• Maxillofacial Plastic and Reconstructive Surgery
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• 제29권4호
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• pp.366-371
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• 2007

Evaluation of the methods of processing allogenic bone must be considered in order to make an effective choice of graft materials in oral surgery. Allograft materials processed by the tissue banking industry have varying capacities of bone reconstruction. The biological function of processed bone can be affected by many factors, like particle size, processing parameters, and inclusion or exclusion of mineral and moisture. For example, freeze drying step offers a safe and economical means for packaging, shipping, storage, and preservation of homologous bone. Demineralization of cortical bone using hydrochloric acid can produce a uniform demineralized surface with a capacity for osteoinduction. The objectives of this review were to evaluate the processing methods for allogenic bone and to characterize processed materials for grafting. It is important to understand the biological, biomechanical healing of different types of allografts to make the right choice for allogenic bone on each clinical application and to achieve a successful outcome for alveolar bone reconstruction in oral surgery.

• Journal of Acupuncture Research
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• 제22권2호
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• pp.55-70
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• 2005

Objective: Ulmus davidiana Planch (Ulmaceae) has long been known to have anti-inflammnatory in the traditional Korean medicine. UD has been reported as a good enhancer for bone healing. Methods : In this experiment, we investigate the Inhibitory effects of UD on bone resorption using the bone cells culture. Different concentrations of crude extract of UD were added to mouse bone cells culture. The mitochondria activity of the bone cells after exposure was determined by colorimetric MIT assay. It was demonstrated that UD has potential effects on bone cells culture without any cytotoxicity. The most effective concentration of UD on bone cells were $100\;{\mu}g/ml$. Cathepsin K (Cat K) is the major cysteine protease expressed in osteoclasts and is thought to play a key role in matrix degradation during bone resorption. Results : When mouse long bone cells including osteoclasts and osteoblast were treated with the PI3-Kinase inhibitor, wortmannin (WT), WT prevented the osteoclast-mediated intracellular processing of Cat K. Similarly, treatment of osteoclasts-containing long bone cells with UD extracts prevented the intracellular maturation of Cat K, suggesting that UD may disrupt the intracellular trafficking of pro Cat K. This is similar to that of WT. Since secreted proenzymes have the potential to reenter the cell via mannose-6-phosphate (M6P) receptor, to prevent this possibility, we tested WT and UD in the absence or presence of M6P. Inhibition of Cat K processing by WT or UD was observed in a dose-dependent manner. Furthermore, the addition of M6P resulted in enhanced potency of WT and UD. Conclusion : UD dose-dependently inhibited in vitro bone resorption with a potency similar to that observed for inhibition of Cat K processing.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2023년도 춘계학술발표대회
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• pp.687-688
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• 2023

Bone age assessment is a crucial task in pediatric radiology for assessing growth and development in children. In this paper, we explore the potential of Vision Transformer, a state-of-the-art deep learning model, for bone age assessment using X-ray images. We generate heatmap outputs using a pre-trained Vision Transformer model on a publicly available dataset of hand X-ray images and show that the model tends to focus on the overall hand and only the bone part of the image, indicating its potential for accurately identifying the regions of interest for bone age assessment without the need for pre-processing to remove background noise. We also suggest two methods for extracting the region of interest from the heatmap output. Our study suggests that Vision Transformer holds great potential for bone age assessment using X-ray images, as it can provide accurate and interpretable output that may assist radiologists in identifying potential abnormalities or areas of interest in the X-ray image.

• Journal of Multimedia Information System
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• 제6권2호
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• pp.67-74
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• 2019

Bone density is one of the factors in the early failure of dental implants and doctors should make a preoperative assessment of jaw bone density using patient's CT data before dental implant surgery in order to find out whether the patient has osteoporosis and osteopenia. The main goal of this study was to propose a method that based on image processing techniques in order to provide accurate information about where to drill and place an abutment screw of implants in the jaw bone for doctors and reduce human activity for the estimation of the local cancellous bone density of mandible using CT data. The experiment was performed on a computed tomography data of the jaw bone of two different individuals. We assumed that the result of the estimation of jaw bone density depends on the angle of drilling and average HU (Hounsfield Unit) values were used to evaluate the quality of local cancellous bone density of mandible. As a result of this study, we have been developed a toolbox that can be used to estimate jaw bone density automatically and found a positive correlation between the angle of the drill and time complexity but a negative correlation between the diameter of the drill and time complexity.

• 한국정보기술응용학회:학술대회논문집
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• 한국정보기술응용학회 2005년도 6th 2005 International Conference on Computers, Communications and System
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• pp.91-97
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• 2005

Bones are dynamic structures, being supported by muscles, tendons, and ligaments. When some or all the structures are disturbed i.e. in fractures, the alignment of the bone in respect to the rest of the body is deranged. This gives rise to axial as well as rotational deformity in three dimensional planes. The correct alignment and position of the long bones are to be maintained to heal the bone in the best possible anatomical and functional position. The objective of this research is to address the problems in the current practice involving surgeon, assistant, fluoroscopy and crude mechanical means and to see if a robotic solution exists to solve the problems of manipulating and reducing long bone fractures. This paper presents various design aspects of the proposed surgeon-instructed, image-guided and robotic system including the system design specification, robot design and analysis, motion control and implementation, and x-ray image processing and incorporation in CAD environment.

• 한국정밀공학회지
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• 제22권8호
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• pp.182-191
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• 2005

It is very important to obtain a high quality of bone image for an accurate ultrasonic measurement of bone mineral density. In this study, we suggested a technique to acquire an optimal image by adapting an acoustic lens and a properly selected ultrasonic probe. Also, we have applied an image processing algorithm with which automatically makes a decision of brightness and contrast of image by generating threshold level, a composition of ultrasonic data, an elimination of noise using modified median filter, and a real time interpolation. We could confirm much improved resolution of bone image with acoustic lens attached to the ultrasonic probe and with the image processing algorithm suggested in this study. Therefore, it became possible to precisely diagnose the osteoprosis using ultrasonic imaging technique.

• Imaging Science in Dentistry
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• 제35권1호
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• pp.33-40
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• 2005

Purpose : (1) To analyse the effect of exposure time, ROI size and one impact factor in the image processing procedure on estimates of fractal dimension; and (2) to analyse the correlated relationship between the fractal dimension and the Cu-Eq value (bone density). Materials and Methods : The cylindric bone phantoms of 6 large and 5 small diameter having different bone densities respectively and human dry mandible segment with copper step wedge were radiographed at 1.0 and 1.2 sec esposure (70 kVp, 7 mA) using one occlusal film and digitized. Eleven rectangular ROIs from 11 cylindric bone phantoms and 4 rectan-gular ROIs from cortical, middle, periodontal regions, and socket of bone were selected. Gaussian blurred Image was subtracted from original image of each ROI and multiplied respectively by 1, 0.8, and 0.5, and then the image was made binary, eroded and dilated once, and skeletonized. The fractal dimension was calculated by means of a box counting method in the software ImageJ. Results : The fractal dimension was decreased gradually with continued bone density decrease showing strong correlations (bone phantom; r> 0.87, bone; r> 0.68) under 70 kVp 1.0 sec M = 0.8. Fractal dimensions showed the significant differerence (p < 0.05) between two different exposure times on the same small ROI of bone phantom. Fractal dimensions between two different sizes of ROI on bone phantom showed the significant differerence (p < 0.05) under 1.2 sec exposure, but did not show it (p > 0.05) under 1.0 sec exposure. Conclusions : Exposure time, ROI size, and modifying factor during subtracting could become impacting on the results of fractal dimension. Fractal analysis with thoroughly evaluated method considering the various impacting factors on the results could be useful in assessing the bone density in dental radiography.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제28권4호
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• pp.365-370
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• 2006

Viral, bacterial and fungal infections can be transmitted via allografts such as bone, skin, cornea and cardiovascular tissues. Allogenic bone grafts have possibility of transmission of hepatitis C, human immunodeficiency virus (HIV-1), human T-Cell leukaemia virus (HTLV), tuberculosis and other bacterias. The tissue bank should have a policy for obtaining information from the patient's medical report as to whether the donor had risk factors for infectious diseases. Over the past several years, improvements in donor screening criteria, such as excluding potential donor with "high risk" for HIV-1 and hepatitis infection, and donor blood testing result in the reduction of transmission of these diseases. During tissue processing, many allografts are exposed to antibiotics, disinfectants and terminal sterilization such as irradiation, which further reduce or remove the risk of transmitting diseases. Because the effectiveness of some tissue grafts such as, fresh frozen osteochondral grafts, depends on cellular viability, not all can be subjected to sterilization and processing steps and, therefore, the risk of transmission of infectious disease remains. This article is review of the transmission of considering infectious disease in allogenic bone transplantation and the processing steps of reducing the risk. The risk of viral transmission in allografts can be reduced in several standards. The most important are donor-screening tests and the removal of blood and soft tissues by processing steps under the aseptic environment. In conclusion, final sterilizations including the irradiation, can be establish the safety of allografts.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2015년도 추계학술발표대회
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• pp.1446-1447
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• 2015

In this paper, we developed the quantification software for evaluating the voxel-based cellular heterogeneity of gadoxetic acid-enhanced magnetic resonance imaging (MRI) in the liver. Our software is clinically applied to accurately quantify and interpret the alterations of liver functions in patients with hepatocellular carcinoma.

• Applied Biological Chemistry
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• 제41권1호
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• pp.67-72
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• 1998

수산가공 부산물을 식품소재와 같이 효율적으로 이용하기 위한 일련의 기초 연구로 6종의 어류뼈(대구뼈, 명태뼈, 각시가자미뼈, 민태뼈, 붕장어뼈 및 고등어뼈)에 대하여 식품 성분 특성을 검토하였다. 건물당 조단백질 함량, 콜라겐 함량 및 amino acid 조성비는 민태뼈가 각각 40.7%, 5.86% 및 189 잔기/1,000 잔기로 기타 어류뼈의 $28.8{\sim}38.8%$, $39.4{\sim}5.73%$ 및 $160{\sim}170$ 잔기/1,000 잔기 보다 높았으나, 가축뼈 콜라겐의 amino acid 조성비(204 잔기/1,000 잔기) 보다는 낮았다. 각시가자미뼈, 붕장어뼈 및 고등어뼈의 경우 건물당 조지방 함량은 $22.8{\sim}43.9%$이었고, 생리작용을 가지고 있는 EPA 및 DHA 등의 조성비는 $15.6{\sim}23.8%$로 오징어 내장의 그 성분들보다 낮았다. 어류뼈의 무기질은 대부분 칼슘$(37.1{\sim}38.6%)$및 인$(18.0{\sim}18.5%)$으로 구성되어 있었고, 이들의 함량은 대구뼈(38.1% 및 18.5%) 및 명태뼈(38.6%, 18.3%)가 다른 어류뼈는 물론이고, 가축뼈보다 많았다. 이상의 결과로 미루어 보아 콜라겐 또는 젤라틴 추출 소재로는 민태뼈가, 칼슘 추출소재로는 대구뼈 및 명태뼈가 적절 하였다.