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Tracheal gas insufflation (TGI) in patients with increased deadspace fraction: the effect and its determining factors (사강호흡율이 증가된 환자에서 기관내 가스주입법(Tracheal Gas Imsufflation)이 가스교환에 미치는 효과와 그 결정인자)

  • Lim, Chae Man;Jung, Bok Hyun;Koh, Youn Suck;Lee, Sang Do;Kim, Woo Sung;Park, Pyung Hwan;Kim, Dong Soon;Kim, Won Dong
    • Tuberculosis and Respiratory Diseases
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    • v.44 no.1
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    • pp.136-145
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    • 1997
  • Background : Tracheal Gas Insufflation (TGI) is one of the newer ancillary measures in mechanical ventilation employed to enhance carbon dioxide elimination. TGI exerts its effect through reduction of deadspace ventilation, but the factors determining its effect are not well studied yet. Method : The subjects were seven mechanically-ventilated patients ($58.8{\pm}10.6$ yrs) who showed increased physiologic deadspace greater than 60%. After 30 nun of stabilization with 100% oxygen on pressure control ventilation, continuous flow TGI was administered via the insufflation lumen of Hi-Lo Jet Tracheal Tube (Mallincrodt, USA) for 15 min at 3 L/min and 5 L/min each. Results : $PaCO_2$ was decreased ($51.4{\pm}17.6$ at baseline, $49.1{\pm}18.9$ at TGJ 3 L/min $45.0{\pm}14.9$ mm Hg at TGI 5 L/min, p=0.050), and pH was increased ($7.37{\pm}0.12$, $7.38{\pm}0.13$, $7.39{\pm}0.12$, respectively, p=0.037) while mixed expired $CO_2$ ($P_ECO_2$) was not changed significantly from baseline (p=0.336) by TGI. Physiologic deadspace(Vdphy) was decreased ($73.0{\pm}7.9$% at baseline, $69.8{\pm}10.0$% at TGI 3 L/min, and $67.1{\pm}10.1$% at TGI 5 L/min, p=0.015). $AaDO_2$(p=0.147), Vt(p=0.2140), Pmean(p=0.7788) and mean arterial pressure(p=0.4169) were not changed. The correlation between % maximal decrease of Vdphy were r=0.790 with the ratio of baseline Vdana/Vdphy(p=0.035) and r=-0.754 with baseline Vdalv(p=0.050). Conclusion: TGI was effective in reducing $PaCO_2$ and deadspace, and the deadspace-reducing effect was best correlated with baseline anatomic/physiologic deadspace ratio.

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Novel Promoter Polymorphism in RUNX2 Is Associated with Serum Triglyceride Level

  • Shin, Hyoung Doo;Jeon, Jae-Pil;Park, Byung Lae;Bae, Joon Seol;Nam, Hye-Young;Shim, Sung-Mi;Park, Kyong Soo;Han, Bok-Ghee
    • Molecules and Cells
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    • v.26 no.5
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    • pp.459-461
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    • 2008
  • Much research evidence supports the hypothesis that chronic, low-grade inflammation related to innate immunity may play an important role in the pathophysiology of type 2 diabetes mellitus (T2DM). Runt-related transcription factor 2 (RUNX2; MIM# 600211) acts as a scaffold that controls the integration, organization, and assembly of nucleic acids. To examine whether the novel promoter variant in RUNX2 is associated with the risk of T2DM and related phenotypes, RUNX2-742G > T was genotyped in 378 T2DM patients and 382 normal controls recruited in the Korean T2DM Study. Statistical analysis revealed that RUNX2-742G > T was associated with serum triglyceride level (TG) in nondiabetic controls, although it was not associated with the risk of T2DM. Individuals who carry T/T, T/G, and G/G genotypes had the highest ($2.061{\pm}0.20$), intermediate ($2.01{\pm}0.19$), and the lowest ($1.97{\pm}0.18$) levels of log [TG (mmol/l)] (P = 0.007), respectively. Our data on this important variant of RUNX2 suggest that lipid metabolism might be affected by genetic polymorphisms in the promoter region.

Dynamic Responses and Fuzzy Control of a Simply Supported Beam Subjected to a Moving Mass

  • Kong, Yong-Sik;Ryu, Bong-Jo;Shin, Kwang-Bok;Lee, Gyu-Seop;Lee, Hong-Gi
    • Journal of Mechanical Science and Technology
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    • v.20 no.9
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    • pp.1371-1381
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    • 2006
  • This paper deals with the active vibration control of a simply-supported beam traversed by a moving mass using fuzzy control. Governing equations for dynamic responses of a beam under a moving mass are derived by Galerkin's mode summation method, and the effect of forces (gravity force, Coliolis force, inertia force caused by the slope of the beam, transverse inertia force of the beam) due to the moving mass on the dynamic response of a beam is discussed. For the active control of dynamic deflection and vibration of a beam under the moving mass, the controller based on fuzzy logic is used and the experiments are conducted by VCM (voice coil motor) actuator to suppress the vibration of a beam. Through the numerical and experimental studies, the following conclusions were obtained. With increasing mass ratio y at a fixed velocity of the moving mass under the critical velocity, the position of moving mass at the maximum dynamic deflection moves to the right end of the beam. With increasing velocity of the moving mass at a fixed mass ratio ${\gamma}$, the position of moving mass at the maximum dynamic deflection moves to the right end of the beam too. The numerical predictions of dynamic deflection of the beam have a good agreement with the experimental results. With the fuzzy control, more than 50% reductions of dynamic deflection and residual vibration of the tested beam under the moving mass are obtained.

In vitro Antioxidative Activities and Phenolic Composition of Hot Water Extract from Different Parts of Cudrania tricuspidata

  • Jeong , Chang-Ho;Choi, Gwi-Nam;Kim, Ji-Hye;Kwak, Ji-Hyun;Heo, Ho-Jin;Shim, Ki-Hwan;Cho, Bok-Rai;Bae, Young-Il;Choi, Jine-Shang
    • Preventive Nutrition and Food Science
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    • v.14 no.4
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    • pp.283-289
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    • 2009
  • We evaluated total phenolics and antioxidative activities of water extracts from different parts of Cudrania tricuspidata (specifically, the leaves, stems, roots, and fruits). The antioxidative activities of these samples were determined using five methods, including 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid (ABTS) radical scavenging, reducing power, ferric reducing ability of plasma (FRAP), and $\beta$-carotene/linoleic acid system. The water extract of leaves exhibited the higher DPPH, ABTS radical scavenging activities, reducing power, and FRAP than water extract of stem, roots, and fruits. Inhibition values on linoleic oxidation of water extracts from leaves, stems, roots, and fruits were calculated as 45.98%, 33.03%, 39.73%, and 25.48% at 10 mg/mL, respectively. The water extract of C. tricuspidata leaves had the highest amount of toal phenolics (73.60$\pm$0.28 mg/g). High-performance liquid chromatography (HPLC) analysis showed that quercetin is the predominant phenolic compound in water extract of leaves. Thus, our study verified that the water extract of leaves has strong antioxidant activities which are correlated with its high level of phenolic compounds, particularly quercetin. This water extract of C. tricuspidata leaves can be used as an effective and safe source of antioxidants.

Curative Effects of Typhae Pollen on the Diet-Induced Hyperlipidemia in Rats (포황이 흰쥐의 식이성 고지혈증 치료에 미치는 영향)

  • Shin Hyung Seop;Kim Gyu Yeol;Kim Ho Hyun;Seo Il Bok
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.17 no.1
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    • pp.225-229
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    • 2003
  • In Oriental Medicine, hyperlipidemia is considered as the phlegm stagnancy(痰飮) and blood stasis(瘀血). Typhae Pollen helps remove blood stasis and hemorrhage and it also has an effect of relieving pains caused by blood stasis. The purpose of this study is to investigate the curative effects of Typhae Pollen on diet-induced hyperlipidemia in rats. Thirty-two rats were divided into normal, control and treated group. Control and treated group were fed with 1.5% cholesterol diet during 4 weeks, and fed with normal diet during next 4 weeks. Treated group was also administrated with extract of Typhae Pollen during last 4 weeks. Blood samples were collected from each of animals at 4, 6 and 8weeks, and used for the blood chemical analysis. Animals were sacrificed at 8 weeks, and chemical analysis was performed on the collected liver samples. The serum total cholesterol(47.82±2.03㎎/㎗), LDL-cholesterol(11.09±1.27㎎/㎗), HDL-cholesterol (19.64±1.23㎎/㎗), triglyceride(85.09±3.48㎎/㎗) values of treated group were significantly decreased compared with the serum total cholesterol(73.73±5.34㎎/㎗), LDL-cholesterol(22.09±3.09㎎/㎗), HDL-cholesterol(25.18±1.45㎎/㎗l), triglyceride(124.27±6.72㎎/㎗) values of control group at 8weeks. The liver total cholesterol and triglyceride values of treated group show no statistically significant differency compared with those values of control group. On the basis of these results, it is confirmed that Typhae Pollen has the curative effects on the hyperlipidemia in rats induced by hyper-cholesterol diets.

Study on waxy corn hybrids - XV. Major botanical characteristic on CNU hybrids using domestic waxy corn germplasm(Zea mays L.) (찰옥수수 연구 - XV. 국내 유전자원을 이용한 찰옥수수 교잡종의 주요 작물학적 특성)

  • Choi, Hyun-Gu;Lee, Moon-Sub;Bok, Tae-Gyu;Na, Woong-Hyun;Ko, Hyuck-Soo;Lee, Sunck-Young;Jo, Yang-Hee;Lee, Hee-Bong
    • Korean Journal of Agricultural Science
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    • v.39 no.1
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    • pp.29-34
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    • 2012
  • This study was carried out to identify the characteristics of 37 corn hybrids, which composed with 18 yellow colored kernel, 9 purple colored kernel, 8 white colored kernel. Days to silking of three colored waxy corn hybrids ranged from 61 to 73 days after sowing as midium-late ecotype. Ear length of hybrids ranged from 10.3 to 22.7 cm, and among them a total 22 waxy corn hybrids including CNU038 showed over 20 cm in ear length. The fresh weight per ear ranged from 58 to 289 g as the 32.9% of large coefficient of variance. In there results, we found yellow colored waxy corn hybrids showed relatively longer in ear length and heavier in fresh weight per ear compare to other colored waxy corn hybrids. In correlation relationships, plant height, ear height, stem diameter, ear length and ear weight showed positive correlation between themselves, while tip filling ratio did negative correlation with silking stage, plant height, ear length, ear weight and kernel thickness. Also, 100 kernel weight did positive correlation between traits related to ear and kernel.

Quality Characteristics and Composition of the Longissimus Muscle from Entire and Castrate Elk in Korea

  • Kim, Sang-Woo;Kim, Kwan-Woo;Park, Seong-Bok;Kim, Myung-Jick;Yim, Dong-Gyun
    • Asian-Australasian Journal of Animal Sciences
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    • v.29 no.5
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    • pp.709-715
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    • 2016
  • The objective of the research was to determine the chemical composition as well as the physicochemical properties of the longissimus muscle from Korean entire and castrate elk. Twelve elk stags were raised and fed on concentrate with ad libitum hay. All animals were equally divided into castrated and non-castrated (entire) males, and slaughtered at 5 year of age. It was found that entire elk, in comparison with castrate elk, had higher content of moisture and lower content of fat (p<0.05). Compared with entire males, the castrates had lower pH and shear force values (p<0.05). However, castrates had higher $L^*$, $a^*$, and $b^*$ values compared with entires (p<0.05). An analysis of the fatty acid profile revealed that the muscles of entire and castrate elk had the most abundant concentrations of the following fatty acids: palmitic acid (C16:0) of the saturated fatty acid, and oleic acid (C18:1n-9) of the unsaturated fatty acid. The entire elk contains higher proportions of linoleic acid (C18:3n6), eicosenoic acid (C20:1n9), and arachidonic acid (C20:4n6) (p<0.05). Cholesterol content in elk was not affected by castration. The predominant free amino acid was glutamic acid related to umami taste. It is apparent that the castrate animals carried higher content of histidine, isoleucine, and leucine than those of the entire group (p<0.05). In this study, it was concluded that venison quality of elk is affected by castration and these results can provide fundamental information for venison production.

Etymological Explanation of the Scientific Names for Trees and the Foreign Names of Them(II) (수목학명(樹木學名)의 어원구명(語源究明) 및 외국명(外國名) 조사(調査)(제(第)2보(報)))

  • Kim, Jyeung Gook
    • Journal of Korean Society of Forest Science
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    • v.31 no.1
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    • pp.53-61
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    • 1976
  • Though it is not easy for those who study dendrology to memorize all the scientific names of trees, the names remaines in their memory can facilitate the understanding of foreign technical books. The scientific name of a tree indicates characteristics of shape, color, and other aspects of the tree and by analyzing the name we can see common element found in other scientific names of trees. It is helpful to those who want to memorize and study the scientific names of trees if they understand their etymology. The preseut study is the seconds report of the investigation which aims at examining the etymology of the scientific names of native and foreign trees growing in Korea and their original names not only at the habitat but in Japan, China, England, Germany, and France. While the first report, which was made known in Theses Vol. 9. (The City College of Seoul 1975), is the examination of the scientific names of trees belonging to Gymnospermae, the present report is that of scientific names of trees belonging to Piperales: 2 families, 2 genera and 2 species; and trees belonging to Salicales: 1 family, 3 genera, 44 species, 16 varieties, and 3 forms. As the etymology of the scientific names of trees is made clear, this study will help those who want memorize the scientific names and study foreign technical books and it is also useful for international interchange of trees. The classification is depended chiefly on Dendrology by Prof. Lee Tchang-bok and "Plant Resources of Korea" shown in Biblography No. 10; the native names of trees on Jumoku Daizusetsu by Dr. Uehara; and etymology on A source-Book of Biological Names and Terms by E.C. Jager. In the column of etymology of the scientific names for genera, species, varieties and forms, Gr. stands for Greek, L. for Latin, NL. for New Latin, and genit. for genitive.

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Occurrence of Tetracyclines Resistant Bacteria in the Soil Applied with Livestock Manure Compost (가축분 퇴비 시용 농경지 내 Tetracyclines 내성균 분포 특성)

  • Kim, Song-Yeob;Kim, Jang Hwan;Kim, Sung Chul;Lee, Yong-Bok
    • Korean Journal of Environmental Agriculture
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    • v.33 no.4
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    • pp.409-413
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    • 2014
  • BACKGROUND: Large amount of veterinary antibiotics have been used in the livestock industry to prevent diseases and promote growth. These antibiotics are excreted through feces and urine in unchanged form and reach to agricultural fields via application of the livestock manure based composts. The purpose of this study was to evaluate the occurrence of tetracyclines-resistant bacteria in the soil received livestock manure compost for a long term. METHODS AND RESULTS: Tetracyclines (tetracycline TC, chlortetracycline CTC, and oxytetracycline OTC) resistance bacteria in the soil of rice-onion field applied pig manure compost (PM), in the soil of grass-rye field received cow manure compost (CM), and in the soil of rice field applied inorganic fertilizer (NPK) were determined. The soil received livestock manure composts clearly showed higher number of TC, CTC, and OTC resistance bacteria compared with the soil treated with inorganic fertilizer. The antibiotic resistant bacteria recovered appeared at 80 mg/L of tetracyclines was identified 1 specie, 6 genera 7 species, and 6 genera 7species in the soils received CM, PM, and NPK, respectively. The dominant resistant bacteria with the CM and PM application were Ochrobactrum and Rhodococcus. CONCLUSION: The application of livestock manure compost in the agricultural field is likely to contribute the occurrence of antibiotic resistance bacteria in the agricultural environment.

Effects of Nitrogen and Phosphorus Starvation on Growth and Fatty Acid Production in Newly Isolated Two Freshwater Green Microalgae from Nakdonggang River (낙동강 수계에서 분리한 녹조류 2종의 질소와 인의 결핍에 따른 생장 및 지방산 변화 연구)

  • Yim, Kyung June;Park, Hanwool;Lee, Chang Soo;Jo, Bok Yeon;Nam, Seung Won;Lee, Choul-Gyun;Kim, Z-Hun
    • Journal of Marine Bioscience and Biotechnology
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    • v.11 no.2
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    • pp.81-88
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    • 2019
  • In this study, effects of nitrogen (N) and phosphorus (P) starvation on the cell growth and fatty acid (FA) production of newly isolated freshwater microalgae were investigated. The microalgae were identified as Chlorella sp. and Parachlorella sp. through 18S rRNA sequencing. Optimal culture temperature and light intensity were investigated using a high-throughput photobioreator, and the result was validated in 0.5 L bubble column photobioreactors using BG-11 without NaNO3 and/or K2HPO4. Under nutrient starvation conditions, total FA contents of the microalgae were significantly changed rather than FA composition. Starvation of both N and P was most effective for increasing FA contents in Parachlorella sp (24.4±0.1%) whereas highest FA contents (42.6±1.8%) was achieved when only P was starved in Chlorella sp. among tested conditions. These results suggest an effective strategy for increasing FA production from microalgae using appropriate nutrient starvation.