty$, in terms of the rate function in the large deviation principle. A subclass of these processes is the Feller class: there exist nonrandom functions b(t) and a(t) > 0 such that {(X(t) - b(t))/a(t) : t > 0} is stochastically compact, i.e., each sequence has a weakly convergent subsequence with a nondegenerate limit. The stable processes are in this class, but it is much larger. We consider processes in this class for which b(t) may be taken to be zero. For any t > 0, we consider the renormalized process ${X(u\psi(t))/a(\psi(t)),u\geq0}$, where $\psi$(t) = $t(log log t)^{-1}$, and obtain large deviation probability estimates for $L_{t}(A)$ := $(log log t)^{-1}$${\int_{0}}^{loglogt}1_A$$(X(u\psi(t))/a(\psi(t)))dv$. It turns out that the upper and lower bounds are sharp and depend on the entire compact set of limit laws of {X(t)/a(t)}. The results extend to random walks in the Feller class as well. Earlier results of this nature were obtained by Donsker and Varadhan for symmetric stable processes and by Jain for random walks in the domain of attraction of a stable law.

• The Transactions of the Korean Institute of Electrical Engineers P
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• v.63 no.2
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• pp.61-68
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• 2014

Function of battery bank stores energy for DC load in general, and DC power system of the nuclear power plant is used to supply DC loads for safety- featured instrumentation and control such as inverter, class 1E power system control and indication, and station annunciation. Class 1E DC power system must provide a power for the design basis accident conditions, and adequate capacity must be available during loss of AC power and subsequent safe shutdown of the plant. In present, batteries of Class 1E DC power system of the nuclear power plant uses lead-acid batteries. Class 1E batteries of nuclear power plants in Korea are summarized in terms of specification, such as capacity, discharge rate, bank configuration and discharge end voltage, etc. This paper summarizes standards of determining battery size for the nuclear power plant, and analyzes duty cycle for the class 1E DC power system of nuclear power plant. Then, battery cell size is calculated as 2613Ah according to the standard. In addition, this paper analyzes performance test results during past 13 years and shows performance degradation in the battery bank. Performance tests in 2001 and 2005 represent that entire battery cells do not reach the discharge-end voltage. Howeyer, the discharge-end voltage is reached in 14.7% of channel A (17 EA), 13.8% of channel B (16 EA), 5.2% of channel C (6 EA) and 16.4% of channel D (19 EA) at 2011 performance test. Based on the performance test results analysis and size calculation, battery capacity and degradation by age in Korearn nuclear power plant is discussed and would be used for new design.

• IMMUNE NETWORK
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• v.6 no.2
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• pp.102-110
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• 2006

Background: Dendritic cells (DC) are professional antigen-presenting cells in the immune system and can induce T cell response against virus infections, microbial pathogens, and tumors. Therefore, immunization using DC loaded with tumor-associated antigens (TAAs) is a powerful method of inducing anti-tumor immunity. For induction of effective anti-tumor immunity, antigens should be efficiently introduced into DC and presented on MHC class I molecules at high levels to activate antigen-specific $CD8^+$ T cells. We have been exploring methods for loading exogenous antigens into APC with high efficiency of Ag presentation. In this study, we tested the effect of the cationic liposome (Lipofectin) for transferring and loading exogenous model antigen (OVA protein) into BM-DC. Methods: Bone marrow-derived DC (EM-DC) were incubated with OVA-Lipofectin complexes and then co-cultured with B3Z cells. B3Z activation, which is expressed as the amount of ${\beta}$-galactosidase induced by TCR stimulation, was determined by an enzymatic assay using ${\beta}$-gal assay system. C57BL/6 mice were immunized with OVA-pulsed DC to monitor the in vivo vaccination effect. After vaccination, mice were inoculated with EG7-OVA tumor cells. Results: BM-DC pulsed with OVA-Lipofectin complexes showed more efficient presentation of OVA-peptide on MHC class I molecules than soluble OVA-pulsed DC. OVA-Lipofectin complexes-pulsed DC pretreated with an inhibitor of MHC class I-mediated antigen presentation, brefeldin A, showed reduced ability in presenting OVA peptide on their surface MHC class I molecules. Finally, immunization of OVA-Lipofectin complexes-pulsed DC protected mice against subsequent tumor challenge. Conclusion: Our data provide evidence that antigen-loading into DC using Lipofectin can promote MHC class I- restricted antigen presentation. Therefore, antigen-loading into DC using Lipofectin can be one of several useful tools for achieving efficient induction of antigen-specific immunity in DC-based immunotherapy.

• Korean Journal of Microbiology
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• v.38 no.4
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• pp.203-203
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• 2002

Cytomegalovirus (CMV), a beta-herpesvirus with worldwide distribution, exhibits host persistence, a distinguishing characteristic of all herpesviruses. This persistence is dependent upon restricted gene expression in infected cells as well as the ability of productively infected cells to escape from normal cell-mediated anti-viral immunosurveillance. Type I (IFN-α/β) and type II (IFN-γ) interferons are major components of the innate defense system against viral infection. They are potent inducers of MHC class I and II antigens and of antigen processing proteins. Additionally, IFNS mediate direct antiviral effects through induction effector molecules that block viral infection and replications such as 2′, 5-oligoadenylate synthetase (2, 5-OAS). IFNS function through activation of well-defined signal transduction pathways that involve phosphorylation of constituent proteins and ultimate formation of active transcription factors. Recent studies have shown that a number of diverse viruses, including CMV, EBV, HPV mumps and Ebola, are capable of inhibiting IFN-mediated signal transduction through a variety of mechanisms. As an example, CMV infection inhibits the ability of infected cells Is transcribe HLA class I and II antigens as well as the antiviral effector molecules 2, 5-OAS and MxA I. EMSA studies have shown that IFN-α and IFN-γ are unable to induce complete signal transduction in the presence of CMV infection, phenomena that are associated with specific decreases in JAKl and p48. Viral inhibition of IFN signal transduction represents a new mechanistic paradigm for increased viral survival, a paradigm predicting widespread consequences in the case of signal transduction factors common to multiple cytokine pathways.

• Computers and Concrete
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• v.28 no.5
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• pp.521-532
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• 2021

Present paper focuses on the modeling of size effect on the compressive strength of normal concrete with the application of Discrete Element Method (DEM). Test specimens with different size and shape were cast and uniaxial compressive strength test was performed on each sample. Five different concrete mixes were used, all belonging to a different normal strength concrete class (C20/25, C30/37, C35/45, C45/55, and C50/60). The numerical simulations were carried out by using the PFC 5 software, which applies rigid spheres and contacts between them to model the material. DEM modeling of size effect could be advantageous because the development of micro-cracks in the material can be observed and the failure mode can be visualized. The series of experiments were repeated with the model after calibration. The relationship of the parallel bond strength of the contacts and the laboratory compressive strength test was analyzed by aiming to determine a relation between the compressive strength and the bond strength of different sized models. An equation was derived based on Bazant's size effect law to estimate the parallel bond strength of differently sized specimens. The parameters of the equation were optimized based on measurement data using nonlinear least-squares method with SSE (sum of squared errors) objective function. The laboratory test results showed a good agreement with the literature data (compressive strength is decreasing with the increase of the size of the specimen regardless of the shape). The derived estimation models showed strong correlation with the measurement data. The results indicated that the size effect is stronger on concretes with lower strength class due to the higher level of inhomogeneity of the material. It was observed that size effect is more significant on cube specimens than on cylinder samples, which can be caused by the side ratios of the specimens and the size of the purely compressed zone. A limit value for the minimum size of DE model for cubes and cylinder was determined, above which the size effect on compressive strength can be neglected within the investigated size range. The relationship of model size (particle number) and computational time was analyzed and a method to decrease the computational time (number of iterations) of material genesis is proposed.

• Journal of applied mathematics & informatics
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• v.32 no.1_2
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• pp.113-128
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• 2014

Consider a class of p(x)-Kirchhoff type equations of the form $$\left\{-M\left({\int}_{\Omega}\;\frac{1}{p(x)}{\mid}{\nabla}u{\mid}^{p(x)}\;dx\right)\;div\;({\mid}{\nabla}u{\mid}^{p(x)-2}{\nabla}u)={\lambda}V(x){\mid}u{\mid}^{q(x)-2}u\;in\;{\Omega},\\u=0\;on\;{\partial}{\Omega},$$ where p(x), $q(x){\in}C({\bar{\Omega}})$ with 1 < $p^-\;:=inf_{\Omega}\;p(x){\leq}p^+\;:=sup_{\Omega}p(x)$ < N, $M:{\mathbb{R}}^+{\rightarrow}{\mathbb{R}}^+$ is a continuous function that may be degenerate at zero, ${\lambda}$ is a positive parameter. Using variational method, we obtain some existence and multiplicity results for such problem in two cases when the weight function V (x) may change sign or not.