• 대한의생명과학회지
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• 제11권3호
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• pp.275-279
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• 2005

High-salted mineral water (Daehan Deep Water, Korea) that is pumped up from below the sedimentary rock layer of Dadaepo, Busan, Korea has a composition similar with that of deep sea water. Under the well-being boom, the mineral water is processed for various uses including washing or oral administration. However, high concentrations of various minerals in the mineral water are suspected to affect on the physiology of human body, especially on blood pressure (BP). Here, we examined the effect of Hot Mineral(R), dried powder of the mineral water, on the change of BP. Sprague­Dawley rats were grouped and orally administered $2.5\%$ Hot Mineral(R) (group M), $2.5\%$ NaCl (group S) or normal water (group C). Excreted urine was collected in metabolic cage for 24 hours. The systolic blood pressure (SBP) of the group S was remarkably increased (P<0.005) compared with that of the group M and the group C, which showed little changes of the SBP during 2 weeks. While average daily sodium intake were 0.32 mg in the group C, 6.64 mg in the group M and 4.07 mg in the group S, average daily sodium excretion were 11.37 mg, 53.70 mg and 7.75 mg, respectively. These results indicate that the sodium excretion in the group M was much higher than the other two groups. In this study, we suppose that the plenty amount of minerals such as calcium, potassium and magnesium in Hot Mineral? have an effect not to increase the SBP and to prompt sodium excretion out of the body. Therefore, these results suggest that oral administration of appropriate amount of Hot Mineral(R) for limited period does not induce increased SBP.

• 농촌의학ㆍ지역보건
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• 제31권3호
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• pp.237-244
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• 2006

이 연구에서는 고혈압 위험군을 대상으로 8주간의 개인별 맞춤형 DASH 식이 교육을 수행하여 고혈압 식단 관련 지식수준과 DASH 식단 실천정도, 혈압 조절 효과를 분석하고자 하였다. 프로그램 대상은 고혈압 발생 위험군으로 JNC에서 정의한 고혈압전단계로 정의한 수축기압이 120-139 mmHg, 또는 이완기혈압이 80-89 mmHg인 경우와, 체질량지수가 25이상인 경우, 그리고 허리둘레와 엉덩이둘레의 비율이 남자 0.95이상, 여자 0.85이상인 경우 중 어느 하나를 만족하는 경우로 하였다. 연구는 강원도 C시에서 2002년-2003년 주민 건강행태 및 건강조사 대상 중 기준에 해당하는 경우와 보건소 및 보건지소에서 외래 환자 중 해당자를 포함하였으며 8주 교육에 참가한 141명에 대하여 효과분석을 수행하였다. 교육프로그램 적용 후 지식수준 및 DASH 식습관 실천정도가 유의하게 증가하였으며 수축기압은 참여 전 $136.03{\pm}12.40mmHg$, 프로그램 참여 후 $126.09{\pm}11.25mmHg$로 프로그램 참여 후의 평균 혈압이 낮아졌으며 이완기 혈압 또한 프로그램 참여 전 $81.80{\pm}6.32mmHg$, 프로그램 참여 후 $76.44{\pm}10.61mmHg$로 통계적으로 유의한 감소를 나타냈다. 고혈압 환자의 혈압 조절을 위한 노력뿐 아니라 고혈압 예방을 위한 보건사업이 필요하며, 이 경우 DASH 프로그램은 효과적인 교육도구로 적용될 수 있다. 향후 관련된 교육 프로그램의 개발과 프로그램 적용이 지역사회를 대상으로 소개되고 확대 적용되기를 기대하는 바이다.

• Journal of Preventive Medicine and Public Health
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• 제29권4호
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• pp.705-719
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• 1996

Since the 1960s, Korea has achieved rapid economic growth, longer life expectancy, accelerated urbanization and a westenization of diet. Cardiovascular disease has become the leading cause of death; however the prevalence of ischemic heart disease(IHD) remains low. A cross-sectional multiphasic screening service for 18,426 persons aged $30\sim64$ years in a Medical Aid Program in Kyonggi-do Province was conducted from 1991 to 1993. Total cholesterol(TC), fasting blood glucose(FBG), blood pressure(BP), and electrocardiographic(EKG) data were collected. The result as follows ; 1. On the EKG findings, the age-adjusted prevalence of myocardial ischemia and myocardial infarction was 1.45% in men and 2.06% in women. 2. The mean blood pressure was 122.9/78.8mmHg. The age-adjusted prevalence of hypertension was 11.05% in men and 9.02% in women. The prevalence of hypertension showed increasing tendency according to age increase. In all age group, the prevalence of hypertension was higher in men than women. 3. The mean total cholesterol level was 184.4mg/dl in men and 189.2mg/dl in women. The age-adjusted prevalence of hypercholesterolemia was 4.88% in men and 5.67% in women. The total cholesterol level showed increasing tendency according to age increase, except $55\sim64$ age group in men. 4. The prevalence of hyperglycemia is 5.8%. The age-adjusted prevalence of hyperglycemia is 6.72% in men and 4.50% in women. The prevalence of hyperglycemia showed increasing tendency according to age increase. 5. On the EKG findings, the prevalence of myocardial ischemia and myocardial infarction was higher in hypertension than normal, in all age group of men and women less than 40 years-old. Only in women more t]fan 40 years-old, the prevalence of myocardial ischemia and myocardial infarction was higher in hypercholesterolemia and hyperglycemia. Nevertheless there is not statistical association between ischemia heart disease and previous risk factors in other age group, the prevalence of myocardial ischemia and myocardial infarction was higher in hypertension, hypercholesterolemia and hyperglycemia than normal. The result of this study suggest that relationships between major risk factor of ischemic heart disease and ischemic heart disease is similar to existing theory.

• 동의생리병리학회지
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• 제17권2호
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• pp.416-422
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• 2003

Jaeumgenby-tang(JGT) have been used in oriental medicine for many centuries as a therapeutic agent of vertigo caused by deficiency of qi(氣) and blood(血). Effect of Aurantii Fructus(AF) take off the phlegm by promoting the circulation of qi, Gastrodae Rhizoma(GR) has effects treating for headache, vertigo by calming the liver and suppressing hyperactivity of the liver-yang(陽). And, We reported that JGT adding AFㆍGR extract(JGTAG) was significantly increased regional cerebral blood f1ow(rCBF) by dilating pial arterial diameter(PAD). Therefor we designed to investigate whether JGTAG is mediated by adrenergic β-receptor, cyclooxygenase or guanylate cyclase in normal rats. The changes of rCBF and mean arterial blood pressure(MABP) were determinated by laser-doppler flowmetry(LDF), and the change of PAD was determinated by video microscope and width analyzer. The results were as follows in normal rats; Pretreatment with propranolol(1mg/kg, i.v.) was significantly inhibited JGTAG induced increase of rCBF, PAD and MABP, and pretreatment with indomethacin(1 mg/kg, i.v.) was significantly inhibited too. But pretreatment with methylene blue(10μg/kg, i.v.) were accelerated JGTAG induced increase of rCBF and MABP, but pretreatment with methylene blue was inhibited JGTAG induced increase of PAD. This results suggest that the mechanism of JGTAG is mediated by adrenergic β-receptor and cyclooxygenase.

• 동의생리병리학회지
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• 제26권1호
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• pp.19-25
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• 2012

This study was designed to investigate the effects of a new herbal medicine named CWS-A on the changes in regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in normal rats, and further to determine the mechanism of action. Also, this study was designed to investigate the effects of CWS-A on the changes in rCBF in cerebral ischemic rats and the safety examination of CWS-A in rats regared to body weight change, renal and liver function test, CBC, $LD_{50}$ and histological observation in rats. The rCBF was significantly and stably increased and MABP was significantly decreased by CWS-A during the period of cerebral reperfusion in normal rats. However, there were no here were no significant changes of rCBF in ischemic rats. In additional, there were no significant changes on the safety examination. In conclusion, these results suggest that medication of CWS-A is effective for the improve the cerebral blood flow and CWS-A can be prescribed as vertigo(眩暈) symptoms treatment.

• 농촌의학ㆍ지역보건
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• 제27권2호
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• pp.149-157
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• 2002

농촌지역 여성의 고혈압 예방과 관리를 위한 기초자료를 제공할 목적으로 충주지역의 고혈압환자 및 정상인 지원자를 대상으로 2001년 5월 11일-15일(5일 동안)에 걸쳐 일반적인 건강 및 영양섭취상태를 조사 분석하였다. 분석결과 고혈압군에서 체중, 허리둘레, 허리와 엉덩이 둘레의 비, 허리와 허벅지 둘레 및 혈청 중성지방 수준이 유의하게 높았다. 지방을 제외한 영양소 섭취량은 고혈압군에서 많았으나 칼슘과 비타민 $B_2$ 섭취량은 권장량의 70% 수준이었다. 뇨중 나트륨 배설량 및 뇨중 나트륨 배설량으로 추정된 나트륨 섭취량은 고혈압 군에서 높은 경향을 보였으며 배추김치의 Na(mg/g) 함량과 Na/K이 고혈압군에서 높게 나타났다. 따라서 조사대상의 나트륨 섭취실태 조사에는 짠맛에 대한 기호도, 염장식품의 염도 및 뇨중 나트륨 배설량 등의 분석도 필요하며, 농촌 고혈압 여성의 혈압 및 건강관리를 위해서는 단순한 식염 섭취의 감소뿐 아니라 싱겁게 먹으려는 개인의 노력과 캄슘, 칼륨 및 비타민 $B_2$ 섭취수준의 적정화 등 다각적인 측면에서의 교육과 지도가 필요할 것으로 생각된다.

• 대한한의학회지
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• 제26권1호
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• pp.115-122
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• 2005

Background and objective: Gastrodiae Rhizoma (GR), the rhizoma of Gastrodia elata BL., is one of the popular drugs to treat headache, dizziness, blackout, numbness of limbs, hemiplegia, facial paralysis, dysphrasia, and infantile convulsions. It has been reported that it provides an antihypertensive effect and lowers cerebrovascular resistance in animal experiments. However, there has been no data about these effects with human subjects. In this study, the author examined the effect of Gastrodiae water extracts on blood pressure and cerebrovascular reactivity in human subjects. Methods: We selected 16 normal volunteers, who were divided into 2 groups: Gastrodiae extract administration group and placebo (creamy powder) group. Using transcranial Doppler ultrasound, we monitored changes of mean flow velocity and breath-holding induced CO2 reactivity of middle cerebral artery in both groups. Mean blood pressure, heart rate and PETCO2 were measured using Compact Anesthesia Monitor. In both groups, all evaluation was performed during basal condition, and repeated at 30, 60, and 90 min after administration. Results: Gastrodiae extract decreased CO2 reactivity after administration, reaching the lowest level at 90 minutes $(-29.1\%\;vs.\;basal\;level)$, which showed significant difference compared with the placebo group (p = 0.004). In the placebo group, the pulse rates tended to decrease over time (at 90 minute, $-5.2\%$ vs. basal level) while in the Gastrodiae group the values showed nearly no change, which showed significant difference between both groups (p = 0.036). However, the changes of mean blood pressure and mean flow velocity did not show significant difference between both groups. Conclusion : This study demonstrated that Gastrodiae extract significantly decreased breath-holding induced CO2 reactivity. This result suggests that the clinical effect of Gastrodiae extract might be caused by increasing cerebral blood flow via dilation of cerebral resistant vessels instead of antihypertensive effect.

• 한국산학기술학회논문지
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• 제14권9호
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• pp.4394-4401
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• 2013

본 연구의 목적은 건강검진을 받은 일반 성인들의 혈압과 혈청지질치 및 비만지표와의 관련성을 검토하고자 하였다. 조사대상은 2012년 한 대학교병원에서 건강검진을 받았던 20세 이상 일반 성인 2,734명(남자 1,344명, 여자 1,390명)을 대상으로 하였다. 조사는 해당 대학병원 연구윤리위원회(IRB)의 승인을 받은 후 대상자들의 종합건강검진 결과표와 문진표로부터 자료를 수집하였으며, 조사항목으로는 피조사자들의 성별, 연령, 안정 시 혈압(SBP, DBP), 혈청지질치(TC, HDL-C, LDL-C, TG, AI) 및 비만관련지표(BMI, 체지방률, 허리둘레) 등이었다. 연구결과, TC, TG, AI는 남녀 모두 고혈압군이 비고혈압군보다 유의하게 높았으며, HDL-C는 여자에서 비고혈압군이 고혈압군보다 유의하게 높은 반면, LDL-C는 고혈압군이 비고혈압군보다 유의하게 높았다. BMI, 체지방률, 허리둘레는 남녀 모두 고혈압군이 비고혈압군보다 유의하게 높았다. SBP와 DBP는 남녀 모두 연령, TC, TG, AI, BMI, 체지방률 및 허리둘레와 유의한 양의 상관관계를 보였다. 그러나 HDL-C와 LDL-C는 여자에서만 각각 음의 상관관계와 양의 상관관계를 보였다. 연령을 조정한 고혈압발생위험비는 남녀 모두에서 TC, TG, BMI, 허리둘레가 정상인 군보다 비정상인 군에서 유의하게 증가하였으며, HDL-C는 여자에서만, 체지방률은 남자에서만 유의하게 증가하였다. 이상과 같은 결과는 혈압이 여러 혈청지질치 및 비만지표들과 유의한 관련성을 갖고 있음을 시사한다.

• Journal of Chest Surgery
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• 제10권2호
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• pp.299-314
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• 1977

Clinical experience on 16 cases of open heart surgery under the extracorporeal circulation with mild or moderate hypothermia and partial hemodilution technique at the National Medical Center during the period from June 1976 to October 1977. Nine of sixteen were congenital heart disease and seven were acquired heart disease. The age of the patient ranged between 6 and 48 years. The body weight varied from 18.5kg to 60kg and body surface area 0. 79-1.70m2. The average priming volume of pump oxygenator was 2080 ml, which was consisted fresh ACD blood, buffered Hartmann`s solution, Mannitol, 50% dextrose in water and Vit. C. The average hemodilution rate was 27%. The average flow 2.3 L/min/m2 or 80 ml/min and the duration of perfusion varied from 31 min to 270 min with average of 107 min. The perfusion was carried out under the mild or moderate hypothermia using core cooling alone in 10 cases, core cooling and local myocardial cooling with $0-4^{\circ}C$ physiologic saline in 2 cases. From a hemodynamic point of view, the blood pressure dropped down around 80 mmHg after the initiation of perfusion follwed by increase to safety level and stable during the perfusion. The central venous pressure remained within normal limits. In most cases, hemoglobin and hematocrit decreased during and after the perfusion. Hemogiobin level was decreased, average of 20.6 %, hematocrit 18.6%, pletelets 55% postoperatively. Plasma hemoglobin increased moderately, from preperfusion average valve of 7.79 mg % to post-perfusion value of 54.7 mg %. Electrolytes changes during cardiopulmonary bypass showed definite hypokalemia but changes of Na, Ca were not definite. Arterial blood gas analysis during cardiopulmonary bypass suggested that the metabolic acidosis which was accompanied by respiratory alkalosis which was corrected postoperatively. As the opera tive complication, transient hemoglobinuria in 4 cases and neurological signs in 2 cases were all cured. There were 2 death cases and operative mortality rate was 12.5%.

• 대한지역사회영양학회지
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• 제7권3호
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• pp.304-315
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• 2002

The purpose of this study was to relate the degree of hypertension to nutritional status, in order to prepare basic data for a nutrition program. The study using the WHO standard divided the residents in Kangbuk-gu into a normal group (NG) of 254 adults with systolic blood pressure (SBP) < 130 or diastolic blood pressure (DBP) < 85; a borderline hypertensive group (BG) of 81 adults with 130 $\leq$ SBP $\leq$ 140 or 85 $\leq$ DBP $\leq$ 90; and a hypertensive group (HG) of 143 adults with SBP > 140 or DBP > 90. The mean age of HG was older than the other groups (p < 0.001). The dietary intake was investigated by the 24-hour recall method. The Ca intake as the percentage of the Korean Recommended Dietary Allowances (RDA) for the HG were higher than that of the other groups (p < 0.01). The Nutrient Adequacy Ratio (NAR) of Ca and Vit. A were below 0.75 for all three groups. The Mean Adequacy Ratio (MAR) was above 0.75 (p > 0.05) for all three groups. The Dietary Variety Score (DVS) of the NG was 22.7, and higher than those of the other groups (p > 0.05) The fasting blood sugar (p < 0.001), total cholesterol (p < 0.001), protein (p < 0.001), albumin (p < 0.01), hemoglobin (Hb) (p < 0.001), alkaline phosphatase (ALP) (p < 0.001), and creatinine (p <0.05) values of the HG were higher than those of the other groups. The Body Mass Index (BMI) and the waist-hip ratio (WHR) of the HG were higher than those of the other groups (p < 0.001) . In conclusion, these results showed that there tended to be differences among the three groups. For effective nutritional education and counseling of each group, we should furtherstudy the differences and understand their characteristics of each group in order to provide nutritional education for controling and preventing hypertension.