• 대한방사선기술학회지:방사선기술과학
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• 제35권4호
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• pp.293-298
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• 2012

디지털 유방촬영술은 유방의 두께 및 유선조직의 밀도에 따라 노출조건이 자동으로 이루어지는 자동노출제어장치를 사용하고 있는데 이는 피폭선량을 증가시키는 원인이 되기도 한다. 이 연구에서는 디지털 유방확대촬영술에서 영상의 질을 유지하며 불필요한 방사선 피폭을 줄이기 위한 최적의 방사선량 촬영조건을 알아보았다. 자동노출방식을 사용할 경우 가장 좋은 영상화질을 얻을 수 있었으나 평균유선선량 역시 가장 높았다. 수동노출방식의 경우 자동노출방식의 55 % 정도의 mAs 값만으로도 기준 팬텀영상 점수와 신호대잡음비를 얻을 수 있으며 평균유선선량은 55 % 이하로 줄일 수 있었다. 위와 같은 결과를 참고로 하면 디지털 유방확대촬영 시 자동노출방식보다는 수동노출방식을 이용함으로써 불필요한 환자의 피폭선량을 줄일 수 있을 것이라 생각된다.

• 한국환경복원기술학회지
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• 제11권3호
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• pp.129-138
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• 2008

This study was carried out to examine the growth condition of Chionanthus retusa, roadside tree in Cheongyechon (CGC) and to investigate the relationship soil characteristics and tree vitality and chlorophyll contents of it. Growth condition of tree (condition of flower, leaves and branch, % of flowering, height, diameter at breast height, width, vitality and chlorophyll contents) and physiochemical relation item (pH, organic matter, K, Mg, Na, Ca, P) were investigated. The result are as follows : 1. The growth condition of flower, leaves and branch in the left side of CGC is better than the right side since the quantity of sunshine of left side of CGC is much more than the right side. 2. The average pH was alkaline. P and organic contents were much lower than the standards. 3. Tree vitality and chlorophyll contents were bad where were high user density and high buildings, such as 1, 2 area near Jong-gak and jongro 3 ga. Among the physiochemical factors of soil which affect tree vitality, K and P were found to be the main factors. Therefore, in order to improve the growth environment of roadside tree in CGC, it is needed to do periodical soil fertilizing and improve physical characteristics of soil such as, permeability and porosity by soil conditioner.

• 한국한의학연구원논문집
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• 제4권1호통권4호
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• pp.129-138
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• 1998

Angiogenesis, the formation of new blood vessels, is considered to be involved in many pathological symptoms such as diabetic retinopathy, arthritis, inflammation and solid tumour. In particular, it is thought that angiogenesis is critical for development and growth of solid tumour. Recent study shows that there is a highly significant association of microvessel density with overall survival and relapse-free survival in patients with breast tumour In this study, the inhibition effect of angiogenesis of traditional herbs used for the treatment of cancer was examined. It was found out that the extract of Agaricus blazei by boiling water is a possible inhibitor of angiogenesis. It inhibited normal developmental angiogenesis In the chorioallantoic membrane of chick embryos and also inhibited capillary-like tube formation by endotherial cells on matrigel in vitro. These results suggest that Agaricus blazei can be a potent angiogenesis inhibitor.

• 한국조경학회지
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• 제23권2호
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• pp.148-156
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• 1995

This study was conducted to investigate the actual vegetation and plant community structure of the urban forest in Kwangju Metropolitan City. Thirty eight plots in the urban forest were set up by the clumped sampling method. The degree of green naturality, 6 that is artifical planting area covered 10.9% in Kwangju Metropolitan City and Pinus densiflora community covered 48.7% of the actual vegetations of urban forest. Canopy height, Diameter of breast height (DBH) and No. of species in urban forest were 13.5m, 21cm and 24 species, respectively. The soil conditions and community structure of the urban forest were differenced by location of urban and suburban area. The plant communities divided into six groups which were Quercus acutissima community, Q. acutissima-Robinia pseudo-acacia community, Pinus rigida Community, P. rigida-P. densiflora community, P. densifrora-Q. acutissima community and Q, serrata-P. densiflora community. Successional series of the urban forest in the surveyed area were proceeding from P. dinsiflora to Quercus species. The species diversity of plant were high in natural plant community but low in artificial plant community. Tree density in the canopy layer varied from 600ea/ha to 2,800ea/ha.

• 한국수산과학회지
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• 제32권4호
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• pp.507-511
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• 1999

The pharmacological effects of hydrocooked extracts of crucian carp have been investigated. All of the hydrocooked extracts showed the contractile effect on the isolated rat duodenum and decreased to a certain extent the normal blood pressure in anesthetized rat. The hydrocooked extracts also exhibited a dose-dependent relaxation on the isolated rat aorta precontracted with 50 mM KCl. All of these except for RM 60 fraction haying cytotoxic effect against MCF-7 human breast cancer cell showed neither antibacterial activity nor antitumor activity. In addition, we found that although body weight gain in the hydrocooked extracts treated group were all reduced significantly compared to control group, there were no significant changes in the hematological parameters, except that the levels of high-density lipoprotein was significantly increased. These results suggest that the hydrocooked extracts of crucian carp may contain a variety of bioactive materials.

• Journal of Microbiology and Biotechnology
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• 제31권9호
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• pp.1281-1287
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• 2021

Clinical and preclinical studies have reported that Lactobacillus gasseri BNR17, a probiotic bacterial strain isolated from human breast milk, reduces body weight and white adipose tissue volume. In order to further explore the actions of L. gasseri BNR17, we investigated the anti-menopausal effects of L. gasseri BNR17 in an ovariectomized (OVX) rat model. The serum alanine aminotransferase levels of the rats in the OVX-BNR17 group were lower than those of the rats in the OVX-vehicle only (OVX-Veh) group. Upon administration of L. gasseri BNR17 after ovariectomy, calcitonin and Serotonin 2A levels increased significantly, whereas serum osteocalcin levels showed a decreasing tendency. Compared to the rats in the OVX-Veh group, those in the OVX-BNR17 group showed lower urine deoxypyridinoline levels, lower pain sensitivity, and improved vaginal cornification. Furthermore, L. gasseri BNR17 administration increased bone mineral density in the rats with OVX-induced femoral bone loss. These results suggest that L. gasseri BNR17 administration could alleviate menopausal symptoms, indicating that this bacterium could be a good functional probiotic for managing the health of older women.

• 통합자연과학논문집
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• 제15권4호
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• pp.145-152
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• 2022

Colon rectal cancer is one of the frequently diagnosed cancers worldwide. In recent times the drug discovery for colon cancer is challenging because of their speedy metastasis and morality of these patients. C-jun N-terminal kinase signaling pathway controls the cell cycle survival and apoptosis. Evidence has shown that JNK1 promotes the tumor progression in various types of cancers like colon cancer, breast cancer and lung cancer. Recent study has shown that inhibiting, JNK1 pathway is identified as one of the important cascades in drug discovery. One of the recent approaches in the field of drug discovery is drug repurposing. In drug repurposing approach we have virtually screened ChEMBL dataset against JNK1 protein and their interactions have been studied through Molecular docking. Cross docking was performed with the top compounds to be more specific with JNK1 comparing the affinity with JNK2 and JNK3.The drugs which exhibited higher binding were subjected to Conceptual - Density functional theory. The results showed mainly Entrectinib and Exatecan showed better binding to the target.

• 한국환경생태학회지
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• 제25권2호
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• pp.132-144
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• 2011

본 연구는 덕유산국립공원의 향적봉지역(A)과 백련사지역(B) 및 안성지역(C)을 대상으로 2010년 4월부터 9월까지 산림환경과 조류군집 특성을 조사하였다. 향적봉지역은 신갈나무 등의 낙엽활엽수림과 주목, 구상나무 등의 아고산대침엽수림과 원추리, 철쭉 등의 초지가 형성되어있고, 백련사지역과 안성지역은 대부분 낙엽활엽수림으로 구성되고 계곡부는 들메나무 군락이 형성되어 있다. 교목의 흉고직경분포는 11~20cm 경급이 가장 많았으며, 30cm이상 대경목 비율은 백련사지역에서 가장 높았고, 향적봉지역이 가장 낮았다. 또한 엽층별 피도량은 향적봉지역은 하층부 피도량이 매우 높았고, 백련사지역은 8~12m의 중층부 피도량이 높았으며, 안성지역은 18m이상 상층부 피도량이 높게 나타났다. 덕유산국립공원에서 조사기간동안 관찰된 조류는 총 53종이었다. 각 지역별 종수와 밀도는 각각 향적봉지역이 25종 45.20 Ind./km, 백련사지역이 50종 58.63 Ind./km, 안성지역 35종 66.89 Ind./km로 백련사지역의 종수가 가장 많았고, 밀도는 안성지역에서 높았다. 우점종은 향적봉지역이 휘파람새를 비롯한 초지와 관목에 서식하는 종들이 우점하였고, 백련사지역과 안성지역은 오목눈이를 비롯한 수관층에 서식하는 종들이 우점하였다. 길드 구조는 모든 지역에서 관목층 영소길드와 채이길드 종이 높게 나타났고, 수동 영소길드와 공중 채이길드 종의 비율이 낮게 나타났다. 이는 흉고직경 30cm이상의 대경목 비율이 낮아 수동 영소길드 종들의 둥지목이 부족한 결과로 생각된다.

• 한국산림과학회지
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• 제102권4호
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• pp.543-549
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• 2013

경상남도 진주지역의 유사한 입지환경에서 생육한 평균 임령 35년생, 51년생, 62년생 곰솔임분을 대상으로 각 연령별 8본의 표본목을 벌채하여 바이오매스 추정을 위한 상대생장식과 줄기밀도 및 현존량 확장계수를 개발하였다. 흉고직경을 독립변수로 하고 각 부위별 건중량을 종속변수로 하는 상대생장식은 62년생 임분의 잎 바이오매스를 제외하고 유의성이 인정되었으며(P<0.05), 결정계수($R^2$)의 값도 0.55-0.98 정도로 나타났다. 또한 각 임분 연령에 대한 상대생장식(Age-specific allometric equations)의 회귀계수(slope)에 유의적인 차가 없어(P>0.05), 35년 이상 곰솔임분의 경우 임분 연령에 관계없이 일괄 상대생장식(Generalized allometric equations)을 이용하여 바이오매스 추정이 가능한 것으로 나타났다. 줄기밀도와 현존량 확장계수도 임분 연령 간 유의적인 차이가 없었으며 줄기밀도는 $0.45-0.51gcm^{-3}$, 현존량 확장계수는 1.32-1.38 정도의 범위에 분포하였다. 본 연구결과에 따르면 35년 이상 성숙한 곰솔임분의 바이오매스 추정을 위한 상대생장식, 줄기밀도, 현존량 확장계수는 임분 연령의 영향이 크지 않는 것으로 나타났다.

• Asian-Australasian Journal of Animal Sciences
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• 제26권5호
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• pp.675-682
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• 2013

One hundred and sixty Taiwan country chickens (d-old chicks) were randomly assigned into four groups with four replicates and equal sex. Basal diets were supplemented with 0, 0.5, 1 and 2% of Bazhen powder, a traditional Chinese herbal medicine complex. The study was conducted for 14 wks. Experimental results indicated that Bazhen supplement did not influence feed intake, body weight gain and feed:gain ratio. Compared with control group, the percentage of serum HDL (high-density lipoprotein) linearly increased (p<0.03) and that of VLDL+LDL (very low-density+low-density lipoprotein) linearly decreased (p<0.03) in Bazhen supplemented groups, that 2% Bazhen was significantly different with control group (p<0.05). Chickens fed diets containing 2% Bazhen displayed reduced (p<0.05) serum GOT (glutamic-oxaloacetic transaminase) levels. The IgG, ${\gamma}$-globulin levels and PHA (phytohemagglutinin) skin challenge results in 1% Bazhan supplemented group were higher (p<0.05) than in the control group, the SRBC (sheep red blood cell) and ND (newcastle disease) titers in Bazhen supplemented groups were linear higher (p<0.05) than in the control group. The liver catalase activity and the capacity of scavenging DPPH (${\alpha}$-${\alpha}$-diphenyl-${\beta}$-picrylhydrazyl) radical were linearly increased (p<0.03) in Bazhen supplemented groups, and the 1 and 2% groups were different from the control group (p<0.05). Liver TBARS (thiobarbituric acid-reactive substances) levels in all Bazhen supplemented groups and total glutathione level in the 2% group were reduced (p<0.05) compared to the control group and displayed a linear response (p<0.05). The TBA (thiobarbituric acid) and pH value of the breast muscle after 24 h post-mortem in the Bazhen supplemented groups was linear lower (p<0.05) than in the control group. Results from this study demonstrated that Bazhen supplement in chicken had several beneficial effects, including increased SRBC and ND titers, HDL and IgG, ${\gamma}$-globulin levels, PHA skin challenge result, decreased VLDL+LDL and GOT levels, and displayed antioxidation effects in serum and carcass meat parameters.