• Genomics & Informatics
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• 제14권3호
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• pp.112-124
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• 2016

Solid tumor is generally observed in tissues of epithelial or endothelial cells of lung, breast, prostate, pancreases, colorectal, stomach, and bladder, where several genes transcription is regulated by the microRNAs (miRNAs). Argonaute (AGO) protein is a family of protein which assists in miRNAs to bind with mRNAs of the target genes. Hence, study of the binding mechanism between AGO protein and miRNAs, and also with miRNAs-mRNAs duplex is crucial for understanding the RNA silencing mechanism. In the current work, 64 genes and 23 miRNAs have been selected from literatures, whose deregulation is well established in seven types of solid cancer like lung, breast, prostate, pancreases, colorectal, stomach, and bladder cancer. In silico study reveals, miRNAs namely, miR-106a, miR-21, and miR-29b-2 have a strong binding affinity towards PTEN, TGFBR2, and VEGFA genes, respectively, suggested as important factors in RNA silencing mechanism. Furthermore, interaction between AGO protein (PDB ID-3F73, chain A) with selected miRNAs and with miRNAs-mRNAs duplex were studied computationally to understand their binding at molecular level. The residual interaction and hydrogen bonding are inspected in Discovery Studio 3.5 suites. The current investigation throws light on understanding miRNAs based gene silencing mechanism in solid cancer.

• 한국의류산업학회지
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• 제8권1호
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• pp.80-88
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• 2006

This study attempted to undertake comparative analysis of woman's jacket pattern and details based on the Crinoline and Bustle style of the 19th century, comprehend the relation and differences between the two styles. And it also presented the resultant characteristics and attempted reproducing the original dress of the past for the development of modern woman's jacket design. Larger portion was occupied for the breast front width than the back width for both Crinoline and Bustle style, which indicated the remarkable difference between these styles and modern jackets in terms of pattern size. Circumferences also showed that both styles had larger size for the front region than for the back. Divided by two types of pattern shape. The Crinoline style has a waist line and flare. On the other hand, the Bustle style does not have a waist line and has pleats. These two styles shows distinct differences of patterns even if they seem similar. It was essential to undertake the designing of models by giving a consideration to the characteristics of patterns of the two styles. With respect to how to sketch the study models which will be applied for the reproduction to modern body sizes were as follows: the front bust circumference; B/4 +1+1 cm, the back bust circumference; B/4 +1-1 cm, front waist circumference; W/4 +1+1 cm, back waist circumference; W/4 +1-1 cm, the height of sleeve crown; AH/3, armhole line; B/4, the back width /2; 17.5 cm, the breast front width /2; 16.5cm. And for the rest parts, sizes reflecting the characteristics of the patterns of two styles have been applied.

• 한국의상디자인학회지
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• 제10권2호
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• pp.57-68
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• 2008

In this study, we prepared reference data needed for clothing design for middle-aged women by analyzing body satisfaction of their body shape, which had been classified by collecting body features of middle-aged women. As for the study method, we have set five scales from 'never satisfied' to 'very much satisfied,' after analyzing body features of middle-aged women by measuring their body shape through the body meter and auxiliary tools. We used the SPSS 12.0 statistics program, and the results are the following: Body shapes of middle-aged women can be classified into the following four types. A middle-age women with an 'A silhouette' has a normal height, but fat nether limbs. A 'Y silhouette' is short with a fat upper body. The 'O silhouette' is short with fat nether limbs and upper body, and 'H silhouette' is tall and thin. Body shape I has displayed satisfaction with her own body shape, and body shape II showed the most dissatisfaction compared to other body shapes. Body shape III showed satisfaction on all items except face size and breast size, whereas body shape IV was dissatisfied with her face size, neck length, shape of her breast, waist, and buttocks. The result of this study is expected to contribute in accomplishing clothing production that will satisfy the desire of the consumers in the clothing business, while being utilized as the basic data for clothing design that fits their body shape by grasping the changing patterns of their body shape.

• Archives of Plastic Surgery
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• 제38권5호
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• pp.703-706
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• 2011

Purpose: Augmentation mammoplasty by cohesive silicone gel implant is becoming more popular nowadays. Many types of complications have been reported, such as hematoma, seroma, infection, capsular contracture and etc. But there were no report of deep vein thrombosis(DVT) after augmentation mammoplasty in Korea. The authors experienced one case of DVT after augmentation mammoplasty using a cohesive silicone gel implant. Methods: A 38-year-old woman with breast cancer underwent reconstruction by tissue expander and augmentation mammoplasty by cohesive silicone gel implant, and exchange of expander to cohesive silicone gel implant. The operation was finished without any complicating event. On 4th day after the operation, the patient complained of intermittent right lower leg pain. By doppler ultrasonography, the patient was diagnosed with acute venous thrombosis of the popliteal vein, posterior tibial vein and peroneal vein. Results: Intravenous heparinization and oral warfarin were started immediately and elastic compression stocking was applied. Intravenous heparinization was continued until INR (blood coagulation unit) reached to target levels. The patient was discharged on 11th day of operation with oral warfarin. Other complication has not been reported after 10 weeks of operation. Conclusion: To our knowledge, this is the first report of DVT after silicone implant based breast augmentation.

• 복식
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• 제62권5호
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• pp.73-87
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• 2012

The purpose of this study is to find the Dart Manipulation with good fitting and evaluate the aesthetics of Dart Manipulation that is used in the designs of the original tops for women in their 30's. Subsequently, it suggests dart manipulation with good body fitting and physical fitness when designing original tops. The findings of this study are as follows. First, in the fitting of Dart Manipulation for different body types, cross direction Dart Manipulation received good marks in the Square Body Type while mixed direction and diagonal direction Dart Manipulation received high evaluation in the Standard Body Type. Also, for the Reverse Triangle Body Type, mixed direction Dart Manipulation received high marks. Since there are only small changes in fitting for the Square Body Type, the position of Dart Manipulation should be determined in regards to the aesthetic view as well as the fitting of the Standard Body Type and Reverse Triangle Body Type. Second, in the fitness of Dart Manipulation for different body types, an approach from the aesthetic view should be considered for Square Body Types because of the differences in fitness according to the position of dart manipulation. The fitness should be considered when positioning Dart Manipulation for the Standard Body Type and Reverse Triangle Body Type because of these differences. Third, for the greater variance of drop for these different body types, the change of the amount of dart received lower evaluation in fitting since the amount of dart increased when the dart was located higher than B.P. The number of dart should likely increase when gathering or tucking is necessary when there is an excessive amount of dart in Dart Manipulation for the different body types. Fourth, as for the changes of wrinkles in accordance with the body type, wrinkles were likely to be formed at the breast or neck area when there was a larger difference in drop. To prevent such problems, one more dart should be made on the wrinkle. In conclusion, the study suggests designing the original top with a better look and comfort by setting the balance between aesthetics and fitting in the design stage.

• 한국의상디자인학회지
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• 제18권2호
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• pp.221-236
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• 2016

The purpose of this study is to make a contribution to the development of creative fashion culture through the expansion of creative fields in the fashion design area and also the combination of fashion and art techniques, by classifying the cases of Trompe $L{\oe}il$ expressed in modern fashion, and also analyzing its aesthetic characteristics. Conducting the qualitative research through the literature study and the analysis of design cases, it targeted the women's wear collections of Paris, Milan, London, and New York, limiting its range from S/S 2010 to F/W 2015. The results are as follows: First, based on the preceding research, the types of Trompe $L{\oe}il$ expressed in modern fashion were shown as realistic expression of clothing, movement of daily objects, double images, and application of human body. Second, the aesthetic characteristics of Trompe $L{\oe}il$ based on its expression types were deconstruction, avant-garde, and amusements. The deconstruction was expressed in the expression type of Trompe $L{\oe}il$ such as freedom of materials using digital printing technique, change in the position of clothes, and movement of daily items using collage technique by collecting objets like daily items or waste. The avant-garde was expressed by switching/overlapping in and out of clothes, intentionally exposing some body parts like breast or torso, displacing body parts, and moving daily items. The amusements was shown by realistically expressing accessories or details of clothes using digital printing technique, or moving daily items such as book and fork.

• 복식
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• 제66권8호
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• pp.46-60
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• 2016

Countries have different brassiere patterns, and this study produced and compared 3/4 brassiere patterns from different countries to determine the difference in patterns, and to investigate the stress distribution and shape of cross section while wearing brassieres using 3D virtual fitting system. Despite the growing interest in underwear, there is a lack of related books and research on brassiere patterns, which causes the difference in sizes and pattern drafting methods by countries. Thus, research on this is needed. 3D virtual fitting system has been introduced to compare patterns, thereby improving visible effects and reducing the loss in cost caused by underwear pattern fitting test. According to the result of pattern analysis, The Secoli type exhibited the least breast cover rate (14.9 cm), while the largest cover rate was shown in Christina and ESMOD types (17.7 cm). It is believed that the difference in pattern drafting causes the difference in the total length of a brassiere. Furthermore, the Secoli, Moda Burgo, and ESMOD brassieres drafted from basic bodice pattern were found to be longer than the Christina and Han Sunmi brassieres attained from direct pattern drafting. Moreover, the darts' volume of upper and lower cups in Christina and Han Sunmi types was similar in shape. The shapes of cradle drafted from basic bodice pattern were a straight line, while those from direct drafting formed a curved shape. In fitting multiple cross sections, the Secoli, Moda Burgo, and ESMOD brassieres had gaps between the brassieres and the body. Among these, the largest number of gaps was observed in the ESMOD type pattern. This study aimed at performing comparative analysis of various brassieres' pattern drafting types as a basic research for developing a brassiere pattern drafting type.

• 한국의류학회지
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• 제38권5호
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• pp.769-782
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• 2014

This study considers the correlation between model pose and clothes in Patrick Demarchelier's fashion photos as well as expression characteristics. The conclusions of the study are as follows. The type of model pose in Patrick Demarchelier's fashion photos can be categorized into five types: maximized type of upper and lower body part, minimized type of upper and lower body part, maximized type of upper body and minimized type of lower body part, minimized type of upper body and maximized type of lower body part, basic type of upper and lower body part. In case of having examined the correlation between body movement and costume, the clothes in the model pose included in the maximization of the body were formed mainstream by silhouette, which was formed by decorative elements or full drapery. In the model poses included in the reduction of the body, the costume tended to expose many parts of the body to provide a simple or structural silhouette form. The costume was expressed in colorful form and poses assumed without body movements. The expression characteristics of the model poses in Patrick Demarchelier's fashion photos were sensuality, dynamicity, and simplicity. First, sensuality was expressed as feminine sensuality accompanying an erotic mood by naturally emphasizing a woman's breast or leg by reducing the body. Second, dynamicity provided a vividness to the image as if directly living and moving by highlighting the rhythmic aspect of the body. Simplicity aroused the effect of paying attention to clothes or other incidental elements rather than the image expressed by the body of a model by excluding body movement.

• Asian Pacific Journal of Cancer Prevention
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• 제15권18호
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• pp.7533-7537
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• 2014

Background: Breast cancer (BC) is the most frequent cancer type, and the leading cause of death from cancer among women in Israel. The Bedouin-Arab (BA) population in southern Israel is characterized by a high rate of consanguinity, common hereditary disorders, and transition from a semi-nomadic, traditional society to a more sedentary and urbanized society. In this hospital-based study, the demographic and the clinicopathological characteristics of BC in BA were compared with Jewish patients. Materials and Methods: 85 BA patients treated at the Soroka Medical Center, Beer Sheba, during the years 2004-2012, were studied and compared with 180 consecutive Jewish patients treated during the year 2007. Clinicopathological features compared included age, menopausal state, number of births, a history of BC in first-degree relatives, tumor size (T), extent of lymph-node involvement (N), distant metastases (M), stage, grade, estrogen and progesterone receptor (ER/PR), and Her2 status. Types of treatment, relapse rate and site, as well as outcome were also studied. Cox's regression models were applied for studying disease-free, and overall survival. Results: Compared with Jewish patients, BA patients were younger (average age $49{\pm}12$ yrs vs $59{\pm}13$, p<0.001), had a lower rate of BC in first-degree relatives (p<0.001), and a larger number of births ($6{\pm}4.2$ vs $2.5{\pm}1.9$, p<0.001). BA patients had larger tumors (p=0.02), more extensive lymph-node involvement (p=0.002), and more advanced stage (p=0.003). Grade, ER, PR, and Her2 status were similar in the two ethnic groups. Relapse type was most commonly systemic in BA patients (p=0.05), and loco-regional in Jewish patients (p=0.02). Median survival was 63, and 35 months for Jewish and BA patients, respectively (log-rank test, p=0.02). In Cox multivariate analysis, stage and PR status (HR-0.14, p<0.0001; HR-3.11, p=0.046), but not ethnicity, influenced overall survival. Conclusions: BC presents a decade earlier, and with more advanced disease in BA compared with Jewish patients. Biologic parameters including grade, ER, PR, and Her2 status were similar in both groups. Although prognosis was worse in BA than in Jewish patients, it was affected only by stage and PR status, but not by ethnicity.

• Asian Pacific Journal of Cancer Prevention
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• 제16권1호
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• pp.133-137
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• 2015

Background: Cancer is a major public health problem and the leading cause of mortality in both males and females in developed and developing countries. The incidence of cancer is gender dependent. Among Iranians, it is the third cause of death. Materials and Methods: The information recorded in the files of all patients (7,695 individuals) pathologically diagnosed with cancer in Imam Reza referral hospital of Kermanshah University of Medical Sciences during the four year period of 2006-2009 were reviewed and analyzed using SPSS statistical software package version 16.0. Results: Around 61.6% of reported cancer cases were males and 38.4% were females. The most prevalent reported malignant tumors occurred at the age group of 70-79 years in males and in females these tumors were presented in the ages of 60-69 years. The most prevalent cancers among studied patients were gastrointestinal (GI) cancers with a frequency of 22.9% [gastric 10.7%, colorectal 6.9%, and esophageal 6%]. The second, third and forth prevalent cancers were blood at 16.4%, lung 13.5% and bladder 12.8%, respectively. In males the cancers of GI (25.6%) were the most prevalent followed in order of frequency by bladder (18%), blood (17.6%), lung (17.4%) and prostate (6.8%). In females the most frequent recorded cancer was breast (24.1%) followed in order of frequency by GI (20.5%), blood (14.4%), lung (7.3%), uterus (6.2%) and ovary (5.1%). Breast cancer was the most prevalent cancer (27%) in the age group of 40-49 years. Conclusions: The present study provides frequency data for various types of cancers in both males and females from a referral hospital of Kermanshah that are comparable with some reports from other areas of the country.