• 보건행정학회지
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• 제31권3호
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• pp.292-300
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• 2021

Background: Medication adherence in hypertension is the most important to control blood pressure and prevent major complications. The purpose of this study was to identify factors affecting medication adherence and to examine the relationship between medication adherence and blood pressure control in Korea. Methods: This study used data from the 7th Korea national health and nutrition examination survey (2016-2018) of the Korea Disease Control and Prevention Agency. We selected 4,063 hypertensive patients from the data. And we choose socio-demographic, health behavior, healthcare utilization, and severity characteristics as hypertensive patient characteristics. Results: Of the patients with hypertension, 92.3% had shown adherence to medication as of 2016-2018 and shows variation according to the characteristic of patients. The cases with male, under 50 years old, urban area, single household, unmet medical services, less than 5 years of hypertension duration, no comorbidities (diabetes mellitus, myocardial infarction) showed significantly low medication adherence. After adjusting for confounders, adherent patients tended to have lower current systolic blood pressure (β=-10.846, p<0.001) and diastolic blood pressure (β=-5.018, p<0.001) than nonadherent patients. And, adherent patients increased the control odds of blood pressure compared with nonadherent patients (odds ratio, 3.02; 95% confidence interval, 2.21-4.12). Conclusion: This study confirmed that adherence to antihypertensive drugs was effective in controlling blood pressure. In order to more actively manage hypertensive patients at the national level, it is necessary to make an effort to improve the medication compliance of nonadherent groups, such as early-diagnosis patients, young patients under 50 years of age, and patients living alone.

• 한국보건간호학회지
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• 제17권1호
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• pp.144-152
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• 2003

The purpose of this study is to identify the prevalence rate of hypertension and diabetes a in the urban communities and to provide the basic data for development of health promot The subjects of this study were 526 people over the age of 20, living in Seoul. Data for this collected from June 19, 2001 to September 25, 2001. The results of this study are as follows: 1. The subject group is comprised of males, $57.4\%$ and females, $42.6\%$. Their ages range from 20 to 89, and the weights from 40 to 94 kilograms. 2. In the systolic blood pressure, $36.1\%$ showed high, $56.5\%$ normal. and $7.4\%$ low. In the diastolic blood pressure, $50.5\%$ showed high, $48.9\%$ normal, and $1.7\%$. low. In the blood glucose, $70.3\%$ showed normal. $27.9\%$ high, and $1.7\%$. low. 3. There was a significant difference in the mean(SD) of the systolic blood pressure by age(p=.017) and weight(p=.005). Another significant difference was found in the mean (SD) of the diastolic blood pressure by age(p=.006) and weight(p=.007). There was a significant difference in the mean(SD) of the blood glucose by sex and age(p=.001). 4. There were significant correlations between the blood pressure and the blood glucose and the sex, age and weight. 5. The multiple regression analysis showed that the age and weight explained $9.9\%$ of the systolic blood pressure, that the weight and age explained $7.1\%$ of the diastolic blood pressure, and that the age and systolic blood pressure explained $7.0\%$ of blood glucose. The results were useful in developing health promotion programs. This study suggests that a further study be needed.

• 지역사회간호학회지
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• 제17권4호
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• pp.472-481
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• 2006

Purpose: Hypertension tends to increase after the age of 65. Proper hypertension management requires physical activities such as habitual activities and exercise. However. it is reported that many elders do not have regular physical activities. This study was to identify physical activity patterns and blood pressure according to physical activity in the elderly with hypertension. Methods: This study assessed physical activity frequency, amount, type during the latest one week, and blood pressure and BMI. The subjects were 53 elders aged over 65 years. Collected data were analyzed through descriptive statistics, $x^2-test$, and logistic regression analysis using SPSS 12.0. Results: It was found that most of the subjects had not been participating in regular physical activities. The most frequent physical activity patterns were walking and home activity at a low or moderate intensity. The elderly who met the normal hypertension and pre-hypertension criteria involved significantly more regular physical activities. Conclusion: This study suggested that regular participation in physical activities should be recommended for elders in order to optimize the state of their blood pressure.

• 한국학교보건학회지
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• 제17권1호
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• pp.55-69
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• 2004

Purpose ： To describe epidemiological characteristics and related factors in school personnel with hypertension. Method ： 5,384 school personnel (2,638 males and 2,746 females) received physical examination at the Seoul School Health Center in 2002. blood pressure(BP) was classified by JNC 7th report. Normal BP is systolic BP <120 and diastolic BP<80, prehypertension BP is 120-139 or 80-89mmHg, stage 1 hypertension BP is 140-159 or 90-99, and stage 2 hypertension >=160 or >=100 mmHg. each group was evaluated by gender. We used multiple regression and logistic regression. Results ： Normotension was 20.13% in males and 48.65% in female, prehypertension 43.4% in males and 38.06% in females, stage 1 hypertension 26.38% in males and 10.99% in females, stage2 hypertension 9.59% in males and 3.2% in females. the older age group had higher distribution of stage 1 hypertension and stage 2 hypertension. The means and abnormal rates of BMI, blood sugar, total cholesterol, GOT, GPT, and GTP was higher when their blood pressure was higher. However, an alcohol habit among lifestyle factors had an inverse effect. Higher Bp was correlated to a higher BMI, FBS, and cholesterol-like dose response. In stage 1 hypertension, the related factors of hypertension for males were BMI, amount of cigarettes smoked, exercise, blood sugar, total cholesterol, and GTP. In stage 1 hypertension, age, BMI, exercise, blood sugar, total cholesterol were related factors in female. In stage 2 hypertension, age and smoking were related factors in male, and age, BMI, and cholesterol in female. Conclusions ： It is possible to intervene in all related factors of hypertension except age through life-style modification and appropriate medical management. Active health promotion is needed in School personnel.

• 한국산업보건학회지
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• 제24권2호
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• pp.137-145
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• 2014

Objectives: The study examines the relation between urinary arsenic concentration and blood pressure, which is a risk factor of cardiovascular disease. Materials: In this study, the urinary arsenic concentration, history of diagnosed disease, and blood pressure of 782 local residents in Gwangyang, Yeosu, and Hadong regions from May 2007 to July 2007. Results: The urinary arsenic concentration of total participants was $9.06{\mu}g/g-ct$. The logistic regression analysis of medical diagnosed history and urinary arsenic concentration, showed statistically significance (p<0.05) of high urinary arsenic concentration in participants with diagnosed hypertension. In addition, diagnosed hypertension it was observed that the high blood pressure was related with the pulse pressure. Conclusions: The arsenic concentration level was low in this study, but the exposure to low levels of arsenic has an effect on hypertension. Also, hypertension is related to pulse pressure and mean arterial blood pressure as well as being risk factor of cardiovascular disease. Therefore, close supervision of low -level arsenic exposure is needed.

• 한국한의학연구원논문집
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• 제13권2호통권20호
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• pp.149-155
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• 2007

Objective : Using a spontaneously hypertensive rat (SHR) model of essential hypertension, this study investigated whether electroacupuncture (EA) could reduce early stage hypertension by examining whether EA increased nitric oxide (NO) levels in plasma, which compensates for elevated blood pressure (BP). Methods : EA was applied to the acupoint, Baekhoe (GV20), and to a non acupoint in the tail at 10 Hz and an intensity of 1 mA for 10 minutes on the first and fourth day of the week for three weeks under isoflurane anesthesia. In conscious SHR and normotensive Wistar Kyoto (WKY) rats, blood pressure was determined the day after EA treatment by the tail cuff method using an automatic BP monitoring system. We also measured NO concentration of blood serum in SHR and WKY. Results : Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were lower after 3 weeks of GV20 treatment than in non EA treated or non acupoint treated SHR rats. The NO level of plasma was significantly lower in hypertensive SHR than in normotensive WKY. EA prevented the augmentation of blood pressure, and also increased NO concentrations from $7.91{\pm}0.42$ ${\mu}M$ to $11.50{\pm}0.93$ ${\mu}M$ in SHR serum. Conclusions : We suggest that acupuncture may be an early intervention to delay the development of hypertension and enhance NO/NOS activity.

• 한국식품위생안전성학회:학술대회논문집
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• 한국식품위생안전성학회 2004년도 추계심포지움 및 학술발표회 : 건강기능식품의 안전성 평가와 개발
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• pp.59-70
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• 2004

A randomized double-blind placebo-controlled study was conducted on 63 subjects to determine the antihypertensive effect of a vegetable drink in which sardine protein hydrolysates containing a dipeptide, Valyl-Tyrosine (VY), were incorporated. The subjects, consisting of people with mild hypertension, high-normal blood pressure and normal blood pressure, were randomly divided into test (male/female=25.6, average age 50.1${\pm}$10.4 years old) and control groups (26/6, 49.0${\pm}$5.0). Each subjects in the test group was given 195g of the vegetable drink containing 0.5g of sardine peptides (sardine protein hydrolysates) with 0.4 mg of VY (test drink) once a day for 13 weeks in a row, and subjects in the control group were given the same amount of the vegetable drink without sardine peptides (control drink) in the same manner. In the test group, 40 subjects with mild hypertension of high-normal blood pressure (130 mmHg${\leq}$systolic blood pressure (SBP)<160 mmHg and/or 80 mmHg${\leq}$diastolic blood the start of the test to 134.4${\pm}$11.1 mmHg during the first week of the test period, after which similar values were seen throughout the test period (13 weeks). Compared to the control group, the difference in SBP from vaseline was statistically significant in the test group throughout the intake period. DBP also decreased significantly from 88.0${\pm}$7.9 mmHg at baseline to 83.5${\pm}$8.6 mmHg after 13 weeks. In the control group, SBP and DBP were 140.8${\pm}$8.4 mmHg and 90.5${\pm}$6.6 mmHg respectively at the start of the test, and neither decreased during the test period. In subjects with normal blood pressure, neither those in the test group nor those in the control group showed a significant change in SBP and DBP during the test period. An excessive ingestion test was performed on 25 subjects with hypertension, mild hypertension, high-normal blood pressure, and normal blood pressure by giving 585g (3 times the recommended amount of intake) of the test drink for 14 days in a row. As a result, a significant decrease of blood pressure was observed in the hypertension, mild hypertension and high-normal blood pressure groups, but no excessive decline in blood pressure or any side-effects were associated with any subjects during the test period. In the groups with normal blood pressure, the excessive ingestion of the test drink did not affect blood pressure. In these two studies, physical check-ups and biochemical analyses of blood and urine were also conducted in all subjects, and no abnormalities were observed. These results suggest that the test drink containing sardine protein hydrolysates exhibited the antihypertensive effect in only the subjects with mild hypertension or high-normal blood pressure. No adverse effects were observed in either hypertensive of normotensive subjects.

• 대한임상검사과학회지
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• 제51권1호
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• pp.57-63
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• 2019

고혈압은 유전적, 환경적 요인들이 복합적으로 작용하여 발생하는 질환으로, 선진국들의 경우에는 성인들의 30% 이상이 고혈압 상태인 매우 유병률이 높은 만성 질환이다. 고혈압에 영향을 미치는 유전적 요인들 중에서 MACROD2 유전자의 변이들이 백인 중심의 코호트 연구에서 혈압 및 고혈압 상태와 상관관계가 있다는 보고들이 있다. 이에 본 연구에서는 질병관리본부에서 생산 구축한 한국인 유전체 역학 자료를 바탕으로 MACROD2 유전자 영역의 유전 변이들을 선택 추출한 후에 고혈압 상태에 대한 로지스틱 회귀분석을 시행하였고, 수축기 혈압과 이완기 혈압에 대해서는 선형 회기 분석을 진행하였다. 그 결과 고혈압 상태에서 16개 SNP들이 유의한 상관관계를 보여 주었고, 이들 중 2개의 SNP (rs16996211, rs6034240)은 혈압에서도 통계적 유의성을 보여주고 있다. 가장 유의성이 높은 rs16996211은 고혈압의 상대적 위험도가 0.85 (CI: 0.76~0.95, $P=3.1{\times}10^{-3}$)이고, 수축기 혈압은 (beta=-0.75, P=0.024)의 이완기 혈압은(beta=-0.59, P=0.01)의 상관 분석 결과를 보여주었다. 이러한 결과들을 통해 MACROD2 유전자의 다형성은 백인 중심의 서양인 뿐만 아니라 한국인에서도 고혈압과 상관관계가 있는 것을 확인할 있었으며, 이러한 사실은 고혈압의 병리 기전에 대한 유전적 상호관계의 이해를 높일 것으로 기대한다.

• 대한본초학회지
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• 제21권2호
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• pp.143-150
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• 2006

Oriental pear was used as treatment of asthma, control of blood pressure tonic medicine diabetes in oriental medicine, Pear Pectin was effective on control of blood pressure in previous report. In this study, it was investigated that Woohwang with pear extractions effects on cardiovascular system as blood pressure and renin and Atrial natriuretic peptide(ANP) in plasma. The 2K1C hypertension model was prepared by constricting the left renal artery with a sliver dip. Animals were then divided into three groups, control, Woowhang:Pear Phenolic compound(1:1), Woowhang:Pear Phenolic compound(2:1),Woowhang:Pear Phenolic compound(1:2) were supplied with them. Direct-blood pressure was measured at femoral vein, Indirect-blood pressure was measured at rodent tail. The results are as follows. The blood pressure was more significantly decreased at 1:2(woohwang:pear phenolic compound)group than other groups. On 6,9,12,15days, the blood pressure was significantly decreased in 1:2(woohwang:pear phenolic compound)group. The plasma ANP was significantly increased in 1:2(woohwang:pear phenolic compound)group. It tenders to decrease in 1:2(woohwang:pear phenolic compound)group on plasma renin. Based on the above results it is assumed that oral administration of Woohwang with Pear Phenolic compound(1:2) can help the treatment of hypertension.

• Journal of Acupuncture Research
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• 제25권6호
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• pp.13-22
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• 2008

Objectives : Aim of this study was to investigate the antihypertensive effect of Gyeok-Pal Sang-Saeng-Yeok-Chim acupuncture treatment in hypertensive patients. Methods : The research subjects were a total of 26 hypertension patients. Eligible participants had systolic blood pressure ${\geq}140mmHg$ or diastolic blood pressure ${\geq}90mmHg$ with antihypertensive drug. Both the experimental and control group were divided into 13 participants respectively with homogeneous consideration. The experimental group had acupuncture treatment, Gyeok-Pal Sang-Saeng-Yeok-Chim, whereas the control group didn't have any treatment. Blood pressure was measured before and after acupuncture treatment for a total of 12 times. Results : After 4 weeks of treatment we could identify a decrease in both systolic and diastolic blood pressure in acupuncture, Gyeok-Pal Sang-Saeng-Yeok-Chim, treated group compared to that of control group. The given results by measuring time on blood pressure were as follows: Significant decrease in systolic blood pressure from the $1^{st}$ to $12^{th}$ day of visit(P<0.05) while diastolic blood pressure did not show significant decrease. Conclusions : The results suggest that Gyeok-Pal Sang-Saeng-Yeok-Chim acupuncture treatment is effective in decreasing blood pressure but with statistical restriction compared to that of control group.