• 여성건강간호학회지
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• 제21권1호
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• pp.43-54
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• 2015

Purpose: This study was conducted to identify the problem of bone health and potential influencing factors of bone mineral density (BMD) for women across the life cycle of menopause. Methods: Complex sampling design data analysis was performed on the fifth Korea National Health and Nutrition Examination Survey 2010 in order to identify the problems with bone health, BMD and its influencing factors in 3,499 women who answered the menopausal status. Women's life cycle was categorized by premenopausal, postmenopausal, and elderly. Results: 35.1% of premenopausal women, 73.3% of postmenopausal women, and 96.0% of elderly women had problems with bone health that were related to low BMD. Influencing factors of BMD were residential area, alcohol drinking, and body mass index (BMI) for premenopausal women; age, residential area, education, marital status, income, and BMI for postmenopausal women; and age, education, and BMI for elderly women. Conclusion: Problems with bone health required to be considered as a major health problem in all women regardless their life cycle. Interventions to maximize BMD need to be developed by considering its influencingfactors across the women's life cycle.

• Clinical and Experimental Reproductive Medicine
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• 제19권1호
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• pp.49-56
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• 1992

Bone mineral density was measured to assess whether the patients with premonopausal hypogonadism, comprised of 19 patients with hypogonadotropic hypogonadism(HH), 55 with premature ovarian failure(POF), 23 with hyperprolactinemia(HPLN), and 8 with Sheehan's syndrome. All aged from 20 to 39, were associated with some decrease in regional bone mass compared with that of 63 normal-associated with some decrease in regional bone mass compared with that of 63 normal-cycling control women matched with age and sex. Measurement of bone mineral density was carried out using Dual photon absorptiometry at four sites; femur neck, ward's triangle, trochanter and spine(L2-L4). Bone mineral density at all four sites were significantly decreased in patients with HH(p<0.01), POF(p<0.01). In hyperprolactinemic patients, the decrease in bone mass was significant at femur neck and Ward's triangle(p<0.05). The patients with POF were noted to be associated with significant bone loss when their duration of amenorrhea exceeded one year. In this study, the degree of loss of bone mass and the affected sites seemed to be different depending on the various types of hypogonadism and POF was noted have caused the appearance of loss of bone mass earlier than other thpes of hypogondism we experienced.

• The Journal of Korean Physical Therapy
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• 제14권4호
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• pp.412-422
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• 2002

The use of biochemical markers of bone turnover may be particular interest in the investigation of bone disorders with osteoporosis. Serum osteocalcin(OC), total alkaline phosphatase and procollagen C, reflecting bone formation, and urinary pyridinium cross-links excretion, reflecting bone reabsorption have been measured in hyperthyroidism, postmenopause women, after testosterone supplementation, androgen, testosterone and estrogen deficiency, bone mineral density degree, age duration. Bone marks which is reflect to metabolic bone disorders are biochemical indices method to measure enzyme activity about bone formation, bone absorption and bone components in blood or urine. Bone metabolism biochemical marks are correlated with osteophorotic agents and also represent significantly different between bone mineral density and bone biochemical marks. Therefore if we develope and use bone metabolism marks which have higher sensitivity and specificity in bone formation and bone absorption, I think that these bone biochemical marks can have utility in the clinical application to predict osteoporosis risk group, bone loss, bone fracture and response degree to treatment of osteoporosis risk groups.

• Journal of Nutrition and Health
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• 제21권5호
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• pp.333-347
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• 1988

The purpose of the present study was to investigate the relationship between nutrient status, and bone mineral state which influenced by aging process. The subjects were 196 people over 65 years old(male 72, female124). The present dietary intake was estimated by the 24-hr, recall method, and individual dietary history concerning consumption of meat, fish and dairy products was obtained by questionaires. The syndrome of senility including seniliy was evaluated according to "Cornell Medical Index". The five subjects who showed 'Good' grade in bone senility, and five subjects who showed 'Risk' and 'Danger' grade were selected and their spine and femur bone density was measured by "Dual Photon Absorptiometry". The bone density measurement showed that the subjects with 'Good' grade in bone senility had bone density above that of normal person, and their nutrient status were satisfactory, whereas the subjects with 'Risk' and 'Danger' grade in bone senility had severe osteoporotic pattern, and their nutrient status were very poor. The food consumption score showed that the subject with higher intake of meat rather than milk had good grade in bone senility (p<0.05). Therefore, past meats consumption can be considered to be a significant factor in the present bone status. The nutrient intakes appeared to be significant factors in bone status in male, whereas there was little effect of nutrients intakes in female. Therefore, the risk of osteoporosis can increase as syndrome of bone senility and nutrient intakes were worse, and its is possible to evaluate bone status and predict osteoporosis simply from informations concerning syndrome of bone senility and nutrient intakes in old population over 65.

• Journal of Periodontal and Implant Science
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• 제29권4호
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• pp.837-846
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• 1999

There were few reports about the fluoride concentration in bone and osteoporotic women. This study was designed to evaluate the relationship between the urinary fluoride concentration and periodontal condition in osteoporotic old women. Twentyeight postmenopausal women(Test group) and twenty-one premenopausal women(Control group) were examined. Bone mineral density(BMD) of lumbar spine(L2-L4) was measured by dual energy X-ray absorptiometry(DEXA). The urine samples were collected at early morning and determined with the help of a fluoride-specific electrode and Tisabbufferd samples. The results were as follows. 1. The mean urinary fluoride concentration in test and control group showed statistically no difference. 2. The bone mineral density(BMD) of the spine in test group was significantly lower than control group(p<0.05). 3. The significant negative correlation was found between BMD level and age after menopause $(p<0.001,\;{\gamma}=-0.526$. 4. The urinary fluoride concentration was not correlated with age, age after menopause and bone mineral density. 5. The urinary fluoride concentration was not correlated with periodontal condition.

• 대한간호학회지
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• 제34권1호
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• pp.63-71
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• 2004

Purpose: This study was to identify the influencing factors of the compliance level to a therapeutic regimen after a bone mineral densitometry test. Method: The sample for the study was 95 people who took the bone mineral densitometry test from March, 2002 to July, 2002. Data was collected by mail using aself reporting questionnaire on the selected variables such as the compliance level, self efficacy, health locus of control, susceptibility, severity, usefulness, barrier, and self esteem. Results: The average compliance level was 63.93. Through multiple regression, three independent variables including chance health locus of control on personality, the result of bone mineral density and self-efficacy were entered in the model as the significant determinants of the compliance level after a bone mineral densitometry test. The coefficients of determination of each variable were 10.9%, 8.3% and 8.1% respectively. Conclusion: The identification of the determinants of the compliance level to the therapeutic regimen after bone mineral densitometry is expected to contribute to the development of an intervention program to improve the compliance level to the therapeutic regimen in osteoporosis patients.

• Advances in biomechanics and applications
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• 제1권1호
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• pp.15-22
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• 2014

Computed tomography (CT) is being utilized in orthopaedics and related research to estimate bone strength. These applications benefit from calibration of Hounsfield units to mineral density typical of long bone, up to $1750mg/cm^3$. This study describes a method for establishing repeatable calibration of Hounsfield units to density, and determines the effects of imaging medium on calibration accuracy. Four hydroxyapatite standards were imaged in air on 7 occasions over 19 weeks using a helical multi-slice CT scanner. Each standard was scanned 5 times in different media: porcine soft tissue, water, and air. Calibrated densities were highly repeatable (CV<3.5%). No difference in density was observed between water and soft tissue conditions (p>0.08). This work provides a model for determining repeatable scanner-specific density calibration, demonstrates that the linear relationship between Hounsfield units and density extends to values typical of cortical bone, and supports the practice of imaging calibration standards in an environment similar to that of the target bone.

• 한국식품영양과학회지
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• 제35권9호
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• pp.1200-1206
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• 2006

단백질과 칼륨의 섭취량으로 산출한 NEAP와 여성의 골밀도 및 골대사지표와의 관련성을 알아보기 위하여 $18\sim81$세의 여성 276명을 대상으로 설문조사와 식사섭취조사, 요추와 대퇴경부의 골밀도 측정, 소변의 디옥시피리디놀린을 분석한 결과는 다음과 같다. 대상자들의 NEAP 수준은 요추 골밀도(p<0.05)와 유의적인 음의 상관성을 보였고 대퇴경부 골밀도와도 유의적인 수준은 아니었으나 음의 상관성을 보였다. NEAP의 수준에 따라 대상자를 4분위수로 분류하고 연령, 신장, 체중의 차이를 보정하여 골밀도를 비교하였을 때 NEAP 수준이 가장 낮은 군의 요추 및 대퇴경부 골밀도가 가장 높았으나 유의적인 차이를 보이지는 않았다. 또한 단백질의 섭취량에 따른 골밀도의 4분위수 분석결과 단백질의 섭취량이 증가함에 따라 요추 골밀도가 감소하였다(p<0.05). 이상의 연구결과를 통하여 체내에서 알칼리를 생성하는 칼륨의 섭취증가와 체내에서 산을 생성하는 단백질의 섭취감소를 통한 체내 산도의 감소가 여성의 골밀도와 긍정적인 관련성을 나타낼 수 있음이 제시되었다. 따라서 칼슘섭취의 부족문제가 좀처럼 해결되고 있지 않은 우리나라의 식생활에서 골용해와 칼슘의 배설을 줄임으로써 골격건강을 유지할 수 있는 방안으로 단백질의 과잉섭취를 제한하고 체내 알칼리를 형성할 수 있는 무기질이 풍부한 식품의 섭취를 늘일 수 있도록 하는 식사지침의 마련이 필요하다고 생각된다. 또한 본 연구에서는 골밀도에 긍정적인 영향을 미치는 체내 알칼리성 유도 영양소를 칼륨으로만 한정했지만, 마그네슘이나 칼슘 등도 체내 알칼리성에 영향을 미치는 요인이기 때문에 다양한 알칼리성 영양소의 섭취가 골밀도에 미치는 영향에 대한 추후 연구가 요구된다.

• Journal of Nutrition and Health
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• 제32권3호
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• pp.287-295
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• 1999

This study was conducted to observe the effect of vitamin K on bone metabolism in postmenopausal women. Twenty-four healthy postmenopausal women recruited for this one-month, double-blind controlled study. Before and after daily administration of 1.0mg of phylloquinone the levels of serum vitamin K, osteocalcin, under-carboxylated osteocalcin, and urinary deoxy-phyidinoline were measured. The serum vitamin K concentration of Koran women as well as the average dietary intake of vitamin K was shown to be higher than the average levels of foreign women. However, no correlation between serum vitamin K concentration and vitamin K intake was found. Also, serum vitamin K concentration showed no special correlation with either bone mineral density or bone turnover markers in the study group. However, women with low serum vitamin K concentration(vitamin K-low group)had lower bone mineral density levels. After supplementation with 1.0mg/day of vitamin K, there were no changes in the levels of serum vitamin K, osteocalcin, ucOC, or u-DPD. Vitamin K supplementation did not seem to have any positive effects on bone metabolism through carboxylation. It can, however, be expected that vitamin K supplementation has a positive effect on bone metabolism in postmenopausal women with especially low serum vitamin K concentrations.

• 대한한방부인과학회지
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• 제19권3호
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• pp.203-213
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• 2006

Purpose : This study was carried out to evaluate correlation between Bone Mineral Density(BMD) and degenerative lumbar disease in postmenopausal low back pain patients. Methods : 69 postmenopausal patients with low back pain were examined. Magnetic resonance imaging was performed to evaluate degenerative lumbar disease and bone mineral density of lumbar spine was measured by Dual energy X-ray absorptiometry. Data were analyzed by Pearson's Linear Correlation Coefficient. Results : In postmenopausal patients with low back pain, BMD(T-score, Z-score) had negative correlation with the grade of intervertebral disc herniation and positive correlation with weight. Other lumbar diseases including Spinal stenosis, Spondylolisthesis and Facet joint arthrosis didn't have significant correlation with BMD. Conclusion : In postmenopausal patients with low back pain, BMD(T-score, Z-score) had inverse relationship with the grade of intervertebral disc herniation.