• 대한지역사회영양학회지
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• 제2권5호
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• pp.721-727
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• 1997

This study investigated whether dietary factors are more influential factor than other health behavior such as drinking, smoking and exercise on abnormal serum cholesterol level inspite of Korean dietary pattern differences compared to Europeans and Americans. A double case control study model has been used for the study design. One model consisted of high blood cholesterol cases and control. the other model consisted of low blood cholesterol cased and controls. 5.398 sedentary male workers who had taken medical examinations at a university hospital were used as the study subjects. Out of the study subjects, 36individuals with high blood cholesterol cases and 30 individuals with low blood cholesterol cases were selected. For the 66 individual control selection, the individual control selection, the individuals matching method was adopted. The food frequency method was used to collect the data for assessment of the dietary factors. A standardized questionnaire was used to investigate other health behavior. logistic regression analysis was employed to measure the relative importance between the factors considered. There were no statistically significant differences observed in nutrients consumption or other health behavior among the low, normal and high blood cholesterol groups, An overmatching effect had been suspected as the cause of those findings. However, the results of logistic regression analysis to identify the factors influencing high serum cholesterol showed that odd ratios of dietary factors such as tocopherol(3.0) and saturated fatty acid(1.6) were higher than I. I of smoking and 1.2 of drinking. Similar results were also observed incases of low serum cholesterol. The above findings imply that although the dietary pattern is quite different from that of Europeans and America, the dietary factor is still a significant factor for abnormal blood cholesterol in Koreans. Therefore, the dietary risk factor identified in high fat consumption populations are still relevant for the relatively healthy Korean as guideline for preventive health practices. (Korean J Community Nutrition 2(5) : 721∼727, 1997)

• 대한의용생체공학회:의공학회지
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• 제24권4호
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• pp.301-307
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• 2003

본 연구에서는 한국형 인공심장의 혈액주머니 내 혈액 유동에 대한 수치적 해석 결과를 제시하였다. 혈액 유동은 2차원 비정상 유동으로 가정하였으며. 이를 해석하기 위하여 유한요소 기반의 상용코드인 ADINA를 사용하였다. 액츄에이터와 혈액주머니사이의 강체-고체 접촉, 그리고 혈액주머니와 혈류 사이의 고체-유체 상호작용을 모두 계산에서 반영하였다. 본 연구에서는 혈액주머니의 형상설계 과정에서 제시되었던 3가지 모델에 대해서 계산을 수행하고 이들의 혈류역학적인 적합성을 분석하였다. 계산결과에 의하면 혈액주머니의 수축 시는 출구로의 강한 흐름과 입구 부분에서의 정체영역이 관찰되었다. 이완 시에는 외부로부터 입구로 강한 혈류가 유입되고 있으며, 닫힌 출구에서 부근에서는 재순환 영역이 발생한다. 수축 시 전단응력은 출구 모서리 부근에서 극한값들을 가지게 되며, 이완 시에는 주로 입구 모서리와 액츄에이터 접촉면에서 최소, 최고치를 보여주고 있다.

• 가정간호학회지
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• 제26권2호
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• pp.210-218
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• 2019

Purpose: The purpose of this study was to identify the nutritional status of elderly individuals according to their household types and to investigate the predictors of their nutritional status. Methods: This study, which was a descriptive research study, involved physical measurements, surveys, and biochemical tests in 87 elderly individuals living in the community. Using SPSS/Win 24.0, logistic regression analysis was performed to identify the general characteristics, blood pressure, body mass index (BMI), mini nutritional assessment (MNA) score, and biochemical indicators in elderly individuals according to the household type. Results: Elderly individuals living with family members had higher MNA scores than those of elderly individuals living alone, while showing lower levels of systolic blood pressure and fasting blood sugar. The results of the logistic regression analysis showed that the risk factors were MNA scores (odds ratio (OR)=1.81, 95% confidence interval (CI)=1.36-2.42), systolic blood pressure (OR=0.96, 95% CI=0.92-1.00), and fasting blood glucose (OR=0.94, 95% CI=0.90-0.99). Conclusion: It was confirmed that elderly individuals living alone need differentiated nutrition intervention, since the results showed that they had lower nutritional levels and improper nutritional management than that in elderly individuals living with family members.

• Journal of Interdisciplinary Genomics
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• 제6권1호
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• pp.6-13
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• 2024

Background: ABO typing is crucial for ensuring safe blood transfusion and is commonly performed by examining antigen-antibody interactions. Determining ABO blood group can be difficult when dealing with ABO discrepancy and ABO subgroups. ABO genotyping may be necessary to resolve ABO discrepancy. ABO genotyping primarily involves direct sequencing, with the possibility of using other molecular methods. Methods: PCR and direct sequencing of exons 6 and 7 were performed for total 108 samples from June 2010 to December 2019. Also, other molecular methods including cloning sequencing and short tandem repeat analysis were carried out just in case. Sequencing data were compared with allele information of blood group antigen mutation databases. Results: The predominant causal allele among 108 ABO discrepant cases was cis-AB01, with 28 cases. This was followed by rare ABO alleles (B309, B306, A204, Bw29, and Ax01) with 14 cases, and blood chimera with 5 cases. Five new alleles were identified during the investigation. Conclusion: This study reaffirms that cis-AB is the most common cause of inherited ABO discrepancies, and cis-AB01 is the most prevalent cis-AB allele in the Korean population, also in the southeastern region. In addition, we discovered five new alleles and five blood chimeras by adopting sequencing analysis and additional molecular techniques to resolve ABO discrepancies, which provide regional data on rare alleles. This study presents rare and new ABO alleles and blood chimeras identified over a ten-year period at two major university hospitals in Southeastern Korea.

• 대한통합의학회지
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• 제12권2호
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• pp.1-10
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• 2024

Purpose : Sarcopenic obesity is associated with adverse health consequences in females. Nevertheless, there has been limited research on the hazardous components and prevailing rates of sarcopenic obesity among younger women. This study aimed to identify the hazardous components and prevailing rates of sarcopenic obesity in younger females. Methods : This study utilized data based on 2008~2011 from the Korea National Health and Nutrition Examination Surveys by the centers for disease control and prevention. The analysis was concentrated on a subset of 1,520 women aged between 30 and 39 years of age. The participants answered a questionnaire to gather demographic information. They then underwent a physical examination to measure the human detention variables, which was conducted utilizing bioelectrical impedance analysis. The blood pressure and blood laboratory tests were determined using established laboratory protocols for evaluating blood parameters. Results : This study included 1,520 patients aged 30~39 years old. The mean age of the participants was 34.97 (years)±2.74 and the overall prevailing rate was 1.84 %. The hazard components in human dimensions were the height, weight, body mass index (BMI), waist circumference (WC) and skeletal muscle mass index (SMI). The hazard components in biochemical and blood pressure were high fasting glucose, increased triglyceride, elevated total cholesterol, high systolic blood pressure, and increased diastolic blood pressure with p-values <.05. Conclusion : This study examined the hazardous components and prevailing rates of sarcopenic obesity in younger women living in the community. The results contribute to the current body of knowledge on sarcopenic obesity and shed light on possible hazardous components in a younger female population. Based on these findings, there should be increased health and medical attention towards the prevention, management, and health promotion related to reducing risk factors for sarcopenic obesity in younger women.

• 한국음향학회지
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• 제36권5호
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• pp.361-369
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• 2017

뇌혈관 질환의 발생 및 진행 기작을 이해하고 그 질환의 조기진단과 진행예측을 위해서는 경동맥 분지에서의 혈류역학 정보가 매우 중요하다. 본 논문에서는 정상인 경동맥 분지 탄성 모형 혈관과 생체 외 돼지혈액을 이용하여 모의박동 혈액 순환 시스템을 구축하여 혈류를 조절하면서 혈관과 혈액의 초음파 영상을 내부 압력과 시간 동기화하여 측정하였다. 박동 펌프의 박동률이 분당 20회, 40회, 60회(r/min)일 때의 초음파 영상의 에코 값, 혈류속도, 혈관 벽의 움직임, 혈압을 펌프의 5주기 동안 평균하여 한 주기의 데이터를 추출하였다. 결과로 박동률이 20 r/min, 40 r/min, 60 r/min일때 수축기 최고 혈류 속도는 각각 20 cm/s, 25 cm/s, 40 cm/s, 혈압 차는 각각 30 mmHg, 70 mmHg, 85 mmHg, 동맥벽은 각각 0.05 mm, 0.15 mm, 0.25 mm로 확장 하였다. 에코의 주기적 변화는 혈류속도와 압력과는 시간 지연이 있었으며 20 r/min에서는 변화량이 최소였다. 이러한 시간 동기화된 인자들의 주기적 변화는 전산혈류역학 실험의 정확한 입력정보와 검증을 위한 중요한 정보이며 경동맥 협착 질환의 발생 및 진행 기작을 밝히는데도 유용한 정보를 제공할 것이다.

• Journal of Chest Surgery
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• 제49권3호
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• pp.145-150
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• 2016

Background: Extracorporeal circulation (ECC) can induce alterations in blood viscoelasticity and cause red blood cell (RBC) aggregation. In this study, the authors evaluated the effects of pump flow pulsatility on blood viscoelasticity and RBC aggregation. Methods: Mongrel dogs were randomly assigned to two groups: a nonpulsatile pump group (n=6) or a pulsatile pump group (n=6). After ECC was started at a pump flow rate of 80 mL/kg/min, cardiac fibrillation was induced. Blood sampling was performed before and at 1, 2, and 3 hours after ECC commencement. To eliminate bias induced by hematocrit and plasma, all blood samples were adjusted to a hematocrit of 45% using baseline plasma. Blood viscoelasticity, plasma viscosity, hematocrit, arterial blood gas analysis, central venous $O_2$ saturation, and lactate were measured. Results: The blood viscosity and aggregation index decreased abruptly 1 hour after ECC and then remained low during ECC in both groups, but blood elasticity did not change during ECC. Blood viscosity, blood elasticity, plasma viscosity, and the aggregation index were not significantly different in the groups at any time. Hematocrit decreased abruptly 1 hour after ECC in both groups due to dilution by the priming solution used. Conclusion: After ECC, blood viscoelasticity and RBC aggregation were not different in the pulsatile and nonpulsatile groups in the adult dog model. Furthermore, pulsatile flow did not have a more harmful effect on blood viscoelasticity or RBC aggregation than nonpulsatile flow.

• 동의생리병리학회지
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• 제31권2호
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• pp.118-125
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• 2017

The purpose of this study is to investigate the blood pressure reducing effect of Qi-Ju-Di-Huang-Wan (QJDHW) in adults with essential hypertension by using methods of systemic review and meta-analysis. Major search engines, such as PubMed, EMBASE, Cochrane library, Web of Science, CNKI, CiNii, J-STAGE, KISS, NDSL, RISS, OASIS, DBpia and so on, were used. The search period we used is from the start date of the search engine to October 30, 2016 and no language limits were placed. Randomized controlled trials using QJDHW in adults with essential hypertension were searched and extracted by two independent researchers. Meta-analysis was performed on outcome variables of the total effective rate (TER), systolic blood pressure (SBP) and diastolic blood pressure (DBP). Risk of bias (RoB) of Cochrane was used to assess methodological quality. Thirteen studies were finally selected. We observed that the combined treatment of QJDHW and antihypertensive drug had 3.6 times the odds ratio of TER for blood pressure lowering than a single use of an antihypertensive drug. Additionally, mean differences of SBP and DBP were -8.88 mmHg (95% Confidential Interval (CI) -12.77 mmHg, -5.00 mmHg, P<0.00001), -7.09 mmHg (95% CI -9.93, -4.25, P <0.00001), respectively. Single use of QJDHW did not reduce blood pressure more than an antihypertensive drug. All items of RoB were unclear and the methodological quality was low. Our analysis suggests that the combination of QJDHW and antihypertensive drugs may be more effective in reducing blood pressure than a single antihypertensive drug. But due to low methodological quality, careful interpretation will be needed and systematic long-term clinical trials will be required.

• 한국임상수의학회지
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• 제18권1호
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• pp.74-77
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• 2001

A ten-year-old, male cat presented with recent loss of body weight, depression, vomiting, anorexia, polydipsia, and polyuria. General physical findings included depression, weakness, severe dehydration and a strong acetone odor on the breath. A complete blood count and serum biochemical profiles were leukocytosis, hyperglycemia (286 mg/dl), hypokalemia (2.6 mEq/L), hyponatremia, and high serum fructosamine (600 $\mu$mol/L). In blood gas analysis the cat had acidosis (pH 7.127, p$CO_2$26.7 mmHg). In urinalysis glycosuria and ketouria were appeared. On the basis of clinical signs, serum chemistry, blood gas analysis and urinalysis, diabetic ketoacidosis was diagnosed. Treatment included subcutaneous administration of protamine zinc insulin (0.75 U/head) and intravenous administration of 0.9% saline. Potassium phosphate and sodium bicarbonate was added to the fluids. Serum fructosamine for assessment of glycemic control was measured on occasion calls. On day 296, the patient improved clinically and did not experience any problems resulting from diabetic ketoacidosis.

• Journal of Nutrition and Health
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• 제27권4호
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• pp.368-377
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• 1994

The purpose of this study was to investigate determining factors which influence the riboflavin and pyridoxin nutritional status of korean newborns. The riboflavin and pyridoxine nutriture were evaluated by measuring the enzymecoenzyme saturation kinetics of erythrocyte glutathione reductase and alanine aminotransferase. The subjects were 259 newborns and their mothers. The average activity coefficent values of the cord blood EALAT was 1.4$\pm$0.11 and 32% of the samples had EALATAC values greater than 1.25. EGRAC was 1.26$\pm$0.12 and 27.4 of the blood samples had EALATAC values greater than 1.25. Vitamine B6 nutrition of the newborns whose mothers consumed more energy, protein and vitamine B6 was better as cord blood EALATAC values were found to the lower in this group. A stepwise multiple regression analysis showed that birth length and mother's age significantly influenced EGRAC values, positive and negative ways, respectively.