• 분석과학
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• 제20권3호
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• pp.204-212
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• 2007

사망사건 중 부패된 생체시료(혈액, 뇨 등)에서 음주여부를 판단하고자 할 때 부패된 사체의 경우 glucose를 비롯한 생체물질들이 미생물에 의하여 alcohol로 대사전환 될 수 있으므로 검출되는 ethanol의 전체 농도를 사망 전의 음주량으로 판단할 수 없다. 따라서 본 실험에서는 감정 의뢰된 사체의 혈액과 뇨를 임의로 선택하여 ethanol의 농도 및 n-propanol의 농도를 측정하여 상대적인 생성 비를 비교하여 보았으며, 5-hydroxytryptophol(5-HTOL)/5-hydroxyindole-3-acetic acid(5-HIAA)의 비를 이용한 음주여부의 판별법을 확립하기 위해서 5-HIAA 및 5-HTOL의 농도 측정법을 확립하였다. 혈액에서 검출되는 ethanol과 n-propanol의 상대적 농도비는 뇨에서 ethanol이 검출되지 않은 시료를 기준으로 할 경우, 약 11~20:1의 농도비를 나타난다. 음주를 한 것으로 판단되는 뇨의 경우 5-HTOL/5-HIAA의 비율은 1 이상으로 나타났고, 음주를 하지 않은 것으로 판단되는 뇨의 경우 5-HTOL/5-HIAA의 비율이 1 미만으로 측정되어, 혈액검사와는 달리 5-HTOL/5-HIAA의 비율이 1 이상인 경우 음주를 한 것으로 간주할 수 있었다.

• 한국식생활문화학회지
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• 제21권6호
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• pp.638-643
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• 2006

This study was performed to determine the effect of Takju(Korean turbid rice wine) lees on the serum glucose level in streptozotocin-induced diabetic rats. 24 Sprague-Dawley male rats were divided into three groups: normal control(NC), diabetic control(DC) and diabetic rats(DS) were fed on experimental diet and water ad libitum for 4 weeks. DS diet was containing 20% Takju lees. Body weight gain and food Efficiency Ratio(FER) were significantly lower in DC and DS than NC. DS tended to have higher weight, weight gain and FEF than DC nevertheless food intake. Therefore Takju lees could possibly complement casein as a protein source. Gastrointestianl transit time in DS significantly decreased than NC while not significantly than DC. Serum lipid profiles and AST. ALT and amylase were not significantly different between diabetic DC and DS. Blood glucose was measured at fasting state and 30, 60, 90 and 120 minute by oral glucose tolerance test, DS tended to lower the mean(${\pm}$ SE) incremental blood glucose concentrations than DC and was significantly low at 120 min. But incremental AUG(area under the curve) of postprandial glucose response was not significantly different. In conclusion, in spite of high contents of carbohydrate Takju lees perhaps have a benefit effect on the diabetes.

• Korean Journal of Radiology
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• 제20권5호
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• pp.781-790
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• 2019

Objective: To assess the relationship between contrast-enhanced ultrasound (CEUS) parameters and perfusion CT (PCT) parameters of gastric cancers and their correlation with histologic features. Materials and Methods: This prospective study was approved by our Institutional Review Board. We included 43 patients with pathologically-proven gastric cancers undergoing CEUS using SonoVue^® (Bracco) and PCT on the same day. Correlation between the CEUS parameters (peak intensity [PI], area under the curve [AUC], rise time [RT] from 10% to 90% of PI, time to peak [TTP_US], and mean transit time [MTT_US]) and PCT parameters (blood flow, blood volume, TTP_CT, MTT_CT, and permeability surface product) of gastric cancers were analyzed using Spearman's rank correlation test. In cases of surgical resection, the CEUS and PCT parameters were compared according to histologic features using Mann-Whitney test. Results: CEUS studies were of diagnostic quality in 88.4% (38/43) of patients. Among the CEUS parameters of gastric cancers, RT and TTP_US showed significant positive correlations with TTP_CT (rho = 0.327 and 0.374, p = 0.045 and 0.021, respectively); PI and AUC were significantly higher in well-differentiated or moderately-differentiated tumors (n = 4) than poorly-differentiated tumors (n = 18) (p = 0.026 and 0.033, respectively), whereas MTT_CT showed significant differences according to histologic types (poorly cohesive carcinoma [PCC] vs. non-PCC), T-staging (≤ T2 vs. ≥ T3), N-staging (N0 vs. N-positive), and epidermal growth factor receptor expression (≤ faint vs. ≥ moderate staining) (p values < 0.05). Conclusion: In patients with gastric cancers, CEUS is technically feasible for the quantification of tumor perfusion and may provide correlative and complementary information to that of PCT, which may allow prediction of histologic features.

• Journal of Animal Science and Technology
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• 제66권5호
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• pp.981-998
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• 2024

This study was to investigate effects of different phytogenic feed additives (PFA) in grower finishing pigs with stressed by high stocking density. A total of 84 growing pigs ([Landrace × Yorkshire] × Duroc) with initial body weight (BW) of 28.23 ± 0.21 kg were used for 10 weeks (4 replicate pens with 3 pigs per pen). The dietary treatment consisted of basal diets in animal welfare density (positive control [PC]), basal diet in high stocking density (negative control [NC]), NC + 0.04% bitter citrus extract (PT1), NC + 0.01% microencapsulated blend of thymol & carvacrol (PT2), NC + 0.10% mixture of 40% bitter citrus extract and 10% microencapsulated blend of thymol and carvacrol (PT3), NC + 0.04% premixture of grape seed and grape marc extract, green tea and hops (PT4), and NC + 0.10% fenugreek seed powder (PT5). The reduction of space allowance significantly decreased (p < 0.05) growth performance (average daily gain, average daily feed intake, feed efficiency) and nutrient digestibility (dry matter, crude protein). Also, the fecal score of NC group increased (p < 0.05) compared with other groups. In blood profiles, lymphocyte decreased (p < 0.05), and neutrophil, cortisol, TNF- α increased (p < 0.05) when pigs were in high stocking density. Basic behaviors (feed intake, standing, lying) were inactive (p < 0.05) and singularity behavior (biting) were increased (p < 0.05) under high stocking density. However, PFA groups alleviated the negative effects such as reducing growth performance, nutrient digestibility, increasing stress indicators in blood and animal behavior. In conclusion, PFA groups improved the health of pigs with stressed by high stocking density and PT3 is the most effective.

• 대한한의학회지
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• 제35권2호
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• pp.60-68
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• 2014

Background: Pattern identification is a unique diagnostic method of traditional Oriental medicine that has recently been the target of questionnaire-based research. Sasang (four-types) constitutional medicine (SCM) is a practice in traditional Korean medicine that seeks to promote objectivity in diagnostics. This paper attempts to illuminate the relationship between constitutions and the pathogenic factors of pattern identification through questionnaires completed by menopausal women about their symptoms. Methods: From March to October 2012, we examined 291 women from the general population, with ages ranging from 40 to 60 years, applying the Kupperman index, the Menopause-Specific Quality of Life Questionnaire (MENQOL), pattern identification based on the Diagnosis System of Oriental Medicine (DSOM), and SCM. We then analyzed the relationship between constitutional type and pathogenic factors. Results: No significant differences were found in the scores of either the Kupperman index or MENQOL questionnaire in relation to constitutional type. However, in a statistical analysis correlating the DSOM pathogenic factor scores (PFS) with the scores of the Kupperman index and MENQOL vasomotor subscale, heat showed a significant positive correlation with SoYang type (SY) and TaeEum type (TE), but not SoEum type (SE), while insufficiency of yin and insufficiency of yang, as well as blood deficiency, showed a significant positive correlation with the TE and SE types. Conclusion: The pathogenic factors in the menopausal symptoms of middle-aged women, specifically the prominent menopausal symptom of facial flushing, differed significantly according to constitutional type.

• 한국임상수의학회지
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• 제25권5호
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• pp.424-428
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• 2008

A 10-year-old castrated male Schnauzer (case 1) and a 13-year-old intact male Schnauzer (case 2) was referred with mass of left hind limb. We performed hemogram, serum chemistry, radiography, ultrasonography, computed tomography, fine needle aspiration and histopathology. The complete blood counts and serum biochemistry results were within the reference range. Radiography showed cutaneous mass with soft tissue density. The lesions of two dogs were revealed a definite marginated hyperechoic mass with vascularization in ultrasonography. Computed tomography showed an isodense mass in the left hind limb region with minimal contrast enhancing in case 1 and heterogenous enhancement in case 2. Cytology from ultrasonographic guided aspiration of the mass was suspected fibrous tissue-derived benign cell in two dogs. A surgical excision was performed in two dogs. In histological examination of the resected mass, cutaneous fibroma was revealed. The two patients were successfully treated by surgery and postoperative care. This report decribes and compares radiographic, ultrasonographic, computed tomographic, cytologic and histopathologic features of the cutaneous fibroma of two schnauzer dogs.

• 대한의용생체공학회:의공학회지
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• 제25권6호
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• pp.623-628
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• 2004

본 논문에서는 원적외선 온열효과가 자율 신경계에 미치는 영향을 심박변동(HRV)을 이용하여 평가 하였다. 측정된 심박변동신호를 FFT 의한 전력스펙트럼을 구함으로써 자율 신경계의 반응 특성을 고찰하고 Poincare plot 분석 방법을 이용하여 결과를 비교 분석하였다. 실험을 통해 심박변동 신호분석해보면 원적외선 온열에 노출되기 전에 비해 노출된 후에 매우 복잡한 모습임을 관찰 할 수 있었는데 이것은 자율신경계가 관여하는 심혈관계 제어 메커니즘이 원적외선 온열에 노출되기 전보다 노출된 후에 더욱 복잡함을 반영하는 것으로 분석된다.

• Journal of Yeungnam Medical Science
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• 제35권2호
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• pp.192-198
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• 2018

Background: Chronic inflammation can lower the seizure threshold and have influence on epileptogenesis. The components of red ginseng (RG) have anti-inflammatory effects. The abundance of peripherally derived immune cells in resected epileptic tissue suggests that the immune system is a potential target for anti-epileptogenic therapies. The present study used continuous electroencephalography (EEG) to evaluate the therapeutic efficacy of RG in intrahippocampal kainic acid (IHKA) animal model of temporal lobe epilepsy. Methods: Prolonged status epilepticus (SE) was induced in 7-week-old C57BL/6J mice via stereotaxic injection of kainic acid (KA, 150 nL; 1 mg/mL) into the right CA3/dorsal hippocampus. The animals were implanted electrodes and monitored for spontaneous seizures. Following the IHKA injections, one group received treatments of RG (250 mg/kg/day) for 4 weeks (RG group, n=7) while another group received valproic acid (VPA, 30 mg/kg/day) (VPA group, n=7). Laboratory findings and pathological results were assessed at D29 and continuous (24 h/week) EEG monitoring was used to evaluate high-voltage sharp waves on D7, D14, D21, and D28. Results: At D29, there were no differences between the groups in liver function test but RG group had higher blood urea nitrogen levels. Immunohistochemistry analyses revealed that RG reduced the infiltration of immune cells into the brain and EEG analyses showed that it had anticonvulsant effects. Conclusion: Repeated treatments with RG after IHKA-induced SE decreased immune cell infiltration into the brain and resulted in a marked decrease in electrographic seizures. RG had anticonvulsant effects that were similar to those of VPA without serious side effects.

• 동의생리병리학회지
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• 제38권2호
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• pp.59-65
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• 2024

Rectal prolapse is a condition where the rectal wall protrudes outside the anus. While it is a rare condition, it can cause discomfort for patients due to the protrusion of the rectal structure, discharge of mucus and blood, fecal incontinence, constipation, and other inconveniences. In this review, we analyzed a randomized controlled trial (RCT) study that used the herbal medicine Bojungikgi-tang(Buzhongyiqi-tang) as a complementary therapy to improve the weaknesses and side effects of the standard treatment, surgical therapy, for rectal prolapse. The analysis included 12 RCT studies, and in all studies, the prescription involved the use of Astragali Radix at the highest dosage. Among the 11 studies that evaluated efficacy, 7 studies showed a significant effect compared to the control group. In all 3 studies that evaluating recurrence rates and all 5 studies investigating complications after surgery, the experimental group showed significant effects. Based on these findings, this study could be considered as a foundational evidence for the application of bojungikgi-tang(Buzhongyiqi-tang) in clinical practice in Korean medicine for patients with rectal prolapse. It could also serve as foundational data for future research.

• Clinical and Experimental Pediatrics
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• 제49권1호
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• pp.93-98
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• 2006

목 적 : 재태연령 34주 이상의 적정체중아(appropriate for gestational age, AGA)에서 제대혈의 ghrelin과 leptin의 농도를 측정하고 출생체중, 체질량지수(body mass index, BMI) 등의 신체계측치와의 연관성 및 IGF-I, IGFBP-3와 같은 성장과 관련된 호르몬과의 관계에 대해 알아보았다. 방 법 : 재태연령 34주에서 42주 미만의 신생아 중 재태기간과 비교해 적정체중을 가진 건강한 남아 31명과 여아 29명을 대상으로 하였다. 대상 신생아의 출생체중, 체질량지수를 계측하고 제대정맥혈을 채취하여 ghrelin, leptin, IGF-I 및 IGFBP-3 농도를 측정하여 분석하였다. 결 과 : 대상 신생아들의 제대혈에서 ghrelin 농도($528.3{\pm}307.3pg/mL$)는 신생아의 출생체중(r=-0.29, P<0.05)과 재태연령(r=-0.28, P<0.05)과 반비례하였다. 한편, 대상 신생아 제대혈의 leptin 농도($4.43{\pm}3.66ng/mL$)는 신생아의 출생체중(r=0.44, P<0.01), 재태연령(r=0.36, P<0.01), 체질량지수(r=0.28, P<0.05) 등과 비례하였다. 제대혈의 ghrelin 농도는 성별에 따른 차이가 없었으나 leptin 농도는 여아($5.45{\pm}4.32ng/mL$)에서가 남아($3.48{\pm}2.64ng/mL$)에서보다 유의하게 높았으며(P<0.05), 특히 재태연령 37주 이상인 군에서 성별에 따라 뚜렷한 차이를 보였다(P<0.01). 제대혈의 ghrelin과 leptin 농도 사이에서는 의미있는 상관관계가 없었으며, ghrelin 농도와 제대혈의 IGF-I 및 IGFBP-3 사이에서도 역시 의미있는 상관관계가 없었다. 결 론 : 적정체중을 가진 신생아의 제대혈 ghrelin 농도는 출생체중 및 재태연령에 반비례하였다. 제대혈의 leptin 농도는 신생아의 출생체중, 재태연령 및 체질량지수 등의 신체계측치에 비례하였으며 여아에서 남아에서보다 더 높은 농도를 나타냈다. 제대혈의 ghrelin과 leptin 농도 사이에는 특별한 상관관계가 없었다. 앞으로 이들 물질이 태아 성장에 생리적, 병리적으로 상호 어떤 역할을 하는지 규명하기 위해 더 많은 연구가 필요할 것으로 생각된다.