• Journal of Korean Neurosurgical Society
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• 제66권5호
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• pp.511-524
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• 2023

Objective : This animal model aimed to compare the rat group that received brain irradiation and did not receive additional treatment (only saline) and the rat group that underwent brain irradiation and received Granulocyte colony stimulating factor (G-CSF) treatment. In addition, the effects of G-CSF on brain functions were examined by magnetic resonance (MR) imaging and histopathologically. Methods : This study used 24 female Wistar albino rats. Drug administration (saline or G-CSF) was started at the beginning of the study and continued for 15 days after whole-brain radiotherapy (WBRT). WBRT was given on day 7 of the start of the study. At the end of 15 days, the behavioral tests, including the three-chamber sociability test, open field test, and passive avoidance learning test, were done. After the behavioral test, the animals performed the MR spectroscopy procedure. At the end of the study, cervical dislocation was applied to all animals. Results : G-CSF treatment positively affected the results of the three-chamber sociability test, open-space test and passive avoidance learning test, cornu Ammonis (CA) 1, CA3, and Purkinje neuron counts, and the brain levels of brain-derived neurotrophic factor and postsynaptic density protein-95. However, G-CSF treatment reduced the glial fibrillary acidic protein immunostaining index and brain levels of malondialdehyde, tumor necrosis factor-alpha, nuclear factor kappa-B, and lactate. In addition, on MR spectroscopy, G-CSF had a reversible effect on brain lactate levels. Conclusion : In this first designed brain irradiation animal model, which evaluated G-CSF effects, we observed that G-CSF had reparative, neuroprotective and anti-neurodegenerative effects and had increased neurotrophic factor expression, neuronal counts, and morphology changes. In addition, G-CSF had a proven lactate-lowering effect in MR spectroscopy and brain materials.

• Annals of Rehabilitation Medicine
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• 제42권6호
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• pp.777-787
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• 2018

Objective To examine the long-term effects of the low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) combined with task-specific training on paretic hand function following subacute stroke. Methods Sixteen participants were randomly selected and grouped into two: the experimental group (real LF-rTMS) and the control group (sham LF-rTMS). All the 16 participants were then taken through a 1-hour task-specific training of the paretic hand. The corticospinal excitability (motor evoke potential [MEP] amplitude) of the non-lesioned hemisphere, and the paretic hand performance (Wolf Motor Function Test total movement time [WMFT-TMT]) were evaluated at baseline, after the LF-rTMS, immediately after task-specific training, 1 and 2 weeks after the training. Results Groups comparisons showed a significant difference in the MEP after LF-rTMS and after the training. Compared to the baseline, the MEP of the experimental group significantly decreased after LF-rTMS and after the training and that effect was maintained for 2 weeks. Group comparisons showed significant difference in WMFT-TMT after the training. Only in the experimental group, the WMFT-TMT of the can lifting item significantly reduced compared to the baseline and the effect was sustained for 2 weeks. Conclusion The results of this study established that the improvement in paretic hand after task-specific training was enhanced by LF-rTMS and it persisted for at least 2 weeks.

• 한국산학기술학회논문지
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• 제10권10호
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• pp.2952-2958
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• 2009

본 연구는 2008년 7월부터 2008년 12월까지 I시 P뇌훈련센타에 정서적 성향이나 학습능력 향상을 위하여 방문한 내담자 48명(실험군 24명, 대조군 24명)의 뇌파를 검사하여 뇌파 조절 훈련 전과 훈련 후의 스트레스저항능력의 변화와 스트레스저항능력이 학업성취도에 미치는 영향을 보고자 하였다. 훈련 전과 후의 스트레스저항능력의 비교는 뇌기능 분석을 통하여 비교하였으며, 학업성취도의 변화를 보기 위하여 5점 척도 설문지를 이용하였다. 연구의 결과로 뇌파 조절 훈련을 적용한 실험군에서 항스트레스지수와 학업성취도에서 유의미한 차이를 보였다. 이는 뇌파 조절 훈련이 초등학생들의 스트레스저항능력을 높여 주었으며 이결과가 학업성취도에 긍정적인 영향을 미쳤다고 본다. 따라서 본 연구 결과는 뇌기능 변화가 학생들의 육체적, 정신적 스트레스나 저항능력 등의 객관적 지표로서 활용될 수 있는 가능성을 제시한 점에서 의의가 있으며, 이에 대한 경험적 증거의 축적을 위한 후속연구가 필요하다고 본다.

• Journal of Korean Neurosurgical Society
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• 제58권6호
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• pp.508-512
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• 2015

Background : Cerebral ischemia is as a result of insufficient cerebral blood flow for cerebral metabolic functions. Resveratrol is a natural phytoalexin that can be extracted from grape's skin and had potent role in treating the cerebral ischemia. Apoptosis, a genetically programmed cellular event which occurs after ischemia and leads to biochemical and morphological changes in cells. There are some useful markers for apoptosis like Bcl-2, bax, and p53. The last reports, researchers verify the apoptosis with early markers like Annexin V. Methods : We preferred in this experimental study a model of global cerebral infarction which was induced by bilateral common carotid artery occlusion method. Rats were randomly divided into 4 groups : sham, ischemia-reperfusion (I/R), I/R plus 20 mg/kg resveratrol and I/R plus 40 mg/kg resveratrol. Statistical analysis was performed using Sigmastat 3.5 ve IBM SPSS Statistics 20. We considered a result significant when p<0.001. Results : After administration of resveratrol, Bcl-2 and Annexin levels were significantly increased (p<0.001). Depending on the dose of resveratrol, Bcl2 levels increased, p53 levels decreased but Annexin V did not effected. P53 levels were significantly increased in ishemia group, so apoptosis is higher compared to other groups. Conclusion : In the acute period, Annexin V levels misleading us because the apoptotic cell counts could not reach a certain level. Therefore we should support our results with bcl-2 and p53.

• 동의신경정신과학회지
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• 제30권1호
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• pp.13-21
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• 2019

Objectives: To investigate the research trends of qigong interventions to make influence on performance enhancement. Methods: Korean databases were searched for papers related to studies of qigong interventions to assist subjects perform better. Results: Twelve articles published in Korean Journals from 2000 to 2017 were reviewed. Among the retrieved papers, eight were applied with breathing exercises, including Dan-jeon breathing training, one applied with brain breathing meditation with DoIn exercise, one applied with qigong meditation, one applied with qi-training, and one applied with brain breathing training. RoBANS was used for assessment. The quality of selected articles was generally low. 10 of the 12 articles on qigong reported that experimental group showed statistically significant increase of performance enhancement both directly and indirectly. Conclusions: Reviewing 12 articles, this study established that qigong interventions might be beneficial for enhancing performance especially in sports. However, more scientifically designed study on qigong therapy are needed to prove the efficacy and effectiveness.

• 대한치매학회지
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• 제21권3호
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• pp.93-102
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• 2022

Background and Purpose: The effects of high-intensity interval training (HIIT) interventions on functional brain changes in older adults remain unclear. This preliminary study aimed to explore the effect of physical exercise intervention (PEI), including HIIT, on cognitive function, physical performance, and electroencephalogram patterns in Korean elderly people. Methods: We enrolled six non-dementia participants aged >65 years from a community health center. PEI was conducted at the community health center for 4 weeks, three times/week, and 50 min/day. PEI, including HIIT, involved aerobic exercise, resistance training (muscle strength), flexibility, and balance. Wilcoxon signed rank test was used for data analysis. Results: After the PEI, there was improvement in the 30-second sit-to-stand test result (16.2±7.0 times vs. 24.8±5.5 times, p=0.027), 2-minute stationary march result (98.3±27.2 times vs. 143.7±36.9 times, p=0.027), T-wall response time (104.2±55.8 seconds vs.71.0±19.4 seconds, p=0.028), memory score (89.6±21.6 vs. 111.0±19.1, p=0.028), executive function score (33.3±5.3 vs. 37.0±5.1, p=0.046), and total Literacy Independent Cognitive Assessment score (214.6±30.6 vs. 241.6±22.8, p=0.028). Electroencephalography demonstrated that the beta power in the frontal region was increased, while the theta power in the temporal region was decreased (all p<0.05). Conclusions: Our HIIT PEI program effectively improved cognitive function, physical fitness, and electroencephalographic markers in elderly individuals; thus, it could be beneficial for improving functional brain activity in this population.

• 재활치료과학
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• 제5권2호
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• pp.35-47
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• 2016

목적: 본 연구의 목적은 도로 주행 능력을 향상시키기 위한 운전재활의 방법과 효과에 대해 체계적 고찰을 통하여 추후에 있을 운전재활 연구의 방향을 제시하고자 한다. 연구방법: 2014년 12월부터 2015년 1월까지 운전재활에 관한 연구를 CINAHL, Embase, Pubmed, PsycINFO, Riss를 통하여 검색하였다. 선정기준에 따라 최종적으로 15편의 연구를 분석하였으며 주요검색용어로는 "On-road" OR "Driving" AND "Driving rehabilitation"AND "Intervention"을 사용하였다. 결과: 고찰한 연구는 총 15개로 근거 수준은 I, III, V이었다. 연구대상은 뇌졸중 환자(40.0%), 고령 운전자(20.0%), 외상성 뇌손상 환자(20.0%), 후천적 뇌손상 환자(13.3%), 척수환자(6.7%)였으며, 실제 도로 주행 능력을 향상시키기 위한 중재 방법은 시뮬레이터를 이용한 훈련(53.3%), 인지 기술을 훈련(26.6%), 운전을 위한 교육(6.7%), 보조 기기의 적용(6.7%), 운전 연수(6.7%)이었다. 중재 효과는 방법에 따라 차이가 있었지만 시뮬레이터를 이용한 모든 연구에서 중재 후 도로 주행 능력의 유의한 향상을 보고하였다. 결론: 도로 주행 능력을 향상시키기 위한 운전재활은 다양한 방법으로 적용되고 있었다. 특히 시뮬레이터를 이용한 중재는 많은 연구를 통해 효과가 입증되고 있었다. 추후 다양한 연구 대상자와 중재 방법을 통해 도로 주행 능력 향상을 위한 운전재활 연구가 지속적으로 이루어져야 할 것이다.

• 한국전문물리치료학회지
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• 제9권3호
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• pp.67-76
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• 2002

We report the reorganization of motor network resulted from intensive unilateral coordination training and the effect of cross education on the untrained side in patient with traumatic brain injury using functional magnetic resonance imaging (fMRI). A 22 year-old male patient who had suffered from diffuse axonal injury for 58 months showed coordination deficit in the left hand at initial examination. Intensive motor training including complex finger movements and coordination activities using a metronome was introduced to the patient 4 hours per day for a week. FMRI was performed on a 3T ISOL Forte scanner. All functional images were analyzed using SPM-99 software. Hand function was improved after training not only in the trained left hand, but also in the untrained right hand. There was no activation in the right primary motor area (M1) during left hand movement before training whereas robust activation of left M1 was demonstrated by the right hand movement. Profuse activation of bilateral prefrontal lobes was seen during both hand movements before training. After training of left hand, right M1 became prominently activated during the left hand motion. The activation of bilateral prefrontal lobes disappeared after training not only for the left hand movement but also for the right, which clearly demonstrated the effect of cross education. This case report demonstrated the learning-dependent reorganization of the M1 and the effect of cross education.

• 한국산학기술학회논문지
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• 제12권8호
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• pp.3486-3491
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• 2011

본 연구는 2010년 1월부터 2010년 7월까지 B. 뇌훈련 센터에 자기주도학습 능력 향상을 위하여 방문한 내담자 60명(실험군 30명, 대조군 30명)의 뇌파를 검사하여 뉴로피드백 훈련 전과 훈련 후의 뇌 기능과 자기주도학습능력 변화를 보고자 하였다. 자기주도학습 능력에 영향을 미치는 특정한 뇌 기능의 훈련 전후 결과를 시계열 선형분석으로 비교하였다. 연구의 결과로 자기조절지수, 훈련모드, 자기주도학습 능력 설문지에서 실험군의 평균이 상승해 집단 간에 유의미한 차이가 나타났다. 이는 뉴로피드백의 기술을 적용한 뇌 훈련은 자기조절지수와 자기주도학습 능력에 긍정적인 영향을 미친다고 볼 수 있겠다.

• 대한의용생체공학회:의공학회지
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• 제28권4호
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• pp.461-470
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• 2007

Human can learn how to shape their brain electrical activity in a desired direction through continuous feedback of the electroencephalogram (EEG), and this technique is known as Neurofeedback (or EEG biofeedback), which has been used since the late 1960s in clinical applications. In this study, a portable wireless EEG (named wEEG) has been designed and implemented, which consists of a mobile station (a wireless two-channel EEG acquisition device) and a base station (a bridge between mobile station and computer). Moreover, a SensoriMotor Rhythm (SMR) training system was also implemented with the wEEG for enhancing attention with virtual environment. Experiment results based on 16 volunteers' (8 females and 8 males, average age is $27{\pm}4$) were reported in this paper. The results show that the SMR ratio of 87.5% subjects increased about 0.7% in training status than that in the stable status. With the proposed system, many training protocol scan be designed easily and can be done at home in our daily life conveniently. Additionally, the proposed system will be useful for disabled and aged people.