• Title/Summary/Keyword: C형

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The Interaction between HCV-Infected huh7.5 Cells and HCV-Specific T Cells (C형 간염 바이러스 감염 간암 세포주와 T 림프구의 상호작용에 대한 연구)

  • Kang, Hyojeung;Cho, Hyosun
    • Korean Journal of Microbiology
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    • v.50 no.2
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    • pp.169-172
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    • 2014
  • Recently, Hepatitis C virus (HCV) replication system has been established using human hepatoma cells (huh cell) and a variety of HCV clones. In this study, we established an infectious HCV replication system using huh7.5 cells and J6/JFH1 clone (genotype 2a). In addition, we investigated the antigen presentation capability of HCV-infected huh7.5 cells to HCV-specific T cells. Interestingly, HCV-infected huh7.5 cells were not capable of activating HCV-specific T cells. However, huh7.5 cells stimulated by exogenous HCV peptide were able to activate HCV-specific T cells, which was shown to produce TNF-${\alpha}$ and IFN-${\gamma}$. We further examined if HCV infection has an inhibitory effect on the expression of MHC class I molecule of huh7.5 cells. We found that HCV infection did not change the expression level of MHC class I molecule on huh7.5 cells.

Behavior of Precast Concrete Shear Walls with C-Type Connections (C형 접합부를 이용한 프리캐스트 콘크리트 전단벽의 거동)

  • Lim, Woo-Young;Hong, Sung-Gul
    • Journal of the Korea Concrete Institute
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    • v.22 no.4
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    • pp.461-472
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    • 2010
  • This paper investigates the behavior of precast concrete (PC) shear walls with a new vertical connections for a fast remodeling construction. The C-type vertical connections for the PC wall systems are proposed for transfer of bending moment between top and bottom walls in the vertical direction while a shear key in the center of wall is prepared to transfer shear forces by bearing action. The proposed vertical connections allows easy fabrication thanks to slots at the edges of wall in opposite directions. The plane PC wall systems subject to lateral load are compared with ordinary wall systems by investigating the effects of connection on the stiffness, strength, ductility, and failure modes of whole systems. The load-displacement relationship and influence of premature failure of connections are examined. The experimental test showed that the longitudinal reinforcing steel bars placed at the edges of walls yielded first and the ultimate deformation were terminated due to premature failure of connections. The diagonal reinforcements for efficient shear transfer in the walls were not effective. The strength and deformation obtained through the section analysis were generally in agreement with the experimental data, and indicated that. Gap opening contributed to the deformation behavior more than any other factors.

Molecular diagnosis of Niemann-Pick type C presenting with neonatal cholestasis and hepatosplenomegaly (지속되는 신생아 담즙 정체증과 간비비대를 주소로 내원하여 유전자분석으로 확진된 C형 Niemann-Pick병)

  • Jeong, Min-Hee;Ko, Jung-Min;Kim, Gu-Hwan;Yoo, Han-Wook
    • Journal of Genetic Medicine
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    • v.4 no.2
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    • pp.200-203
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    • 2007
  • Niemann-Pick type C is an inborn error of metabolism that affects lipid degradation and storage, which is characterized by hepatosplenomegaly and progressive neurological symptoms. A 7-month-old girl with jaundice was presented cholestasis and hepatosplenomegaly. Laboratory study showed elevated acid phosphatase, angiotensin converting enzyme and mild decrease of cholesterol. Characteristic foamy cell and sea-blue histiocytes in bone marrow biopsy consistent with Niemann-Pick disease. Niemann-Pick type C was suspected by past medical history and findings of physical examination. Therefore, molecular analysis was performed and found mutations of NPC1 gene. We report the first Korean case of type C Niemann-Pick disease confirmed by mutation analysis.

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A Case of Chronic Hepatitis C Acquired through Ear Piercing and Acupuncture (침술과 피어싱으로 발생한 만성 C형 간염 1예)

  • Rim, Jee-Yeon;Moon, Kyung-Rye
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.12 no.1
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    • pp.88-92
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    • 2009
  • Although transfusion of blood and plasma products are accepted as the principle means of transmission of HCV, other parenteral methods, such as acupuncture, tattooing needles, piercing, and surgery are possible methods of transmission of HCV. We managed a case of chronic hepatitis C acquired through ear piercing and acupuncture. A 10-year old girl presented with nausea, abdominal pain, and anorexia for 1 month. Her laboratory finding showed the following: AST/ALT, 865/1,290 IU/L; positive anti-HCV Ab; and HCV RNA. One year previously, she was treated with acupuncture for an ankle sprain and 2 years previously, she had her ears pierced. Laboratory findings of family members showed AST/ALT in the normal ranges, and negative anti-HCV Ab and HCV RNA. The pathologic findings of a liver biopsy revealed chronic hepatitis with mild lobular activity, moderate porto-periportal activity, and portal fibrosis. She was treated with pegylated interferon ${\alpha}$-2a and oral ribavirin for 6 months, after which the clinical symptoms and laboratory findings improved.

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The study on Development and characteristic of ultrasound biopsy training phantom of breast (유방 초음파 팬텀의 제작과 특성에 관한 연구)

  • Ma, Sang-Chull;Kong, Young-Kun;Ahn, Young-Man
    • Journal of radiological science and technology
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    • v.26 no.3
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    • pp.19-24
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    • 2003
  • We carried out studies on development and characteristic of ultrasound brast training biopsy phantom. the major finding were of follow ; (1) C type TMM was shown good homogeneity, brightness and attenuation as like human soft tissue. (2) $TiO_2$ 4.10%w/v TMM was shown good homogeneous echo texture and propagated speed as like the human Tissue. (3) $TiO_2$ type TMM was appeared lower brightness and higher penetration rate than C type TMM. Therefor, Breast TM phantom and target material TMM will be useful $TiO_2$ 4.10 %w/v TMM and C 2.09 %w/v TMM.

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Thermal Analysis on the LNG Storage Tank of LNG Bunkering System Applied with Double Shield Insulation Method (LNG 벙커링용 이중 단열적용 LNG 저장탱크 열해석)

  • Jung, Il-Young;Kim, Nam-Guk;Yun, Sang-Kook
    • Journal of the Korean Institute of Gas
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    • v.22 no.4
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    • pp.1-6
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    • 2018
  • An LNG bunkering system stores LNG in a horizontal IMO's C-Type tank insulated with perlite powder, and $10^{-2}$ Torr vacuum in the annular space between the double walls. Current storage tanks have high heat leakage, evaporating over 2.0% daily. A more efficiently insulated storage tank reducing the evaporation rate is required to develope. This research carried out thermal analysis on a new effective insulation method, i.e. double shield insulation system, that separates high super vacuum in the annular space between two tanks with a perlite vacuum in the back side of outer tank. This highly efficient insulation system obtained an evaporation rate of 0.16% per day under a $10^{-4}$ Torr vacuum. Even if the space loses its vacuum, the new insulation system showed a lower evaporation rate of 5.23% than the present perlite system of 4.9%.

Development of Connection Details of RC Wale-Steel Beam Joint Subjected to Axile and Shear Load (축력 및 전단력을 받는 RC 띠장-철골 보 접합부의 접합연결재 개발)

  • Kim, Seung-Hun
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.8 no.3
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    • pp.189-196
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    • 2004
  • The RC wale-steel beam stud connection may have smaller moment and shear resistance because the tensile and shear capacity of the studs are limited by the depth of RC beam. Especially, they are subjected to compressive axial load. This paper describes the experimental works to develop the connection details of RC wale-steel beam joints subjected to shear and axial loads. Shear connectors developed in this study are closed C type deformed bar, opened C type deformed bar, and U type deformed bar. From shear test, the shear performance of RC wale-steel beam joint with the developed connectors are compared with the stud connection. Test results indicated that the developed connectors were very effiecive to increase the shear strength.