• 한국과학교육학회지
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• 제30권5호
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• pp.647-667
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• 2010

이 연구의 목적은 과학 교수-학습프로그램을 평가하기 위한 두뇌기반 분석틀을 개발하는 것이다. 분석틀의 개발을 위해, 이 연구는 과학 교수-학습과 관련된 선행연구들로부터 교수-학습 프로그램의 분석항목을 3가지로 범주화 하였다: 인지, 동기, 감성. 첫 번째로, 각 항목에 관련된 두뇌활성 영역을 파악하기위하여 과학수업과 관련된 두뇌 기능에 대한 93편의 뇌과학 문헌들을 분석하였다. 두 번째로, 두뇌의 해부학적 영역별로 범주화된 연구결과를 바탕으로 과학 교수-학습프로그램 분석을 위한 분석틀을 제작하였다. 분석틀의 제작은 R & D 방법을 따랐다. 그 결과, 두뇌활성 결과들은 대뇌 피질, 보상계, 변연계의 세 영역으로 범주화되어 나타났다. 이를 바탕으로 개발된 두뇌기반 과학 교수-학습 프로그램 분석틀인 'CORE Brain Map'은 양측 배외측전전두피질, 양측 복외측 전전두피질, 양측 안와전두피질, 전대상이랑, 양측 두정피질, 양측 측두피질, 양측 후두피질, 양측 해마, 양측 편도체, 양측 측좌핵, 양측 선조체 그리고 중뇌영역으로 구성된다. 두뇌기반 과학 교수-학습프로그램 분석틀은 다양한 과학 교수-학습프로그램의 분석 및 진단에 활용 가능할 것으로 전망된다.

• 한국지구과학회지
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• 제31권2호
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• pp.172-184
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• 2010

본 연구는 과학영재교육원의 지구과학영재들을 대상으로 좌/우뇌 활용 선호도에 따른 문제해결의 접근 방식에 관한 유형을 알아보기 위한 것이다. 지구과학 영재 16명을 대상으로 뇌활용 선호도를 알아보기 위하여 R/LCT, BPI를 실시하였고, 문제해결방식을 알아보기 위하여 S-CPST를 실시하였다. R/LCT에서 좌뇌 성향의 학생은 8명, 우뇌 성향은 7명, 중간 점수를 보인 학생은 1명이었다. BPI에서는 좌뇌 성향의 학생이 8명, 우뇌 성향은 8명이었다. S-CPST 에서 좌뇌 성향의 학생들은 먼저 구성 요소에 흥미를 갖고 그 특징을 탐색했다. 또, 숫자나 기호 등을 사용해 논리적이고 객관적으로 문제를 해결하는 반면 자신의 아이디어를 그림으로 표현하는 것을 어려워했다. 우뇌 성향의 학생들은 3단계문제해결방식을 나타냈다. 먼저 전체적인 형태에 관심을 갖고, 둘째, 각각의 구성요소 분석하고, 셋째, 이들을 종합하여 다시 전체로 조직하였다. 또, 직관적 패턴을 보고 문제의 해결 방법을 여러 가지로 제시하며 그림을 사용하여 구체화시켰다. 결과적으로 지구과학 영재들은 좌/우뇌 성향에 따라 서로 다른 방식으로 문제를 해결하였다. 따라서 보다 효과적인 지구과학 영재교육을 위하여 영재들의 좌/우뇌 성향을 고려한 교수학습방법이 요구된다.

• The Korean Journal of Physiology and Pharmacology
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• 제12권5호
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• pp.231-236
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• 2008

Heparin is a well-known anticoagulant widely used in various clinical settings. Interestingly, recent studies have indicated that heparin also has anti-inflammatory effects on neuroinflammation-related diseases, such as Alzheimer's disease and meningitis. However, the underlying mechanism of its actions remains unclear. In the present study, we examined the anti-inflammatory mechanism of heparin in cultured cerebral endothelial cells (CECs), and found that heparin inhibited the tumor necrosis factor $\alpha$ ($TNF{\alpha}$)-induced and nuclear factor kappa B (NF-${\kappa}B$)-dependent expression of adhesion molecules, such as intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), which are crucial for inflammatory responses. Heparin selectively interfered with NF-${\kappa}B$ DNA-binding activity in the nucleus, which is stimulated by $TNF{\alpha}$. In addition, non-anticoagulant 2,3-O desulfated heparin (ODS) prevented NF-${\kappa}B$ activation by $TNF{\alpha}$, suggesting that the anti-inflammatory mechanism of heparin action in CECs lies in heparin's ability to inhibit the expression of cell adhesion molecules, as opposed to its anticoagulant actions.

• Bulletin of the Korean Chemical Society
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• 제35권8호
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• pp.2304-2310
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• 2014

The synthesis and in vivo evaluation of 5-methoxy-2-(phenylethynyl)quinoline (MPEQ) 3 as a potential mGluR5 selective radioligand is described. We have identified MPEQ 3 exhibiting the analgesic effect in the neuropathic pain animal model. The effect of mGluR5 on neuronal activity in rat brain was evaluated through FDG/PET imaging in the presence of MPEQ 3. In addition, the PET study of [$^{11}C$]MPEQ 3 proved that accumulation of [$^{11}C$]MPEQ 3 in rat brain was correlated to the localization of the mGluR5.

• Progress in Superconductivity
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• 제13권1호
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• pp.18-23
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• 2011

We developed a four-channel first order gradiometer system to measure magnetoencephalogram for mice. We used double relaxation oscillation SQUID (DROS). The diameter of the pickup coil is 4 mm and the distance between the coils is 5 mm. Coil distance was designed to have good spatial resolution for a small mouse brain. We evaluated the current dipole localization confidence region for a mouse brain, using the spherical conductor model. The white noise of the measurement system was about 30 fT/$Hz^{1/2}$/cm when measured in a magnetically shielded room. We measured magnetic signal from a phantom having the same size of a mouse brain, which was filled with 0.9% saline solution. The results suggest that the developed system has a feasibility to study the functions of brain of small animals.

• Journal of the Korean Data and Information Science Society
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• 제18권3호
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• pp.721-733
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• 2007

The purpose of this research was to determine the effects of the functional lateralization of the brain variables related to the sex, the scientific attitude and the scientific exploration skills. The science instruction is divided in each type of the lecturing class with the experiment class. As for the degree of SMR brainwave activation in each stage are presented while accumulating the brain waves from the right, left and the whole brain waves are analyzed during the science learning activities. It is therefore reasonable to consider the science instruction types and brain lateralization to enhance the science learning effectiveness. Sensorimotor rhythm brainwave as the low Beta is represented well to show the thought process. Category quantification scores and objective scores are calculated to show the visual positioning map for the relationships of the categories by homogeneity analysis.

• Molecules and Cells
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• 제19권3호
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• pp.402-407
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• 2005

Bone marrow mesenchymal stem cells (MSCs) have shown potential for cardiac repair following myocardial injury, but this approach is limited by their poor viability after transplantation. To reduce cell loss after transplantation, we introduced the fibroblast growth factor-2 (FGF-2) gene ex vivo before transplantation. The isolated MSCs produced colonies with a fibroblast-like morphology in 2 weeks; over 95% expressed CD71, and 28% expressed the cardiomyocyte-specific transcription factor, Nkx2.5, as well as ${\alpha}$-skeletal actin, Nkx2.5, and GATA4. In hypoxic culture, the FGF-2-transfected MSCs (FGF-2-MSCs) secreted increased levels of FGF-2 and displayed a threefold increase in viability, as well as increased expression of the anti-apoptotic gene, Bcl2, and reduced DNA laddering. They had functional adrenergic receptors, like cardiomyocytes, and exposure to norepinephrine led to phosphorylation of ERK1/2. Viable cells persisted 4 weeks after implantation of $5.0{\times}10^5$ FGF-2-MSCs into infarcted myocardia. Expression of cardiac troponin T (CTn T) and a voltage-gated $Ca^{2+}$ channel (CaV2.1) increased, and new blood vessels formed. These data suggest that genetic modification of MSCs before transplantation could be useful for treating myocardial infarction and end-stage cardiac failure.

• 한국조리학회지
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• 제24권3호
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• pp.144-155
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• 2018

This study was conducted to explore the direction of culinary education based brain-based education with analysis of comprehensive research. Questionnaire was completed by frequency analysis, factor analysis, reliability analysis and regression analysis by using SPSS 21. The purpose of this study was to investigate the educational system for creative development through cooking sources and to develop brain-based learning theory, and thus to generate the characteristics and effects of the practice in culinary educational context. The basic principles of brain- based learning are brain plasticity, emotional brain, and ecological brain. Students need to be able to enrich their understanding of social interaction so that social brain's function will be activated through consistent and high-quality feedback. Likewise, students should be capable of collecting everything what they have learned. Defining main ideas and goal of the lesson, four factors were derived from development of competency, personality, application, and diversity. Regarding to the result of this study, the implications for the development of a brain-base program were suggested.

• 운동영양학회지
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• 제24권1호
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• pp.14-18
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• 2020

[Purpose] Functional foods are thought to strongly influence the structure and function of the brain. Previous studies have reported that brain-boosting diets may enhance neuroprotective functions. Certain foods are particularly rich in nutrients like phytochemicals that are known to support brain plasticity; such foods are commonly referred to as brain foods. [Methods] In this review, we briefly explore the scientific evidence supporting the neuroprotective activity of a number of phytochemicals with a focus on phenols and polyunsaturated fatty acids such as flavonoid, olive oil, and omega-3 fatty acid. [Results] The aim of this study was to systematically examine the primary issues related to phytochemicals in the brain. These include (a) the brain-gut-microbiome axis; (b) the effects of phytochemicals on gut microbiome and their potential role in brain plasticity; (c) the role of polyunsaturated fatty acids in brain health; and (d) the effects of nutrition and exercise on brain function. [Conclusion] This review provides evidence supporting the view that phytochemicals from medicinal plants play a vital role in maintaining brain plasticity by influencing the brain-gut-microbiome axis. The consumption of brain foods may have neuroprotective effects, thus protecting against neurodegenerative disorders and promoting brain health.

• 한국과학교육학회지
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• 제30권8호
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• pp.1031-1043
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• 2010

이 연구의 목적은 과학 교수-학습프로그램의 두뇌 기반 분석을 위한 정성적 정량적 분석방법을 제시하는 것이다. 연구목적 달성을 위해, 첫 번째로 두뇌기반 분석을 위한 분석방법의 고안에는 중학교 과학 교수-학습프로그램 중 한 단원을 연구대상으로 선정하여 분석하였다. 제시된 분석방법의 유용성 검증에는 7차 및 2007 개정 교육과정의 초등학교 과학 교수-학습프로그램 중 네 단원을 연구대상으로 선정하여 검증하였다. 그 결과, 교수-학습 프로그램을 CORE Brain Map을 통해 정성적으로 컨설팅 할 수 있었다. 또한 네트워크 이론으로부터 정량적 분석을 위한 두뇌맞춤지수 산출식(BCI=$\frac{L_o}{11(N_o-1)}{\cdot}{\sum}\limits_{i=1}^4l_iw_i$)을 유도하였다. 이를 통해 단원 및 교육과정에 따른 연구대상 교수-학습프로그램들 간의 정량적 차이를 확인할 수 있었다. 이 연구를 통해 개발된 두뇌기반 과학 교수-학습 프로그램의 정성적 정량적 분석방법은 두뇌기반 다양한 과학 교수-학습 프로그램의 분석 및 진단에 활용 가능할 것으로 전망된다.