• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.7
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• pp.3072-3081
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• 2011

The purpose of this study was to investigate the association of blood pressures, hematological and blood biochemical properties according to the degree of obesity based on differential combinations of BMI in health checkup examinees. Study subjects were 3,731 adults of 20 years and over (2,312 males, 1,419 females), not recognized as taking medicines for or having cardiovascular diseases, who underwent health package check-up at the Korea Association of Health Promotion, Daejeon Branch from Jan. 2007 to Dec. 2009. As a results, the mean values of SBP, DBP, TG, TC, LDL-C, ALT, AST, GGT, ALP were significantly increased with higher level of BMI, but the HDL-C was significantly decreased with higher level of BMI. On correlation of BMI with various factors, the BMI was positively correlated with SBP, DBP, TG, TC, LDL-C and GGT, while the HDL-C was negatively correlated. Based on the result of ordinal logistic regression analysis, the risk ratio to the abnormal level of SBP, DBP, TG, ALT and GGT were significantly increased as BMI increased.

• Journal of Veterinary Clinics
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• v.18 no.4
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• pp.334-340
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• 2001

This study was conducted to investigate changes in blood properties of high potassium (HK) phenotype Jindo dogs (15kg$\pm$2kg) after daily oral administration with water celery extracts (10 ml/kg) for 7 days. Blood samples were collected for three days in a row before administration of water celery extracts. After water celery extracts administration, blood samples were collected at 3h, 6h, 9h and then on daily basis until day 10 post administration (PA). At day 15, final sample was collected. Blood samples were analyzed on the basis of red blood cell (RBC), white blood cell (WBC), packed cell volume (PCV), hemoglobin (Hb) concentration, mean corpuscular volume(MCV), mean corpuscular hemoglobin concentration(MCHC), gluthathione concentration(GSH) and met-hemoglobin(Met-Hb) concentration. The significant changes (p<0.01, p<0.05) of RBCs were shown at 3 h to day 5, and days 7 and 9 after administration. PCV values were decreased form 3 h to day 10 after administration. Mean Hb concentration showed significant increase as 3 h to day 3, and day 6 to day 9 after administration. The significant changes (p<0.05) of WBCs were shown at 9 h and day 1 after administration. The increased numbers of MCV were detected at days 6 to 9 after administration (p<0.05, p<0.01). The significant changes of MCHC were shown at 9h and day 1 after administration. The significant increases (p<0.01, p<0.05) of GSH concentration were detected at days 1, 6 and 7 after administration. In Met-Hb concentration, the significant increases (p<0.05) occurred at only 9h and day 7 after administration, The significant increases (p<0.01, p<0.05) of reticulocyte were detected at days 2, 4, 5, 6 and 7. Data from blood samples collected at day 15 after administration showed that all of blood analysis results returned to normal level, compared to controls.

• International Journal of Vascular Biomedical Engineering
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• v.1 no.2
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• pp.4-12
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• 2003

The present study investigated the effect of transverse vibration on the hemorheological characteristics of blood using a newly designed pressure-scanning capillary viscometer. As vibration was applied, aggregated blood cells (rouleaux) were disaggregated. The range of vibration frequency and amplitude are $0{\sim}100\;Hz$ and $0{\sim}0.8\;mm$, respectively for a capillary diameter 0.84 mm. As vibration increased, blood viscosity initially increased and tended to decrease. In order to delineate the unexpected results, the present study proposed two counteracting mechanisms of vibration related with red blood cell (RBC) aggregation affecting hemo-rheological properties. One is the reduction of RBC aggregation due to vibration causing an increase of blood viscosity. The other is forced cell migration due to the transverse vibration, which in turn forms a cell-free layer near the tube wall and causes a decrease of flow resistance.

• Proceedings of the Korea Society for Simulation Conference
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• 2005.05a
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• pp.149-153
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• 2005

In the cardiovascular system, the waveform of the pulsatory blood pressure appears variously due to the cardiac impulse and compliance of blood vessels and arm tissue. We have constructed a blood pressure simulator to investigate effects of mechanical properties of artery walls and tissue on blood pressure measurements. The blood pressure simulator is designed to reproduce wave forms of blood pressure in human arteries. To minimize tracking error, we use a linear control valve, and adapt a hybrid control scheme which consists of a feedback controller and a feedforward controller. Any form of the pressure wave can be reproduced, changing function of the wave form in the computer connected to the simulator for control. From experiments, it has been shown that the simulator reproduces wave forms very well, and that the hybrid scheme adapted is superior to the feedback controller.

• Proceedings of the Korean Fiber Society Conference
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• 2003.10b
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• pp.55-58
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• 2003

Segmented polyurethanes have been widely used for various commercial and experimental blood-contacting and tissue-contacting applications such as vascular prostheses, blood pumps, heart valves, pacemaker lead wire insulation, catheters, artificial hearts, and cardiac assist devices due to their generally favorable physical and mechanical properties, as well as fairly good biocompatibility and antithrombogenicity characteristics. (omitted)

• Journal of Advanced Marine Engineering and Technology
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• v.33 no.7
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• pp.981-986
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• 2009

The application of a cryogenic storage system is growing fast in different kinds of fields including to keep umbilical cord blood. Umbilical cord blood stem plays an important role in the treatment of a blood and immune system related genetic diseases, cancers and blood disorders. This study gives the optimal cryogenic system for cord blood banking. Three-dimensional models are employed and finite element method is used to do structure analyses of all designed models. The results shows model 3 have a good structure properties, and model 4 shows the best structure property as its maximum is 92.9 MPa. The other is too dangerous or infeasible to support load condition that allowed by STS 304. The results can be used in the design of these kinds of systems to obtain good predictions of trends over a wide range of design alternatives and operating conditions.

• Journal of Applied Biological Chemistry
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• v.50 no.4
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• pp.187-195
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• 2007

The cord blood serves as a vehicle for the transportation of oxygen and nutrients to the fetus. In the past, the human cord blood has generally been discarded after birth. However, numerous studies have described the regenerative ability of the cord blood cells in various incurable diseases. The umbilical cord blood (UCB)-derived stem cells are obtained through non-invasive methods that are not harmful to both the mother and the fetus. Furthermore, the cord blood stem cells are more immature than the adult stem cells and expand readily in vitro. The mesenchymal stem cells (MSCs) have the capacity to differentiate in vitro into various mesodermal (bone, cartilage, tendon, muscle, and adipose), endodermal (hepatocyte), and ectodermal (neurons) tissues. This review describes the immunological properties of the human UCB-MSCs to assess their potential usefulness in the allogeneic transplantation for the regenerative medicine.

• Journal of Korean Medical classics
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• v.21 no.1
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• pp.295-302
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• 2008

Until the middle of the 20th century, exogenous febrile disease was the most common disease that threatened the human health. For a long time, oriental medicine doctors developed many ways to cure this disease by studying pathogenic factors. The phthogenic factors and treatments of exogenous febrile disease with time are as followings. "Naegyeong(內經)" : Cold pathogen. Diaphoretic therapy, purgation therapy. Hwata : Cold pathogen. Diaphoretic therapy, emetic therapy, purgation therapy. Jangjunggyeong(張仲景) : Cold pathogen. Eight principal therapeutic methods except diaphoretic therapy with pungent and cool properties. Yuhagan(劉河間) : Fire pathogen. Diaphoretic therapy with pungent and cool properties. Idongwon(李東垣) : Improper diet and overstrain. Reinforcing therapy. Ouga(吳又可) : Epidemic pathogenic factors. Diaphoretic therapy with pungent and cool properties, Heat-reducing therapy. purgation therapy Seopcheonsa(葉天士) : Warm pathogen. diaphoretic therapy, Heat-reducing therapy, expel Heat therapy, cooling the blood and eliminating stagnation of blood. Oguktong(吳鞠通) : Six pathogenic factors. Eight principal therapeutic methods including diaphoretic therapy with pungent and cool properties.

• Journal of Mechanical Science and Technology
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• v.19 no.9
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• pp.1761-1772
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• 2005

In blood flow passing through the mechanical heart valve (MHV) and elastic blood vessel, hemolysis and platelet activation causing thrombus formation can be seen owing to the shear stress in the blood. Also, fracture and deformation of leaflets can be observed depending on the shape and material properties of the leaflets which is opened and closed in a cycle. Hence, comprehensive study is needed on the hemodynamics which is associated with the motion of leaflet and elastic blood vessel in terms of fluid-structure interaction. In this paper, a numerical analysis has been performed for a three-dimensional pulsatile blood flow associated with the elastic blood vessel and curved bileaflet for multiple cycles in light of fluid-structure interaction. From this analysis fluttering phenomenon and rebound of the leaflet have been observed and recirculation and regurgitation have been found in the flow fields of the blood. Also, the pressure distribution and the radial displacement of the elastic blood vessel have been obtained. The motion of the leaflet and flow fields of the blood have shown similar tendency compared with the previous experiments carried out in other studies. The present study can contribute to the design methodology for the curved bileaflet mechanical heart valve. Furthermore, the proposed fluid-structure interaction method will be effectively used in various fields where the interaction between fluid flow and structure are involved.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.1
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• pp.152-158
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• 2005

This study was carried out to understand the physiological properties and the effects of Bambusae Caulis in Liquamen manufactured by three different production process on blood glucose of the mice induced with streptozotocin. Original, filtered and refined Bambusae Caulis in Liquamen manufactured by three different production process were used. The physiochemical properties of original, filtered and refined Bambusae Caulis in Liquamen manufactured by three different production process were compared. Furthermore, the effects of original, filtered and refined Bambusae Caulis in Liquamen were observed in terms of blood glucose, BUN, ALT in the mice induced with streptozotocin. The results were as follows : The range of the pH manufactured by three different production processes was $2.28{\sim}3.17$ Concentration of methanol and phenolic compounds which are related to toxicity were lowest in filtered Bambusae Caulis in Liquamen(L-BCL [E] B) manufactured by using electric furnace at $215{\circ}C$ during 8.10/hour. The blood glucose contents was decreased in the experimental groups compared with the control. The amount of BUN and ALT did not show any differences between control and experimental group.