• 대한수의학회지
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• 제20권2호
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• pp.105-112
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• 1980

The bursa of Fabricius from thyroxine-treated group showed increased number of large lymphocytes with well-developed cytoplasm, immunoblasts and proplasmacytes accompanied with active cell divisions. More prominent development of Golgi apparatus and mitochondria in the cytoplasm of the cells in the bursa from this group were also observed. The bursa of Fabricius from the propylthiouracil-treated group, however, distinctively revealed proliferation of fibroblasts in the interstitial tissues, decreased number of lymphocytes, and necrotic lymphocytes in the follicles.

• 대한수의학회지
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• 제2권1호
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• pp.51-54
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• 1962

Chang et al. 및 Glick 등은 어린 닭에있어 Fabricius' Bursa가 면역항체형성(免疫抗體形成)에 영향(影響)를 미치는것을 관찰보고(觀察報告)한바있다. 즉(卽) S.typhimurium antigen 또는 양적혈구(羊赤血球)를 주사(注射)하였을경우 Fabricius' Bursa를 적출(摘出)한 어린 닭에 있어서는 면역항체형성(免疫抗體形成)의 감소(減少)를 보았다고 하며 또한 Bursectany를 한 닭에 있어서는 S.typhimurium 주사(注射)로 인(因)한 폐사율(斃死率)이 보다 높았다고 한다. 이러한 Fabricius' Bursa의 영향(影響)은 부화후(孵化後) 처음 몇주(週)에 있어 가장 현저(顯著)하며 닭의 성장(成長)과 덥으로 점차 감소(減少)됨을 보고(報告)하고 있다. 그러나 이들의 연구(硏究)에는 그의 본질(本質)이 같은 세포성(細胞性)인 항원(抗原)만이 사용(使用)되었을 뿐만 아니라 그의 접종방법(接種方法)도 근육내(筋肉內) 및 정맥내(靜脈內)의 두 방법(方法)에 한(限)하였다. 면역항체(免疫抗體)를 형성(形成)하는 여러 기관조직(器官組織)의 항체형성(抗體形成)에의 비율적관여(比率的關與)는 항원(抗原)의 본질(本質) 그의 접종방법(接種方法)등에 따라 다르므로 여기에 필자(筆者)들은 Virus 항원(抗原)인 Newcastle Virus ($B_1$ strain)를 경비적(經鼻的)으로 접종(接種)하였을 경우의 Fabricius' Bursa의 항체(抗體) 형성(形成)에 미치는 영향(影響)을 연구(硏究)하였다. 부화후(孵化後) 3주(週)되는 Leghorn종(種)의 어린 닭의 Fabricius' Bursa를 적출(摘出)하고 1주일후(週日後)에 Newcastle Virus ($B_1$ strain)를 경비적(經鼻的)으로 접종(接種)하였던 바 HI반응(反應)에 의(依)한 그의 혈청역가(血淸力價)(serum titer)는 정상(v)Control group의 그것에 비(比)하여 통계학적(統計學的)으로 의의(意義)있는 차(差)가 없음을(P>0.1) 보았다.

• 대한수의학회지
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• 제20권1호
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• pp.17-24
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• 1980

In order to know the effects of thyroid hormone on the bursa of Fabricius in chicken, the bursae were studied with the light microscope after administration of thyroxine(TX) or propylthiouracil(PPT). Macroscopically, the bursa of TY-treated group showed increase in size and thickened folds. while those of the PPT-treated group decrease in size, compared with those of control group. In the light microscopic studies, the bursa of Fabricius of the TX-treated group showed active cell-divisions in the medulla, and increased number of pyroninophilic large lymphocytes and plasma cells containing PAS positive materials in the cytoplasms. On the other hand, the bursa from PPT-treated group revealed decreased number of lymphocytes, significant increase of necrotic lymphocytes in the follicles, and the proliferation of the interfollicular connective tissues. A large number of pyroninophilic lymphocytes and plasma cells were also appeared in the spleen of the TX-treated group.

• 대한수의학회지
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• 제38권3호
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• pp.461-466
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• 1998

The histological profiles and endocrine cells in the bursa of Fabricius of the duck (Anas platyrhynchos platyrhyncos, Linne) were studied at 23 days of incubation, at hatching, 1 week, 2 weeks, 3 weeks, 5 weeks, 6 weeks, 7 weeks, 9 weeks, 10 weeks and 32 weeks after hatching. Histologically epithelium of bursa Fabricius were pseudostratified columnar and simple columnar epithelium. Numerous lymphatic follicles and well developed plica were observed in this study. The sections were reacted immunohistochemically using antisera specific to bovine chromogranin(BCG), serotonin and somatostatin antisera using immunohistochemical methods. A few number of BCG-immunoreactive cells were detected from 23 days of incubation to 5 weeks after hatching and serotonin-immunoreactive cells were also observed from 23 days of incubation to 3 weeks after hatching. No somatostatin-immunoreactive cells were detected in this study.

• 대한수의학회지
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• 제28권1호
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• pp.175-177
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• 1988

Light-microscope studies of the coccidial organisms found in the bursa of Fabricius from chickens shelwng some specific signs were carried out, and the etiological agent was estimated as the parasite belonging to the Family Cryptosporiidae. The specific gross Pathological signs were intestinal hemorrhage and atrophy of the bursa of Fabricius and hyperplasia was associated with the presence of organisms attached to the epithelial cells lining the plicae of the bursa of Fabricius in the microscopical findings.

• 대한수의사회지
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• 제28권1호
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• pp.2-7
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• 1992

• Journal of Veterinary Science
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• 제22권3호
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• pp.33.1-33.6
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• 2021

Very virulent infectious bursal disease virus (vvIBDV) causes high mortality in chickens but measures to reduce the mortality have not been explored. Chickens (8-9 weeks) were treated with 3 agents before and during vvIBDV inoculation. Dexamethasone treatment reduced the mortality of infected chickens (40.7% vs. 3.7%; p < 0.001), but treatment with aspirin or vitamin E plus selenium did not affect the mortality. The bursa of Fabricius appeared to have shrunk in both dead and surviving chickens (p < 0.01). The results indicate that dexamethasone can reduce mortality in vvIBDV-infected chickens and may provide therapeutic clues for saving individual birds infected by the virus.

• Parasites, Hosts and Diseases
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• 제53권6호
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• pp.675-682
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• 2015

The effects of diclazuril on the bursa of Fabricius (BF) structure and secretory IgA (SIgA) expression in chickens infected with Eimeria tenella were examined. The morphology of the BF was observed by hematoxylin and eosin staining, while ultrastructural changes were monitored by transmission electron microscopy. E. tenella infection caused the BF cell volumes to decrease, irregularly arranged, as well as, enlargement of the intercellular space. Diclazuril treatment alleviated the physical signs of damages associated with E. tenella infection. The SIgA expression in BF was analyzed by immunohistochemistry technique. The SIgA expression increased significantly by 350.4% (P<0.01) after E. tenella infection compared to the normal control group. With the treatment of diclazuril, the SIgA was relatively fewer in the cortex, and the expression level was significantly decreased by 46.7% (P<0.01) compared with the infected and untreated group. In conclusion, E. tenella infection in chickens induced obvious harmful changes in BF morphological structure and stimulated the expression of SIgA in the BF. Diclazuril treatment effectively alleviated the morphological changes. This result demonstrates a method to develop an immunological strategy in coccidiosis control.

• Journal of Animal Science and Technology
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• 제58권11호
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• pp.39.1-39.12
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• 2016

Background: The current study investigates the anti-stress effects of clove (Eugenia caryophyllus) extracts (0, 200, 400, and 600 mg/kg) on serum antioxidant biomarkers, immune response, immunological organ growth index, and expression levels of acute phase proteins (APPs); ovotransferrin (OVT), ceruloplasmin (CP), ceruloplasmin (AGP), C-reactive protein (CRP), and serum amyloid-A (SAA) mRNA in the immunological organs of 63-d-old male black-meated Silkie fowls subjected to 21 d chronic heat stress at $35{\pm}2^{\circ}C$. Results: The results demonstrated that clove extract supplementation in the diet of Silkie fowls subjected to elevated temperature (ET) improve growth performance, immune responses, and suppressed the activities of glutathion peroxidase (GSH-Px), superoxide dismutase (SOD), catalase (CAT), and thioredoxin reductase (TXNRD); reduced serum malonaldehyde (MDA) and glutathione (GSH) concentrations when compared with fowls raised under thermoneutral condition (TC). Upon chronic heat stress and supplementation of clove extracts, the Silkie fowls showed a linear increase in GSH-Px, SOD, CAT, and TXNRD activities (P = 0.01) compared with fowls fed diets without clove extract. ET decreased (P < 0.05) the growth index of the liver, spleen, bursa of Fabricius and thymus. However, the growth index of the liver, spleen, bursa of Fabricius and thymus increased significantly (P < 0.05) which corresponded to an increase in clove supplemented levels. The expression of OVT, CP, AGP, CRP, and SAA mRNA in the liver, spleen, bursa of Fabricius and thymus were elevated (P < 0.01) by ET compared with those maintained at TC. Nevertheless, clove mitigates heat stress-induced overexpression of OVT, CP, AGP, CRP and SAA mRNA in the immune organs of fowls fed 400 mg clove/kg compared to other groups. Conclusions: The results showed that clove extracts supplementation decreased oxidative stress in the heat-stressed black-meated fowls by alleviating negative effects of heat stress via improvement in growth performance, antioxidant defense mechanisms, immunity, and regulate the expression of acute phase genes in the liver and immunological organs.

• 한국수의병리학회지
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• 제2권1호
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• pp.1-8
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• 1998

Chickens at 3-weeks of age were inoculated with a highly virulent strain (SH/92) of Infectious Bursal Disease Virus(IBDV) through ocular and cloacal routes. The infected chickens were killed at 6, 12, 24, 48, 72, and 96 hrs post inoculation (PI) and Bursa of Fabricius(BF) were collected. The sizes of bursal follicules in infected chickens decreased at 48 to 96 hrs PI. Histologically the cellular changes were first evident at 12 hrs PI and characterized by condensation of nuclear chromatin of bursal lymphocytes indicating apoptosis. By 24 hrs PI apoptotic lymphocytes dramatically increased. In addition infiltration of heterophils were also seen in the follicles and in the interfollicular connective tissues. At 48 hrs PI, cystic cavities were observed in the follicles. As the infection advanced the bursal follicles showed atrophy accompanied by disappearance of heterophils and reduction in number of lymphocytes in the cystic cavities which was replaced by proteineous materials. The nuclei of most affected lymphocyte stained positively with the in situ end labeling for apoptosis. Electron microscopy showed viral particles with crystalline array in the lymphocytes of BF infected with IBOV. These results indicated that SH/92 IBDV infection in chickens caused increased apoptosis in the BF.