• 디자인학연구
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• 제13권1호
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• pp.237-245
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• 2000

디자이너라면 누구나 디자인의 결과물을 얻어내는 과정의 첫 단계로서 디자인의 컨셉을 만족시킬 수 있는 발상의 단계를 거치게 될 것이다. 그러나 새로움을 요구하는 발상은 누구에게나 노력하는 정도만큼 비례하여 얻어지는 속성을 지니고 있지 않다. 왜냐하면 인간이 노력하여 얻어낼 수 있는 합리적이고 논리적인 사고의 틀 속에는 새로운 것이 존재하지 않기 때문이다. 그러므로 좋은 발상의 핵심은 어떻게 하면 비논리적 사고영역에 자기 자신을 원하는 시간 동안 머물 수 있게 하는가에 있다고 말할 수 있다. 본고에서 제시하고 있는 "결과미리보기"의 사고법은 광고기획서에서 최종 단계에서 제시되고 있는 광고컨셉을 만족시키면서도 최종 단계에서 제시되고 있는 광고컨셉을 만족시키면서도 수평적사고의 영지에 인간의 사고활동을 일정 시간 묶어 둘 수 있는 발상모델이 될수 있다고 생각한다. 뇌기능이론에서, 우뇌나 좌뇌의 활동지수의 높고 낮음이 실제 작품제작에 미치는 영향은 유의할 정도가 아니라는 사실이 연구결과 드러났다.연구결과 드러났다.

• The Korean Journal of Physiology and Pharmacology
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• 제25권4호
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• pp.281-296
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• 2021

The beneficial effects of hypoxic preconditioning are abolished in the diabetes. The present study was designed to investigate the protective effects and mechanisms of repeated episodes of whole body hypoxic preconditioning (WBHP) in db/db mice. The protective effects of preconditioning were explored on diabetes-induced vascular dysfunction, cognitive impairment and ischemia-reperfusion (IR)-induced increase in myocardial injury. Sixteen-week old db/db (diabetic) and C57BL/6 (non-diabetic) mice were employed. There was a significant impairment in cognitive function (Morris Water Maze test), endothelial function (acetylcholine-induced relaxation in aortic rings) and a significant increase in IR-induced heart injury (Langendorff apparatus) in db/db mice. WBHP stimulus was given by exposing mice to four alternate cycles of low (8%) and normal air O₂ for 10 min each. A single episode of WBHP failed to produce protection; however, two and three episodes of WBHP significantly produced beneficial effects on the heart, brain and blood vessels. There was a significant increase in the levels of brain-derived neurotrophic factor (BDNF) and nitric oxide (NO) in response to 3 episodes of WBHP. Moreover, pretreatment with the BDNF receptor, TrkB antagonist (ANA-12) and NO synthase inhibitor (L-NAME) attenuated the protective effects imparted by three episodes of WBHP. These pharmacological agents abolished WBHP-induced restoration of p-GSK-3β/GSK-3β ratio and Nrf2 levels in IR-subjected hearts. It is concluded that repeated episodes of WHBP attenuate cognitive impairment, vascular dysfunction and enhancement in IR-induced myocardial injury in diabetic mice be due to increase in NO and BDNF levels that may eventually activate GSK-3β and Nrf2 signaling pathway to confer protection.

• 한국콘텐츠학회논문지
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• 제13권2호
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• pp.370-377
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• 2013

외상성 뇌손상(TBI)은 외부적 충격에 의해 뇌가 손상되는 것을 의미한다. 이로 인해 주의력, 기억력, 추론력, 집행기능, 화용언어 등이 전반적으로 저하된다. 본 연구에서는 외상성 뇌손상 환자의 인지-화용언어 능력 평가도구(CAPTBI)를 개발한 후, 그 신뢰도 및 타당도를 구축하고, 정상군과 환자군 간 변별에 유용한 인지-화용언어의 하위 영역들이 무엇인지를 분석하였다. 연구 대상은 정상군 226명, TBI 환자군 62명으로 평균 연령은 각각 43.95(${\pm}11.92$), 46.37(${\pm}11.87$)세, 남녀 비율은 각각 110:116, 48:14였다. CAPTBI는 내적일관성 신뢰도와 검사-재검사 신뢰도가 높았고, 내적 구성타당도와 공인타당도가 입증되었다. 또한, 두 집단은 CAPTBI 총점 및 9개 하위 영역 모두에서 유의미한 차이를 보여 CAPTBI가 집단 간 변별에 유용한 것으로 입증되었다. 두 집단 간 변별에 기여하는 하위 영역은 조직화 능력, 기억력, 집행기능, 지남력, 문제해결력, 화용언어, 추론력, 주의력, 시지각력 순으로 높았다. CAPTBI의 판별기능 적중률은 95.5%로 전체 집단 사례 중 정상군의 97.3%, 환자군의 88.7%를 정확히 판별하였다. 이에 따라, CAPTBI는 TBI 환자의 인지-화용언어 능력 평가도구로서 신뢰도와 타당도가 높고, 정상군과 환자군 간 변별에 유용한 도구임을 확인하였다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제36권5호
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• pp.386-391
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• 2010

Introduction: Bone resorption is a unique function of osteoclasts. Osteoclasts are a specialized macrophage polykaryon whose differentiation is regulated principally by macrophage colony-stimulating factors, receptor activator of nuclear factor ${\kappa}B$ ligand (RANK) ligand, osteoprotegerin (OPG), and interleukins (IL). Reflecting the integrin-mediated signals, osteoclasts develop a specialized cytoskeleton that allows it to establish an isolated micro-environment between itself and the bone, wherein matrix degradation occurs by a process involving proton transport. The levels of IL-1, IL-6, OPG, and prostaglandin $E_2$ ($PGE_2$) expression were evaluated to study the correlations between dental implant teeth and the adjacent teeth. Materials and Methods: The exudate of the gingival crevice acquired from dental implants, adjacent teeth, opposite teeth and contralateral teeth of 24 patients. Results: 1. The levels of IL-1, IL-6, OPG and $PGE_2$ expression in dental implant teeth were higher than those of the contralateral teeth. 2. IL-1 revealed a higher expression level in the adjacent teeth than in dental implant teeth. 3. The dental implant teeth and adjacent teeth did not show a remarkable difference in the level of IL-1 expression. 4. All the other cytokines were strongly expressed in the dental implant compared to the adjacent teeth. Conclusion: These results suggest that there might be close correlation between dental implant teeth and adjacent teeth in terms of the expressions of cytokines that affect the development and regulation of osteoclasts.

• Molecules and Cells
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• 제43권10호
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• pp.870-879
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• 2020

Dendrites require precise and timely delivery of protein substrates to distal areas to ensure the correct morphology and function of neurons. Many of these protein substrates are supplied in the form of ribonucleoprotein (RNP) complex consisting of RNA-binding proteins (RBPs) and mRNAs, which are subsequently translated in distal dendritic areas. It remains elusive, however, whether key RBPs supply mRNA according to local demands individually or in a coordinated manner. In this study, we investigated how Drosophila sensory neurons respond to the dysregulation of a disease-associated RBP, Ataxin-2 (ATX2), which leads to dendritic defects. We found that ATX2 plays a crucial role in spacing dendritic branches for the optimal dendritic receptive fields in Drosophila class IV dendritic arborization (C4da) neurons, where both expression level and subcellular location of ATX2 contribute significantly to this effect. We showed that translational upregulation through the expression of eukaryotic translation initiation factor 4E (eIF4E) further enhanced the ATX2-induced dendritic phenotypes. Additionally, we found that the expression level of another disease-associated RBP, fragile X mental retardation protein (FMRP), decreased in both cell bodies and dendrites when neurons were faced with aberrant upregulation of ATX2. Finally, we revealed that the PAM2 motif of ATX2, which mediates its interaction with poly(A)-binding protein (PABP), is potentially necessary for the decrease of FMRP in certain neuronal stress conditions. Collectively, our data suggest that dysregulation of RBPs triggers a compensatory regulation of other functionally-overlapping RBPs to minimize RBP dysregulation-associated aberrations that hinder neuronal homeostasis in dendrites.

• 대한한의학회지
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• 제26권2호
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• pp.77-84
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• 2005

Objectives: Chunghyul-dan is a combinatorial herbal medicine, and previous studies reported it had therapeutic effects for microangiopathy, which is a major part. in the progression of stroke, as well as having anti-hypertensive, anti-hyperlipidemic, anti-apoptotic, anti-oxidative, and anti-inflammatory activities, Therefore, we examined the inhibitory effect of Chunghyul-dan on stroke occurrence in patients with silent brain infarction. Methods: We prescribed Chunghyul-dan at 600 mg a day to patients with silent brain infarction confirmed by brain MRI, and monitored stroke occurrence, drug compliances, and adverse effects for 1 year, We then performed follow-up brain MRI to detect new vascular lesions after 1 year of Chunghyul-dan medication. As for the subjects lost to follow-up, we assessed their prognosis after 1 year by telephone. Results: There were twenty-one subjects who were treated with Chunghyul-dan for more than 1 year, None of them experienced new clinical syndromes characterized by rapidly developing clinical symptoms and signs of focal and at times global loss of brain function, which could be accompanied with evidence of stroke occurrence, or any adverse effects during the Chunghyul-dan medication period. These results might be explained by various biochemical effects of Chunghyul-dan on microangiopathy, which is closely related with cell cycle progression, hypertension, hyperlipidemia, vascular inflammation, and oxidative damage. Of the 10 subjects lost to follow-up, six were reached; two of them had stroke occurrence. Conclusions: We suggest Chunghyul-dan could be useful for prevention of stroke occurrence in patients with silent brain infarction by preventing the progression of microangiopathy. Further study with a randomized controlled trial is needed to confirm this suggestion.

• 감성과학
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• 제19권4호
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• pp.119-126
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• 2016

본 연구는 구강 호흡이 뇌기능에 미치는 영향을 뇌전도(EEG : electroencephalogram)를 통해 관찰하고자 한다. 신체가 건강한 12명의 피험자(남성: 6명, 여성: 6명, 나이: 21~27, 비흡연자)는 뇌파를 측정하기 위해 두피에 전극을 부착한 상태로 휴지기 상태에서 비강(Rest_N) 및 구강 호흡(Rest_M)을 수행하였고, 영어 대본을 사용한 청각언어자극이 주어지는 상황에서 비강(Eng_N) 및 구강 호흡(Eng_M)을 수행하였다. 각각의 뇌파는 뇌의 기능별로 크게 4 구역(R1~R4)으로 나뉘어 FFT (Fast Fourier Transform)을 통해 각각의 채널별(e.g., Pf1 and Pf2) 및 주파수 대역별(${\alpha}$, ${\beta}$, ${\gamma}$, ${\theta}$)로 절대 파워(Absolute Power) 비율을 살펴보았다. 도출된 결과에서는 Rest_N과 Rest_M 상태의 뇌파는 서로 유의미한 차이를 보이지 않았다. 비강 호흡 수행 중 청각언어자극이 주어졌을 때(Rest_N/Eng_N)의 뇌파를 비교했을 경우, 뇌파의 활동이 휴지기 상태의 뇌파 활동보다 통계적으로 유의미하게 높은 것으로 나타났다. 하지만 같은 조건상에서 구강호흡을 했을 때(Rest_M/Eng_M)는 비강 호흡을 실시했을 때와 달리 대부분의 뇌 구역과 주파수 대역에서 유의미한 차이가 나타나지 않았다. 동일한 조건의 자극에도 불구하고 구강 호흡을 하는 경우는 뇌기능의 변화가 비강 호흡과 다른 결과를 나타내었다.

• 수면정신생리
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• 제5권2호
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• pp.185-193
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• 1998

연구배경 : 양성 및 음성 정신분열병 환자간의 뇌파를 비선형적으로 분석하고 그 결과를 대조군과 비교하여 뇌파의 비선형 분석을 통한 정신분열병의 병태생리를 이해하기 위하여 양성 정신분열병 환자 8명, 음성 정신분열병 환자 9명과 정상 대조군 8명을 대상으로 하여 16전극에서 뇌파를 기록하여 비선형 분석을 시행하였다. 결과 : 좌측측두부 최대 양수 리아프노프 지수 값이 음성 정신분열병군에서 양성 정신분열병군과 정상 대조군에 비하여 유의하게 낮았으며, 일부 전극에서 양성증상은 좌측 두뇌의 카오스적 성상과 정상관이 있었으며 우측두뇌의 카오스적 성상과는 역상관이 있었다. 결론 : 본 연구결과를 통하여 정신분열병 환자의 두뇌 기능을 조사하는 데에 있어서 카오스적 역동을 응용한 뇌파분석이 임상적 유용성이 있음을 알 수 있었으며, 임상적 변인을 잘 통제한 연구가 필요하다는 것을 확인할 수 있었다.

• Molecules and Cells
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• 제43권3호
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• pp.276-285
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• 2020

Circadian rhythm is an endogenous oscillation of about 24-h period in many physiological processes and behaviors. This daily oscillation is maintained by the molecular clock machinery with transcriptional-translational feedback loops mediated by clock genes including Period2 (Per2) and Bmal1. Recently, it was revealed that gut microbiome exerts a significant impact on the circadian physiology and behavior of its host; however, the mechanism through which it regulates the molecular clock has remained elusive. 3-(4-hydroxyphenyl)propionic acid (4-OH-PPA) and 3-phenylpropionic acid (PPA) are major metabolites exclusively produced by Clostridium sporogenes and may function as unique chemical messengers communicating with its host. In the present study, we examined if two C. sporogenes-derived metabolites can modulate the oscillation of mammalian molecular clock. Interestingly, 4-OH-PPA and PPA increased the amplitude of both PER2 and Bmal1 oscillation in a dose-dependent manner following their administration immediately after the nadir or the peak of their rhythm. The phase of PER2 oscillation responded differently depending on the mode of administration of the metabolites. In addition, using an organotypic slice culture ex vivo, treatment with 4-OH-PPA increased the amplitude and lengthened the period of PER2 oscillation in the suprachiasmatic nucleus and other tissues. In summary, two C. sporogenes-derived metabolites are involved in the regulation of circadian oscillation of Per2 and Bmal1 clock genes in the host's peripheral and central clock machineries.

• Annals of Clinical Neurophysiology
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• 제13권1호
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• pp.1-12
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• 2011

Transcranial magnetic stimulation (TMS) is a non-invasive tool used to study aspects of human brain physiology, including motor function and the pathophysiology of various brain disorders. A brief electric current passed through a magnetic coil produces a high-intensity magnetic field, which can excite or inhibit the cerebral cortex. Although various brain regions can be evaluated by TMS, most studies have focused on the motor cortex where motor evoked potentials (MEPs) are produced. Single-pulse and paired-pulse TMS can be used to measure the excitability of the motor cortex via various parameters, while repetitive TMS induces cortical plasticity via long-term potentiation or long-term depression-like mechanisms. Therefore, TMS is useful in the evaluation of physiological mechanisms of various neurological diseases, including movement disorders and epilepsy. In addition, it has diagnostic utility in spinal cord diseases, amyotrophic lateral sclerosis and demyelinating diseases. The therapeutic effects of repetitive TMS on stroke, Parkinson disease and focal hand dystonia are limited since the duration and clinical benefits seem to be temporary. New TMS techniques, which may improve clinical utility, are being developed to enhance clinical utilities in various neurological diseases.