• Progress in Medical Physics
• /
• v.8 no.1
• /
• pp.75-82
• /
• 1997

The human physiological systems are so complex and irregular dynamics. Dynamics of peripheral blood vessel, in particular, have quite sensitive and complex. Before, the linear analytic method have been used to analyze the system. But, the method have many problems to predict the following results. In the other hand, the nonlinear analytic method, chaotic time series analysis method, is suitable for measuring complex, vary system. In this study, the scalar data of the blood flow of peripheral blood vessel of rabbits, in accordance with injection of glucose, was obtained and redefined as multi-dimensional vectors, with time-series analytic methods. This study also intended to confirm that the peripheral blood flow is chaotic dynamics and evaluate the availability of non-linear analytic method. As a result, the existing FFT, and mean could show the difference of blood flow of peripheral blood vessel by injection of glucose, but the nonlinear analytic method could show the definite difference. The hemodynamics is a chaotic phenomenon.

• Journal of Environmental Health Sciences
• /
• v.33 no.5
• /
• pp.386-391
• /
• 2007

Mercury contamination and its health effects have become major concern of environmental health study in Korea. Mercury exposure of some group were investigated to get the accurate data for policy making and study. About 2,000 children at 26 elementary schools participated in this survey to evaluate the exposure levels and to investigate main exposure source of mercury. Analysis of mercury levels in the whole blood and urine samples were conducted and questionnaire survey was done about the factors influencing exposures simultaneously. Mercury exposure levels of domestic children were N.D. to 17.26 ppb in blood, 0.17 to $21.67{\mu}g/g$-creatinine in urine. The mean(arithmetic) levels are 2.42 ppb in blood and $2.53{\mu}g/g$-creatinine in urine. Both of them were below the recommendation levels of US EPA and German CHBM I $5.8{\mu}g/l$ and $5{\mu}g/l$ in blood, $5{\mu}g/g$-creatinine of German CHBM I in urine. But 1%, 0.51% of levels in blood exceed the level of CHBM I and US EPA, 8%, 0.85% of children were over the level of CHBM I and CHBM II in urine. Multi-valuable regression analysis showed that the existence of road near the residence in addition to the preference for fish have significance with blood mercury exposure level of domestic children. The existence of factory near the house and the experience of dental amalgam treatment had statistical relations with urine mercury level.

• Journal of Environmental Health Sciences
• /
• v.38 no.6
• /
• pp.482-492
• /
• 2012

Objectives: The main purpose of this study is to produce background data which can be compared with data on vulnerable areas such as industrial complexes in Ulsan, SihwaBanwol, Gwangyang, Yeosu, Pohang, Cheongju and Daesan in Korea. Methods: This study was performed on 1,007 local residents in Gangneung using personal questionnaires and medical check-up. Environmental pollutants including heavy metals in blood and urine were analyzed and the results are as follows. Results: According to the results of medical check-up, 705 subjects were "Normal (A and B)", 232 subjects were "Disease doubtful (R1)" and 70 subjects were "High blood pressure or Diabetes doubtful (R2)". Regarding geometric mean concentration, blood lead was 1.57 ${\mu}g/dL$, urine cadmium was 0.82 ${\mu}g/g-cr$, urine mercury was 0.98 ${\mu}g/g-cr$ and urine arsenic was 15.78 ${\mu}g/g-cr$. In the analysis of 11 kinds of VOCs in blood, vinyl chloride, 1,3-butadiene and dichloroethylene were not detected, while the detection rate of other chemicals was above 70% except chloroform(49.7%) and trichloroethylene(19.0%). In analysis of 16 kinds of PAHs in blood, 10 kinds showed more than 80% in detection rate. Also, detection rate of 4 kinds of PCBs in blood ranged 52 to 78%. Conclusions: Compared with industrial compelxes, the concentration of blood lead was lower, while urine cadmium and mercury levels were similar. Also, urine arsenic ranged at a significant level. Further study is required to find the cause of regional differences in concentrations of environmental pollutants.

• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.5
• /
• pp.3105-3108
• /
• 2013

Background: This study used National Health and Nutrition Examination Survey III to study the relationship between blood lead concentration and all cause, all cancer and lung cancer mortality in adults. Patients and Methods: Public use National Health and Nutrition Examination Survey (NHANES III) data were used. NHANES III uses stratified, multistage probabilistic methods to sample nationally representative samples. Household adult, laboratory and mortality data were merged. Sample persons who were available to be examined in aMobile Examination Center (MEC) were included in this study. Specialized survey analysis software was used. Results: A total of 3,482 sample participants with complete information for all variables were included in this analysis. For all cause death, the odds ratios (S.E.) for statistically significant variables were body mass index, 1.03 (1.01-1.06); 1.01 (1.01-1.01); blood lead concentration, 1.05 (1.01-1.08); poverty income ratio, 0.823 (0.76-0.89); and drinking hard liquor, 1.01 (1.00-1.02). For all cancer mortality, the odds ratios (S.E.) of the statistically signigicant variables were: age, 1.01 (1.01-1.01); blood lead concentration, 1.07 (1.04-1.12), black race, using non-Hispanic white as reference, 1.69 (1.12-2.56); and smoking, 1.02 (1.01-1.04). For lung cancer mortality, the odds ratios (S.E.) of the statistically significant variables were: age, 1.01(1.01-1.01); blood lead concentration, 1.09 (1.05-1.13); Mexican Americans, using non-Hispanic white as refrence, 0.33 (0.129-0.850); other races, 1.80 (0.53-6.18); and smoking, 1.03 (1.02-1.05). Conclusion: Blood lead concentration correlated with all cause, all cancer, and lung cancer mortality in adults.

• The Journal of Korean Physical Therapy
• /
• v.17 no.3
• /
• pp.403-412
• /
• 2005

The purpose of this investigation is examining how treatment for foot reflex massage affect the changes in body temperature and blood composition. The cases of experiment are 10 male(n=2) and female(n=8) who don't have special clinical problems. This is the process of experiment. First, we photograph the anterior part and posterior of the upper, lower half of the body with an infrared imaging system. Second, among same parts, we compare the temperature of the whole body before treatment for foot reflex massage with the temperature after it. Then we draw blood from the body and observe a change: in numerical value of blood before and after treatment. Before and after treatment, we come to measure temperature of the whole body, the numerical value of WBC, RBC, platelet, HCT, Hb through analysis of blood, and the result of AST(GOT), ALT(GPT), ALP, GGT through analysis of serum enzyme activity of blood. There were no significant differences in blood composition. In terms of SPSS statistic program, when we explain each numerical value before and after foot massage, the abdominal, the buttocks, the femoral region universally take successful results about a change in body temperature(p<0.05).

• Journal of the Korea Convergence Society
• /
• v.10 no.8
• /
• pp.53-58
• /
• 2019

Recently, product research has been continuously conducted to enhance accessibility to blood pressure measurement for the purpose of healthcare for the chronic patient. In previous studies, electrocardiogram (ECG) and photoelectric pulse wave (PPG) are analyzed to calculate systolic and diastolic blood pressure. The problem is the development of analysis algorithms for accuracy and reproducibility. In this study, in the development stage of a micro blood pressure measuring device, the size of the device was reduced and the measurement method was simplified, while the algorithm was to extract systolic blood pressure (SBP) using only two PPGs and obtain diastolic blood pressure (DBP). The difference value of PPG, DF_P, is inversely related to SBP, and has a proportional relationship with DBP, which can be leaked by algorithm, and DBP can be tracked through SBP.

• Journal of Korean Society of Occupational and Environmental Hygiene
• /
• v.29 no.2
• /
• pp.195-207
• /
• 2019

Objectives: This study was performed to confirm whether plasma lead can be used as a chronic biomarker for the biological monitoring of exposure to lead. Methods: Lead concentrations in 66 plasma samples from retired lead workers (G.M. 60.25 years, Median 61.00 years) and 42 plasma samples from the general population (G.M. 53.76 years, Median 56.50 years) were measured using ICP/Mass. Tibia, whole blood, hemoglobin, hematocrit, and blood zinc protophorphyrin (ZPP) concentrations and urinary ${\delta}$-aminolevulinic acid (${\delta}-ALA$) were measured for correlation analysis with plasma lead. Results: The geometric mean concentration of lead in plasma was $0.23{\mu}g/L$ for the retired lead workers and $0.10{\mu}g/L$ for the general population sample. A simple correlation analysis of biomarkers showed that plasma lead concentration among the retired lead workers was highly correlated with lead concentration in the tibia and with blood lead concentration, and the plasma lead concentration among the general population correlated with ZPP concentration in the blood. The lead concentration in the tibia and the lead concentration in the whole blood increased with length of working period. As the period in the lead workplace increased, the ratio of lead in plasma to lead concentration in whole blood decreased. Conclusion: This study confirmed the possibility of a chronic biomarker of lead concentration in blood plasma as a biomarker. In the future, comparative studies with specific indicators will lead to more fruitful results.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.24 no.11
• /
• pp.1411-1416
• /
• 2020

In this paper, we propose a method of extraction analysis of blood flow area on color doppler ultrasonography by using 4-directional contour tracking and K-Means algorithm. In the proposed method, ROI is extracted and a binarization method with maximum contrast as a threshold is applied to the extracted ROI. 4-directional contour algorithm is applied to extract the trapezoid shaped region which has blood flow area of brachial artery from the binarized ROI. K-Means based quantization is then applied to accurately extract the blood flow area of brachial artery from the trapezoid shaped region. In experiment, the proposed method successfully extracts the target area in 28 out of 30 cases (93.3%) with field expert's verification. And comparison analysis of proposed K-Means based blood flow area extraction on 30 color doppler ultrasonography and brachial artery blood flow ultrasonography provided by a specialist yielded a result of 94.27% accuracy on average.

• Journal of Environmental Science International
• /
• v.22 no.1
• /
• pp.59-72
• /
• 2013

The purpose of this study is to assess the effects of heavy metal concentrations in the blood and urine of the general population. This research had been conducted from April to December 2008, studying 545 residents of Daejeon and Chungcheong Province. Through the concentrations of heavy metals(Pb, Cd, Hg, As, Mn) in the biota samples and questionnaires, the residents heavy metal exposure level and the influential factors according to personal characteristics or lifestyle were evaluated. As to the heavy metal concentration in the blood and urine of the comparing region, were As and Mn statistically significant(p<0.01, p<0.05). Blood lead and urinary mercury concentrations were higher in males than females. The heavy metal concentration for each age group increased blood mercury. The concentration of all heavy metals were higher in the drinkers than in the non-drinkers. Blood lead and mercury concentrations were higher in the smokers than in the non-smokers, but the urinary cadmium, arsenic and blood manganese was higher in the non-smokers than in the smokers. As to the blood lead and urinary cadmium concentration according to the food preference fish showed high concentration. To clarify the factors affecting the heavy metal concentration in biota among subjects multiple regression analysis was conducted. As a results, it turned out that as to lead content in blood, sex, age and smoking have influence on the subjects with explanatory adequacy of 14.0 %. These results demonstrated that the factors affected the concentrations of heavy metals in blood and urine. The results of this study could be used as the foundational data for setting the health risk assessment.

• Environmental Analysis Health and Toxicology
• /
• v.24 no.3
• /
• pp.193-202
• /
• 2009

In this study, we analyzed the blood cadmium concentration in general population of Korea, and followed the analyses the relations with epidemiologic factors, life-style and body iron store. The geometric mean concentration of blood cadmium was 1.20 ${\mu}g/L$ in study subject, the level of blood cadmium was higher in female (1.27 ${\mu}g/L$) than in male (1.11 ${\mu}g/L$). The mean concentration of blood cadmium was the highest in coastal area (1.80 ${\mu}g/L$) and followed in urban (1.01 ${\mu}g/L$) and rural area (0.90 ${\mu}g/L$). The cadmium concentration in whole blood was increased with age-dependent pattern, such as 0.64 ${\mu}g/L$ in the below 30 years, 0.95 ${\mu}g/L$ in the 30~44 years, 1.28 ${\mu}g/L$ in the 45~59 years and 1.31 ${\mu}g/L$ in the over 60 years. The level of blood cadmium was higher in smokers than in non-smokers, but was not significant by alcoholic habit. The blood cadmium level was different from occupations, which was the highest in the fishers as 1.87 ${\mu}g/L$. The inversed relation was observed between blood cadmium and serum Fe, while was correlated positively with the ferritin level. In summary, the environmental exposure to cadmium in Korean is not so much compared to other countries, and the blood cadmium is influenced by genetic factors (age and sex), life-styles (dietary habit, occupation and smoking habit) and nutrition such as serum iron.