• Journal of Pharmaceutical Investigation
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• 제33권1호
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• pp.29-36
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• 2003

Clenbuterol, a selective ${\beta}_2-adrenergic$ receptor stimulant, has been introduced as a potent bronchodilator for patients with bronchial asthma, chronic obstructive bronchial disease, chronic bronchitis and pulmonary emphysema. The percutaneous permeation of clenbuterol was investigated in hairless mouse skin after application of 50/50 buffer(pH 10)/propylene glycol solvent mixture. The enhancing effects of various penetration enhancers such as terpenes, non-ionic surfactants, pyrrolidones, fatty acids and some other enhancers on the permeation of clenbuterol were evaluated using Franz diffusion cell. Among terpenes studied, 1,8-cineole was the most effective enhancer, which increased the permeability of clenbuterol approximately 39.33-fold compared with the control without penetration enhancer, followed by menthone with enhancement ratio of 23.57. Nonionic surfactants did not have significant enhancing effects. N-Lauryl-2-pyrrolidone increased the permeability of clenbuterol approximately 4.51-fold compared with the control. Lauric acid increased the permeability of clenbuterol approximately 35.57-fold with decreasing the lag time from 2.64 to 0.52 hr. Oleic acid, linoleic acid, linolenic acid and capric acid showed enhancement ratio of 22.62, 19.60, 17.45 and 16.51, respectively. $Labrafil^{\circledR}$ enhanced the permeability of clenbuterol 9.24-fold compared with that without enhancer.

• 대한한의학방제학회지
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• 제21권1호
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• pp.1-15
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• 2013

Objectives : This article is a study on to which categories of modern diseases blood stasis patterns are assigned and the meaning of blood stasis interpreted with perspectives of Korean Medicine and modern medicine. Methods : We reviewed "Neijing", "Shanghanlun", "Yilingaicuo", "Xuezhenglun" and other books and modern clinical papers related with blood stasis. Results : 1. Blood stasis patterns are related with disorders of hemorrheology, hemodynamics, platelet function, microcirculation, microelements and endothelial damage. 2. From the types of syndrome differentiation, diverse diseases classified in type of qi deficiency with blood stasis and type of blood stasis due to qi stagnation are reported, which reflects qi and blood are closely connected. And many diseases are classified in type of kidney deficiency with blood stasis, which has something in common with chronic diseases can achieve effect from treatment considering blood stasis. 3. Diseases related with kidney involve menopausal disorder, mazoplasia, prostatitis, erectile dysfunction, chronic nephritis, renal calculus, osteoporosis and bursitis. Diseases related with heart involve coronary artery disease, arrhythmia and cerebral thrombosis. Diseases related with spleen involve gastritis, colonitis and digestive organ ulcer. Diseases related with liver involve hepatitis, hyperthyroidism and stroke. Diseases related with lung involve neurodermatitis, bronchitis and paranasal sinusitis. Conclusions : Blood stasis pattern which is one of the areas to draw medicine's attention has broad clinical application.

• Tuberculosis and Respiratory Diseases
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• 제85권4호
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• pp.313-319
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• 2022

Environmental exposure to air pollution is known to have adverse effects on various organs. Air pollution has greater effects on the pulmonary system as the lungs are directly exposed to contaminants in the air. Here, we review the associations of air pollution with the development, morbidity, and mortality of pulmonary diseases. Short-and long-term exposure to air pollution have been shown to increase mortality risk even at concentrations below the current national guidelines. Ambient air pollution has been shown to be associated with lung cancer. Particularly long-term exposure to particulate matter with a diameter <2.5 ㎛ (PM_2.5) has been reported to be associated with lung cancer even at low concentrations. In addition, exposure to air pollution has been shown to increase the incidence risk of chronic obstructive pulmonary disease (COPD) and has been correlated with exacerbation and mortality of COPD. Air pollution has also been linked to exacerbation, mortality, and development of asthma. Exposure to nitrogen dioxide (NO₂) has been demonstrated to be related to increased mortality in patients with idiopathic pulmonary fibrosis. Additionally, air pollution increases the incidence of infectious diseases, such as pneumonia, bronchitis, and tuberculosis. Furthermore, emerging evidence supports a link between air pollution and coronavirus disease 2019 transmission, susceptibility, severity and mortality. In conclusion, the stringency of air quality guidelines should be increased and further therapeutic trials are required in patients at high risk of adverse health effects of air pollution.

• Tuberculosis and Respiratory Diseases
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• 제67권6호
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• pp.565-568
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• 2009

Yellow nail syndrome is a rare cause of pleural effusions. This syndrome is characterized by yellow discoloration of nails, lymphedema, and respiratory disorders, including pleural effusion, chronic bronchitis, bronchiectasis, and chronic sinusitis. The etiology of this syndrome is obscure, but the pathogenesis seems to be related with impaired lymphatic drainage. We report a case of yellow nail syndrome in a 70-year-old female with the typical clinical findings (yellow discoloration of nails, lymphedema, and chronic pleural effusion) of this disorder and with proven lymphatic obstruction on lymphoscintigraphy.

• Tuberculosis and Respiratory Diseases
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• 제49권1호
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• pp.82-92
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• 2000

연구배경 : 만성기도질환에서 객담내 세포의 성상이 변화가 있다는 것은 이미 알려져 있으며 mucin의 분비가 증가한다는 것은 잘 알려진 사실이나 임상적인 이용이 제한되어 왔다. 만성기도질환 환자의 객담내 세포성상과 임상적 특성을 단클론항체($HMO_2$)를 이용하여 측정 된 mucin이 상관관계가 있는지를 알아보고자 하였다. 방법 : 최근 개발된 mucin에 대한 단클론항체를 사용하여 만성기도질환환자를 대상으로 객담의 세포분석과 mucin의 양을 측정하였다. 자발적 배출된 객당과 고장성 생리식염수를 이용한 유도객담으로 얻은 검체를 처리하여 전체 세포수와 생존률을 측정하였으며 분별 검사를 하였다. 단클론항체 $HMO_2$가 객담내의 당단백인 mucin과 반응함을 확인하기 위하여 Western blot과 PAS 영색으로 검증하였다. 검증된 단클론항체를 이용하여 면역효소측정으로 mucin을 정량하였다. 또한 연구결과와 환자의 입상적인 특성과 상관관계를 규명하였다. 결과 : 기관지확장증에서 전체세포수가 천식과 만성기관지염에 비하여 유의한 증가를 보였으며 분별검사에서 천식 환자에서는 호산구외 증가를, 기관지확장증과 만성기관지염 환자에서는 호중구의 증가를 확인하였다. 환자의 임상적인 특징과 객담에서 측정된 전체 세포수와 생존률 그리고 세포분획과 비교에서 상관관계를 발견 할 수 없었다. 측정된 mucin은 질환별 차이는 발견할 수 없었으며 세포의 생존률과 mucin의 양과의 역상관관계를 확인할 수 있었으나, 그 밖의 다른 지표사이의 관련은 없었다. 결론 : 만성기도질환의 객담의 분석은 객관적인 질환별 감별 평가에 이용될 수 있는 가능성올 보여주고 있으며 객담내 mucin의 분비는 세포의 생존률이 영향을 주는 것으로 판단된다.

• 대한한방내과학회지
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• 제27권1호
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• pp.221-227
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• 2006

Kyumsuyukgun-jun has been used for the chronic bronchitis, asthma and other illnesses. This study was carried out for the purpose of determining what effect KS has against allergic inflammatory reaction. The results obtained was that KS had inhibitory effects of following administration routes on PCA in rats. According to the above results, KS is beneficial against allergic inflammatory reaction through inhibition of PCA.

• Journal of Chest Surgery
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• 제11권3호
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• pp.260-264
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• 1978

Sixty-one bronchiectatic patients were reviewed who were treated by surgical intervention in the Department of Thoracic and Cardiovascular Surgery, Chonnam University Hospital during the recent 14 years from January of 1965 to August of 1978. 1. Various pulmonary resection was performed; lobectomy was 55.5%, lobectomy and segmental resection 20.6%, bilobectomy 13.1%, lobectomy, segmental resection and thoracoplasty 4.9% and pneumonectomy was 3. 2%. 2. The most common associated disease was pulmonary Tbc, its frequency was 47.5% and next was chronic bronchitis [31%]. 3. The postoperative complication was observed in 19.6% [12 cases] and the most common was wound infection. 4. The possibility of recurrence was relatively high in the cases of residual lesion and it needs more intensive medical care. 5. The surgical result was satisfactory in 86.9% (53 cases), slight improvement in 4.9% (3 cases) and the mortality rate was 1.6% (1 case).

• 월간양계
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• 제36권10호통권420호
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• pp.154-155
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• 2004

마이코플라즈마는 양계 산업에 경제적 손실을 임하는 질병중의 하나이다. 그 중에서도 마이코플라즈마 갈리셉티컴(MG, mycoplasma gallisepticum)은 호흡기 질병을 유발하고 산란율을 떨어뜨리며, 마이코플라즈마 시노바에(MS, mycoplasma synoviae)는 호흡기와 관절이상을 가져온다. MG는 MS보다 더 큰 경제적 손실을 입히고 있다. 본 고에서는 MG에 대한 일반 이해와 미국에서의 예방 실태를 알아 본다. MG는 축제를 떠나면 덥고 건조한 조건에서는 불과 몇 시간밖에 생존하지 못하는 유기체이다. MG는 감염 닭과의 직접접촉, 가까운 거리에서는 공기를 통해, 또는 오염된 기구나 작업자들을 통해 수평 감염되거나 종란을 통해 수직감염 된다. MG 감염은 만성호흡기(CRD, Chronic respriatory disease)의 원인이 되는데 특히 어린 병아리와 브로일러에서 그러하다. CRD 즉 만성 호흡기증의 정도는 MG병원성, 전염성 기관지염(IBV, intectious bronchitis virus), 그리고 대장균증과 같은 2차 감염에 의해 더욱 악화 되게 된다.

• 대한한의학방제학회지
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• 제7권1호
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• pp.65-76
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• 1999

According to the study of literature on RADIX STEMONAE about its efficacy, pharmacological action, and clinical adaptive disease, the results are as follows; 1. About the efficacy of RADIX STEMONAE, it is known as moistening the lungs to arrest cough, and intestinal parasites from ancient to now, and dispelling phlegm is also known. 2. The clinical adaptation of RADIX STEMONAE is chronic bronchitis, pertussis, pulmonary tuberculosis in respiratory disease, and ascaricide for Ascaris, Enterobius vermicularis or eczema, pruritus, destroy louse for endermic liniment. 3. The pharmacological action of RADIX STEMONAE are antitussive, tuberculostatic, anthelmintic, antibacterial, antivirus, antifungal. 4. The antitussive mechanism of RADIX STEMONAE is central inhibitor for cough center of medulla oblongata, and the mechanisms of bronchial smooth muscle relax, and expectorant is also known.

• Journal of Chest Surgery
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• 제18권4호
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• pp.582-588
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• 1985

We have observed 165 cases of spontaneous pneumothorax from Aug. 1978 to May. 1985 at the department of Thoracic and Cardiovascular Surgery, School of Medicine, Keimyung University. The ratio of male to female cases were 8.2:1 in male predominance, and the incidence was highest in the adolescence between 21 to 30 year of age. There were 85 patients of primary spontaneous pneumothorax and 80 patients of secondary spontaneous pneumothorax. The etiologic factors of secondary spontaneous pneumothorax were tuberculous origin in 50 cases, chronic bronchitis with emphysematous bullae or blebs in 17 cases, asthma in 10 cases and lung cancer in 3 cases. Closed thoracotomy was performed for reexpansion of collapsed lung in 153 cases, bed rest in 3 cases, needle aspiration in 5 cases and open thoracotomy in 14 cases. Closed thoracotomy was the main therapeutic approach of choice in the great majority of spontaneous pneumothorax with recurrence rate of 21.6%. However, open thoracotomy was undertaken in patients with continuous air leakage, recurrent episodes, bilateral pneumothorax and large visible apical blebs or bullae.