• Preventive Nutrition and Food Science
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• v.11 no.1
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• pp.48-53
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• 2006

Although garlic has been reported to have impressive effects in lowering serum lipids, there have been controversial evaluations on these effects. To find the potential fator causing the inconsistency in the previous studies, we examined the effects of two types of garlic according to the producing-area (hangihyung garlic, nangihyung garlic) on serum lipid profiles and leptin level. Thirthy six of 4 wk old Sprague Dawley male rats fed high fat diet (40% of calories as fat) for 6 wks to induce obesity, and subsequently fed 5% garlic powder supplemented (HF+H: hangihyung garlic powder, HF+N: nangihyung garlic powder) high fat diets (w/w) for further 5 wk. For the comparison, normal control group fed AIN-76A diet (11.7% of calories as fat). Supplementation with hangihyung and nangihyung garlic resulted in a significant reduction of high fat induced body weight gain, white fat (i.e., epididymal, visceral and peritoneal fat) development, adipocyte hypertrophy and the development of hyperinsulinemia and hyperliptinemia. Serum triglyceride and total cholesterol level was greatly reduced by hangihyung garlic supplementation (p<0.05). The HDL-cholesterol level was increased by dietary hangihyung and nangihyung garlic. There were slight non-significant decreases in triglyceride and total cholesterol of HF+N group as compared to those of HF group. Leptin level of HF+H group was found to be significantly lower than HF group (p<0.05). There was no significant difference among N group and HF+N group. These results suggest that hangihyung garlic may lead to the higher activity in improving lipid profiles than nangihyung garlic. Whether the hypolipidemic effect of garlic increases in a species-dependent has yet to be determined and awaits further research.

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.3
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• pp.642-648
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• 2008

The aim of this study is to investigate Chegameuiin-tang water extracts (CETE) have potent anti-obesity activities in a high fat diet-induced obesity mouse model. In this study, we designed three group (normal diet group, high fat diet group, high fat diet plus CETE group for 13-week oral administration). Increases in body weight and fat storage were inhibited by 13-week oral administration of CETE at a 500 mg/kg concentration in this animal model, while the amount of food intake was not affected. Results from blood lipid analysis showed that the levels of triglyceride, total cholesterol and LDL-cholesterol were significantly lowered by CETE administration, also HDL-cholesterol was increased more than high fat diet-induced obese mouse. To understand the underlying mechanism at the molecular level, the effects of CETE were examined on the expression of the genes involved in lipogenesis and lipolysis by real-time PCR. In epididymal fat of CETE-treated mice, the mRNA level of lipogenic genes such as sterol regulatory element binding protein 1 and fatty acid synthase were decreased, which was well correlated with the reduction of the epididymal fat weight. Also, CETE administration inhibited decreases of the hormone-sensitve lipase and lipoprotein lipase mRNA expressions, which are genes related with lipolysis. These results suggest that Chegameuiin-tang may have great potential as a novel anti-obesity agent.

• Journal of Nutrition and Health
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• v.49 no.6
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• pp.411-419
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• 2016

Purpose: Dysregulation of adipokines caused by excess adipose tissue has been implicated in the development of obesity-related metabolic diseases. This study evaluated the effects of mugwort (Artemisia princeps Pampanini) ethanol extract on lipid metabolic changes, insulin resistance, adipokine balance, and body fat reduction in obese rats. Methods: Male Sprague-Dawley rats were fed either a control diet (NC), high-fat diet (HF, 40% kcal from fat), or high-fat diet with 1% mugwort extract (HFM) for 6 weeks. Results: Epididymal and retroperitoneal fat mass increased in the HF group compared with the NC group, and epididymal fat mass was reduced in the HFM group (p < 0.05). No difference was observed in serum levels of total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C) among the groups. However, triglyceride (TG), TG/HDL-C ratio, and TC/HDL-C ratio increased in the HF group and significantly decreased in the HFM group. TG and TC levels in the liver were significantly higher in the HF group, whereas these levels were significantly reduced in the HFM group. HF rats had lower insulin sensitivity as indicated by increased homeostasis model assessment of the insulin resistance (HOMA-IR) value. HOMA-IR values significantly decreased in the HFM group. Adiponectin levels were higher in NC rats, and their leptin and PAI-1 levels were lower. Relative balance of adipokines was reversed in the HF group, with lower adiponectin levels but higher leptin and PAI-1 levels. In contrast, the HFM group maintained balance of adiponectin/leptin and adiponectin/PAI-1 levels similar to NC by reducing leptin and PAI-1 levels. Conclusion: Overall data indicated that mugwort extract can be effective in alleviating metabolic dislipidemia, insulin resistance, and adipokine dysregulation induced by a high-fat diet.

• Asian-Australasian Journal of Animal Sciences
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• v.32 no.9
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• pp.1407-1413
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• 2019

Objective: This experiment aimed to investigate the effect of different sources and inclusion levels of dietary fat on productive performance and egg quality in laying hens raised under hot environmental conditions. Methods: A total of 480 Hy-Line Brown laying hens at 31 wk of age were randomly allotted to 1 of 5 experimental diets. The control diet contained 2,800 kcal/kg nitrogen-corrected apparent metabolizable energy with no fat addition. Four additional diets were prepared by adding 2.0% or 4.0% of animal fat (AF) or soybean oil (SO). Energy and nutrient concentrations were consistent among all diets. Diets were fed to hens for 4 weeks. Average daily room temperature and humidity were $26.7^{\circ}C{\pm}1.52^{\circ}C$ and $77.4%{\pm}4.50%$. The heat stress index was approximately 76, indicating that hens were raised under heat stress conditions. Results: Final body weight (BW) was greater (p<0.05) for hens fed diets containing 2.0% or 4.0% AF than for those fed the control diet or diets containing 2.0% or 4.0% SO. The BW gain and feed intake were greater (p<0.05) for hens fed diets containing additional AF or SO than those fed the control diet. Eggshell thickness was the greatest (p<0.05) for hens fed the control diet, but the least (p<0.05) for hens fed diets containing 4.0% SO. Egg yolk color was the greatest (p<0.05) for hens fed the control diet, but the least (p<0.05) for hens fed diets containing 4.0% SO. Conclusion: Inclusion of supplemental fat (AF and SO) in diets exhibits preventative effects on BW loss for hens raised under hot environmental conditions when energy and nutrient concentrations in diets were maintained. The effects were greater for AF than for SO. However, inclusion of supplemental fat in diets decreases eggshell thickness and egg yolk yellowness, possibly due to a reduction in Ca absorption and intake of egg yolk colorants.

• Journal of the Korean Applied Science and Technology
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• v.37 no.4
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• pp.878-892
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• 2020

The purpose of this study is to explore the effects of pregnant women's taking of probiotics and pilates exercise on Postnatal women's body composition, gut-microbiota, obesity hormones, blood lipid, inflammatory cytokine. Overall clinical trial procedures are as follows. First, a total of 15 pregnant women were classified into 3 groups, probiotics intake+exercise group(PEX, n=5), exercise group(EX, n=5), and control group(CON, n=5). The PEX and EX groups participated in the pilates exercise twice a week for eight weeks, with 10 min for warm-up, 30 min for main exercise and 10 min for cool-dawn. The probiotics had to take one capsule a day on its empty stomach every day. The results showed that intestinal harmful bacteria were inhibited after childbirth in PEX group, and body fat, WHR reduction. There were also positive effects on the decrease of leptin hormone in PEX group and on IL-6, TNF-a levels. The caesarean section ratio of CON group compared to PEX and EX group was found to be high. Conclusion pregnant women's probiotics intake and pilates exercise will be effective in women's abdominal fat reduction after childbirth, and will have positive effects on inflammatory levels and appetite control hormones, which will be effective in preventing and treating obesity for after childbirth.

• The Korean Journal of Community Living Science
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• v.27 no.3
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• pp.477-493
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• 2016

This research was conducted to investigate the performance of a weight control program in university students in Daejeon during 3 months from November 2014 to February 2015. This program measured body measurement and composition analysis, nutritional education, and counseling every month. The status of students' weight control was surveyed before and after the program. The participants were 17 males (24.5 years old) and 15 females (20.8 years old). Their weights before the program were 78.2 kg (male) and 57.2 kg (female), whereas after the program, weights were 77.6 kg (male) and 56.2 kg (female). Weight reduction in students was 53.1%, and weight increase was 40.6% by the weight control program. Body mass index (BMI) tended to decrease after the program. Body fat % and muscle masses were not significantly different by program practice. Body image decision of females showed mainly 'normal' status while that of male was 'over fatty constitution', Before and after the program, the most prevalent method of weight control was exercise for all students. The most selected exercise was 'walking and jogging' during the program. For the most effective weight control method, female acknowledged both 'reducing amount of meals' and 'increasing exercise' while males selected 'increasing exercise.' On the side effects of weight control, over 40% of all students chose 'no experience' and 'loss of volition'. The degree of student's goal achievement was largely 20 ~-20% compared with their goal weights. Accordingly, this program didn't show significant effects. For effective weight control, it is recommended to conduct nutritional education. Students can exercise regularly and control diet to sustain a healthy and satisfactory body status.

• The Korean Journal of Food And Nutrition
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• v.20 no.3
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• pp.325-333
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• 2007

This study was conducted to investigate the weight concerns of female university students living in Jeonju, as well as their control on behavior. Self-administered questionnaires were collected from 285 students. Statistical data analysis was completed using the SPSS v. 11.0 program. The results are summarized as follows: The average weight, height, and BMI of the subjects were 21.43 kg, 161.93 cm, and 19.8, respectively. With regard to body image, most were dissatisfied with their figures, especially the hips and thighs. About 42% of the students estimated their figures as 'slightly fat', while 5.4% stated 'very fat', even though their BMI classified as 'normal'. Four percent of the underweight students described themselves as being 'fatty'. Approximately 93% of the students had strongly pursued weight control, and 45.3% reported wanting to lose about $2{\sim}5$ kg. Almost 73% of the respondents had weight loss experience. The primary reason for weight control was to improve self-confidence. Only 19.6% had succeeded in losing weight, while nearly 48% had stopped dieting. To reduce weight, about two thirds of the students ate less(e.g. no snacks, no sweets). Fifty percent tried to reduce weight by more physical activity(e.g. sports). Television(50.9%), friends(48.4%), and newspapers/magazines(40.4%) were essential sources of pertinent information. In conclusion, the results show that female students in Jeonju have a great interest in weight reduction. Thus, the majority are willing to try several methods for weight reduction, which however, are not promising and not based on a lasting nutritional change. Therefore, it's necessary to increase cooperation among those concerned(e.g. dietitians, teachers, parents, media) and to develop weight-control programs that take into consideration lifestyle and daily habits, as well as combine physical activity, nutrition, and behavioral and personality training.

• Preventive Nutrition and Food Science
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• v.17 no.1
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• pp.1-7
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• 2012

The inhibitory effect of polyphenol extracts (Seapolynol$^{TM}$, SPN) of the marine brown algae Ecklonia cava and dieckol, a major component of SPN, on hyperlipidemia was investigated in ICR mice fed a high-fat diet (HFD) for five weeks. For analysis of the anti-hyperlipidemic effects of SPN and dieckol, these two agents were given orally on a daily basis to HFD-fed mice for four weeks, starting one week after the beginning of HFD feeding. Groups administered with SPN as well as dieckol showed lower body weight gains than the HFD only group. Administration of SPN and dieckol also resulted in a significant reduction of the level of total cholesterol (TCHO), triglyceride (TG), and low-density lipoprotein (LDL) cholesterol in the serum of HFD-fed mice. In Oil Red O staining using 3T3-L1 preadipocytes, it was shown that both SPN and dieckol markedly inhibited lipid accumulation of 3T3-L1 cells. Furthermore, SPN and dieckol (50 ${\mu}g$/mL) significantly inhibited 3-hydroxyl-methyl glutaryl coenzyme A (HMGCoA) reductase activity in vitro. Taken together, these results suggest that polyphenols of Ecklonia cava (SPN) and dieckol reduce body weight gain and fat accumulation in HFD-induced obese mice, and that their hypolipidemic effect is related to the inhibition of adipogenesis of adipocytes and HMGCoA reductase activity.

• BMB Reports
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• v.40 no.4
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• pp.525-531
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• 2007

As a $\beta_2$-adrenergic agonist, clenbuterol decreases body fat, but the molecular mechanism underlying this process is unclear. In the present study, we treated 293T and L-02 cells with clenbuterol and found that clenbuterol downregulates SREBP-1c expression and upregulates CREB1 expression. Considering SREBP-1c has the function of regulating the transcription of several lipogenic enzymes, we considered that the downregulation of SREBP-1c is responsible for body fat reduction by clenbuterol. Many previous studies have found that clenbuterol markedly increases intracellular cAMP levels, therefore, we also investigated whether CREB1 is involved in this process. The data from our experiments indicate that CREB1 overexpression inhibits SREBP-1c transcription, and that this action is antagonized by CREB2, a competitive inhibitor of CREB1. Furthermore, since PPARs are able to repress SREBP-1c transcription, we investigated whether clenbuterol and CREB1 function via a pathway involving PPAR activation. However, our results showed that clenbuterol or CREB1 overexpression suppressed PPARs transcription in 293T and L-02 cells, which suggested that they impair SREBP-1c expression in other ways.

• Korean Journal of Community Nutrition
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• v.15 no.1
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• pp.73-82
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• 2010

This study was conducted to investigate the effects of a weight control programs on BMI, nutrition knowledge, physical fitness and stress level of adult obese women. The subjects of this study were 36 adult obese women aged 30-65 years whose BMI were above $23\;kg/m^2$. The weight control program for obese women included nutritional education, exercise and cognitive behavioral therapy for 12 weeks. The BMI of the subjects was significantly decreased (p < 0.001) from $27.1\;kg/m^2$ to $26.4\;kg/m^2$ after the 12 weeks of the weight control program. In addition, the weight of body fat was significantly decreased (p < 0.001) and % body fat was significantly decreased (p < 0.05) from 35.4% to 34.9% after completion of the weight control program. In addition, nutritional knowledge (p < 0.001) and eating behavior scores (p < 0.01) were significantly increased. However, the food intake scores were not changed after the program. Stress levels of the adult obese women were significantly decreased (p < 0.001) from 85.63 to 66.88 and also obesity stress levels were significantly decreased (p < 0.01) after the weight control program. In the physical fitness levels of the subjects, muscle endurance (p < 0.05) and ability of balance (p < 0.01) were significantly improved after completion of the weight control program. There were positive significant correlations between general stress and obesity stress level (p < 0.05), and negative correlations between stress level and food intake score (p < 0.05). These results showed that the weight control program for adult obese women may be effectively used to improve weight reduction, physical fitness and stress levels.