• Journal of Acupuncture Research
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• v.19 no.4
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• pp.132-139
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• 2002

This study was carried to identify whether acupuncture at several meridian points can affect the human anesthesia or not using the EEG mapping. We observe the change in the brain wave patterns obtained by electroencephalogram after acupuncture. 1. It is concluded that the pattern of resting computerized EEG map in intact human is normal and acupunctuation at determined meridian points induced lesser narrow field of alpha activity, more extensive field of ${\delta}$, ${\theta}$ activity, father resulted in marked shift to cerebrofrontal dominance in field of ${\delta}$, ${\theta}$ activity by t-SPM. 2. It seems likely that acupunctuation at experimental meridian points acts on slight anesthesia or hypnosis.

• Journal of Korean Neurosurgical Society
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• v.51 no.2
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• pp.102-104
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• 2012

Although decompressive craniectomy is an effective treatment for various situations of increased intracranial pressure, it may be accompanied by several complications. Paradoxical herniation is known as a rare complication of lumbar puncture in patients with decompressive craniectomy. A 38-year-old man underwent decompressive craniectomy for severe brain swelling. He remained neurologically stable for five weeks, but then showed mental deterioration right after a lumbar puncture which was performed to rule out meningitis. A brain computed tomographic scan revealed a marked midline shift. The patient responded to the Trendelenburg position and intravenous fluids, and he achieved full neurologic recovery after successive cranioplasty. The authors discuss the possible mechanism of this rare case with a review of the literature.

• Journal of Korean Neurosurgical Society
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• v.40 no.1
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• pp.51-53
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• 2006

Decompressive craniectomy is usually performed to relieve raised intracranial pressure[ICP] caused by various intracranial lesions. A 67-year-old man presented with acute subdural hematoma and traumatic intracerebral hematoma. The patient underwent a decompressive craniectomy. Four weeks later, the patient presented with acute neurological deterioration. Brain computed tomographic[CT] scans revealed the marked concavity of the brain at the site of the craniectomy and associated with midline shift which was reversed by cranioplasty. We report an unusual case of cerebral herniation from intracranial hypotension after decompressive craniectomy for a traumatic subdural hematoma. The cranioplasty may be helpful to prevent paradoxial cerebral herniation.

• Journal of Korean Neurosurgical Society
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• v.54 no.1
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• pp.68-70
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• 2013

A 39-year old female presented with chronic spinal subdural hematoma manifesting as low back pain and radiating pain from both legs. Magnetic resonance imaging (MRI) showed spinal subdural hematoma (SDH) extending from L4 to S2 leading to severe central spinal canal stenosis. One day after admission, she complained of nausea and severe headache. Computed tomography of the brain revealed chronic SDH associated with midline shift. Intracranial chronic SDH was evacuated through two burr holes. Back pain and radiating leg pain derived from the spinal SDH diminished about 2 weeks after admission and spinal SDH was completely resolved on MRI obtained 3 months after onset. Physicians should be aware of such a condition and check the possibility of concurrent cranial SDH in patients with spinal SDH, especially with non-traumatic origin.

• Journal of Trauma and Injury
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• v.25 no.4
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• pp.275-277
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• 2012

An eipdural hematoma in an infant is a very rare entity. We report a case of an acute traumatic intracranial epidural hematoma that developed with a lucid interval in a 4-month-old infant after a fall down from a bed. The infant was admitted at the emergency room. The child had initially cried and may have had a decreased level of consciouseness due to brain injury, but then returned to normal level of consciousness for several hours prior to admission. However, the infant had vomited twice after taking milk and then was lethargic. The brain CT revealed a lentiform-shaped huge hematoma on the right parietal area with a midline shift of 8 mm. An osteoplastic craniotomy was performed, and the intracranial epidural hematoma was totally removed. Postoperatively, the infant recovered well and was dischaged.

• YAKHAK HOEJI
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• v.29 no.4
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• pp.223-226
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• 1985

0.1%-Merthiolate solutions were applied to rats with or without sodium selenite. Rat organs were excised under ether anesthesia. Mercury contents in rat tissues were determined by quartz tube combustion gold amalgamation method. Mercury contents were accumulated at about 3-fold in the brain, 143-fold in the kidney, 62-fold in the blood cell, 22-fold in the liver than those of untreated rats respectively, on the 1st day after application of mert iolate for 7 days. On the other hand, the addition of sodium selenite caused a shift in the tissue mercury distribution. Our study showed that simultaneous administration of sodium selenite increased the accumulation of mercury in the brain, but became to decrease it after 9 days, while decreased it in the kidney, but grew to increase it, respectively.

• The Korean Journal of Physiology and Pharmacology
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• v.10 no.5
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• pp.223-229
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• 2006

The emerging concept of the 'neurovascular unit' may enable a powerful paradigm shift for neuroscience. Instead of a pure focus on the 'neurobiology' of disease, an opportunity now exists to return to a more integrative approach. The neurovascular unit emphasizes that signaling between vascular and neuronal compartments comprise the basis for both function and dysfunction in brain. Hence, brain disorders are not just due to death of neurons, but instead manifested as cell signaling perturbations at the neurovascular interface. In this mini-review, we will examine 3 examples of this hypothesis: neurovascular mechanisms involved in the thrombolytic therapy of stroke, the crosstalk between neurogenesis and angiogenesis, and the link between vascular dysfunction and amyloid pathology in Alzheimer's disease. An understanding of cell-cell and cell-matrix signaling at the neurovascular interface may yield new approaches for targeting CNS disorders.

• Journal of the Korean Society of Physical Medicine
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• v.8 no.3
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• pp.351-360
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• 2013

PURPOSE: The purpose of this study was to investigate the effects of observed action gait training on stroke patients. METHODS: 22 subjects were randomized into two groups. The observed action gait training performed that watched a video of normal gait before gait training and the general gait training without watching it. The experimental group(n=11) performed observed action gait training and the control group(n=11) performed general gait training. Both group received gait training for 3 times per week during 8 weeks. RESULTS: The experimental group showed significant differences in the cadence, gait velocity, stride, step, single limb support, double limb support, stride length and step length(p<.05). The control group showed significant differences only in the stride(p<.05). CONCLUSION: The observed action gait training affected coordination and weight shift, as well as symmetry of the body. Plasticity of the brain was facilitated by repetitive visual and sensory stimulation. The observed action gait training promoted the normal gait by watching the normal gait pattern. In conclusion, motor learning through the sensory stimulation promotes brain plasticity that could improve motor function, and observed action gait training indirectly identified stimulated brain activities.

• Journal of Trauma and Injury
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• v.30 no.4
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• pp.140-144
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• 2017

Purpose: The optic nerve sheath diameter (ONSD) measured by ultrasonography is among the indicators of intracranial pressure (ICP) elevation. However, whether ONSD measurement is useful for initial treatment remains controversial. Thus, this study aimed to investigate the relationship between ONSD measured by computed tomography (CT) and ICP in patients with traumatic brain injury (TBI). Methods: A total of 246 patients with severe trauma from January 1, 2015 until December 31, 2015 were included in the study. A total of 179 patients with brain damage with potential for ICP elevation were included in the TBI group. The remaining 67 patients comprised the non-TBI group. A comparison was made between the two groups. Receiver operating characteristic (ROC) curve analysis was performed to determine the accuracy of ONSD when used as a screening test for the TBI group including those with TBI with midline shift (with elevated ICP). Results: The mean injury severity score (ISS) and glasgow coma scale (GCS) of all patients were $24.2{\pm}6.1$ and $5.4{\pm}0.8$, respectively. The mean ONSD of the TBI group ($5.5{\pm}1.0mm$) was higher than that of the non-TBI group ($4.7{\pm}0.6mm$). Some significant differences in age ($55.3{\pm}18.1$ vs. $49.0{\pm}14.8$, p<0.001), GCS ($11.7{\pm}4.1$ versus $13.3{\pm}3.0$, p<0.001), and ONSD ($5.5{\pm}1.0$ vs. $4.7{\pm}0.6$, p<0.001) were observed between the TBI and the non-TBI group. An ROC analysis was used to assess the correlation between TBI and ONSD. Results showed an area under the ROC curve (AUC) value of 0.752. The same analysis was used in the TBI with midline shift group, which showed an AUC of 0.912. Conclusions: An ONSD of >5.5 mm, measured on CT, is a good indicator of ICP elevation. However, since an ONSD is not sensitive enough to detect an increased ICP, it should only be used as one of the parameters in detecting ICP along with other screening tests.

• Molecules and Cells
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• v.25 no.4
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• pp.559-565
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• 2008

Members of the TGA family of basic domain/leucine zipper transcription factors regulate defense genes through physical interaction with NON-EXPRESSOR OF PR1 (NPR1). Of the seven TGA family members, TGA4/octopine synthase (ocs)-element-binding factor 4 (OBF4) is the least understood. Here we present evidence for a novel function of OBF4 as a regulator of flowering. We identified CONSTANS (CO), a positive regulator of floral induction, as an OBF4-interacting protein, in a yeast two-hybrid library screen. OBF4 interacts with the B-box region of CO. The abundance of OBF4 mRNA cycles with a 24 h rhythm under both long-day (LD) and short-day (SD) conditions, with significantly higher levels during the night than during the day. Electrophoretic mobility shift assays revealed that OBF4 binds to the promoter of the FLOWERING LOCUS T (FT) gene, a direct target of CO. We also found that, like CO and FT, an OBF4:GUS construct was prominently expressed in the vascular tissues of leaf, indicating that OBF4 can regulate FT expression through the formation of a protein complex with CO. Taken together, our results suggest that OBF4 may act as a link between defense responses and flowering.