• Biomolecules & Therapeutics
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• v.30 no.4
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• pp.368-379
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• 2022

Hyaluronic acid (HA), a ligand of CD44, accumulates in some types of tumors and is responsible for tumor progression. The nuclear factor erythroid 2-like 2 (NRF2) regulates cytoprotective genes and drug transporters, which promotes therapy resistance in tumors. Previously, we showed that high levels of CD44 are associated with NRF2 activation in cancer stem like-cells. Herein, we demonstrate that HA production was increased in doxorubicin-resistant breast cancer MCF7 cells (MCF7-DR) via the upregulation of HA synthase-2 (HAS2). HA incubation increased NRF2, aldo-keto reductase 1C1 (AKR1C1), and multidrug resistance gene 1 (MDR1) levels. Silencing of HAS2 or CD44 suppressed NRF2 signaling in MCF7-DR, which was accompanied by increased doxorubicin sensitivity. The treatment with a HAS2 inhibitor, 4-methylumbelliferone (4-MU), decreased NRF2, AKR1C1, and MDR1 levels in MCF7-DR. Subsequently, 4-MU treatment inhibited sphere formation and doxorubicin resistance in MCF7-DR. The Cancer Genome Atlas (TCGA) data analysis across 32 types of tumors indicates the amplification of HAS2 gene is a common genetic alteration and is negatively correlated with the overall survival rate. In addition, high HAS2 mRNA levels are associated with increased NRF2 signaling and poor clinical outcome in breast cancer patients. Collectively, these indicate that HAS2 elevation contributes to chemoresistance and sphere formation capacity of drug-resistant MCF7 cells by activating CD44/NRF2 signaling, suggesting a potential benefit of HAS2 inhibition.

• Korean Journal of Human Ecology
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• v.7 no.1
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• pp.147-165
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• 1998

The object of this study was to help designing of well-fit and comfortable brassieres for the elementary school girls through the survey on actual condition of wearing brassieres. The subjects of investigation for this study was the elementary school girls in the province of Jeonbuk and Taejeon city. The conclusion of this study was as follows; The 40.2% of the total subjects were wearing brassieres like the 63.3% of the fourth, the 85.4% of the fifth, and the 89.7% of the sixth grade students. The main reason of non wearing brassieres was for the underdeveloped breast, and also that of wearing brassieres was for the good shape of the breast. The main types of brassieres were ranked "Tank Top type", "Mold type", and "Adolescent girl-Bra". They had started to wear brassieres by the recommendation of adults who were their mother or teachers, and usually wearing brassieres all day. They usually purchased brassieres "with mother together" or "only by their mother". The standard of choosing brassieres was also ranked by FASHION, CONVENIENCE, SIZE, TOUCH, and SWEAT ABSORPTION. The total score of satisfaction for wearing brassieres was showed "Average score" and the score higher in Jeonju and Taejeon than in Kunsan. The higher grade and fatter was showed decreasing the score of satisfaction. The higher grade became, the more various for the size and preferable a pure cotton fabric for brassieres. The favorite types of brassieres were "Sport Bra" and "Volume-up Bra". They usually purchased a little larger size than their original size of that.

• Journal of the Korean Society of Costume
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• v.56 no.2 s.101
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• pp.101-111
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• 2006

The purpose of this research is to define body shapes of Plus-sized women at ages between 21 and 69 whose satisfied the Plus-sized judgment criteria took part in this study. This research also classifies different body types, and provides basic data for designing prototypes according to each body type. Based on factor analysis of the measured data, nine key factors are grouped. And four different body types are classified based on the cluster analysis using factor marks. Type 1 refers to those who are tall and characterized by 'Y' body shape when looked from the front. Looking from the side, this type is comparatively balanced obese type which has flat breast and abdomen, and which has a jutting back and buttocks. Type 2 refers to those who are the shortest of all the obese with 'X' front. This type is Sway-back shape which has jutting back and abdomen but flat buttocks when looked from the side. Type 3 is characterized by 'H' body shape when looked from the front. This type is Pway-back shape which has flat back, abdomen and buttocks when looked from the side. The prominent breast part of this type is the most outstanding figure. Type 4 is characterized by 'X' when looked from the front. This type has a jutting waist and prominent buttocks when looked from the side.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.11
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• pp.6459-6463
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• 2013

We investigated the cancer screening rates for five types of cancer (stomach, liver, colorectal, breast, and cervix uteri) using data from the Korean National Cancer Screening Survey (KNCSS), which is a nationwide, annual cross-sectional survey. The eligible study population included cancer-free men 40 years of age and older and women 30 years of age and older. The lifetime screening rate and screening rate with recommendation were calculated. The lifetime screening rates for gastric, liver, colorectal, breast, and cervical cancers were 77.9%, 69.9%, 65.8%, 82.9%, and 77.1%, respectively. The screening rates with recommendation were 70.9%, 21.5%, 44.7%, 70.9%, and 67.9%, respectively. The most common reason for all types of cancer was "no symptoms", followed by "lack of time" and "fear of the examination procedure". Efforts to facilitate participation in liver and colorectal cancer screening among Korean men and women are needed.

• Journal of the Korean Society of Costume
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• v.50 no.3
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• pp.73-86
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• 2000

This study is to develop the well-fit brassieres by wearing test of available brassieres for girls . The 11 elementary school girls aged 12 participated in the wearing test. The test procedure consisted of a rating on fit and performance according to brassiere types, a try on test of 3 types of brassiere and a sensory test on fit. The results of this study are as follows ; 1. The results of fit rating on different brassieres. Compared among brassiere types, tank top type proved the most effective, from a viewpoint of wearing effects. All types of brassiere performed well in bust up effect. Especially tank top type brassiere showed the best of them. 2. The results of the sensory test and comparative test. With regard to wear comfort, most of the subject assessed tank top brassiere to be the most comfortable . As for freedom of movement, it is disclosed that the subjects prefer tank top brassiere. As a result, brassiere for girls strongly require size adjustment, physical and psychological comfort through full overage of breast area.

• Proceedings of the ESK Conference
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• 1997.10a
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• pp.72-96
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• 1997

To investigate the difference of sweating reaction on somato types. We measured total sweat rate, locl sweat rate, skin temperature, physiological reactions and psyschological reactions at $25{\pm}1^{\circ}C$ and $25{\pm}1^{\circ}C$ under laboratory conditions. Nine healthy adult females were divided into three somato types (slender(3), normal(3) and obese type(3)). The results were as follows; Total sweat rate was highest in obese type, and then comes normal type and slender type in order. Local sweat rate was highest in infrascapular area, and then breast, the back of the hand, upperarm, ant. leg, and ant. thigh in order in all somato types. Mean skin temperature was highest in slender type, and then normal type and obese type in order. Rectal temperature, blood pressure and pulse rate were highest in boese type. Psychological reactions were appeared 'hot' 'humid' 'sweat' as ambient temperature go up. And somato types make little difference in psychological reactions.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.22
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• pp.9631-9634
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• 2014

Background: : In 2012, the breast cancer estimate worldwide stood at 1.67 million new cases, these accounting for 25% of all types of cancer diagnosed in women. For 2014, 57,120 new cases are expected, with a risk estimated at 56.1 cases for every 100,000 women. The objective of this study was to analyze the satisfaction regarding the use of external breast prostheses by women undergoing mastectomy. Materials and Methods: This cross-sectional study was conducted with 76 women who used an external breast prosthesis (EBP), registered in the services of the Cuiaba Center for Comprehensive Rehabilitation, Mato Grosso, Brazil, from 2009 to 2012. Data were collected from the records of women who had requested the opening of a process of external breast prosthesis concession. Results: Satisfaction with the EBP was identified in 56.6% of the women. Those satisfied with the EBP reported that its weight was not annoying (p<0.01). Although the women felt body sensations of stitches, pains, pulling, dormancy and phantom limb, they are satisfied with the EBP. The variable related to the displacement of the breast prosthesis during activity of everyday life has demonstrated that even though the women have reported the possibility of displacements, they are satisfied with the EBP. The satisfaction with the use of external breast prosthesis did not affect the sexuality of the women with mastectomy. Conclusions: Learning the specificities of the EBP, taking into consideration the satisfaction of its use, allows the rehabilitation team, by listening to their clientele more attentively, following up this woman throughout her life journey, supporting and guiding the best way of use, with an eye to her personal, emotional and social life, as well as to her self-esteem.

• The Korean Journal of Cytopathology
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• v.9 no.2
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• pp.221-225
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• 1998

Malignant tumors of the breast with stromal multinucleated giant cells are rare entity of uncertain clinical significance. There have been few reports on the fine needle aspiration cytologic(FNAC) findings about these rare tumors. We report a FNAC case of invasive mammary carcinoma with osteoclast-like giant cells not only for its rare occurrence but in particular for its distinctive cytologic picture on aspirated material. The patient was a 40-year-old woman who presented with a right breast mass for one month. Mammography showed a well-demarcated rounded mass density without calcification. The aspirates of FNAC were highly cellular and two main cell types were seen; malignant epithelial cells and osteoclast-like multinucleated giant cells. The carcinoma cells occurred singly or arranged in loose clusters with ill-defined cytoplasm, oval nuclei, coarse chromatin and small but distinct nucleoli. The multinucleated giant cells showed variable number of nuclei with prominent nucleoli and abundant dense oxyphilic cytoplasm. The immunocytochemical studies suggested that osteoclast-like giant cells were not of epithelial origin, but rather of histlocytic origin.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.12
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• pp.4745-4751
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• 2014

Oxidative stress is caused by an imbalance in the redox status of the body. In such a state, increase of free radicals in the body can lead to tissue damage. One of the most important species of free radicals is reactive oxygen species (ROS) produced by various metabolic pathways, including aerobic metabolism in the mitochondrial respiratory chain. It plays a critical role in the initiation and progression of various types of cancers. ROS affects different signaling pathways, including growth factors and mitogenic pathways, and controls many cellular processes, including cell proliferation, and thus stimulates the uncontrolled growth of cells which encourages the development of tumors and begins the process of carcinogenesis. Increased oxidative stress caused by reactive species can reduce the body's antioxidant defense against angiogenesis and metastasis in cancer cells. These processes are main factors in the development of cancer. Bimolecular reactions cause free radicals in which create such compounds as malondialdehyde (MDA) and hydroxyguanosine. These substances can be used as indicators of cancer. In this review, free radicals as oxidizing agents, antioxidants as the immune system, and the role of oxidative stress in cancer, particularly breast cancer, have been investigated in the hope that better identification of the factors involved in the occurrence and spread of cancer will improve the identification of treatment goals.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.3
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• pp.2013-2017
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• 2013

Background: To compare the effects of two adjuvant chemotherapy regimens, anthracycline-based and cyclophosphamide, methotrexate, fluorourical (CMF) on disease free survival for breast cancer patients in the Eastern Mediterranean region and Asia. Methods: In a systematic review with a multivariate mixed model meta-analysis, the reported survival proportion at multiple time points in different studies were combined. Our data sources were studies linking the two chemotherapy regimens on an adjuvant basis with disease free survival published in English and Persian in the Eastern Mediterranean region and Asia. All survival curves were generated with Graphdigitizer software. Results: 14 retrospective cohort studies were located from electronic databases. We analyzed data for 1,086 patients who received anthracycline-based treatment and 1,109 given CMF treatment. For determination of survival proportions and time we usesb the transformation Ln (-Ln(S)) and Ln (time) to make precise estimations and then fit the model. All analyses were carried out with STATA software. Conclusions: Our findings showed a significant efficacy of anthracycline-based adjuvant therapy regarding disease free survival of breast cancer. As a limitation in this meta-analysis we used studies with different types of anthracycline-based regimens.