• Biomedical Science Letters
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• v.7 no.2
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• pp.91-98
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• 2001

The present study was prospectively designed to assess the clinical effect of leukocyte-depleted blood cardioplegic solution (BCS) on myocardium during cardiac surgery with cardiopulmonary bypass (CPB). 30 adult patients scheduled for elective cardiac surgery were divided into control group (n＝15), which infused routine BCS, and leukocyte-depleted (LD) group (n＝15), which infused leukocyte-depleted BCS. Total and differential leukocyte counts in BCS, malondialdehyde (MDA) and troponin-T (TnT) concentrations in coronary sinus blood, and cardiac index (CI) were measured at preoperative and postoperative period. The BCS in LD group had less total leukocyte counts with neutropenia than that in control group (P＜0.01). MDA (3.70$\pm$0.35 vs 5.90$\pm$0.57 $\mu$mol/L, p<0.05) and TnT (0.42$\pm$0.03 vs 0.60$\pm$0.09 ng/mL, p<0.05) were significantly low in LD group compared with control group, while LD group had higher CI (3.28$\pm$0.16 L/min/$m^2$, p<0.05) than control group (2.69$\pm$0.18 L/min/$m^2$). These results suggest that leukocyte-depleted blood cardioplegic solution has a better myocardial protective effect with less generations of oxygen free radicals and ischemia/reperfusion injury.

• Journal of Korean Academy of Nursing
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• v.31 no.6
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• pp.998-1011
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• 2001

In order to improve self-management of elderly hypertensives in this study, the researcher examined the effect of blood pressure regulation by an abdominal relaxed breathing training which regulates physical response to stress and lessens the activity of the sympathetic nerve. Method: A quasi-experimental pre-test and post-test design was used. Thirty elderly hypertensive patient ; Sixteen in the abdominal breathing group and fourteen in the control group participated in this study. The abdominal relaxed breathing training consisted of eight sessions twice a week for four weeks. There was no intervention for the control group. Result: 1. There was a significant decrease in systolic and diastolic blood pressure between the experimental group and control group over three different times, and interaction by groups and over time. 2. There was no significant difference in the level of total stress response, physical stress response, behavioral-cognitive stress response between the experimental group and control group over three different times, and interaction by groups and over time. Conclusion: Findings indicate that this study will contribute to develop nursing strategies for the regulation of blood pressure for the elderly, which is easy for the elderly to learn as a nonpharmacologic approach.

• Korean Journal of Adult Nursing
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• v.14 no.2
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• pp.233-243
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• 2002

Purpose: This study is aimed at testing the effect of health promotion program on health promoting behavior and cardiovascular risk factors of middle-aged women. Method: The research design was the nonequivalent control group pre-post test. Twelve middle-aged women were the experimental group and ten were the control group. The 8-week health promotion program was given to the experimental group. There were health promotion theories, flexibility and muscle strength exercise, cardiopulmonary endurance exercise, nutrition, stress management, cancer prevention and early detection, management of menopause and wrap-up in health promotion program for middle-aged women. The measurement tool was Health Promoting Behavior developed by researcher using serum cholesterol, obesity rate, systolic blood pressure, and diastolic blood pressure as cardiovascular risk factors. Result: The experimental group showed a higher score of health promoting behavior than the control group. There were no differences on cardiovascular risk factors(cholesterol, obesity rate, diastolic blood pressure) between the experimental and control groups except systolic blood pressure. Conclusion: Conclusively, this health promotion program for middle-aged women was effective in increasing health promotion behaviors, but wasn't effective in decreasing cardiovascular risk factors except the systolic blood pressure. It seems it's necessary to re-study this using more samples and a longer duration of the program, and smaller mortality rate.

• Journal of Korean Academy of Nursing
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• v.42 no.4
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• pp.579-588
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• 2012

Purpose: The purpose of this study was to identify the effects of heating on the non-affected hand on blood flow velocity, wound healing, and pain for hand microsurgery patients. Methods: This study was designed using the nonequivalent control group pretest-posttest design. Thirty-nine patients were assigned either to the experimental group (20 patients) or control group (19 patients). Data were analyzed with $x^2$-test, Fisher's exact test, t-test, and repeated measure ANOVA using SPSS/WIN 17.0 program. Results: After treatment in this program, blood flow velocity (F=5.13, p=.008) and wound healing (F=4.11, p=.020) improved significantly in the experimental group compared to the control group. But there was no significant improvement in pain in the experimental group compared to the control group (F=2.40, p=.097). Conclusion: Based upon these results, the non-affected side hand heating was recommended as an independent nursing intervention for the patients who need improvement in blood flow velocity and wound healing such as patients who have microsurgery. As the heating was effective even when applied on the non-affected side, it is the applicable to patients who cannot tolerate any therapy on affected side.

• Journal of Korean Physical Therapy Science
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• v.29 no.2
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• pp.48-56
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• 2022

Background: This study was to identify the effects of blood flow restriction on gluteus muscles thickness, density, and white area index for children with cerebral palsy. Design: Randomized controlled trial. Methods: Twenty children with cerebral palsy were assigned randomly to an experimental (n=10) or control (n=10) group. The experimental group performed a bicycle exercise after blood flow restriction. The control group performed a bicycle exercise. The study used an ultrasonic instrument to measure gluteus muscles thickness, density, and WAI. Wilcoxon signed ranks test was used for determination of differences before and after treatment, and a Mannn-whitney U test was used for determination of differences between treatment groups. Results: As a result of comparison within groups, the experimental and control group showed significant difference for gluteus muscles thickness, density, and WAI after the experiment (p<0.05). In comparison between two groups, the experimental group showed more significant difference in gluteus muscles thickness, density, and WAI than the control group (p<0.05). Conclusion: Based on these results, a bicycle exercise after blood flow restriction effectively improved the gluteus muscles thickness, density, and WAI of children with cerebral palsy.

• PNF and Movement
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• v.20 no.1
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• pp.31-39
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• 2022

Purpose: The purpose of this study was to identify the effects of general exercise after blood flow restriction on trunk muscles thickness in children with spastic cerebral palsy. Methods: Twenty children with cerebral palsy were assigned randomly to an experimental (n = 10) or a control (n = 10) group. The experimental group performed general exercise after blood flow restriction, while the control group performed general exercise alone. The study used an ultrasonic instrument to measure trunk muscles thickness. The Wilcoxon signed-rank test was used to determine differences before and after treatment, and the Mann-Whitney U test was used to determine differences between treatment groups. Results: From a comparison within the groups, the experimental and control groups showed significant difference in trunk muscle thickness after the experiment (p < 0.05). In a comparison between the two groups, the experimental group showed more significant difference in trunk muscle thickness than the control group (p < 0.05). Conclusion: Based on these results, general exercise after blood flow restriction effectively improves trunk muscle thickness in children with cerebral palsy.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1996.04a
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• pp.194-194
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• 1996

Pathogenesis of experimental allergic encephalomyelitis was involved with infection, inflammatory reaction, immune reaction etc. We studied on relation of blood vessel system and EAE. So, we measured blood pressure, heart rate and relaxation of isolated blood vessel in control and EAE-induced lewis rats. Blood pressure was decreased before EAE clinical sign (0-20day), but was increased from 23day. In isolated blood vessel, acetylcholine-treated relaxation was different on control, maximum EAE stage, recovery stage. Acetylcholine-treated relaxation was reduced 30% in recovery stage. but, sodium nitroprusside had similar relaxation reaction.

• Journal of Environmental Health Sciences
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• v.17 no.2
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• pp.127-139
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• 1991

Four group(Control I II, Treatment I II ) of Rats, each consisting of 10 rats, were studied Methylmercury Chloride MMc was orally given to Sprague-Dawley male at does of 10mg/kg (5 mg/kg $\cdot$ day), 10mg/kg after two weeks. This study was designed to investigate the distribution, the difference and the ratio of organic mercury, total mercury, zinc and copper in tissue, in each others group. The result were as follows: 1. There was no significantly difference in the body weight between two groups( p > 0.05). 2. There was significantly difference in the distribution of zinc concentration in liver, kidndey, blood, spleen between control I and treatment I, and in blood, spleen between control II and treatment II (P < 0.05). 3. There was significantly difference in the distribution of copper concentration in kidney, blood between control I and treatment I, and in spleen brain between control II and treatment II. 4. The ratio of zinc concentration in treatment/control was high at spleen. 5. The ratio of methylmercury/totalmercury was high at spleen.

• Korean Journal of Adult Nursing
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• v.14 no.1
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• pp.34-43
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• 2002

More and more non-injured operations are being implemented these days, thanks to the development of medical technology. Still, however, most operations leave direct scars on patient' bodies, as well as accompanying pain. The massage as an independent nursing intervention can stimulate the circulation of the blood of tissue and muscle and increase the relationship between a patient and a nurse. The purpose of this study is to investigate the effect of foot massage on pain in post abdominal operative patients. The nonequivalent control group, pre-post test design is used for this study. From July 7, 2000 to February 20, 2001, the 40 patients who were operated under general anesthesia in a university hospital in Seoul were studied. They were divided into two groups ; 20 patients were part of the experimental group, and the others, in the control group. In order to evaluate the effect of foot massage, severity of pain was checked with the VAS (Visual Analog Scale) and also each patients' vital signs were measured with pulse rate, systolic blood pressure and diastolic blood pressure. The collected datas were processed by SAS version 6.12 program and analyzed by the Chi-square, Fisher's exact test, t-test and repeated measures ANOVA. The results of this study were as follows. 1. The severity of pain decreased significantly in the experimental group as compared to the control group following foot massage (t=-3.317, p= .002). 2. Measured vital signs in the experimental group had more reduction of that than in the control group following foot massage. - The pulse rate in the experimental group was lower than that in the control group following foot massage (F=7.73, p=.008). - The systolic blood pressure in the experimental group was lower than that in the control group following foot massage (F=25.75, p=.000). - The diastolic blood pressure in the experimental group was lower than that in the control group following foot massage (F=15.27, p=.000). In conclusion, foot massage is an effective dependent nursing intervention for pain control of post abdominal operative patients.

• Herbal Formula Science
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• v.13 no.2
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• pp.41-57
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• 2005

This study has been carried out to understand the effect of Danchisoyosangagambang (DC) on the hyperglycemic mice induced with streptozotocin(STZ). Experimental groups were made diabetic mice by intraperitoneal injection of STZ(60 mg/kg of body weight) tw ice by 24 h interval and then 120 mg/kg STZ was injected again 3 days after the earlier treatment. Control group was administered mice with 0.9 % saline(2 mL/kg), and experim ental groups were administered DC extract(DCA group, 10 mg/kg/day; DCB group, 30 mg/kg/day) after hyperglycemic induction for 6 weeks. The body weight of experimental groups was lower than control. The blood glucose concentration increased continuously, rea ching to 298.9 mg/dL after 6 weeks, however, experimental groups of the DCA and DCB groups significantly(p<0.0l) decreased in the 4, 5, and 6 weeks groups. Blood glucose tolerance test was not significant between control and experimental groups. We examined the blood transaminase activities to know the effect of herbal medicine on liver function. The GOT activities were lower in group DCB than in control. The GPT activities were lower in group DCA and DCB than in control. The content of triglyceride was significantly increased in group DCA compared to control. The SOD and catalase activities were higher in the group DCA compared to control. The results of immunohistochemical study, a few of insulin positive cells observed in the control and experimental group. These results suggest that administration of DC extract to the hyperglycemic mice decreased the blood glucose level.